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Q91YY5

- SO1A5_MOUSE

UniProt

Q91YY5 - SO1A5_MOUSE

Protein

Solute carrier organic anion transporter family member 1A5

Gene

Slco1a5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Mediates the Na+-independent transport of organic anions such as taurocholate and thyroid hormones.By similarity

    GO - Molecular functioni

    1. bile acid transmembrane transporter activity Source: MGI
    2. thyroid hormone transmembrane transporter activity Source: Ensembl

    GO - Biological processi

    1. intestinal absorption Source: Ensembl
    2. organ regeneration Source: Ensembl

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_210189. Transport of organic anions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier organic anion transporter family member 1A5
    Alternative name(s):
    Organic anion-transporting polypeptide 3
    Short name:
    OATP-3
    Sodium-independent organic anion transporter 3
    Solute carrier family 21 member 7
    Gene namesi
    Name:Slco1a5
    Synonyms:Oatp1a5, Oatp3, Slc21a7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1351865. Slco1a5.

    Subcellular locationi

    GO - Cellular componenti

    1. brush border membrane Source: Ensembl
    2. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 670670Solute carrier organic anion transporter family member 1A5PRO_0000191043Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi124 – 1241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi439 ↔ 465PROSITE-ProRule annotation
    Disulfide bondi443 ↔ 454PROSITE-ProRule annotation
    Disulfide bondi445 ↔ 469PROSITE-ProRule annotation
    Glycosylationi483 – 4831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi492 – 4921N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ91YY5.
    PRIDEiQ91YY5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ91YY5.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4997889.
    STRINGi10090.ENSMUSP00000107456.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91YY5.
    SMRiQ91YY5. Positions 437-468.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini41 – 5919ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini81 – 866CytoplasmicSequence Analysis
    Topological domaini112 – 15544ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini185 – 20319CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini225 – 24218ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini268 – 31144CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini334 – 35320ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini378 – 3814CytoplasmicSequence Analysis
    Topological domaini406 – 513108ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini537 – 5459CytoplasmicSequence Analysis
    Topological domaini572 – 60534ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini624 – 67047CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4020Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei87 – 11125Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei156 – 18429Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei243 – 26725Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei312 – 33322Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei354 – 37724Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei382 – 40524Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei514 – 53623Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei546 – 57126Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei606 – 62318Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini433 – 48856Kazal-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Kazal-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG256971.
    GeneTreeiENSGT00740000115555.
    HOGENOMiHOG000231269.
    HOVERGENiHBG063896.
    InParanoidiQ91YY5.
    KOiK03460.
    OrthoDBiEOG7GFB4C.
    PhylomeDBiQ91YY5.
    TreeFamiTF317540.

    Family and domain databases

    InterProiIPR002350. Kazal_dom.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view]
    PANTHERiPTHR11388. PTHR11388. 1 hit.
    PfamiPF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view]
    SMARTiSM00280. KAZAL. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 3 hits.
    TIGRFAMsiTIGR00805. oat. 1 hit.
    PROSITEiPS51465. KAZAL_2. 1 hit.
    PS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91YY5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGETEKRIAT HGVRCFSKIK MFLLALTCAY VSKSLSGIYM NSMLTQIERQ    50
    FDIPTSIVGL INGSFEIGNL LLIILVSYFG TKLHRPIMIG IGCVIMGLGC 100
    FLMSLPHFLM GRYEYETTIS PTSNLSSNSF LCMENRTQTL KPTQDPAECV 150
    KEMKSLMWIY VLVGNIIRGI GETPIMPLGI SYIEDFAKSE NSPLYIGILE 200
    SGKMIGPIVG LLLGSFCARI YVDTGSVNTD DLTITPTDTR WVGAWWIGFL 250
    VCAGVNILTS IPFFFFPKTL PKEGLQDNVA RTENDKEEKH REKAKEENRG 300
    ITKDFLPFMK SLSCNPIYML LILTSVLQIN AFINMFTFLP KYLEQQYGKS 350
    TSEVVLLIGV CNLPPICIGY LLIGFIMKKF RITVKKAAYM AFCLSLFEYL 400
    LSYFHFMISC DNFQVAGLTT SYEGVQHPLY VENKVLADCN TRCSCLTNTW 450
    DPVCGDNGLS YMSACLAGCE KSVGMGTHMV FQNCSCIQSS GNSSAVLGLC 500
    KKGPECANKL QYFLIMSVIG SFIYSITAIP GYMVLLRCIK SEEKSLGIGL 550
    HAFCTRIFAG IPAPIYFGAL IDRTCLHWGT LKCGEPGACR IYNINNFRRI 600
    YLVLPAALRG SSYLPAFFIL ILMRKFQLPG EMYSSETELA DMKQTVKKSE 650
    CTDVHGIPKV ENDGELKTKL 670
    Length:670
    Mass (Da):74,663
    Last modified:December 1, 2001 - v1
    Checksum:iAF802A903FCD457D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti280 – 2801A → D in AAK39416. (PubMed:11093941)Curated
    Sequence conflicti591 – 5911I → M in AAK39416. (PubMed:11093941)Curated
    Sequence conflicti644 – 6441Q → L in AAK39416. (PubMed:11093941)Curated
    Sequence conflicti656 – 6561G → R in AAK39416. (PubMed:11093941)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF240694 mRNA. Translation: AAK39416.1.
    BC013594 mRNA. Translation: AAH13594.1.
    CCDSiCCDS57464.1.
    RefSeqiNP_001254636.1. NM_001267707.1.
    NP_570931.1. NM_130861.3.
    XP_006506920.1. XM_006506857.1.
    UniGeneiMm.206599.

