Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q91YY5 (SO1A5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier organic anion transporter family member 1A5
Alternative name(s):
Organic anion-transporting polypeptide 3
Short name=OATP-3
Sodium-independent organic anion transporter 3
Solute carrier family 21 member 7
Gene names
Name:Slco1a5
Synonyms:Oatp1a5, Oatp3, Slc21a7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length670 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates the Na+-independent transport of organic anions such as taurocholate and thyroid hormones By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the organo anion transporter (TC 2.A.60) family. [View classification]

Contains 1 Kazal-like domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 670670Solute carrier organic anion transporter family member 1A5
PRO_0000191043

Regions

Topological domain1 – 2020Cytoplasmic Potential
Transmembrane21 – 4020Helical; Name=1; Potential
Topological domain41 – 5919Extracellular Potential
Transmembrane60 – 8021Helical; Name=2; Potential
Topological domain81 – 866Cytoplasmic Potential
Transmembrane87 – 11125Helical; Name=3; Potential
Topological domain112 – 15544Extracellular Potential
Transmembrane156 – 18429Helical; Name=4; Potential
Topological domain185 – 20319Cytoplasmic Potential
Transmembrane204 – 22421Helical; Name=5; Potential
Topological domain225 – 24218Extracellular Potential
Transmembrane243 – 26725Helical; Name=6; Potential
Topological domain268 – 31144Cytoplasmic Potential
Transmembrane312 – 33322Helical; Name=7; Potential
Topological domain334 – 35320Extracellular Potential
Transmembrane354 – 37724Helical; Name=8; Potential
Topological domain378 – 3814Cytoplasmic Potential
Transmembrane382 – 40524Helical; Name=9; Potential
Topological domain406 – 513108Extracellular Potential
Transmembrane514 – 53623Helical; Name=10; Potential
Topological domain537 – 5459Cytoplasmic Potential
Transmembrane546 – 57126Helical; Name=11; Potential
Topological domain572 – 60534Extracellular Potential
Transmembrane606 – 62318Helical; Name=12; Potential
Topological domain624 – 67047Cytoplasmic Potential
Domain433 – 48856Kazal-like

Amino acid modifications

Glycosylation1241N-linked (GlcNAc...) Potential
Glycosylation1351N-linked (GlcNAc...) Potential
Glycosylation4831N-linked (GlcNAc...) Potential
Glycosylation4921N-linked (GlcNAc...) Potential
Disulfide bond439 ↔ 465 By similarity
Disulfide bond443 ↔ 454 By similarity
Disulfide bond445 ↔ 469 By similarity

Experimental info

Sequence conflict2801A → D in AAK39416. Ref.1
Sequence conflict5911I → M in AAK39416. Ref.1
Sequence conflict6441Q → L in AAK39416. Ref.1
Sequence conflict6561G → R in AAK39416. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q91YY5 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: AF802A903FCD457D

FASTA67074,663
        10         20         30         40         50         60 
MGETEKRIAT HGVRCFSKIK MFLLALTCAY VSKSLSGIYM NSMLTQIERQ FDIPTSIVGL 

        70         80         90        100        110        120 
INGSFEIGNL LLIILVSYFG TKLHRPIMIG IGCVIMGLGC FLMSLPHFLM GRYEYETTIS 

       130        140        150        160        170        180 
PTSNLSSNSF LCMENRTQTL KPTQDPAECV KEMKSLMWIY VLVGNIIRGI GETPIMPLGI 

       190        200        210        220        230        240 
SYIEDFAKSE NSPLYIGILE SGKMIGPIVG LLLGSFCARI YVDTGSVNTD DLTITPTDTR 

       250        260        270        280        290        300 
WVGAWWIGFL VCAGVNILTS IPFFFFPKTL PKEGLQDNVA RTENDKEEKH REKAKEENRG 

       310        320        330        340        350        360 
ITKDFLPFMK SLSCNPIYML LILTSVLQIN AFINMFTFLP KYLEQQYGKS TSEVVLLIGV 

       370        380        390        400        410        420 
CNLPPICIGY LLIGFIMKKF RITVKKAAYM AFCLSLFEYL LSYFHFMISC DNFQVAGLTT 

       430        440        450        460        470        480 
SYEGVQHPLY VENKVLADCN TRCSCLTNTW DPVCGDNGLS YMSACLAGCE KSVGMGTHMV 

       490        500        510        520        530        540 
FQNCSCIQSS GNSSAVLGLC KKGPECANKL QYFLIMSVIG SFIYSITAIP GYMVLLRCIK 

       550        560        570        580        590        600 
SEEKSLGIGL HAFCTRIFAG IPAPIYFGAL IDRTCLHWGT LKCGEPGACR IYNINNFRRI 

       610        620        630        640        650        660 
YLVLPAALRG SSYLPAFFIL ILMRKFQLPG EMYSSETELA DMKQTVKKSE CTDVHGIPKV 

       670 
ENDGELKTKL 

« Hide

References

« Hide 'large scale' references
[1]"Expression, transport properties, and chromosomal location of organic anion transporter subtype 3."
Walters H.C., Craddock A.L., Fusegawa H., Willingham M.C., Dawson P.A.
Am. J. Physiol. 279:G1188-G1200(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF240694 mRNA. Translation: AAK39416.1.
BC013594 mRNA. Translation: AAH13594.1.
RefSeqNP_001254636.1. NM_001267707.1.
NP_570931.1. NM_130861.3.
XP_006506920.1. XM_006506857.1.
UniGeneMm.206599.

3D structure databases

ProteinModelPortalQ91YY5.
SMRQ91YY5. Positions 163-221, 441-503.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4997889.
STRING10090.ENSMUSP00000107456.

Proteomic databases

PaxDbQ91YY5.
PRIDEQ91YY5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000081380; ENSMUSP00000080116; ENSMUSG00000063975.
ENSMUST00000111825; ENSMUSP00000137607; ENSMUSG00000063975.
GeneID108096.
KEGGmmu:108096.

Organism-specific databases

CTD108096.
MGIMGI:1351865. Slco1a5.

Phylogenomic databases

eggNOGNOG256971.
GeneTreeENSGT00740000115555.
HOGENOMHOG000231269.
HOVERGENHBG063896.
InParanoidQ91YY5.
KOK03460.
OrthoDBEOG7GFB4C.
PhylomeDBQ91YY5.
TreeFamTF317540.

Gene expression databases

GenevestigatorQ91YY5.

Family and domain databases

InterProIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view]
PANTHERPTHR11388. PTHR11388. 1 hit.
PfamPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SMARTSM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 3 hits.
TIGRFAMsTIGR00805. oat. 1 hit.
PROSITEPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSlco1a5. mouse.
NextBio360050.
PROQ91YY5.
SOURCESearch...

Entry information

Entry nameSO1A5_MOUSE
AccessionPrimary (citable) accession number: Q91YY5
Secondary accession number(s): Q91XS2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot