Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q91Z83

- MYH7_MOUSE

UniProt

Q91Z83 - MYH7_MOUSE

Protein

Myosin-7

Gene

Myh7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Muscle contraction.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi178 – 1858ATP

    GO - Molecular functioni

    1. actin-dependent ATPase activity Source: Ensembl
    2. ATP binding Source: UniProtKB-KW
    3. motor activity Source: InterPro
    4. structural constituent of muscle Source: Ensembl

    GO - Biological processi

    1. adult heart development Source: Ensembl
    2. muscle filament sliding Source: Ensembl
    3. regulation of heart rate Source: Ensembl
    4. ventricular cardiac muscle tissue morphogenesis Source: Ensembl

    Keywords - Molecular functioni

    Motor protein, Muscle protein, Myosin

    Keywords - Ligandi

    Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myosin-7
    Alternative name(s):
    Myosin heavy chain 7
    Myosin heavy chain slow isoform
    Short name:
    MyHC-slow
    Myosin heavy chain, cardiac muscle beta isoform
    Short name:
    MyHC-beta
    Gene namesi
    Name:Myh7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:2155600. Myh7.

    Subcellular locationi

    Cytoplasmmyofibril By similarity
    Note: Thick filaments of the myofibrils.By similarity

    GO - Cellular componenti

    1. focal adhesion Source: Ensembl
    2. myofibril Source: MGI
    3. myosin complex Source: MGI
    4. myosin filament Source: UniProtKB-KW
    5. nucleolus Source: Ensembl
    6. stress fiber Source: MGI
    7. Z disc Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Thick filament

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19351935Myosin-7PRO_0000274177Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei129 – 1291N6,N6,N6-trimethyllysineSequence Analysis
    Cross-linki207 – 207Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Cross-linki213 – 213Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Cross-linki1531 – 1531Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
    Cross-linki1537 – 1537Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

    Keywords - PTMi

    Isopeptide bond, Methylation, Ubl conjugation

    Proteomic databases

    MaxQBiQ91Z83.
    PaxDbiQ91Z83.
    PRIDEiQ91Z83.

    PTM databases

    PhosphoSiteiQ91Z83.

    Expressioni

    Gene expression databases

    ArrayExpressiQ91Z83.
    BgeeiQ91Z83.
    CleanExiMM_MYH7.
    GenevestigatoriQ91Z83.

    Interactioni

    Subunit structurei

    Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with ECM29.By similarity

    Protein-protein interaction databases

    IntActiQ91Z83. 2 interactions.
    MINTiMINT-4122197.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91Z83.
    SMRiQ91Z83. Positions 2-961.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini85 – 778694Myosin motorAdd
    BLAST
    Domaini781 – 81030IQPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni655 – 67723Actin-bindingAdd
    BLAST
    Regioni757 – 77115Actin-bindingAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili840 – 19351096Sequence AnalysisAdd
    BLAST

    Domaini

    The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
    Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).

    Sequence similaritiesi

    Contains 1 IQ domain.PROSITE-ProRule annotation
    Contains 1 myosin motor domain.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5022.
    GeneTreeiENSGT00720000108683.
    HOGENOMiHOG000173959.
    HOVERGENiHBG004704.
    InParanoidiQ91Z83.
    KOiK17751.
    OMAiITAIQAR.
    OrthoDBiEOG7RBZ7G.
    PhylomeDBiQ91Z83.
    TreeFamiTF314375.