    Genome annotation databases

    EnsembliENSMUST00000081380; ENSMUSP00000080116; ENSMUSG00000063975.
    ENSMUST00000111825; ENSMUSP00000137607; ENSMUSG00000063975.
    GeneIDi108096.
    KEGGimmu:108096.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF240694 mRNA. Translation: AAK39416.1 .
    BC013594 mRNA. Translation: AAH13594.1 .
    CCDSi CCDS57464.1.
    RefSeqi NP_001254636.1. NM_001267707.1.
    NP_570931.1. NM_130861.3.
    XP_006506920.1. XM_006506857.1.
    UniGenei Mm.206599.

    3D structure databases

    ProteinModelPortali Q91YY5.
    SMRi Q91YY5. Positions 437-468.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4997889.
    STRINGi 10090.ENSMUSP00000107456.

    Proteomic databases

    PaxDbi Q91YY5.
    PRIDEi Q91YY5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000081380 ; ENSMUSP00000080116 ; ENSMUSG00000063975 .
    ENSMUST00000111825 ; ENSMUSP00000137607 ; ENSMUSG00000063975 .
    GeneIDi 108096.
    KEGGi mmu:108096.

    Organism-specific databases

    CTDi 108096.
    MGIi MGI:1351865. Slco1a5.

    Phylogenomic databases

    eggNOGi NOG256971.
    GeneTreei ENSGT00740000115555.
    HOGENOMi HOG000231269.
    HOVERGENi HBG063896.
    InParanoidi Q91YY5.
    KOi K03460.
    OrthoDBi EOG7GFB4C.
    PhylomeDBi Q91YY5.
    TreeFami TF317540.

    Enzyme and pathway databases

    Reactomei REACT_210189. Transport of organic anions.

    Miscellaneous databases

    ChiTaRSi Slco1a5. mouse.
    NextBioi 360050.
    PROi Q91YY5.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q91YY5.

    Family and domain databases

    InterProi IPR002350. Kazal_dom.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004156. OA_transporter.
    [Graphical view ]
    PANTHERi PTHR11388. PTHR11388. 1 hit.
    Pfami PF07648. Kazal_2. 1 hit.
    PF03137. OATP. 1 hit.
    [Graphical view ]
    SMARTi SM00280. KAZAL. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 3 hits.
    TIGRFAMsi TIGR00805. oat. 1 hit.
    PROSITEi PS51465. KAZAL_2. 1 hit.
    PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression, transport properties, and chromosomal location of organic anion transporter subtype 3."
      Walters H.C., Craddock A.L., Fusegawa H., Willingham M.C., Dawson P.A.
      Am. J. Physiol. 279:G1188-G1200(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiSO1A5_MOUSE
    AccessioniPrimary (citable) accession number: Q91YY5
    Secondary accession number(s): Q91XS2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3