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Q91Z83 (MYH7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myosin-7
Alternative name(s):
Myosin heavy chain 7
Myosin heavy chain slow isoform
Short name=MyHC-slow
Myosin heavy chain, cardiac muscle beta isoform
Short name=MyHC-beta
Gene names
Name:Myh7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1935 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Muscle contraction By similarity.

Subunit structure

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2) By similarity. Interacts with ECM29 By similarity.

Subcellular location

Cytoplasmmyofibril By similarity. Note: Thick filaments of the myofibrils By similarity.

Domain

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.

Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).

Miscellaneous

The cardiac alpha isoform isa 'fast' ATPase myosin, while the beta isoform isa 'slow' ATPase.

Sequence similarities

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

Contains 1 IQ domain.

Contains 1 myosin motor domain.

Caution

Represents a conventional myosin. This protein should not be confused with the unconventional myosin-7 (MYO7).

Ontologies

Keywords
   Cellular componentCytoplasm
Thick filament
   DomainCoiled coil
   LigandActin-binding
ATP-binding
Calmodulin-binding
Nucleotide-binding
   Molecular functionMotor protein
Muscle protein
Myosin
   PTMIsopeptide bond
Methylation
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadult heart development

Inferred from electronic annotation. Source: Ensembl

muscle filament sliding

Inferred from electronic annotation. Source: Ensembl

regulation of heart rate

Inferred from electronic annotation. Source: Ensembl

ventricular cardiac muscle tissue morphogenesis

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentZ disc

Inferred from direct assay PubMed 21126233. Source: MGI

focal adhesion

Inferred from electronic annotation. Source: Ensembl

myofibril

Inferred from direct assay PubMed 21884692PubMed 9884344. Source: MGI

myosin complex

Inferred from direct assay PubMed 8482409PubMed 9884344. Source: MGI

myosin filament

Inferred from electronic annotation. Source: UniProtKB-KW

nucleolus

Inferred from electronic annotation. Source: Ensembl

stress fiber

Inferred from direct assay PubMed 21126233. Source: MGI

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

actin-dependent ATPase activity

Inferred from electronic annotation. Source: Ensembl

motor activity

Inferred from electronic annotation. Source: InterPro

structural constituent of muscle

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 19351935Myosin-7
PRO_0000274177

Regions

Domain85 – 778694Myosin motor
Domain781 – 81030IQ
Nucleotide binding178 – 1858ATP
Region655 – 67723Actin-binding
Region757 – 77115Actin-binding
Coiled coil840 – 19351096 Potential

Amino acid modifications

Modified residue1291N6,N6,N6-trimethyllysine Potential
Cross-link207Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.4
Cross-link213Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.4
Cross-link1531Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.4
Cross-link1537Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q91Z83 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 08CDD03573B10CF0

FASTA1,935222,879
        10         20         30         40         50         60 
MADAEMAAFG AAAPFLRKSE KERLEAQTRP FDLKKDVFVP DDKEEFVKAK IVSREGGKVT 

        70         80         90        100        110        120 
AETENGKTVT VKEDQVMQQN PPKFDKIEDM AMLTFLHEPA VLYNLKERYA SWMIYTYSGL 

       130        140        150        160        170        180 
FCVTVNPYKW LPVYNAEVVA AYRGKKRSEA PPHIFSISDN AYQYMLTDRE NQSILITGES 

       190        200        210        220        230        240 
GAGKTVNTKR VIQYFAVIAA IGDRSKKDQT PGKGTLEDQI IQANPALEAF GNAKTVRNDN 

       250        260        270        280        290        300 
SSRFGKFIRI HFGATGKLAS ADIETYLLEK SRVIFQLKAE RDYHIFYQIL SNKKPELLDM 

       310        320        330        340        350        360 
LLITNNPYDY AFISQGETTV ASIDDSEELM ATDSAFDVLG FTPEEKNSIY KLTGAIMHFG 