    Family and domain databases

    Gene3Di4.10.270.10. 1 hit.
    InterProiIPR000048. IQ_motif_EF-hand-BS.
    IPR027401. Myosin-like_IQ_dom.
    IPR001609. Myosin_head_motor_dom.
    IPR004009. Myosin_N.
    IPR002928. Myosin_tail.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00063. Myosin_head. 1 hit.
    PF02736. Myosin_N. 1 hit.
    PF01576. Myosin_tail_1. 1 hit.
    [Graphical view]
    PRINTSiPR00193. MYOSINHEAVY.
    SMARTiSM00015. IQ. 1 hit.
    SM00242. MYSc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS50096. IQ. 1 hit.
    PS51456. MYOSIN_MOTOR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91Z83-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADAEMAAFG AAAPFLRKSE KERLEAQTRP FDLKKDVFVP DDKEEFVKAK     50
    IVSREGGKVT AETENGKTVT VKEDQVMQQN PPKFDKIEDM AMLTFLHEPA 100
    VLYNLKERYA SWMIYTYSGL FCVTVNPYKW LPVYNAEVVA AYRGKKRSEA 150
    PPHIFSISDN AYQYMLTDRE NQSILITGES GAGKTVNTKR VIQYFAVIAA 200
    IGDRSKKDQT PGKGTLEDQI IQANPALEAF GNAKTVRNDN SSRFGKFIRI 250
    HFGATGKLAS ADIETYLLEK SRVIFQLKAE RDYHIFYQIL SNKKPELLDM 300
    LLITNNPYDY AFISQGETTV ASIDDSEELM ATDSAFDVLG FTPEEKNSIY 350
    KLTGAIMHFG NMKFKQKQRE EQAEPDGTEE ADKSAYLMGL NSADLLKGLC 400
    HPRVKVGNEY VTKGQNVQQV SYAIGALAKS VYEKMFNWMV TRINATLETK 450
    QPRQYFIGVL DIAGFEIFDF NSFEQLCINF TNEKLQQFFN HHMFVLEQEE 500
    YKKEGIEWTF IDFGMDLQAC IDLIEKPMGI MSILEEECMF PKATDMTFKA 550
    KLYDNHLGKS NNFQKPRNVK GKQEAHFSLV HYAGTVDYNI LGWLQKNKDP 600
    LNETVVGLYQ KSSLKLLSNL FANYAGADAP ADKGKGKAKK GSSFQTVSAL 650
    HRENLNKLMT NLRSTHPHFV RCIIPNETKS PGVMDNPLVM HQLRCNGVLE 700
    GIRICRKGFP NRILYGDFRQ RYRILNPAAI PEGQFIDSRK GAEKLLGSLD 750
    IDHNQYKFGH TKVFFKAGLL GLLEEMRDER LSRIITRIQA QSRGVLSRME 800
    FKKLLERRDS LLIIQWNIRA FMGVKNWPWM KLYFKIKPLL KSAETEKEMA 850
    TMKEEFGRVK DALEKSEARR KELEEKMVSL LQEKNDLQLQ VQAEQDNLAD 900
    AEERCDQLIK NKIQLEAKVK EMTERLEDEE EMNAELTAKK RKLEDECSEL 950
    KRDIDDLELT LAKVEKEKHA TENKVKNLTE EMAGLDEIIV KLTKEKKALQ 1000
    EAHQQALDDL QAEEDKVNTL TKAKVKLEQQ VDDLEGSLEQ EKKVRMDLER 1050
    AKRKLEGDLK LTQESIMDLE NDKQQLDERL KKKDFELNAL NARIEDEQAL 1100
    GSQLQKKLKE LQARIEELEE ELEAERTARA KVEKLRSDLS RELEEISERL 1150
    EEAGGATSVQ IEMNKKREAE FQKMRRDLEE ATLQHEATAA ALRKKHADSV 1200
    AELGEQIDNL QRVKQKLEKE KSEFKLELDD VTSNMEQIIK AKANLEKMCR 1250
    TLEDQMNEHR SKAEETQRSV NDLTSQRAKL QTENGELSRQ LDEKEALISQ 1300
    LTRGKLTYTQ QLEDLKRQLE EEVKAKNALA HALQSARHDC DLLREQYEEE 1350
    TEAKAELQRV LSKANSEVAQ WRTKYETDAI QRTEELEEAK KKLAQRLQDA 1400
    EEAVEAVNAK CSSLEKTKHR LQNEIEDLMV DVERSNAAAA ALDKKQRNFD 1450
    KILAEWKQKY EESQSELESS QKEARSLSTE LFKLKNAYEE SLEHLETFKR 1500
    ENKNLQEEIS DLTEQLGSTG KSIHELEKIR KQLEAEKLEL QSALEEAEAS 1550
    LEHEEGKILR AQLEFNQIKA EIERKLAEKD EEMEQAKRNH LRMVDSLQTS 1600
    LDAETRSRNE ALRVKKKMEG DLNEMEIQLS HANRMAAEAQ KQVKSLQSLL 1650
    KDTQIQLDDA VRANDDLKEN IAIVERRNNL LQAELEELRA VVEQTERSRK 1700
    LAEQELIETS ERVQLLHSQN TSLINQKKKM DADLSQLQTE VEEAVQECRN 1750
    AEEKAKKAIT DAAMMAEELK KEQDTSAHLE RMKKNMEQTI KDLQHRLDEA 1800
    EQIALKGGKK QLQKLEARVR ELENELEAEQ KRNAESVKGM RKSERRIKEL 1850
    TYQTEEDRKN LLRLQDLVDK LQLKVKAYKR QAEEAEEQAN TNLSKFRKVQ 1900
    HELDEAEERA DIAESQVNKL RAKSRDIGAK GLNEE 1935
    Length:1,935
    Mass (Da):222,879
    Last modified:December 1, 2001 - v1
    Checksum:i08CDD03573B10CF0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY056464 mRNA. Translation: AAL17913.1.
    AK147031 mRNA. Translation: BAE27623.1.
    AK157742 mRNA. Translation: BAE34176.1.
    AK168677 mRNA. Translation: BAE40526.1.
    AK169198 mRNA. Translation: BAE40973.1.
    AK169371 mRNA. Translation: BAE41119.1.
    BC121789 mRNA. Translation: AAI21790.1.
    CCDSiCCDS27106.1.
    RefSeqiNP_542766.1. NM_080728.2.
    UniGeneiMm.457983.

