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Q91Z83

- MYH7_MOUSE

UniProt

Q91Z83 - MYH7_MOUSE

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Protein

Myosin-7

Gene
Myh7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Muscle contraction By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi178 – 1858ATP

GO - Molecular functioni

  1. actin-dependent ATPase activity Source: Ensembl
  2. ATP binding Source: UniProtKB-KW
  3. motor activity Source: InterPro
  4. structural constituent of muscle Source: Ensembl

GO - Biological processi

  1. adult heart development Source: Ensembl
  2. muscle filament sliding Source: Ensembl
  3. regulation of heart rate Source: Ensembl
  4. ventricular cardiac muscle tissue morphogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-7
Alternative name(s):
Myosin heavy chain 7
Myosin heavy chain slow isoform
Short name:
MyHC-slow
Myosin heavy chain, cardiac muscle beta isoform
Short name:
MyHC-beta
Gene namesi
Name:Myh7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:2155600. Myh7.

Subcellular locationi

Cytoplasmmyofibril By similarity
Note: Thick filaments of the myofibrils By similarity.

GO - Cellular componenti

  1. focal adhesion Source: Ensembl
  2. myofibril Source: MGI
  3. myosin complex Source: MGI
  4. myosin filament Source: UniProtKB-KW
  5. nucleolus Source: Ensembl
  6. stress fiber Source: MGI
  7. Z disc Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Thick filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19351935Myosin-7PRO_0000274177Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei129 – 1291N6,N6,N6-trimethyllysine Reviewed prediction
Cross-linki207 – 207Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki213 – 213Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki1531 – 1531Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki1537 – 1537Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Methylation, Ubl conjugation

Proteomic databases

MaxQBiQ91Z83.
PaxDbiQ91Z83.
PRIDEiQ91Z83.

PTM databases

PhosphoSiteiQ91Z83.

Expressioni

Gene expression databases

ArrayExpressiQ91Z83.
BgeeiQ91Z83.
CleanExiMM_MYH7.
GenevestigatoriQ91Z83.

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2) By similarity. Interacts with ECM29 By similarity.

Protein-protein interaction databases

IntActiQ91Z83. 2 interactions.
MINTiMINT-4122197.

Structurei

3D structure databases

ProteinModelPortaliQ91Z83.
SMRiQ91Z83. Positions 2-961.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini85 – 778694Myosin motorAdd
BLAST
Domaini781 – 81030IQAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni655 – 67723Actin-bindingAdd
BLAST
Regioni757 – 77115Actin-bindingAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili840 – 19351096 Reviewed predictionAdd
BLAST

Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).

Sequence similaritiesi

Contains 1 IQ domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5022.
GeneTreeiENSGT00720000108683.
HOGENOMiHOG000173959.
HOVERGENiHBG004704.
InParanoidiQ91Z83.
KOiK17751.
OMAiITAIQAR.
OrthoDBiEOG7RBZ7G.
PhylomeDBiQ91Z83.
TreeFamiTF314375.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91Z83-1 [UniParc]FASTAAdd to Basket