       370        380        390        400        410        420 
NMKFKQKQRE EQAEPDGTEE ADKSAYLMGL NSADLLKGLC HPRVKVGNEY VTKGQNVQQV 

       430        440        450        460        470        480 
SYAIGALAKS VYEKMFNWMV TRINATLETK QPRQYFIGVL DIAGFEIFDF NSFEQLCINF 

       490        500        510        520        530        540 
TNEKLQQFFN HHMFVLEQEE YKKEGIEWTF IDFGMDLQAC IDLIEKPMGI MSILEEECMF 

       550        560        570        580        590        600 
PKATDMTFKA KLYDNHLGKS NNFQKPRNVK GKQEAHFSLV HYAGTVDYNI LGWLQKNKDP 

       610        620        630        640        650        660 
LNETVVGLYQ KSSLKLLSNL FANYAGADAP ADKGKGKAKK GSSFQTVSAL HRENLNKLMT 

       670        680        690        700        710        720 
NLRSTHPHFV RCIIPNETKS PGVMDNPLVM HQLRCNGVLE GIRICRKGFP NRILYGDFRQ 

       730        740        750        760        770        780 
RYRILNPAAI PEGQFIDSRK GAEKLLGSLD IDHNQYKFGH TKVFFKAGLL GLLEEMRDER 

       790        800        810        820        830        840 
LSRIITRIQA QSRGVLSRME FKKLLERRDS LLIIQWNIRA FMGVKNWPWM KLYFKIKPLL 

       850        860        870        880        890        900 
KSAETEKEMA TMKEEFGRVK DALEKSEARR KELEEKMVSL LQEKNDLQLQ VQAEQDNLAD 

       910        920        930        940        950        960 
AEERCDQLIK NKIQLEAKVK EMTERLEDEE EMNAELTAKK RKLEDECSEL KRDIDDLELT 

       970        980        990       1000       1010       1020 
LAKVEKEKHA TENKVKNLTE EMAGLDEIIV KLTKEKKALQ EAHQQALDDL QAEEDKVNTL 

      1030       1040       1050       1060       1070       1080 
TKAKVKLEQQ VDDLEGSLEQ EKKVRMDLER AKRKLEGDLK LTQESIMDLE NDKQQLDERL 

      1090       1100       1110       1120       1130       1140 
KKKDFELNAL NARIEDEQAL GSQLQKKLKE LQARIEELEE ELEAERTARA KVEKLRSDLS 

      1150       1160       1170       1180       1190       1200 
RELEEISERL EEAGGATSVQ IEMNKKREAE FQKMRRDLEE ATLQHEATAA ALRKKHADSV 

      1210       1220       1230       1240       1250       1260 
AELGEQIDNL QRVKQKLEKE KSEFKLELDD VTSNMEQIIK AKANLEKMCR TLEDQMNEHR 

      1270       1280       1290       1300       1310       1320 
SKAEETQRSV NDLTSQRAKL QTENGELSRQ LDEKEALISQ LTRGKLTYTQ QLEDLKRQLE 

      1330       1340       1350       1360       1370       1380 
EEVKAKNALA HALQSARHDC DLLREQYEEE TEAKAELQRV LSKANSEVAQ WRTKYETDAI 

      1390       1400       1410       1420       1430       1440 
QRTEELEEAK KKLAQRLQDA EEAVEAVNAK CSSLEKTKHR LQNEIEDLMV DVERSNAAAA 

      1450       1460       1470       1480       1490       1500 
ALDKKQRNFD KILAEWKQKY EESQSELESS QKEARSLSTE LFKLKNAYEE SLEHLETFKR 

      1510       1520       1530       1540       1550       1560 
ENKNLQEEIS DLTEQLGSTG KSIHELEKIR KQLEAEKLEL QSALEEAEAS LEHEEGKILR 

      1570       1580       1590       1600       1610       1620 
AQLEFNQIKA EIERKLAEKD EEMEQAKRNH LRMVDSLQTS LDAETRSRNE ALRVKKKMEG 

