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Protein

F-box only protein 32

Gene

Fbxo32

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1 (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

  • ubiquitin-protein transferase activity Source: RGD

GO - Biological processi

  • muscle atrophy Source: RGD
  • negative regulation of cardiac muscle hypertrophy Source: BHF-UCL
  • positive regulation of cardiac muscle cell apoptotic process Source: BHF-UCL
  • protein ubiquitination Source: UniProtKB
  • response to denervation involved in regulation of muscle adaptation Source: UniProtKB
  • response to electrical stimulus involved in regulation of muscle adaptation Source: UniProtKB
  • ubiquitin-dependent protein catabolic process Source: RGD

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 32
Alternative name(s):
Atrogin-1
Muscle atrophy F-box protein
Short name:
MAFbx
Gene namesi
Name:Fbxo32
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620373 Fbxo32

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199241 – 350F-box only protein 32Add BLAST350

Proteomic databases

PaxDbiQ91Z62

Expressioni

Tissue specificityi

Specifically expressed in cardiac and skeletal muscle.

Interactioni

Subunit structurei

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO32) formed of CUL1, SKP1, RBX1 and FBXO32.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010361

Structurei

3D structure databases

ProteinModelPortaliQ91Z62
SMRiQ91Z62
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini218 – 266F-boxAdd BLAST49

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi57 – 62Nuclear localization signalBy similarity6
Motifi164 – 168Nuclear export signalBy similarity5
Motifi275 – 290Bipartite nuclear localization signalBy similarityAdd BLAST16

Phylogenomic databases

eggNOGiKOG3926 Eukaryota
ENOG410YPWK LUCA
HOGENOMiHOG000263478
HOVERGENiHBG051572
InParanoidiQ91Z62
KOiK10305

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
SUPFAMiSSF81383 SSF81383, 1 hit

Sequencei

Sequence statusi: Complete.

Q91Z62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFLGQDWRS PGQSWVKTAD GWKRFLDEKS GTFVSDLSSY CNKENLFNSL
60 70 80 90 100
NYDVAAKKRK KDIQNSKTKT QYFHQEKWIY VHKGSTKERH GYCTLGEAFN
110 120 130 140 150
RLDFSTAILD SRRFNYVVRL LELIAKSQLT SLSGIAQKNF MNILEKVVLK
160 170 180 190 200
VLEDQQNIRL IRELLQTLYT SLCTLVQRVG KSVLVGNINM WVYRMETTLH
210 220 230 240 250
WQQQLNSIQI SRPAFKGLTI TDLPVCLQLN IMQRLSDGRD LVSLGQAAPD
260 270 280 290 300
LHVLSEDRLL WKRLCQYHFS ERQIRKRLIL SDKGQLDWKK MYFKLVRCYP
310 320 330 340 350
RREQYGVTLQ LCKHCHILSW KGTDHPCTAN NPESCSVSLS PQDFINLFKF
Length:350
Mass (Da):40,926
Last modified:December 1, 2001 - v1
Checksum:i24AB59BC74F72472
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY059628 mRNA Translation: AAL16406.1
RefSeqiNP_598205.1, NM_133521.1
UniGeneiRn.72619

Genome annotation databases

GeneIDi171043
KEGGirno:171043
UCSCiRGD:620373 rat

Similar proteinsi

Entry informationi

Entry nameiFBX32_RAT
AccessioniPrimary (citable) accession number: Q91Z62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

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