« Hide

MADAEMAAFG AAAPFLRKSE KERLEAQTRP FDLKKDVFVP DDKEEFVKAK     50
IVSREGGKVT AETENGKTVT VKEDQVMQQN PPKFDKIEDM AMLTFLHEPA 100
VLYNLKERYA SWMIYTYSGL FCVTVNPYKW LPVYNAEVVA AYRGKKRSEA 150
PPHIFSISDN AYQYMLTDRE NQSILITGES GAGKTVNTKR VIQYFAVIAA 200
IGDRSKKDQT PGKGTLEDQI IQANPALEAF GNAKTVRNDN SSRFGKFIRI 250
HFGATGKLAS ADIETYLLEK SRVIFQLKAE RDYHIFYQIL SNKKPELLDM 300
LLITNNPYDY AFISQGETTV ASIDDSEELM ATDSAFDVLG FTPEEKNSIY 350
KLTGAIMHFG NMKFKQKQRE EQAEPDGTEE ADKSAYLMGL NSADLLKGLC 400
HPRVKVGNEY VTKGQNVQQV SYAIGALAKS VYEKMFNWMV TRINATLETK 450
QPRQYFIGVL DIAGFEIFDF NSFEQLCINF TNEKLQQFFN HHMFVLEQEE 500
YKKEGIEWTF IDFGMDLQAC IDLIEKPMGI MSILEEECMF PKATDMTFKA 550
KLYDNHLGKS NNFQKPRNVK GKQEAHFSLV HYAGTVDYNI LGWLQKNKDP 600
LNETVVGLYQ KSSLKLLSNL FANYAGADAP ADKGKGKAKK GSSFQTVSAL 650
HRENLNKLMT NLRSTHPHFV RCIIPNETKS PGVMDNPLVM HQLRCNGVLE 700
GIRICRKGFP NRILYGDFRQ RYRILNPAAI PEGQFIDSRK GAEKLLGSLD 750
IDHNQYKFGH TKVFFKAGLL GLLEEMRDER LSRIITRIQA QSRGVLSRME 800
FKKLLERRDS LLIIQWNIRA FMGVKNWPWM KLYFKIKPLL KSAETEKEMA 850
TMKEEFGRVK DALEKSEARR KELEEKMVSL LQEKNDLQLQ VQAEQDNLAD 900
AEERCDQLIK NKIQLEAKVK EMTERLEDEE EMNAELTAKK RKLEDECSEL 950
KRDIDDLELT LAKVEKEKHA TENKVKNLTE EMAGLDEIIV KLTKEKKALQ 1000
EAHQQALDDL QAEEDKVNTL TKAKVKLEQQ VDDLEGSLEQ EKKVRMDLER 1050
AKRKLEGDLK LTQESIMDLE NDKQQLDERL KKKDFELNAL NARIEDEQAL 1100
GSQLQKKLKE LQARIEELEE ELEAERTARA KVEKLRSDLS RELEEISERL 1150
EEAGGATSVQ IEMNKKREAE FQKMRRDLEE ATLQHEATAA ALRKKHADSV 1200
AELGEQIDNL QRVKQKLEKE KSEFKLELDD VTSNMEQIIK AKANLEKMCR 1250
TLEDQMNEHR SKAEETQRSV NDLTSQRAKL QTENGELSRQ LDEKEALISQ 1300
LTRGKLTYTQ QLEDLKRQLE EEVKAKNALA HALQSARHDC DLLREQYEEE 1350
TEAKAELQRV LSKANSEVAQ WRTKYETDAI QRTEELEEAK KKLAQRLQDA 1400
EEAVEAVNAK CSSLEKTKHR LQNEIEDLMV DVERSNAAAA ALDKKQRNFD 1450
KILAEWKQKY EESQSELESS QKEARSLSTE LFKLKNAYEE SLEHLETFKR 1500
ENKNLQEEIS DLTEQLGSTG KSIHELEKIR KQLEAEKLEL QSALEEAEAS 1550
LEHEEGKILR AQLEFNQIKA EIERKLAEKD EEMEQAKRNH LRMVDSLQTS 1600
LDAETRSRNE ALRVKKKMEG DLNEMEIQLS HANRMAAEAQ KQVKSLQSLL 1650
KDTQIQLDDA VRANDDLKEN IAIVERRNNL LQAELEELRA VVEQTERSRK 1700
LAEQELIETS ERVQLLHSQN TSLINQKKKM DADLSQLQTE VEEAVQECRN 1750
AEEKAKKAIT DAAMMAEELK KEQDTSAHLE RMKKNMEQTI KDLQHRLDEA 1800
EQIALKGGKK QLQKLEARVR ELENELEAEQ KRNAESVKGM RKSERRIKEL 1850
TYQTEEDRKN LLRLQDLVDK LQLKVKAYKR QAEEAEEQAN TNLSKFRKVQ 1900
HELDEAEERA DIAESQVNKL RAKSRDIGAK GLNEE 1935
Length:1,935
Mass (Da):222,879
Last modified:December 1, 2001 - v1
Checksum:i08CDD03573B10CF0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY056464 mRNA. Translation: AAL17913.1.
AK147031 mRNA. Translation: BAE27623.1.
AK157742 mRNA. Translation: BAE34176.1.
AK168677 mRNA. Translation: BAE40526.1.
AK169198 mRNA. Translation: BAE40973.1.
AK169371 mRNA. Translation: BAE41119.1.
BC121789 mRNA. Translation: AAI21790.1.
CCDSiCCDS27106.1.
RefSeqiNP_542766.1. NM_080728.2.
UniGeneiMm.457983.

