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Q91Z53 (GRHPR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glyoxylate reductase/hydroxypyruvate reductase

EC=1.1.1.79
EC=1.1.1.81
Gene names
Name:Grhpr
Synonyms:Glxr
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate By similarity.

Catalytic activity

Glycolate + NADP+ = glyoxylate + NADPH.

D-glycerate + NAD(P)+ = hydroxypyruvate + NAD(P)H.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 328328Glyoxylate reductase/hydroxypyruvate reductase
PRO_0000075945

Regions

Nucleotide binding162 – 1643NADP By similarity
Nucleotide binding185 – 1884NADP By similarity
Region83 – 842Substrate binding By similarity
Region293 – 2964Substrate binding By similarity

Sites

Active site2931Proton donor By similarity
Binding site2171NADP By similarity
Binding site2431NADP; via carbonyl oxygen By similarity
Binding site2451Substrate By similarity
Binding site2691Substrate By similarity
Binding site2951NADP; via amide nitrogen By similarity
Site2741Raises pKa of active site His By similarity

Sequences

Sequence LengthMass (Da)Tools
Q91Z53 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: BDEC1ADEC1E18153

FASTA32835,329
        10         20         30         40         50         60 
MKPARLMKVF VTGPLPAEGR AALAQAADCE VEQWNSDDPI PRKDLEQGVV GAHGLLCRLS 

        70         80         90        100        110        120 
DRVDKKLLDA AGANLRVIST LSVGVDHLAL DEIKKRGIRV GYTPGVLTDA TAELAVSLLL 

       130        140        150        160        170        180 
TTCRRLPEAI EEVKNGGWSS WSPLWMCGYG LSQSTVGIVG LGRIGQAIAR RLKPFGVQRF 

       190        200        210        220        230        240 
LYTGRQPRPQ EAAEFQAEFV PIAQLAAESD FIVVSCSLTP DTMGLCSKDF FQKMKNTAIF 

       250        260        270        280        290        300 
INISRGDVVN QEDLYQALAS GQIAAAGLDV TTPEPLPPSH PLLTLKNCVI LPHIGSATYK 

       310        320 
TRNTMSLLAA NNLLAGLRGE AMPSELKL 

« Hide

References

« Hide 'large scale' references
[1]"Identification of the mouse GRHPR cDNA from liver."
Cramer S.D.
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/SvEv.
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
[3]Lubec G., Klug S.
Submitted (MAR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 44-58 AND 303-318, IDENTIFICATION BY MASS SPECTROMETRY.
Tissue: Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY113690 mRNA. Translation: AAM52985.1.
BC010194 mRNA. Translation: AAH10194.1.
RefSeqNP_525028.1. NM_080289.1.
UniGeneMm.196574.

3D structure databases

ProteinModelPortalQ91Z53.
SMRQ91Z53. Positions 5-328.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ91Z53. 4 interactions.
MINTMINT-1868690.

PTM databases

PhosphoSiteQ91Z53.

2D gel databases

REPRODUCTION-2DPAGEQ91Z53.

Proteomic databases

PaxDbQ91Z53.
PRIDEQ91Z53.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000045078; ENSMUSP00000047218; ENSMUSG00000035637.
GeneID76238.
KEGGmmu:76238.
UCSCuc008ssb.1. mouse.

Organism-specific databases

CTD9380.
MGIMGI:1923488. Grhpr.

Phylogenomic databases

eggNOGCOG1052.
GeneTreeENSGT00510000046913.
HOGENOMHOG000136700.
HOVERGENHBG051838.
InParanoidQ91Z53.
KOK00049.
OMAERSMKPS.
OrthoDBEOG7K3TMJ.
PhylomeDBQ91Z53.
TreeFamTF324791.

Gene expression databases

ArrayExpressQ91Z53.
BgeeQ91Z53.
CleanExMM_GRHPR.
GenevestigatorQ91Z53.

Family and domain databases

Gene3D3.40.50.720. 2 hits.
InterProIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_2_OHA_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEPS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio344835.
PROQ91Z53.
SOURCESearch...

Entry information

Entry nameGRHPR_MOUSE
AccessionPrimary (citable) accession number: Q91Z53
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot