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Q91Z46

- DUS7_MOUSE

UniProt

Q91Z46 - DUS7_MOUSE

Protein

Dual specificity protein phosphatase 7

Gene

Dusp7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 4 (28 Jun 2011)
      Previous versions | rss
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    Functioni

    Regulates the activity of the MAP kinase family in response to changes in the cellular environment.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei334 – 3341Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. MAP kinase tyrosine/serine/threonine phosphatase activity Source: Ensembl
    2. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    3. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein dephosphorylation Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Enzyme and pathway databases

    ReactomeiREACT_210064. ERKs are inactivated.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 7 (EC:3.1.3.16, EC:3.1.3.48)
    Gene namesi
    Name:Dusp7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:2387100. Dusp7.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosol Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 422422Dual specificity protein phosphatase 7PRO_0000094808Add
    BLAST

    Proteomic databases

    PaxDbiQ91Z46.
    PRIDEiQ91Z46.

    PTM databases

    PhosphoSiteiQ91Z46.

    Expressioni

    Gene expression databases

    ArrayExpressiQ91Z46.
    BgeeiQ91Z46.
    CleanExiMM_DUSP7.
    GenevestigatoriQ91Z46.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91Z46.
    SMRiQ91Z46. Positions 58-196, 246-388.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini71 – 190120RhodanesePROSITE-ProRule annotationAdd
    BLAST
    Domaini311 – 37969Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Contains 1 rhodanese domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2453.
    GeneTreeiENSGT00750000117282.
    HOGENOMiHOG000294079.
    HOVERGENiHBG007347.
    InParanoidiQ91Z46.
    KOiK04459.
    OMAiLRDDGCK.
    OrthoDBiEOG793B7W.
    TreeFamiTF105122.

    Family and domain databases

    Gene3Di3.40.250.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR008343. MKP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR001763. Rhodanese-like_dom.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    PF00581. Rhodanese. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000939. MAPK_Ptase. 1 hit.
    PRINTSiPR01764. MAPKPHPHTASE.
    SMARTiSM00195. DSPc. 1 hit.
    SM00450. RHOD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    SSF52821. SSF52821. 1 hit.
    PROSITEiPS50206. RHODANESE_3. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q91Z46-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKNQLRGPPV RAHMSTSGAA AAAAAGGTRA GSEPGAGSGS GAGIGAGATT    50
    GAGAMPCKSA EWLQEELEAR GGASLLLLDC RPHELFESSH IETAINLAIP 100
    GLMLRRLRKG NLPIRSIIPN HADKERFATR CKAATVLLYD EATAEWQPEP 150
    GAPASVLGLL LQKLRDDGCQ AYYLQGGFNK FQTEYSEHCE TNVDSSSSPS 200
    GSPPTSVLGL GGLRISSDCS DGESDRELPS SATESDGSPV PSSQPAFPVQ 250
    ILPYLYLGCA KDSTNLDVLG KYGIKYILNV TPNLPNAFEH GGEFTYKQIP 300
    ISDHWSQNLS QFFPEAISFI DEARSKKCGV LVHCLAGISR SVTVTVAYLM 350
    QKMNLSLNDA YDFVKRKKSN ISPNFNFMGQ LLDFERTLGL SSPCDNHAPS 400
    EQLYFSTPTN HNLFPINTLE ST 422
    Length:422
    Mass (Da):45,220
    Last modified:June 28, 2011 - v4
    Checksum:i1CD040E34B1D339A
    GO
    Isoform 2 (identifier: Q91Z46-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-54: Missing.

    Show »
    Length:368
    Mass (Da):40,531
    Checksum:iF05AF25F6768BB73
    GO

    Sequence cautioni

    The sequence BAE24360.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti241 – 2411P → S in BAE24360. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5454Missing in isoform 2. CuratedVSP_041462Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK140372 mRNA. Translation: BAE24360.1. Different initiation.
    AC140202 Genomic DNA. No translation available.
    BC010207 mRNA. Translation: AAH10207.1.
    CCDSiCCDS23475.2. [Q91Z46-1]
    RefSeqiNP_703189.3. NM_153459.4. [Q91Z46-1]
    UniGeneiMm.275584.

    Genome annotation databases

    EnsembliENSMUST00000172306; ENSMUSP00000126984; ENSMUSG00000053716. [Q91Z46-1]
    GeneIDi235584.
    KEGGimmu:235584.
    UCSCiuc009rjm.2. mouse. [Q91Z46-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK140372 mRNA. Translation: BAE24360.1 . Different initiation.
    AC140202 Genomic DNA. No translation available.
    BC010207 mRNA. Translation: AAH10207.1 .
    CCDSi CCDS23475.2. [Q91Z46-1 ]
    RefSeqi NP_703189.3. NM_153459.4. [Q91Z46-1 ]
    UniGenei Mm.275584.

    3D structure databases

    ProteinModelPortali Q91Z46.
    SMRi Q91Z46. Positions 58-196, 246-388.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q91Z46.

    Proteomic databases

    PaxDbi Q91Z46.
    PRIDEi Q91Z46.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000172306 ; ENSMUSP00000126984 ; ENSMUSG00000053716 . [Q91Z46-1 ]
    GeneIDi 235584.
    KEGGi mmu:235584.
    UCSCi uc009rjm.2. mouse. [Q91Z46-1 ]

    Organism-specific databases

    CTDi 1849.
    MGIi MGI:2387100. Dusp7.

    Phylogenomic databases

    eggNOGi COG2453.
    GeneTreei ENSGT00750000117282.
    HOGENOMi HOG000294079.
    HOVERGENi HBG007347.
    InParanoidi Q91Z46.
    KOi K04459.
    OMAi LRDDGCK.
    OrthoDBi EOG793B7W.
    TreeFami TF105122.

    Enzyme and pathway databases

    Reactomei REACT_210064. ERKs are inactivated.

    Miscellaneous databases

    NextBioi 382765.
    PROi Q91Z46.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91Z46.
    Bgeei Q91Z46.
    CleanExi MM_DUSP7.
    Genevestigatori Q91Z46.

    Family and domain databases

    Gene3Di 3.40.250.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR008343. MKP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR001763. Rhodanese-like_dom.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    PF00581. Rhodanese. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000939. MAPK_Ptase. 1 hit.
    PRINTSi PR01764. MAPKPHPHTASE.
    SMARTi SM00195. DSPc. 1 hit.
    SM00450. RHOD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    SSF52821. SSF52821. 1 hit.
    PROSITEi PS50206. RHODANESE_3. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Brain cortex.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 65-422.

    Entry informationi

    Entry nameiDUS7_MOUSE
    AccessioniPrimary (citable) accession number: Q91Z46
    Secondary accession number(s): E9PVF4, E9QMS8, Q3USH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: June 28, 2011
    Last modified: October 1, 2014
    This is version 113 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3