Q91Z84 (IL23A_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-23 subunit alpha
Short name=IL-23 subunit alpha
Short name=IL-23-A

Alternative name(s):
Interleukin-23 subunit p19
Short name=IL-23p19

Gene names

Name:

Il23a

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis By similarity.
Subunit structure	Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23 By similarity.
Subcellular location	Secreted By similarity. Note: Secreted upon association with IL12B By similarity.
Sequence similarities	Belongs to the IL-6 superfamily.

Ontologies

Keywords
Biological process	Antiviral defense Immunity Inflammatory response Innate immunity Tissue remodeling
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T cell proliferation Inferred from electronic annotation. Source: Compara defense response to Gram-negative bacterium Inferred from electronic annotation. Source: Compara defense response to virus Inferred from electronic annotation. Source: UniProtKB-KW inflammatory response Inferred from electronic annotation. Source: UniProtKB-KW innate immune response Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of interleukin-10 production Inferred from electronic annotation. Source: Compara positive regulation of NK T cell activation Inferred from electronic annotation. Source: Compara positive regulation of NK T cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of T cell mediated cytotoxicity Inferred from electronic annotation. Source: Compara positive regulation of T-helper 1 type immune response Inferred from electronic annotation. Source: Compara positive regulation of T-helper 17 cell lineage commitment Inferred from electronic annotation. Source: Compara positive regulation of T-helper 17 type immune response Inferred from electronic annotation. Source: Compara positive regulation of activated T cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of activation of JAK2 kinase activity Inferred from electronic annotation. Source: Compara positive regulation of defense response to virus by host Inferred from electronic annotation. Source: Compara positive regulation of granulocyte macrophage colony-stimulating factor production Inferred from electronic annotation. Source: Compara positive regulation of interferon-gamma production Inferred from electronic annotation. Source: Compara positive regulation of interleukin-10 production Inferred from electronic annotation. Source: Compara positive regulation of interleukin-12 production Inferred from electronic annotation. Source: Compara positive regulation of interleukin-17 production Inferred from electronic annotation. Source: Compara positive regulation of memory T cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of natural killer cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of neutrophil chemotaxis Inferred from electronic annotation. Source: Compara positive regulation of osteoclast differentiation Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara positive regulation of tumor necrosis factor production Inferred from electronic annotation. Source: Compara positive regulation of tyrosine phosphorylation of Stat3 protein Inferred from electronic annotation. Source: Compara positive regulation of tyrosine phosphorylation of Stat4 protein Inferred from electronic annotation. Source: Compara positive regulation of tyrosine phosphorylation of Stat5 protein Inferred from electronic annotation. Source: Compara regulation of tyrosine phosphorylation of Stat1 protein Inferred from electronic annotation. Source: Compara tissue remodeling Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	interleukin-23 complex Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 196	175	Interleukin-23 subunit alpha		PRO_0000259491

Sequences

	Sequence		Length	Mass (Da)
	Q91Z84 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 188FF74BC409A961	FASTA	196	21,986
	10 20 30 40 50 60 MLDCRAIILL WLLPWATQGL AVPRSSSPDW AQCQQLSRNL CTLAWSAHTP VGQMDLLREE 70 80 90 100 110 120 GEEETKSDVP RIQCGDGCDP QGLKDNSQFC LQRIRQGLVF YKHLLDSDIF TGEPSLLPDS 130 140 150 160 170 180 PVDQLHTSLL GLSQLLQPED HHWETQQMPR LSPSQQWQRS LLRSKILRSL QAFLAIAARV 190 FAHGAATLTE PLVPTA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Rattus norvegicus IL-23 mRNA." Tran G., Hodgkinson S. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Lewis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Brown Norway. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY055379 mRNA. Translation: AAL18229.1. BC098907 mRNA. Translation: AAH98907.1.
IPI	IPI00209334.
RefSeq	NP_569094.1. NM_130410.2.
UniGene	Rn.81073.
3D structure databases
ProteinModelPortal	Q91Z84.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000004363.
Proteomic databases
PaxDb	Q91Z84.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000004363; ENSRNOP00000004363; ENSRNOG00000003254.
GeneID	155140.
KEGG	rno:155140.
UCSC	RGD:620873. rat.
Organism-specific databases
CTD	51561.
RGD	620873. Il23a.
Phylogenomic databases
eggNOG	NOG42887.
GeneTree	ENSGT00390000006482.
HOGENOM	HOG000048728.
HOVERGEN	HBG081786.
InParanoid	Q91Z84.
KO	K05426.
OMA	IHQGLVF.
OrthoDB	EOG43BMQ2.
Gene expression databases
Genevestigator	Q91Z84.
GermOnline	ENSRNOG00000003254. Rattus norvegicus.
Family and domain databases
Gene3D	1.20.1250.10. 1 hit.
InterPro	IPR009079. 4_helix_cytokine-like_core. IPR012351. 4_helix_cytokine_core. IPR010831. IL23A. IPR003573. IL6_MGF_GCSF. [Graphical view]
PANTHER	PTHR15947. PTHR15947. 1 hit.
Pfam	PF00489. IL6. 1 hit. [Graphical view]
SUPFAM	SSF47266. 4_helix_cytokine. 1 hit.
ProtoNet	Search...
Other
NextBio	620879.

Entry information

Entry name

IL23A_RAT

Accession

Primary (citable) accession number: Q91Z84

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program