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Q91YY5

- SO1A5_MOUSE

UniProt

Q91YY5 - SO1A5_MOUSE

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Protein

Solute carrier organic anion transporter family member 1A5

Gene

Slco1a5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Mediates the Na+-independent transport of organic anions such as taurocholate and thyroid hormones.By similarity

GO - Molecular functioni

  1. bile acid transmembrane transporter activity Source: MGI
  2. thyroid hormone transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. intestinal absorption Source: Ensembl
  2. organ regeneration Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_210189. Transport of organic anions.
REACT_239346. Recycling of bile acids and salts.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1A5
Alternative name(s):
Organic anion-transporting polypeptide 3
Short name:
OATP-3
Sodium-independent organic anion transporter 3
Solute carrier family 21 member 7
Gene namesi
Name:Slco1a5
Synonyms:Oatp1a5, Oatp3, Slc21a7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1351865. Slco1a5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei21 – 4020Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini41 – 5919ExtracellularSequence AnalysisAdd
BLAST
Transmembranei60 – 8021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini81 – 866CytoplasmicSequence Analysis
Transmembranei87 – 11125Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini112 – 15544ExtracellularSequence AnalysisAdd
BLAST
Transmembranei156 – 18429Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini185 – 20319CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei204 – 22421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini225 – 24218ExtracellularSequence AnalysisAdd
BLAST
Transmembranei243 – 26725Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini268 – 31144CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei312 – 33322Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini334 – 35320ExtracellularSequence AnalysisAdd
BLAST
Transmembranei354 – 37724Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini378 – 3814CytoplasmicSequence Analysis
Transmembranei382 – 40524Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini406 – 513108ExtracellularSequence AnalysisAdd
BLAST
Transmembranei514 – 53623Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini537 – 5459CytoplasmicSequence Analysis
Transmembranei546 – 57126Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini572 – 60534ExtracellularSequence AnalysisAdd
BLAST
Transmembranei606 – 62318Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini624 – 67047CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. brush border membrane Source: Ensembl
  2. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 670670Solute carrier organic anion transporter family member 1A5PRO_0000191043Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi439 ↔ 465PROSITE-ProRule annotation
Disulfide bondi443 ↔ 454PROSITE-ProRule annotation
Disulfide bondi445 ↔ 469PROSITE-ProRule annotation
Glycosylationi483 – 4831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi492 – 4921N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ91YY5.
PRIDEiQ91YY5.

Expressioni

Gene expression databases

ExpressionAtlasiQ91YY5. differential.
GenevestigatoriQ91YY5.

Interactioni

Protein-protein interaction databases

MINTiMINT-4997889.
STRINGi10090.ENSMUSP00000107456.

