Reviewed, UniProtKB/Swiss-Prot Q91Z53 (GRHPR_MOUSE)

Names and origin

Protein names

Recommended name:
    Glyoxylate reductase/hydroxypyruvate reductase
    EC=1.1.1.79

Gene names

Name:	Grhpr
Synonyms:	Glxr

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	328 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities By similarity.
Catalytic activity	Glycolate + NADP+ = glyoxylate + NADPH.
Subunit structure	Monomer By similarity.
Sequence similarities	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro glyoxylate reductase (NADP) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 328	328	Glyoxylate reductase/hydroxypyruvate reductase		PRO_0000075945
Sites
	Active site	245	1	By similarity
	Active site	274	1	By similarity
	Active site	293	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q91Z53-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: BDEC1ADEC1E18153	FASTA	328	35,329
	10 20 30 40 50 60 MKPARLMKVF VTGPLPAEGR AALAQAADCE VEQWNSDDPI PRKDLEQGVV GAHGLLCRLS 70 80 90 100 110 120 DRVDKKLLDA AGANLRVIST LSVGVDHLAL DEIKKRGIRV GYTPGVLTDA TAELAVSLLL 130 140 150 160 170 180 TTCRRLPEAI EEVKNGGWSS WSPLWMCGYG LSQSTVGIVG LGRIGQAIAR RLKPFGVQRF 190 200 210 220 230 240 LYTGRQPRPQ EAAEFQAEFV PIAQLAAESD FIVVSCSLTP DTMGLCSKDF FQKMKNTAIF 250 260 270 280 290 300 INISRGDVVN QEDLYQALAS GQIAAAGLDV TTPEPLPPSH PLLTLKNCVI LPHIGSATYK 310 320 TRNTMSLLAA NNLLAGLRGE AMPSELKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of the mouse GRHPR cDNA from liver." Cramer S.D. Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: 129/SvEv. Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary tumor.
[3]	Lubec G., Klug S. Submitted (MAR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 44-58 AND 303-318, MASS SPECTROMETRY. Tissue: Hippocampus.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY113690 mRNA. Translation: AAM52985.1. BC010194 mRNA. Translation: AAH10194.1.
IPI	IPI00130530.
RefSeq	NP_525028.1.
UniGene	Mm.196574
3D structure databases
HSSP	HSSP built from PDB template 1GDH based on UniProtKB P36234.
SMR	Q91Z53. Positions 5-328.
ModBase	Search...
2-D gel databases
REPRODUCTION-2DPAGE	Q91Z53.
Proteomic databases
PRIDE	Q91Z53.
Genome annotation databases
Ensembl	ENSMUSG00000035637. Mus musculus. [Contig view]
GeneID	76238.
KEGG	mmu:76238.
NMPDR	fig|10090.3.peg.9510.
Organism-specific databases
MGI	MGI:1923488. Grhpr.
Phylogenomic databases
HOGENOM	Q91Z53.
HOVERGEN	Q91Z53.
OMA	Q91Z53. QAADCEV.
Enzyme and pathway databases
BRENDA	1.1.1.79. 244.
Gene expression databases
Bgee	Q91Z53.
CleanEx	MM_GRHPR.
GermOnline	ENSMUSG00000035637. Mus musculus.
Family and domain databases
InterPro	IPR006139. D-isomer_2_OHA_DH. IPR006140. D-isomer_2_OHA_DH_NAD-bd. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF00389. 2-Hacid_dh. 1 hit. PF02826. 2-Hacid_dh_C. 1 hit. [Graphical view]
PROSITE	PS00065. D_2_HYDROXYACID_DH_1. False negative. PS00670. D_2_HYDROXYACID_DH_2. False negative. PS00671. D_2_HYDROXYACID_DH_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	344835.
SOURCE	Search...

Entry information

Entry name

GRHPR_MOUSE

Accession

Primary (citable) accession number: Q91Z53

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	December 1, 2001
Last modified:	June 16, 2009
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)