Genome annotation databases

EnsembliENSMUST00000102803; ENSMUSP00000099867; ENSMUSG00000053093.
ENSMUST00000168485; ENSMUSP00000126840; ENSMUSG00000053093.
GeneIDi140781.
KEGGimmu:140781.
UCSCiuc007txv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY056464 mRNA. Translation: AAL17913.1 .
AK147031 mRNA. Translation: BAE27623.1 .
AK157742 mRNA. Translation: BAE34176.1 .
AK168677 mRNA. Translation: BAE40526.1 .
AK169198 mRNA. Translation: BAE40973.1 .
AK169371 mRNA. Translation: BAE41119.1 .
BC121789 mRNA. Translation: AAI21790.1 .
CCDSi CCDS27106.1.
RefSeqi NP_542766.1. NM_080728.2.
UniGenei Mm.457983.

3D structure databases

ProteinModelPortali Q91Z83.
SMRi Q91Z83. Positions 2-961.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q91Z83. 2 interactions.
MINTi MINT-4122197.

PTM databases

PhosphoSitei Q91Z83.

Proteomic databases

MaxQBi Q91Z83.
PaxDbi Q91Z83.
PRIDEi Q91Z83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102803 ; ENSMUSP00000099867 ; ENSMUSG00000053093 .
ENSMUST00000168485 ; ENSMUSP00000126840 ; ENSMUSG00000053093 .
GeneIDi 140781.
KEGGi mmu:140781.
UCSCi uc007txv.1. mouse.

Organism-specific databases

CTDi 4625.
MGIi MGI:2155600. Myh7.

Phylogenomic databases

eggNOGi COG5022.
GeneTreei ENSGT00720000108683.
HOGENOMi HOG000173959.
HOVERGENi HBG004704.
InParanoidi Q91Z83.
KOi K17751.
OMAi ITAIQAR.
OrthoDBi EOG7RBZ7G.
PhylomeDBi Q91Z83.
TreeFami TF314375.

Miscellaneous databases

NextBioi 369981.
PROi Q91Z83.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q91Z83.
Bgeei Q91Z83.
CleanExi MM_MYH7.
Genevestigatori Q91Z83.

Family and domain databases

Gene3Di 4.10.270.10. 1 hit.
InterProi IPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view ]
PRINTSi PR00193. MYOSINHEAVY.
SMARTi SM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: FVB.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Heart.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "A proteomics approach to identify the ubiquitinated proteins in mouse heart."
    Jeon H.B., Choi E.S., Yoon J.H., Hwang J.H., Chang J.W., Lee E.K., Choi H.W., Park Z.-Y., Yoo Y.J.
    Biochem. Biophys. Res. Commun. 357:731-736(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-207; LYS-213; LYS-1531 AND LYS-1537.
    Tissue: Heart.

Entry informationi

Entry nameiMYH7_MOUSE
AccessioniPrimary (citable) accession number: Q91Z83
Secondary accession number(s): Q3TGM2, Q3TZN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase.

Caution

Represents a conventional myosin. This protein should not be confused with the unconventional myosin-7 (MYO7).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi