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Protein

Solute carrier organic anion transporter family member 1A5

Gene

Slco1a5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the Na+-independent transport of organic anions such as taurocholate and thyroid hormones.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1A5
Alternative name(s):
Organic anion-transporting polypeptide 3
Short name:
OATP-3
Sodium-independent organic anion transporter 3
Solute carrier family 21 member 7
Gene namesi
Name:Slco1a5
Synonyms:Oatp1a5, Oatp3, Slc21a7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1351865. Slco1a5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 40Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini41 – 59ExtracellularSequence analysisAdd BLAST19
Transmembranei60 – 80Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini81 – 86CytoplasmicSequence analysis6
Transmembranei87 – 111Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini112 – 155ExtracellularSequence analysisAdd BLAST44
Transmembranei156 – 184Helical; Name=4Sequence analysisAdd BLAST29
Topological domaini185 – 203CytoplasmicSequence analysisAdd BLAST19
Transmembranei204 – 224Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini225 – 242ExtracellularSequence analysisAdd BLAST18
Transmembranei243 – 267Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini268 – 311CytoplasmicSequence analysisAdd BLAST44
Transmembranei312 – 333Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini334 – 353ExtracellularSequence analysisAdd BLAST20
Transmembranei354 – 377Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini378 – 381CytoplasmicSequence analysis4
Transmembranei382 – 405Helical; Name=9Sequence analysisAdd BLAST24
Topological domaini406 – 513ExtracellularSequence analysisAdd BLAST108
Transmembranei514 – 536Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini537 – 545CytoplasmicSequence analysis9
Transmembranei546 – 571Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini572 – 605ExtracellularSequence analysisAdd BLAST34
Transmembranei606 – 623Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini624 – 670CytoplasmicSequence analysisAdd BLAST47

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910431 – 670Solute carrier organic anion transporter family member 1A5Add BLAST670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi124N-linked (GlcNAc...)Sequence analysis1
Glycosylationi135N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi439 ↔ 465PROSITE-ProRule annotation
Disulfide bondi443 ↔ 454PROSITE-ProRule annotation
Disulfide bondi445 ↔ 469PROSITE-ProRule annotation
Glycosylationi483N-linked (GlcNAc...)Sequence analysis1
Glycosylationi492N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ91YY5.
PRIDEiQ91YY5.

PTM databases

iPTMnetiQ91YY5.
PhosphoSitePlusiQ91YY5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000063975.

Interactioni

Protein-protein interaction databases

MINTiMINT-4997889.
STRINGi10090.ENSMUSP00000080116.

Structurei

3D structure databases

ProteinModelPortaliQ91YY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini433 – 488Kazal-likePROSITE-ProRule annotationAdd BLAST56

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiQ91YY5.
KOiK03460.
PhylomeDBiQ91YY5.
TreeFamiTF317540.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91YY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGETEKRIAT HGVRCFSKIK MFLLALTCAY VSKSLSGIYM NSMLTQIERQ
60 70 80 90 100
FDIPTSIVGL INGSFEIGNL LLIILVSYFG TKLHRPIMIG IGCVIMGLGC
110 120 130 140 150
FLMSLPHFLM GRYEYETTIS PTSNLSSNSF LCMENRTQTL KPTQDPAECV
160 170 180 190 200
KEMKSLMWIY VLVGNIIRGI GETPIMPLGI SYIEDFAKSE NSPLYIGILE
210 220 230 240 250
SGKMIGPIVG LLLGSFCARI YVDTGSVNTD DLTITPTDTR WVGAWWIGFL
260 270 280 290 300
VCAGVNILTS IPFFFFPKTL PKEGLQDNVA RTENDKEEKH REKAKEENRG
310 320 330 340 350
ITKDFLPFMK SLSCNPIYML LILTSVLQIN AFINMFTFLP KYLEQQYGKS
360 370 380 390 400
TSEVVLLIGV CNLPPICIGY LLIGFIMKKF RITVKKAAYM AFCLSLFEYL
410 420 430 440 450
LSYFHFMISC DNFQVAGLTT SYEGVQHPLY VENKVLADCN TRCSCLTNTW
460 470 480 490 500
DPVCGDNGLS YMSACLAGCE KSVGMGTHMV FQNCSCIQSS GNSSAVLGLC
510 520 530 540 550
KKGPECANKL QYFLIMSVIG SFIYSITAIP GYMVLLRCIK SEEKSLGIGL
560 570 580 590 600
HAFCTRIFAG IPAPIYFGAL IDRTCLHWGT LKCGEPGACR IYNINNFRRI
610 620 630 640 650
YLVLPAALRG SSYLPAFFIL ILMRKFQLPG EMYSSETELA DMKQTVKKSE
660 670
CTDVHGIPKV ENDGELKTKL
Length:670
Mass (Da):74,663
Last modified:December 1, 2001 - v1
Checksum:iAF802A903FCD457D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti280A → D in AAK39416 (PubMed:11093941).Curated1
Sequence conflicti591I → M in AAK39416 (PubMed:11093941).Curated1
Sequence conflicti644Q → L in AAK39416 (PubMed:11093941).Curated1
Sequence conflicti656G → R in AAK39416 (PubMed:11093941).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF240694 mRNA. Translation: AAK39416.1.
BC013594 mRNA. Translation: AAH13594.1.
CCDSiCCDS57464.1.
RefSeqiNP_001254636.1. NM_001267707.1.
NP_570931.1. NM_130861.3.
UniGeneiMm.206599.

Genome annotation databases

GeneIDi108096.
KEGGimmu:108096.
UCSCiuc009epa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF240694 mRNA. Translation: AAK39416.1.
BC013594 mRNA. Translation: AAH13594.1.
CCDSiCCDS57464.1.
RefSeqiNP_001254636.1. NM_001267707.1.
NP_570931.1. NM_130861.3.
UniGeneiMm.206599.

3D structure databases

ProteinModelPortaliQ91YY5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4997889.
STRINGi10090.ENSMUSP00000080116.

PTM databases

iPTMnetiQ91YY5.
PhosphoSitePlusiQ91YY5.

Proteomic databases

PaxDbiQ91YY5.
PRIDEiQ91YY5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi108096.
KEGGimmu:108096.
UCSCiuc009epa.2. mouse.

Organism-specific databases

CTDi108096.
MGIiMGI:1351865. Slco1a5.

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiQ91YY5.
KOiK03460.
PhylomeDBiQ91YY5.
TreeFamiTF317540.

Miscellaneous databases

ChiTaRSiSlco1a5. mouse.
PROiQ91YY5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063975.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSO1A5_MOUSE
AccessioniPrimary (citable) accession number: Q91YY5
Secondary accession number(s): Q91XS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.