Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glyoxylate reductase/hydroxypyruvate reductase

Gene

Grhpr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate (By similarity).By similarity

Catalytic activityi

Glycolate + NADP+ = glyoxylate + NADPH.
D-glycerate + NAD(P)+ = hydroxypyruvate + NAD(P)H.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei217NADPBy similarity1
Binding sitei243NADP; via carbonyl oxygenBy similarity1
Binding sitei245SubstrateBy similarity1
Binding sitei269SubstrateBy similarity1
Sitei274Raises pKa of active site HisBy similarity1
Active sitei293Proton donorBy similarity1
Binding sitei295NADP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi162 – 164NADPBy similarity3
Nucleotide bindingi185 – 188NADPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

ReactomeiR-MMU-389661 Glyoxylate metabolism and glycine degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Glyoxylate reductase/hydroxypyruvate reductase (EC:1.1.1.79, EC:1.1.1.81)
Gene namesi
Name:Grhpr
Synonyms:Glxr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1923488 Grhpr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000759451 – 328Glyoxylate reductase/hydroxypyruvate reductaseAdd BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36PhosphoserineBy similarity1
Modified residuei298PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ91Z53
MaxQBiQ91Z53
PaxDbiQ91Z53
PRIDEiQ91Z53

2D gel databases

REPRODUCTION-2DPAGEiQ91Z53

PTM databases

iPTMnetiQ91Z53
PhosphoSitePlusiQ91Z53
SwissPalmiQ91Z53

Expressioni

Gene expression databases

BgeeiENSMUSG00000035637
CleanExiMM_GRHPR
ExpressionAtlasiQ91Z53 baseline and differential
GenevisibleiQ91Z53 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ91Z53, 4 interactors
MINTiQ91Z53
STRINGi10090.ENSMUSP00000047218

Structurei

3D structure databases

ProteinModelPortaliQ91Z53
SMRiQ91Z53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni83 – 84Substrate bindingBy similarity2
Regioni293 – 296Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0069 Eukaryota
COG1052 LUCA
GeneTreeiENSGT00510000046913
HOGENOMiHOG000136700
HOVERGENiHBG051838
InParanoidiQ91Z53
KOiK00049
OMAiKWIAHNG
OrthoDBiEOG091G0VB7
PhylomeDBiQ91Z53
TreeFamiTF324791

Family and domain databases

InterProiView protein in InterPro
IPR006139 D-isomer_2_OHA_DH_cat_dom
IPR029753 D-isomer_DH_CS
IPR006140 D-isomer_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00389 2-Hacid_dh, 1 hit
PF02826 2-Hacid_dh_C, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00671 D_2_HYDROXYACID_DH_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q91Z53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPARLMKVF VTGPLPAEGR AALAQAADCE VEQWNSDDPI PRKDLEQGVV
60 70 80 90 100
GAHGLLCRLS DRVDKKLLDA AGANLRVIST LSVGVDHLAL DEIKKRGIRV
110 120 130 140 150
GYTPGVLTDA TAELAVSLLL TTCRRLPEAI EEVKNGGWSS WSPLWMCGYG
160 170 180 190 200
LSQSTVGIVG LGRIGQAIAR RLKPFGVQRF LYTGRQPRPQ EAAEFQAEFV
210 220 230 240 250
PIAQLAAESD FIVVSCSLTP DTMGLCSKDF FQKMKNTAIF INISRGDVVN
260 270 280 290 300
QEDLYQALAS GQIAAAGLDV TTPEPLPPSH PLLTLKNCVI LPHIGSATYK
310 320
TRNTMSLLAA NNLLAGLRGE AMPSELKL
Length:328
Mass (Da):35,329
Last modified:December 1, 2001 - v1
Checksum:iBDEC1ADEC1E18153
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY113690 mRNA Translation: AAM52985.1
BC010194 mRNA Translation: AAH10194.1
CCDSiCCDS18128.1
RefSeqiNP_525028.1, NM_080289.2
UniGeneiMm.196574

Genome annotation databases

EnsembliENSMUST00000045078; ENSMUSP00000047218; ENSMUSG00000035637
GeneIDi76238
KEGGimmu:76238
UCSCiuc008ssb.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGRHPR_MOUSE
AccessioniPrimary (citable) accession number: Q91Z53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health