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Q91Z53

- GRHPR_MOUSE

UniProt

Q91Z53 - GRHPR_MOUSE

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Protein

Glyoxylate reductase/hydroxypyruvate reductase

Gene
Grhpr, Glxr
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate By similarity.

Catalytic activityi

Glycolate + NADP+ = glyoxylate + NADPH.
D-glycerate + NAD(P)+ = hydroxypyruvate + NAD(P)H.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei217 – 2171NADP By similarity
Binding sitei243 – 2431NADP; via carbonyl oxygen By similarity
Binding sitei245 – 2451Substrate By similarity
Binding sitei269 – 2691Substrate By similarity
Sitei274 – 2741Raises pKa of active site His By similarity
Active sitei293 – 2931Proton donor By similarity
Binding sitei295 – 2951NADP; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi162 – 1643NADP By similarity
Nucleotide bindingi185 – 1884NADP By similarity

GO - Molecular functioni

  1. carboxylic acid binding Source: Ensembl
  2. glycerate dehydrogenase activity Source: Ensembl
  3. glyoxylate reductase (NADP) activity Source: UniProtKB-EC
  4. hydroxypyruvate reductase activity Source: UniProtKB-EC
  5. NAD binding Source: Ensembl
  6. NADPH binding Source: Ensembl

GO - Biological processi

  1. dicarboxylic acid metabolic process Source: Ensembl
  2. excretion Source: Ensembl
  3. protein oligomerization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Glyoxylate reductase/hydroxypyruvate reductase (EC:1.1.1.79, EC:1.1.1.81)
Gene namesi
Name:Grhpr
Synonyms:Glxr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1923488. Grhpr.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Glyoxylate reductase/hydroxypyruvate reductasePRO_0000075945Add
BLAST

Proteomic databases

MaxQBiQ91Z53.
PaxDbiQ91Z53.
PRIDEiQ91Z53.

2D gel databases

REPRODUCTION-2DPAGEQ91Z53.

PTM databases

PhosphoSiteiQ91Z53.

Expressioni

Gene expression databases

ArrayExpressiQ91Z53.
BgeeiQ91Z53.
CleanExiMM_GRHPR.
GenevestigatoriQ91Z53.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

IntActiQ91Z53. 4 interactions.
MINTiMINT-1868690.

Structurei

3D structure databases

ProteinModelPortaliQ91Z53.
SMRiQ91Z53. Positions 5-328.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni83 – 842Substrate binding By similarity
Regioni293 – 2964Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1052.
GeneTreeiENSGT00510000046913.
HOGENOMiHOG000136700.
HOVERGENiHBG051838.
InParanoidiQ91Z53.
KOiK00049.
OMAiRGPIMNE.
OrthoDBiEOG7K3TMJ.
PhylomeDBiQ91Z53.
TreeFamiTF324791.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEiPS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91Z53-1 [UniParc]FASTAAdd to Basket

« Hide

MKPARLMKVF VTGPLPAEGR AALAQAADCE VEQWNSDDPI PRKDLEQGVV    50
GAHGLLCRLS DRVDKKLLDA AGANLRVIST LSVGVDHLAL DEIKKRGIRV 100
GYTPGVLTDA TAELAVSLLL TTCRRLPEAI EEVKNGGWSS WSPLWMCGYG 150
LSQSTVGIVG LGRIGQAIAR RLKPFGVQRF LYTGRQPRPQ EAAEFQAEFV 200
PIAQLAAESD FIVVSCSLTP DTMGLCSKDF FQKMKNTAIF INISRGDVVN 250
QEDLYQALAS GQIAAAGLDV TTPEPLPPSH PLLTLKNCVI LPHIGSATYK 300
TRNTMSLLAA NNLLAGLRGE AMPSELKL 328
Length:328
Mass (Da):35,329
Last modified:December 1, 2001 - v1
Checksum:iBDEC1ADEC1E18153
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY113690 mRNA. Translation: AAM52985.1.
BC010194 mRNA. Translation: AAH10194.1.
CCDSiCCDS18128.1.
RefSeqiNP_525028.1. NM_080289.1.
UniGeneiMm.196574.

Genome annotation databases

EnsembliENSMUST00000045078; ENSMUSP00000047218; ENSMUSG00000035637.
GeneIDi76238.
KEGGimmu:76238.
UCSCiuc008ssb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY113690 mRNA. Translation: AAM52985.1 .
BC010194 mRNA. Translation: AAH10194.1 .
CCDSi CCDS18128.1.
RefSeqi NP_525028.1. NM_080289.1.
UniGenei Mm.196574.

3D structure databases

ProteinModelPortali Q91Z53.
SMRi Q91Z53. Positions 5-328.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q91Z53. 4 interactions.
MINTi MINT-1868690.

PTM databases

PhosphoSitei Q91Z53.

2D gel databases

REPRODUCTION-2DPAGE Q91Z53.

Proteomic databases

MaxQBi Q91Z53.
PaxDbi Q91Z53.
PRIDEi Q91Z53.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000045078 ; ENSMUSP00000047218 ; ENSMUSG00000035637 .
GeneIDi 76238.
KEGGi mmu:76238.
UCSCi uc008ssb.1. mouse.

Organism-specific databases

CTDi 9380.
MGIi MGI:1923488. Grhpr.

Phylogenomic databases

eggNOGi COG1052.
GeneTreei ENSGT00510000046913.
HOGENOMi HOG000136700.
HOVERGENi HBG051838.
InParanoidi Q91Z53.
KOi K00049.
OMAi RGPIMNE.
OrthoDBi EOG7K3TMJ.
PhylomeDBi Q91Z53.
TreeFami TF324791.

Miscellaneous databases

NextBioi 344835.
PROi Q91Z53.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q91Z53.
Bgeei Q91Z53.
CleanExi MM_GRHPR.
Genevestigatori Q91Z53.

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view ]
PROSITEi PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the mouse GRHPR cDNA from liver."
    Cramer S.D.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/SvEv.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  3. Lubec G., Klug S.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 44-58 AND 303-318, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hippocampus.

Entry informationi

Entry nameiGRHPR_MOUSE
AccessioniPrimary (citable) accession number: Q91Z53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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