    Genome annotation databases

    EnsembliENSMUST00000102803; ENSMUSP00000099867; ENSMUSG00000053093.
    ENSMUST00000168485; ENSMUSP00000126840; ENSMUSG00000053093.
    GeneIDi140781.
    KEGGimmu:140781.
    UCSCiuc007txv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY056464 mRNA. Translation: AAL17913.1 .
    AK147031 mRNA. Translation: BAE27623.1 .
    AK157742 mRNA. Translation: BAE34176.1 .
    AK168677 mRNA. Translation: BAE40526.1 .
    AK169198 mRNA. Translation: BAE40973.1 .
    AK169371 mRNA. Translation: BAE41119.1 .
    BC121789 mRNA. Translation: AAI21790.1 .
    CCDSi CCDS27106.1.
    RefSeqi NP_542766.1. NM_080728.2.
    UniGenei Mm.457983.

    3D structure databases

    ProteinModelPortali Q91Z83.
    SMRi Q91Z83. Positions 2-961.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q91Z83. 2 interactions.
    MINTi MINT-4122197.

    PTM databases

    PhosphoSitei Q91Z83.

    Proteomic databases

    MaxQBi Q91Z83.
    PaxDbi Q91Z83.
    PRIDEi Q91Z83.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000102803 ; ENSMUSP00000099867 ; ENSMUSG00000053093 .
    ENSMUST00000168485 ; ENSMUSP00000126840 ; ENSMUSG00000053093 .
    GeneIDi 140781.
    KEGGi mmu:140781.
    UCSCi uc007txv.1. mouse.

    Organism-specific databases

    CTDi 4625.
    MGIi MGI:2155600. Myh7.

    Phylogenomic databases

    eggNOGi COG5022.
    GeneTreei ENSGT00720000108683.
    HOGENOMi HOG000173959.
    HOVERGENi HBG004704.
    InParanoidi Q91Z83.
    KOi K17751.
    OMAi ITAIQAR.
    OrthoDBi EOG7RBZ7G.
    PhylomeDBi Q91Z83.
    TreeFami TF314375.

    Miscellaneous databases

    NextBioi 369981.
    PROi Q91Z83.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91Z83.
    Bgeei Q91Z83.
    CleanExi MM_MYH7.
    Genevestigatori Q91Z83.

    Family and domain databases

    Gene3Di 4.10.270.10. 1 hit.
    InterProi IPR000048. IQ_motif_EF-hand-BS.
    IPR027401. Myosin-like_IQ_dom.
    IPR001609. Myosin_head_motor_dom.
    IPR004009. Myosin_N.
    IPR002928. Myosin_tail.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00063. Myosin_head. 1 hit.
    PF02736. Myosin_N. 1 hit.
    PF01576. Myosin_tail_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00193. MYOSINHEAVY.
    SMARTi SM00015. IQ. 1 hit.
    SM00242. MYSc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS50096. IQ. 1 hit.
    PS51456. MYOSIN_MOTOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: FVB.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Heart.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "A proteomics approach to identify the ubiquitinated proteins in mouse heart."
      Jeon H.B., Choi E.S., Yoon J.H., Hwang J.H., Chang J.W., Lee E.K., Choi H.W., Park Z.-Y., Yoo Y.J.
      Biochem. Biophys. Res. Commun. 357:731-736(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-207; LYS-213; LYS-1531 AND LYS-1537.
      Tissue: Heart.

    Entry informationi

    Entry nameiMYH7_MOUSE
    AccessioniPrimary (citable) accession number: Q91Z83
    Secondary accession number(s): Q3TGM2, Q3TZN2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase.

    Caution

    Represents a conventional myosin. This protein should not be confused with the unconventional myosin-7 (MYO7).Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3