Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q91Z53

- GRHPR_MOUSE

UniProt

Q91Z53 - GRHPR_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glyoxylate reductase/hydroxypyruvate reductase

Gene

Grhpr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate (By similarity).By similarity

Catalytic activityi

Glycolate + NADP+ = glyoxylate + NADPH.
D-glycerate + NAD(P)+ = hydroxypyruvate + NAD(P)H.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei217 – 2171NADPBy similarity
Binding sitei243 – 2431NADP; via carbonyl oxygenBy similarity
Binding sitei245 – 2451SubstrateBy similarity
Binding sitei269 – 2691SubstrateBy similarity
Sitei274 – 2741Raises pKa of active site HisBy similarity
Active sitei293 – 2931Proton donorBy similarity
Binding sitei295 – 2951NADP; via amide nitrogenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi162 – 1643NADPBy similarity
Nucleotide bindingi185 – 1884NADPBy similarity

GO - Molecular functioni

  1. carboxylic acid binding Source: Ensembl
  2. glycerate dehydrogenase activity Source: Ensembl
  3. glyoxylate reductase (NADP) activity Source: UniProtKB-EC
  4. hydroxypyruvate reductase activity Source: UniProtKB-EC
  5. NAD binding Source: Ensembl
  6. NADPH binding Source: Ensembl

GO - Biological processi

  1. dicarboxylic acid metabolic process Source: Ensembl
  2. excretion Source: Ensembl
  3. protein oligomerization Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiREACT_261828. Glyoxylate metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Glyoxylate reductase/hydroxypyruvate reductase (EC:1.1.1.79, EC:1.1.1.81)
Gene namesi
Name:Grhpr
Synonyms:Glxr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1923488. Grhpr.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Glyoxylate reductase/hydroxypyruvate reductasePRO_0000075945Add
BLAST

Proteomic databases

MaxQBiQ91Z53.
PaxDbiQ91Z53.
PRIDEiQ91Z53.

2D gel databases

REPRODUCTION-2DPAGEQ91Z53.

PTM databases

PhosphoSiteiQ91Z53.

Expressioni

Gene expression databases

BgeeiQ91Z53.
CleanExiMM_GRHPR.
ExpressionAtlasiQ91Z53. baseline and differential.
GenevestigatoriQ91Z53.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

IntActiQ91Z53. 4 interactions.
MINTiMINT-1868690.

Structurei

3D structure databases

ProteinModelPortaliQ91Z53.
SMRiQ91Z53. Positions 5-328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni83 – 842Substrate bindingBy similarity
Regioni293 – 2964Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1052.
GeneTreeiENSGT00510000046913.
HOGENOMiHOG000136700.
HOVERGENiHBG051838.
InParanoidiQ91Z53.
KOiK00049.
OMAiRGPIMNE.
OrthoDBiEOG7K3TMJ.
PhylomeDBiQ91Z53.
TreeFamiTF324791.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEiPS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91Z53-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKPARLMKVF VTGPLPAEGR AALAQAADCE VEQWNSDDPI PRKDLEQGVV
60 70 80 90 100
GAHGLLCRLS DRVDKKLLDA AGANLRVIST LSVGVDHLAL DEIKKRGIRV
110 120 130 140 150
GYTPGVLTDA TAELAVSLLL TTCRRLPEAI EEVKNGGWSS WSPLWMCGYG
160 170 180 190 200
LSQSTVGIVG LGRIGQAIAR RLKPFGVQRF LYTGRQPRPQ EAAEFQAEFV
210 220 230 240 250
PIAQLAAESD FIVVSCSLTP DTMGLCSKDF FQKMKNTAIF INISRGDVVN
260 270 280 290 300
QEDLYQALAS GQIAAAGLDV TTPEPLPPSH PLLTLKNCVI LPHIGSATYK
310 320
TRNTMSLLAA NNLLAGLRGE AMPSELKL
Length:328
Mass (Da):35,329
Last modified:December 1, 2001 - v1
Checksum:iBDEC1ADEC1E18153
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY113690 mRNA. Translation: AAM52985.1.
BC010194 mRNA. Translation: AAH10194.1.
CCDSiCCDS18128.1.
RefSeqiNP_525028.1. NM_080289.1.
UniGeneiMm.196574.

Genome annotation databases

EnsembliENSMUST00000045078; ENSMUSP00000047218; ENSMUSG00000035637.
GeneIDi76238.
KEGGimmu:76238.
UCSCiuc008ssb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY113690 mRNA. Translation: AAM52985.1 .
BC010194 mRNA. Translation: AAH10194.1 .
CCDSi CCDS18128.1.
RefSeqi NP_525028.1. NM_080289.1.
UniGenei Mm.196574.

3D structure databases

ProteinModelPortali Q91Z53.
SMRi Q91Z53. Positions 5-328.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q91Z53. 4 interactions.
MINTi MINT-1868690.

PTM databases

PhosphoSitei Q91Z53.

2D gel databases

REPRODUCTION-2DPAGE Q91Z53.

Proteomic databases

MaxQBi Q91Z53.
PaxDbi Q91Z53.
PRIDEi Q91Z53.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000045078 ; ENSMUSP00000047218 ; ENSMUSG00000035637 .
GeneIDi 76238.
KEGGi mmu:76238.
UCSCi uc008ssb.1. mouse.

Organism-specific databases

CTDi 9380.
MGIi MGI:1923488. Grhpr.

Phylogenomic databases

eggNOGi COG1052.
GeneTreei ENSGT00510000046913.
HOGENOMi HOG000136700.
HOVERGENi HBG051838.
InParanoidi Q91Z53.
KOi K00049.
OMAi RGPIMNE.
OrthoDBi EOG7K3TMJ.
PhylomeDBi Q91Z53.
TreeFami TF324791.

Enzyme and pathway databases

Reactomei REACT_261828. Glyoxylate metabolism.

Miscellaneous databases

NextBioi 344835.
PROi Q91Z53.
SOURCEi Search...

Gene expression databases

Bgeei Q91Z53.
CleanExi MM_GRHPR.
ExpressionAtlasi Q91Z53. baseline and differential.
Genevestigatori Q91Z53.

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR029753. D-isomer_DH_CS.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view ]
PROSITEi PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the mouse GRHPR cDNA from liver."
    Cramer S.D.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/SvEv.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  3. Lubec G., Klug S.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 44-58 AND 303-318, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hippocampus.

Entry informationi

Entry nameiGRHPR_MOUSE
AccessioniPrimary (citable) accession number: Q91Z53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3