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Protein

F-box only protein 32

Gene

Fbxo32

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1 (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • ubiquitin-protein transferase activity Source: RGD

GO - Biological processi

  • muscle atrophy Source: RGD
  • response to denervation involved in regulation of muscle adaptation Source: UniProtKB
  • response to electrical stimulus involved in regulation of muscle adaptation Source: UniProtKB
  • ubiquitin-dependent protein catabolic process Source: RGD
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 32
Alternative name(s):
Atrogin-1
Muscle atrophy F-box protein
Short name:
MAFbx
Gene namesi
Name:Fbxo32
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620373. Fbxo32.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Shuttles between Cytoplasm and the nucleus.By similarity

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleus Source: GO_Central
  • SCF ubiquitin ligase complex Source: GO_Central
  • ubiquitin ligase complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350F-box only protein 32PRO_0000119924Add
BLAST

Proteomic databases

PaxDbiQ91Z62.

Expressioni

Tissue specificityi

Specifically expressed in cardiac and skeletal muscle.

Interactioni

Subunit structurei

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO32) formed of CUL1, SKP1, RBX1 and FBXO32.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010361.

Structurei

3D structure databases

ProteinModelPortaliQ91Z62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini218 – 26649F-boxAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi57 – 626Nuclear localization signalBy similarity
Motifi164 – 1685Nuclear export signalBy similarity
Motifi275 – 29016Bipartite nuclear localization signalBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.Curated

Phylogenomic databases

eggNOGiKOG3926. Eukaryota.
ENOG410YPWK. LUCA.
HOGENOMiHOG000263478.
HOVERGENiHBG051572.
InParanoidiQ91Z62.
KOiK10305.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91Z62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFLGQDWRS PGQSWVKTAD GWKRFLDEKS GTFVSDLSSY CNKENLFNSL
60 70 80 90 100
NYDVAAKKRK KDIQNSKTKT QYFHQEKWIY VHKGSTKERH GYCTLGEAFN
110 120 130 140 150
RLDFSTAILD SRRFNYVVRL LELIAKSQLT SLSGIAQKNF MNILEKVVLK
160 170 180 190 200
VLEDQQNIRL IRELLQTLYT SLCTLVQRVG KSVLVGNINM WVYRMETTLH
210 220 230 240 250
WQQQLNSIQI SRPAFKGLTI TDLPVCLQLN IMQRLSDGRD LVSLGQAAPD
260 270 280 290 300
LHVLSEDRLL WKRLCQYHFS ERQIRKRLIL SDKGQLDWKK MYFKLVRCYP
310 320 330 340 350
RREQYGVTLQ LCKHCHILSW KGTDHPCTAN NPESCSVSLS PQDFINLFKF
Length:350
Mass (Da):40,926
Last modified:December 1, 2001 - v1
Checksum:i24AB59BC74F72472
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY059628 mRNA. Translation: AAL16406.1.
RefSeqiNP_598205.1. NM_133521.1.
UniGeneiRn.72619.

Genome annotation databases

GeneIDi171043.
KEGGirno:171043.
UCSCiRGD:620373. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY059628 mRNA. Translation: AAL16406.1.
RefSeqiNP_598205.1. NM_133521.1.
UniGeneiRn.72619.

3D structure databases

ProteinModelPortaliQ91Z62.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010361.

Proteomic databases

PaxDbiQ91Z62.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi171043.
KEGGirno:171043.
UCSCiRGD:620373. rat.

Organism-specific databases

CTDi114907.
RGDi620373. Fbxo32.

Phylogenomic databases

eggNOGiKOG3926. Eukaryota.
ENOG410YPWK. LUCA.
HOGENOMiHOG000263478.
HOVERGENiHBG051572.
InParanoidiQ91Z62.
KOiK10305.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ91Z62.

Family and domain databases

InterProiIPR001810. F-box_dom.
[Graphical view]
SUPFAMiSSF81383. SSF81383. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiFBX32_RAT
AccessioniPrimary (citable) accession number: Q91Z62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.