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Q91Z84

- IL23A_RAT

UniProt

Q91Z84 - IL23A_RAT

Protein

Interleukin-23 subunit alpha

Gene

Il23a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis By similarity.By similarity

    GO - Biological processi

    1. defense response to Gram-negative bacterium Source: Ensembl
    2. defense response to virus Source: UniProtKB-KW
    3. inflammatory response Source: UniProtKB-KW
    4. innate immune response Source: UniProtKB-KW
    5. negative regulation of interleukin-10 production Source: Ensembl
    6. positive regulation of activated T cell proliferation Source: Ensembl
    7. positive regulation of activation of JAK2 kinase activity Source: Ensembl
    8. positive regulation of defense response to virus by host Source: Ensembl
    9. positive regulation of granulocyte macrophage colony-stimulating factor production Source: Ensembl
    10. positive regulation of interferon-gamma production Source: Ensembl
    11. positive regulation of interleukin-10 production Source: Ensembl
    12. positive regulation of interleukin-12 production Source: Ensembl
    13. positive regulation of interleukin-17 production Source: Ensembl
    14. positive regulation of memory T cell differentiation Source: Ensembl
    15. positive regulation of natural killer cell proliferation Source: Ensembl
    16. positive regulation of neutrophil chemotaxis Source: Ensembl
    17. positive regulation of NK T cell activation Source: Ensembl
    18. positive regulation of NK T cell proliferation Source: Ensembl
    19. positive regulation of osteoclast differentiation Source: Ensembl
    20. positive regulation of T cell mediated cytotoxicity Source: Ensembl
    21. positive regulation of T-helper 17 cell lineage commitment Source: Ensembl
    22. positive regulation of T-helper 17 type immune response Source: Ensembl
    23. positive regulation of T-helper 1 type immune response Source: Ensembl
    24. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    25. positive regulation of tumor necrosis factor production Source: Ensembl
    26. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
    27. positive regulation of tyrosine phosphorylation of Stat4 protein Source: Ensembl
    28. positive regulation of tyrosine phosphorylation of Stat5 protein Source: Ensembl
    29. regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
    30. T cell proliferation Source: Ensembl
    31. tissue remodeling Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Antiviral defense, Immunity, Inflammatory response, Innate immunity, Tissue remodeling

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-23 subunit alpha
    Short name:
    IL-23 subunit alpha
    Short name:
    IL-23-A
    Alternative name(s):
    Interleukin-23 subunit p19
    Short name:
    IL-23p19
    Gene namesi
    Name:Il23a
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi620873. Il23a.

    Subcellular locationi

    Secreted By similarity
    Note: Secreted upon association with IL12B.By similarity

    GO - Cellular componenti

    1. interleukin-23 complex Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 196175Interleukin-23 subunit alphaPRO_0000259491Add
    BLAST

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ91Z84.

    Expressioni

    Gene expression databases

    GenevestigatoriQ91Z84.

    Interactioni

    Subunit structurei

    Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-23 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000004363.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91Z84.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-6 superfamily.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42887.
    GeneTreeiENSGT00390000006482.
    HOGENOMiHOG000048728.
    HOVERGENiHBG081786.
    InParanoidiQ91Z84.
    KOiK05426.
    OMAiIHQGLVF.
    OrthoDBiEOG76HQ32.
    PhylomeDBiQ91Z84.
    TreeFamiTF337234.

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR010831. IL-23_alpha.
    IPR003573. IL-6/IL-23/GCSF/MGF.
    [Graphical view]
    PANTHERiPTHR15947. PTHR15947. 1 hit.
    PfamiPF00489. IL6. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q91Z84-1 [UniParc]FASTAAdd to Basket

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    MLDCRAIILL WLLPWATQGL AVPRSSSPDW AQCQQLSRNL CTLAWSAHTP    50
    VGQMDLLREE GEEETKSDVP RIQCGDGCDP QGLKDNSQFC LQRIRQGLVF 100
    YKHLLDSDIF TGEPSLLPDS PVDQLHTSLL GLSQLLQPED HHWETQQMPR 150
    LSPSQQWQRS LLRSKILRSL QAFLAIAARV FAHGAATLTE PLVPTA 196
    Length:196
    Mass (Da):21,986
    Last modified:December 1, 2001 - v1
    Checksum:i188FF74BC409A961
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY055379 mRNA. Translation: AAL18229.1.
    BC098907 mRNA. Translation: AAH98907.1.
    RefSeqiNP_569094.1. NM_130410.2.
    UniGeneiRn.81073.

    Genome annotation databases

    EnsembliENSRNOT00000004363; ENSRNOP00000004363; ENSRNOG00000003254.
    GeneIDi155140.
    KEGGirno:155140.
    UCSCiRGD:620873. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY055379 mRNA. Translation: AAL18229.1 .
    BC098907 mRNA. Translation: AAH98907.1 .
    RefSeqi NP_569094.1. NM_130410.2.
    UniGenei Rn.81073.

    3D structure databases

    ProteinModelPortali Q91Z84.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000004363.

    Proteomic databases

    PaxDbi Q91Z84.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000004363 ; ENSRNOP00000004363 ; ENSRNOG00000003254 .
    GeneIDi 155140.
    KEGGi rno:155140.
    UCSCi RGD:620873. rat.

    Organism-specific databases

    CTDi 51561.
    RGDi 620873. Il23a.

    Phylogenomic databases

    eggNOGi NOG42887.
    GeneTreei ENSGT00390000006482.
    HOGENOMi HOG000048728.
    HOVERGENi HBG081786.
    InParanoidi Q91Z84.
    KOi K05426.
    OMAi IHQGLVF.
    OrthoDBi EOG76HQ32.
    PhylomeDBi Q91Z84.
    TreeFami TF337234.

    Miscellaneous databases

    NextBioi 620879.
    PROi Q91Z84.

    Gene expression databases

    Genevestigatori Q91Z84.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR010831. IL-23_alpha.
    IPR003573. IL-6/IL-23/GCSF/MGF.
    [Graphical view ]
    PANTHERi PTHR15947. PTHR15947. 1 hit.
    Pfami PF00489. IL6. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Rattus norvegicus IL-23 mRNA."
      Tran G., Hodgkinson S.
      Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Lewis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Brown Norway.
      Tissue: Testis.

    Entry informationi

    Entry nameiIL23A_RAT
    AccessioniPrimary (citable) accession number: Q91Z84
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3