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Q91Z53

- GRHPR_MOUSE

UniProt

Q91Z53 - GRHPR_MOUSE

Protein

Glyoxylate reductase/hydroxypyruvate reductase

Gene

Grhpr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate By similarity.By similarity

    Catalytic activityi

    Glycolate + NADP+ = glyoxylate + NADPH.
    D-glycerate + NAD(P)+ = hydroxypyruvate + NAD(P)H.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei217 – 2171NADPBy similarity
    Binding sitei243 – 2431NADP; via carbonyl oxygenBy similarity
    Binding sitei245 – 2451SubstrateBy similarity
    Binding sitei269 – 2691SubstrateBy similarity
    Sitei274 – 2741Raises pKa of active site HisBy similarity
    Active sitei293 – 2931Proton donorBy similarity
    Binding sitei295 – 2951NADP; via amide nitrogenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi162 – 1643NADPBy similarity
    Nucleotide bindingi185 – 1884NADPBy similarity

    GO - Molecular functioni

    1. carboxylic acid binding Source: Ensembl
    2. glycerate dehydrogenase activity Source: Ensembl
    3. glyoxylate reductase (NADP) activity Source: UniProtKB-EC
    4. hydroxypyruvate reductase activity Source: UniProtKB-EC
    5. NAD binding Source: Ensembl
    6. NADPH binding Source: Ensembl

    GO - Biological processi

    1. dicarboxylic acid metabolic process Source: Ensembl
    2. excretion Source: Ensembl
    3. protein oligomerization Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glyoxylate reductase/hydroxypyruvate reductase (EC:1.1.1.79, EC:1.1.1.81)
    Gene namesi
    Name:Grhpr
    Synonyms:Glxr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1923488. Grhpr.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 328328Glyoxylate reductase/hydroxypyruvate reductasePRO_0000075945Add
    BLAST

    Proteomic databases

    MaxQBiQ91Z53.
    PaxDbiQ91Z53.
    PRIDEiQ91Z53.

    2D gel databases

    REPRODUCTION-2DPAGEQ91Z53.

    PTM databases

    PhosphoSiteiQ91Z53.

    Expressioni

    Gene expression databases

    ArrayExpressiQ91Z53.
    BgeeiQ91Z53.
    CleanExiMM_GRHPR.
    GenevestigatoriQ91Z53.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    IntActiQ91Z53. 4 interactions.
    MINTiMINT-1868690.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91Z53.
    SMRiQ91Z53. Positions 5-328.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni83 – 842Substrate bindingBy similarity
    Regioni293 – 2964Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1052.
    GeneTreeiENSGT00510000046913.
    HOGENOMiHOG000136700.
    HOVERGENiHBG051838.
    InParanoidiQ91Z53.
    KOiK00049.
    OMAiRGPIMNE.
    OrthoDBiEOG7K3TMJ.
    PhylomeDBiQ91Z53.
    TreeFamiTF324791.

    Family and domain databases

    Gene3Di3.40.50.720. 2 hits.
    InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
    IPR006140. D-isomer_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00389. 2-Hacid_dh. 1 hit.
    PF02826. 2-Hacid_dh_C. 1 hit.
    [Graphical view]
    PROSITEiPS00671. D_2_HYDROXYACID_DH_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91Z53-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKPARLMKVF VTGPLPAEGR AALAQAADCE VEQWNSDDPI PRKDLEQGVV    50
    GAHGLLCRLS DRVDKKLLDA AGANLRVIST LSVGVDHLAL DEIKKRGIRV 100
    GYTPGVLTDA TAELAVSLLL TTCRRLPEAI EEVKNGGWSS WSPLWMCGYG 150
    LSQSTVGIVG LGRIGQAIAR RLKPFGVQRF LYTGRQPRPQ EAAEFQAEFV 200
    PIAQLAAESD FIVVSCSLTP DTMGLCSKDF FQKMKNTAIF INISRGDVVN 250
    QEDLYQALAS GQIAAAGLDV TTPEPLPPSH PLLTLKNCVI LPHIGSATYK 300
    TRNTMSLLAA NNLLAGLRGE AMPSELKL 328
    Length:328
    Mass (Da):35,329
    Last modified:December 1, 2001 - v1
    Checksum:iBDEC1ADEC1E18153
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY113690 mRNA. Translation: AAM52985.1.
    BC010194 mRNA. Translation: AAH10194.1.
    CCDSiCCDS18128.1.
    RefSeqiNP_525028.1. NM_080289.1.
    UniGeneiMm.196574.

    Genome annotation databases

    EnsembliENSMUST00000045078; ENSMUSP00000047218; ENSMUSG00000035637.
    GeneIDi76238.
    KEGGimmu:76238.
    UCSCiuc008ssb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY113690 mRNA. Translation: AAM52985.1 .
    BC010194 mRNA. Translation: AAH10194.1 .
    CCDSi CCDS18128.1.
    RefSeqi NP_525028.1. NM_080289.1.
    UniGenei Mm.196574.

    3D structure databases

    ProteinModelPortali Q91Z53.
    SMRi Q91Z53. Positions 5-328.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q91Z53. 4 interactions.
    MINTi MINT-1868690.

    PTM databases

    PhosphoSitei Q91Z53.

    2D gel databases

    REPRODUCTION-2DPAGE Q91Z53.

    Proteomic databases

    MaxQBi Q91Z53.
    PaxDbi Q91Z53.
    PRIDEi Q91Z53.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000045078 ; ENSMUSP00000047218 ; ENSMUSG00000035637 .
    GeneIDi 76238.
    KEGGi mmu:76238.
    UCSCi uc008ssb.1. mouse.

    Organism-specific databases

    CTDi 9380.
    MGIi MGI:1923488. Grhpr.

    Phylogenomic databases

    eggNOGi COG1052.
    GeneTreei ENSGT00510000046913.
    HOGENOMi HOG000136700.
    HOVERGENi HBG051838.
    InParanoidi Q91Z53.
    KOi K00049.
    OMAi RGPIMNE.
    OrthoDBi EOG7K3TMJ.
    PhylomeDBi Q91Z53.
    TreeFami TF324791.

    Miscellaneous databases

    NextBioi 344835.
    PROi Q91Z53.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91Z53.
    Bgeei Q91Z53.
    CleanExi MM_GRHPR.
    Genevestigatori Q91Z53.

    Family and domain databases

    Gene3Di 3.40.50.720. 2 hits.
    InterProi IPR006139. D-isomer_2_OHA_DH_cat_dom.
    IPR006140. D-isomer_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00389. 2-Hacid_dh. 1 hit.
    PF02826. 2-Hacid_dh_C. 1 hit.
    [Graphical view ]
    PROSITEi PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the mouse GRHPR cDNA from liver."
      Cramer S.D.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/SvEv.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.
    3. Lubec G., Klug S.
      Submitted (MAR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 44-58 AND 303-318, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiGRHPR_MOUSE
    AccessioniPrimary (citable) accession number: Q91Z53
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3