Structurei

3D structure databases

ProteinModelPortaliQ91YY5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini433 – 48856Kazal-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG256971.
GeneTreeiENSGT00760000119014.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiQ91YY5.
KOiK03460.
OrthoDBiEOG7GFB4C.
PhylomeDBiQ91YY5.
TreeFamiTF317540.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91YY5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGETEKRIAT HGVRCFSKIK MFLLALTCAY VSKSLSGIYM NSMLTQIERQ
60 70 80 90 100
FDIPTSIVGL INGSFEIGNL LLIILVSYFG TKLHRPIMIG IGCVIMGLGC
110 120 130 140 150
FLMSLPHFLM GRYEYETTIS PTSNLSSNSF LCMENRTQTL KPTQDPAECV
160 170 180 190 200
KEMKSLMWIY VLVGNIIRGI GETPIMPLGI SYIEDFAKSE NSPLYIGILE
210 220 230 240 250
SGKMIGPIVG LLLGSFCARI YVDTGSVNTD DLTITPTDTR WVGAWWIGFL
260 270 280 290 300
VCAGVNILTS IPFFFFPKTL PKEGLQDNVA RTENDKEEKH REKAKEENRG
310 320 330 340 350
ITKDFLPFMK SLSCNPIYML LILTSVLQIN AFINMFTFLP KYLEQQYGKS
360 370 380 390 400
TSEVVLLIGV CNLPPICIGY LLIGFIMKKF RITVKKAAYM AFCLSLFEYL
410 420 430 440 450
LSYFHFMISC DNFQVAGLTT SYEGVQHPLY VENKVLADCN TRCSCLTNTW
460 470 480 490 500
DPVCGDNGLS YMSACLAGCE KSVGMGTHMV FQNCSCIQSS GNSSAVLGLC
510 520 530 540 550
KKGPECANKL QYFLIMSVIG SFIYSITAIP GYMVLLRCIK SEEKSLGIGL
560 570 580 590 600
HAFCTRIFAG IPAPIYFGAL IDRTCLHWGT LKCGEPGACR IYNINNFRRI
610 620 630 640 650
YLVLPAALRG SSYLPAFFIL ILMRKFQLPG EMYSSETELA DMKQTVKKSE
660 670
CTDVHGIPKV ENDGELKTKL
Length:670
Mass (Da):74,663
Last modified:December 1, 2001 - v1
Checksum:iAF802A903FCD457D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti280 – 2801A → D in AAK39416. (PubMed:11093941)Curated
Sequence conflicti591 – 5911I → M in AAK39416. (PubMed:11093941)Curated
Sequence conflicti644 – 6441Q → L in AAK39416. (PubMed:11093941)Curated
Sequence conflicti656 – 6561G → R in AAK39416. (PubMed:11093941)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF240694 mRNA. Translation: AAK39416.1.
BC013594 mRNA. Translation: AAH13594.1.
CCDSiCCDS57464.1.
RefSeqiNP_001254636.1. NM_001267707.1.
NP_570931.1. NM_130861.3.
XP_006506920.1. XM_006506857.1.
UniGeneiMm.206599.

Genome annotation databases

EnsembliENSMUST00000081380; ENSMUSP00000080116; ENSMUSG00000063975.
ENSMUST00000111825; ENSMUSP00000137607; ENSMUSG00000063975.
GeneIDi108096.
KEGGimmu:108096.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF240694 mRNA. Translation: AAK39416.1 .
BC013594 mRNA. Translation: AAH13594.1 .
CCDSi CCDS57464.1.
RefSeqi NP_001254636.1. NM_001267707.1.
NP_570931.1. NM_130861.3.
XP_006506920.1. XM_006506857.1.
UniGenei Mm.206599.

3D structure databases

ProteinModelPortali Q91YY5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4997889.
STRINGi 10090.ENSMUSP00000107456.

Proteomic databases

PaxDbi Q91YY5.
PRIDEi Q91YY5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000081380 ; ENSMUSP00000080116 ; ENSMUSG00000063975 .
ENSMUST00000111825 ; ENSMUSP00000137607 ; ENSMUSG00000063975 .
GeneIDi 108096.
KEGGi mmu:108096.

Organism-specific databases

CTDi 108096.
MGIi MGI:1351865. Slco1a5.

Phylogenomic databases

eggNOGi NOG256971.
GeneTreei ENSGT00760000119014.
HOGENOMi HOG000231269.
HOVERGENi HBG063896.
InParanoidi Q91YY5.
KOi K03460.
OrthoDBi EOG7GFB4C.
PhylomeDBi Q91YY5.
TreeFami TF317540.

Enzyme and pathway databases

Reactomei REACT_210189. Transport of organic anions.
REACT_239346. Recycling of bile acids and salts.

Miscellaneous databases

ChiTaRSi Slco1a5. mouse.
NextBioi 360050.
PROi Q91YY5.
SOURCEi Search...

Gene expression databases

ExpressionAtlasi Q91YY5. differential.
Genevestigatori Q91YY5.

Family and domain databases

InterProi IPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view ]
PANTHERi PTHR11388. PTHR11388. 1 hit.
Pfami PF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view ]
SMARTi SM00280. KAZAL. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 3 hits.
TIGRFAMsi TIGR00805. oat. 1 hit.
PROSITEi PS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression, transport properties, and chromosomal location of organic anion transporter subtype 3."
    Walters H.C., Craddock A.L., Fusegawa H., Willingham M.C., Dawson P.A.
    Am. J. Physiol. 279:G1188-G1200(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.

Entry informationi

Entry nameiSO1A5_MOUSE
AccessioniPrimary (citable) accession number: Q91YY5
Secondary accession number(s): Q91XS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3