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Q91Z84 (IL23A_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-23 subunit alpha

Short name=IL-23 subunit alpha
Short name=IL-23-A
Alternative name(s):
Interleukin-23 subunit p19
Short name=IL-23p19
Gene names
Name:Il23a
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length196 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis By similarity.

Subunit structure

Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23 By similarity.

Subcellular location

Secreted By similarity. Note: Secreted upon association with IL12B By similarity.

Sequence similarities

Belongs to the IL-6 superfamily.

Ontologies

Keywords
   Biological processAntiviral defense
Immunity
Inflammatory response
Innate immunity
Tissue remodeling
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processT cell proliferation

Inferred from electronic annotation. Source: Ensembl

defense response to Gram-negative bacterium

Inferred from electronic annotation. Source: Ensembl

defense response to virus

Inferred from electronic annotation. Source: UniProtKB-KW

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

innate immune response

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of interleukin-10 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of NK T cell activation

Inferred from electronic annotation. Source: Ensembl

positive regulation of NK T cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of T cell mediated cytotoxicity

Inferred from electronic annotation. Source: Ensembl

positive regulation of T-helper 1 type immune response

Inferred from electronic annotation. Source: Ensembl

positive regulation of T-helper 17 cell lineage commitment

Inferred from electronic annotation. Source: Ensembl

positive regulation of T-helper 17 type immune response

Inferred from electronic annotation. Source: Ensembl

positive regulation of activated T cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of activation of JAK2 kinase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of defense response to virus by host

Inferred from electronic annotation. Source: Ensembl

positive regulation of granulocyte macrophage colony-stimulating factor production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interferon-gamma production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-10 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-12 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-17 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of memory T cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of natural killer cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of neutrophil chemotaxis

Inferred from electronic annotation. Source: Ensembl

positive regulation of osteoclast differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

positive regulation of tumor necrosis factor production

Inferred from electronic annotation. Source: Ensembl

positive regulation of tyrosine phosphorylation of Stat3 protein

Inferred from electronic annotation. Source: Ensembl

positive regulation of tyrosine phosphorylation of Stat4 protein

Inferred from electronic annotation. Source: Ensembl

positive regulation of tyrosine phosphorylation of Stat5 protein

Inferred from electronic annotation. Source: Ensembl

regulation of tyrosine phosphorylation of Stat1 protein

Inferred from electronic annotation. Source: Ensembl

tissue remodeling

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentinterleukin-23 complex

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 196175Interleukin-23 subunit alpha
PRO_0000259491

Sequences

Sequence LengthMass (Da)Tools
Q91Z84 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 188FF74BC409A961

FASTA19621,986
        10         20         30         40         50         60 
MLDCRAIILL WLLPWATQGL AVPRSSSPDW AQCQQLSRNL CTLAWSAHTP VGQMDLLREE 

        70         80         90        100        110        120 
GEEETKSDVP RIQCGDGCDP QGLKDNSQFC LQRIRQGLVF YKHLLDSDIF TGEPSLLPDS 

       130        140        150        160        170        180 
PVDQLHTSLL GLSQLLQPED HHWETQQMPR LSPSQQWQRS LLRSKILRSL QAFLAIAARV 

       190 
FAHGAATLTE PLVPTA 

« Hide

References

« Hide 'large scale' references
[1]"Rattus norvegicus IL-23 mRNA."
Tran G., Hodgkinson S.
Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Lewis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Brown Norway.
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY055379 mRNA. Translation: AAL18229.1.
BC098907 mRNA. Translation: AAH98907.1.
RefSeqNP_569094.1. NM_130410.2.
UniGeneRn.81073.

3D structure databases

ProteinModelPortalQ91Z84.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000004363.

Proteomic databases

PaxDbQ91Z84.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000004363; ENSRNOP00000004363; ENSRNOG00000003254.
GeneID155140.
KEGGrno:155140.
UCSCRGD:620873. rat.

Organism-specific databases

CTD51561.
RGD620873. Il23a.

Phylogenomic databases

eggNOGNOG42887.
GeneTreeENSGT00390000006482.
HOGENOMHOG000048728.
HOVERGENHBG081786.
InParanoidQ91Z84.
KOK05426.
OMAIHQGLVF.
OrthoDBEOG76HQ32.
PhylomeDBQ91Z84.
TreeFamTF337234.

Gene expression databases

GenevestigatorQ91Z84.

Family and domain databases

Gene3D1.20.1250.10. 1 hit.
InterProIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR010831. IL-23_alpha.
IPR003573. IL-6/IL-23/GCSF/MGF.
[Graphical view]
PANTHERPTHR15947. PTHR15947. 1 hit.
PfamPF00489. IL6. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
ProtoNetSearch...

Other

NextBio620879.
PROQ91Z84.

Entry information

Entry nameIL23A_RAT
AccessionPrimary (citable) accession number: Q91Z84
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families