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Protein

Interleukin-23 subunit alpha

Gene

Il23a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity).By similarity

GO - Molecular functioni

  1. interleukin-23 receptor binding Source: GO_Central

GO - Biological processi

  1. defense response to Gram-negative bacterium Source: Ensembl
  2. defense response to virus Source: UniProtKB-KW
  3. inflammatory response Source: UniProtKB-KW
  4. innate immune response Source: UniProtKB-KW
  5. negative regulation of interleukin-10 production Source: Ensembl
  6. positive regulation of activated T cell proliferation Source: Ensembl
  7. positive regulation of activation of JAK2 kinase activity Source: GO_Central
  8. positive regulation of defense response to virus by host Source: Ensembl
  9. positive regulation of granulocyte macrophage colony-stimulating factor production Source: Ensembl
  10. positive regulation of interferon-gamma production Source: Ensembl
  11. positive regulation of interleukin-10 production Source: Ensembl
  12. positive regulation of interleukin-12 production Source: Ensembl
  13. positive regulation of interleukin-17 production Source: Ensembl
  14. positive regulation of memory T cell differentiation Source: Ensembl
  15. positive regulation of natural killer cell proliferation Source: Ensembl
  16. positive regulation of neutrophil chemotaxis Source: Ensembl
  17. positive regulation of NK T cell activation Source: Ensembl
  18. positive regulation of NK T cell proliferation Source: Ensembl
  19. positive regulation of osteoclast differentiation Source: Ensembl
  20. positive regulation of T cell mediated cytotoxicity Source: Ensembl
  21. positive regulation of T cell proliferation Source: GO_Central
  22. positive regulation of T-helper 17 cell lineage commitment Source: GO_Central
  23. positive regulation of T-helper 1 type immune response Source: Ensembl
  24. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  25. positive regulation of tumor necrosis factor production Source: Ensembl
  26. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
  27. positive regulation of tyrosine phosphorylation of Stat4 protein Source: Ensembl
  28. positive regulation of tyrosine phosphorylation of Stat5 protein Source: Ensembl
  29. regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
  30. T cell proliferation Source: Ensembl
  31. tissue remodeling Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Antiviral defense, Immunity, Inflammatory response, Innate immunity, Tissue remodeling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-23 subunit alpha
Short name:
IL-23 subunit alpha
Short name:
IL-23-A
Alternative name(s):
Interleukin-23 subunit p19
Short name:
IL-23p19
Gene namesi
Name:Il23a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi620873. Il23a.

Subcellular locationi

  1. Secreted By similarity

  2. Note: Secreted upon association with IL12B.By similarity

GO - Cellular componenti

  1. interleukin-23 complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 196175Interleukin-23 subunit alphaPRO_0000259491Add
BLAST

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ91Z84.

Expressioni

Gene expression databases

GenevestigatoriQ91Z84.

Interactioni

Subunit structurei

Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004363.

Structurei

3D structure databases

ProteinModelPortaliQ91Z84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42887.
GeneTreeiENSGT00390000006482.
HOGENOMiHOG000048728.
HOVERGENiHBG081786.
InParanoidiQ91Z84.
KOiK05426.
OMAiIHQGLVF.
OrthoDBiEOG76HQ32.
PhylomeDBiQ91Z84.
TreeFamiTF337234.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR010831. IL-23_alpha.
IPR003573. IL-6/IL-23/GCSF/MGF.
[Graphical view]
PANTHERiPTHR15947. PTHR15947. 1 hit.
PfamiPF00489. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91Z84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDCRAIILL WLLPWATQGL AVPRSSSPDW AQCQQLSRNL CTLAWSAHTP
60 70 80 90 100
VGQMDLLREE GEEETKSDVP RIQCGDGCDP QGLKDNSQFC LQRIRQGLVF
110 120 130 140 150
YKHLLDSDIF TGEPSLLPDS PVDQLHTSLL GLSQLLQPED HHWETQQMPR
160 170 180 190
LSPSQQWQRS LLRSKILRSL QAFLAIAARV FAHGAATLTE PLVPTA
Length:196
Mass (Da):21,986
Last modified:December 1, 2001 - v1
Checksum:i188FF74BC409A961
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY055379 mRNA. Translation: AAL18229.1.
BC098907 mRNA. Translation: AAH98907.1.
RefSeqiNP_569094.1. NM_130410.2.
UniGeneiRn.81073.

Genome annotation databases

EnsembliENSRNOT00000004363; ENSRNOP00000004363; ENSRNOG00000003254.
GeneIDi155140.
KEGGirno:155140.
UCSCiRGD:620873. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY055379 mRNA. Translation: AAL18229.1.
BC098907 mRNA. Translation: AAH98907.1.
RefSeqiNP_569094.1. NM_130410.2.
UniGeneiRn.81073.

3D structure databases

ProteinModelPortaliQ91Z84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004363.

Proteomic databases

PaxDbiQ91Z84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004363; ENSRNOP00000004363; ENSRNOG00000003254.
GeneIDi155140.
KEGGirno:155140.
UCSCiRGD:620873. rat.

Organism-specific databases

CTDi51561.
RGDi620873. Il23a.

Phylogenomic databases

eggNOGiNOG42887.
GeneTreeiENSGT00390000006482.
HOGENOMiHOG000048728.
HOVERGENiHBG081786.
InParanoidiQ91Z84.
KOiK05426.
OMAiIHQGLVF.
OrthoDBiEOG76HQ32.
PhylomeDBiQ91Z84.
TreeFamiTF337234.

Miscellaneous databases

NextBioi620879.
PROiQ91Z84.

Gene expression databases

GenevestigatoriQ91Z84.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR010831. IL-23_alpha.
IPR003573. IL-6/IL-23/GCSF/MGF.
[Graphical view]
PANTHERiPTHR15947. PTHR15947. 1 hit.
PfamiPF00489. IL6. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Rattus norvegicus IL-23 mRNA."
    Tran G., Hodgkinson S.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Lewis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Brown Norway.
    Tissue: Testis.

Entry informationi

Entry nameiIL23A_RAT
AccessioniPrimary (citable) accession number: Q91Z84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 1, 2001
Last modified: February 4, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.