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Protein

Interleukin-23 subunit alpha

Gene

Il23a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense, Immunity, Inflammatory response, Innate immunity, Tissue remodeling

Enzyme and pathway databases

ReactomeiR-RNO-9020933 Interleukin-23 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-23 subunit alpha
Short name:
IL-23 subunit alpha
Short name:
IL-23-A
Alternative name(s):
Interleukin-23 subunit p19
Short name:
IL-23p19
Gene namesi
Name:Il23a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi620873 Il23a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000025949122 – 196Interleukin-23 subunit alphaAdd BLAST175

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ91Z84

Expressioni

Gene expression databases

BgeeiENSRNOG00000003254
GenevisibleiQ91Z84 RN

Interactioni

Subunit structurei

Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004363

Structurei

3D structure databases

ProteinModelPortaliQ91Z84
SMRiQ91Z84
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IGBY Eukaryota
ENOG411142Q LUCA
GeneTreeiENSGT00390000006482
HOGENOMiHOG000048728
HOVERGENiHBG081786
InParanoidiQ91Z84
KOiK05426
OMAiPMGHVDL
OrthoDBiEOG091G0Q9J
PhylomeDBiQ91Z84
TreeFamiTF337234

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR010831 IL-23_alpha
PANTHERiPTHR15947 PTHR15947, 1 hit
PfamiView protein in Pfam
PF16649 IL23, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91Z84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDCRAIILL WLLPWATQGL AVPRSSSPDW AQCQQLSRNL CTLAWSAHTP
60 70 80 90 100
VGQMDLLREE GEEETKSDVP RIQCGDGCDP QGLKDNSQFC LQRIRQGLVF
110 120 130 140 150
YKHLLDSDIF TGEPSLLPDS PVDQLHTSLL GLSQLLQPED HHWETQQMPR
160 170 180 190
LSPSQQWQRS LLRSKILRSL QAFLAIAARV FAHGAATLTE PLVPTA
Length:196
Mass (Da):21,986
Last modified:December 1, 2001 - v1
Checksum:i188FF74BC409A961
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY055379 mRNA Translation: AAL18229.1
BC098907 mRNA Translation: AAH98907.1
RefSeqiNP_569094.1, NM_130410.2
UniGeneiRn.81073

Genome annotation databases

EnsembliENSRNOT00000004363; ENSRNOP00000004363; ENSRNOG00000003254
GeneIDi155140
KEGGirno:155140
UCSCiRGD:620873 rat

Similar proteinsi

Entry informationi

Entry nameiIL23A_RAT
AccessioniPrimary (citable) accession number: Q91Z84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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