ID   GRHPR_MOUSE             Reviewed;         328 AA.
AC   Q91Z53;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   16-JUN-2009, entry version 59.
DE   RecName: Full=Glyoxylate reductase/hydroxypyruvate reductase;
DE            EC=1.1.1.79;
GN   Name=Grhpr; Synonyms=Glxr;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=129/SvEv; TISSUE=Liver;
RA   Cramer S.D.;
RT   "Identification of the mouse GRHPR cDNA from liver.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PROTEIN SEQUENCE OF 44-58 AND 303-318, AND MASS SPECTROMETRY.
RC   TISSUE=Hippocampus;
RA   Lubec G., Klug S.;
RL   Submitted (MAR-2007) to UniProtKB.
CC   -!- FUNCTION: Enzyme with hydroxy-pyruvate reductase, glyoxylate
CC       reductase and D-glycerate dehydrogenase enzymatic activities (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Glycolate + NADP(+) = glyoxylate + NADPH.
CC   -!- SUBUNIT: Monomer (By similarity).
CC   -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC       dehydrogenase family.
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DR   EMBL; AY113690; AAM52985.1; -; mRNA.
DR   EMBL; BC010194; AAH10194.1; -; mRNA.
DR   IPI; IPI00130530; -.
DR   RefSeq; NP_525028.1; -.
DR   UniGene; Mm.196574; -.
DR   HSSP; P36234; 1GDH.
DR   SMR; Q91Z53; 5-328.
DR   REPRODUCTION-2DPAGE; Q91Z53; -.
DR   PRIDE; Q91Z53; -.
DR   Ensembl; ENSMUSG00000035637; Mus musculus.
DR   GeneID; 76238; -.
DR   KEGG; mmu:76238; -.
DR   NMPDR; fig|10090.3.peg.9510; -.
DR   MGI; MGI:1923488; Grhpr.
DR   HOGENOM; Q91Z53; -.
DR   HOVERGEN; Q91Z53; -.
DR   OMA; Q91Z53; QAADCEV.
DR   BRENDA; 1.1.1.79; 244.
DR   NextBio; 344835; -.
DR   Bgee; Q91Z53; -.
DR   CleanEx; MM_GRHPR; -.
DR   GermOnline; ENSMUSG00000035637; Mus musculus.
DR   GO; GO:0030267; F:glyoxylate reductase (NADP) activity; IEA:EC.
DR   GO; GO:0051287; F:NAD or NADH binding; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR006139; D-isomer_2_OHA_DH.
DR   InterPro; IPR006140; D-isomer_2_OHA_DH_NAD-bd.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF00389; 2-Hacid_dh; 1.
DR   Pfam; PF02826; 2-Hacid_dh_C; 1.
DR   PROSITE; PS00065; D_2_HYDROXYACID_DH_1; FALSE_NEG.
DR   PROSITE; PS00670; D_2_HYDROXYACID_DH_2; FALSE_NEG.
DR   PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; NADP; Oxidoreductase.
FT   CHAIN         1    328       Glyoxylate reductase/hydroxypyruvate
FT                                reductase.
FT                                /FTId=PRO_0000075945.
FT   ACT_SITE    245    245       By similarity.
FT   ACT_SITE    274    274       By similarity.
FT   ACT_SITE    293    293       Proton donor (By similarity).
SQ   SEQUENCE   328 AA;  35329 MW;  BDEC1ADEC1E18153 CRC64;
     MKPARLMKVF VTGPLPAEGR AALAQAADCE VEQWNSDDPI PRKDLEQGVV GAHGLLCRLS
     DRVDKKLLDA AGANLRVIST LSVGVDHLAL DEIKKRGIRV GYTPGVLTDA TAELAVSLLL
     TTCRRLPEAI EEVKNGGWSS WSPLWMCGYG LSQSTVGIVG LGRIGQAIAR RLKPFGVQRF
     LYTGRQPRPQ EAAEFQAEFV PIAQLAAESD FIVVSCSLTP DTMGLCSKDF FQKMKNTAIF
     INISRGDVVN QEDLYQALAS GQIAAAGLDV TTPEPLPPSH PLLTLKNCVI LPHIGSATYK
     TRNTMSLLAA NNLLAGLRGE AMPSELKL
//