      1630       1640       1650       1660       1670       1680 
DLNEMEIQLS HANRMAAEAQ KQVKSLQSLL KDTQIQLDDA VRANDDLKEN IAIVERRNNL 

      1690       1700       1710       1720       1730       1740 
LQAELEELRA VVEQTERSRK LAEQELIETS ERVQLLHSQN TSLINQKKKM DADLSQLQTE 

      1750       1760       1770       1780       1790       1800 
VEEAVQECRN AEEKAKKAIT DAAMMAEELK KEQDTSAHLE RMKKNMEQTI KDLQHRLDEA 

      1810       1820       1830       1840       1850       1860 
EQIALKGGKK QLQKLEARVR ELENELEAEQ KRNAESVKGM RKSERRIKEL TYQTEEDRKN 

      1870       1880       1890       1900       1910       1920 
LLRLQDLVDK LQLKVKAYKR QAEEAEEQAN TNLSKFRKVQ HELDEAEERA DIAESQVNKL 

      1930 
RAKSRDIGAK GLNEE 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of myosin heavy chain functionality in the heart."
Krenz M., Sanbe A., Bouyer-Dalloz F., Gulick J., Klevitsky R., Hewett T.E., Osinska H.E., Lorenz J.N., Brosseau C., Federico A., Alpert N.R., Warshaw D.M., Perryman M.B., Helmke S.M., Robbins J.
J. Biol. Chem. 278:17466-17474(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: FVB.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Heart.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"A proteomics approach to identify the ubiquitinated proteins in mouse heart."
Jeon H.B., Choi E.S., Yoon J.H., Hwang J.H., Chang J.W., Lee E.K., Choi H.W., Park Z.-Y., Yoo Y.J.
Biochem. Biophys. Res. Commun. 357:731-736(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-207; LYS-213; LYS-1531 AND LYS-1537.
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY056464 mRNA. Translation: AAL17913.1.
AK147031 mRNA. Translation: BAE27623.1.
AK157742 mRNA. Translation: BAE34176.1.
AK168677 mRNA. Translation: BAE40526.1.
AK169198 mRNA. Translation: BAE40973.1.
AK169371 mRNA. Translation: BAE41119.1.
BC121789 mRNA. Translation: AAI21790.1.
CCDSCCDS27106.1.
RefSeqNP_542766.1. NM_080728.2.
UniGeneMm.457983.

3D structure databases

ProteinModelPortalQ91Z83.
SMRQ91Z83. Positions 2-961.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ91Z83. 2 interactions.
MINTMINT-4122197.

PTM databases

PhosphoSiteQ91Z83.

Proteomic databases

MaxQBQ91Z83.
PaxDbQ91Z83.
PRIDEQ91Z83.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000102803; ENSMUSP00000099867; ENSMUSG00000053093.
ENSMUST00000168485; ENSMUSP00000126840; ENSMUSG00000053093.
GeneID140781.
KEGGmmu:140781.
UCSCuc007txv.1. mouse.

Organism-specific databases

CTD4625.
MGIMGI:2155600. Myh7.

Phylogenomic databases

eggNOGCOG5022.
GeneTreeENSGT00720000108683.
HOGENOMHOG000173959.
HOVERGENHBG004704.
InParanoidQ91Z83.
KOK17751.
OMAITAIQAR.
OrthoDBEOG7RBZ7G.
PhylomeDBQ91Z83.
TreeFamTF314375.

Gene expression databases

ArrayExpressQ91Z83.
BgeeQ91Z83.
CleanExMM_MYH7.
GenevestigatorQ91Z83.

Family and domain databases

Gene3D4.10.270.10. 1 hit.
InterProIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSPR00193. MYOSINHEAVY.
SMARTSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio369981.
PROQ91Z83.
SOURCESearch...

Entry information

Entry nameMYH7_MOUSE
AccessionPrimary (citable) accession number: Q91Z83
Secondary accession number(s): Q3TGM2, Q3TZN2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot