Solute carrier organic anion transporter family member 1A5

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Q91YY5 (SO1A5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 92. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Solute carrier organic anion transporter family member 1A5

Alternative name(s):
Organic anion-transporting polypeptide 3
Short name=OATP-3
Sodium-independent organic anion transporter 3
Solute carrier family 21 member 7

Gene names

Name:	Slco1a5
Synonyms:	Oatp1a5, Oatp3, Slc21a7

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	670 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function

Mediates the Na⁺-independent transport of organic anions such as taurocholate and thyroid hormones By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the organo anion transporter (TC 2.A.60) family. [View classification]

Contains 1 Kazal-like domain.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intestinal absorption Inferred from electronic annotation. Source: Compara organ regeneration Inferred from electronic annotation. Source: Compara
Cellular_component	brush border membrane Inferred from electronic annotation. Source: Compara integral to plasma membrane Inferred from sequence orthology Ref.1. Source: MGI
Molecular_function	bile acid transmembrane transporter activity Inferred from sequence orthology Ref.1. Source: MGI thyroid hormone transmembrane transporter activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 670

670

Solute carrier organic anion transporter family member 1A5

PRO_0000191043

Regions

Topological domain

1 – 20

Cytoplasmic Potential

Transmembrane

21 – 40

Helical; Name=1; Potential

Topological domain

41 – 59

Extracellular Potential

Transmembrane

60 – 80

Helical; Name=2; Potential

Topological domain

81 – 86

Cytoplasmic Potential

Transmembrane

87 – 111

Helical; Name=3; Potential

Topological domain

112 – 155

Extracellular Potential

Transmembrane

156 – 184

Helical; Name=4; Potential

Topological domain

185 – 203

Cytoplasmic Potential

Transmembrane

204 – 224

Helical; Name=5; Potential

Topological domain

225 – 242

Extracellular Potential

Transmembrane

243 – 267

Helical; Name=6; Potential

Topological domain

268 – 311

Cytoplasmic Potential

Transmembrane

312 – 333

Helical; Name=7; Potential

Topological domain

334 – 353

Extracellular Potential

Transmembrane

354 – 377

Helical; Name=8; Potential

Topological domain

378 – 381

Cytoplasmic Potential

Transmembrane

382 – 405

Helical; Name=9; Potential

Topological domain

406 – 513

108

Extracellular Potential

Transmembrane

514 – 536

Helical; Name=10; Potential

Topological domain

537 – 545

Cytoplasmic Potential

Transmembrane

546 – 571

Helical; Name=11; Potential

Topological domain

572 – 605

Extracellular Potential

Transmembrane

606 – 623

Helical; Name=12; Potential

Topological domain

624 – 670

Cytoplasmic Potential

Domain

433 – 488

Kazal-like

Amino acid modifications

Modified residue

634

Phosphoserine By similarity

Modified residue

635

Phosphoserine By similarity

Glycosylation

124

N-linked (GlcNAc...) Potential

Glycosylation

135

N-linked (GlcNAc...) Potential

Glycosylation

483

N-linked (GlcNAc...) Potential

Glycosylation

492

N-linked (GlcNAc...) Potential

Disulfide bond

439 ↔ 465

By similarity

Disulfide bond

443 ↔ 454

By similarity

Disulfide bond

445 ↔ 469

By similarity

Experimental info

Sequence conflict

280

A → D in AAK39416. Ref.1

Sequence conflict

591

I → M in AAK39416. Ref.1

Sequence conflict

644

Q → L in AAK39416. Ref.1

Sequence conflict

656

G → R in AAK39416. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q91YY5 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: AF802A903FCD457D
Show »

FASTA

670

74,663

        10         20         30         40         50         60 
MGETEKRIAT HGVRCFSKIK MFLLALTCAY VSKSLSGIYM NSMLTQIERQ FDIPTSIVGL 

        70         80         90        100        110        120 
INGSFEIGNL LLIILVSYFG TKLHRPIMIG IGCVIMGLGC FLMSLPHFLM GRYEYETTIS 

       130        140        150        160        170        180 
PTSNLSSNSF LCMENRTQTL KPTQDPAECV KEMKSLMWIY VLVGNIIRGI GETPIMPLGI 

       190        200        210        220        230        240 
SYIEDFAKSE NSPLYIGILE SGKMIGPIVG LLLGSFCARI YVDTGSVNTD DLTITPTDTR 

       250        260        270        280        290        300 
WVGAWWIGFL VCAGVNILTS IPFFFFPKTL PKEGLQDNVA RTENDKEEKH REKAKEENRG 

       310        320        330        340        350        360 
ITKDFLPFMK SLSCNPIYML LILTSVLQIN AFINMFTFLP KYLEQQYGKS TSEVVLLIGV 

       370        380        390        400        410        420 
CNLPPICIGY LLIGFIMKKF RITVKKAAYM AFCLSLFEYL LSYFHFMISC DNFQVAGLTT 

       430        440        450        460        470        480 
SYEGVQHPLY VENKVLADCN TRCSCLTNTW DPVCGDNGLS YMSACLAGCE KSVGMGTHMV 

       490        500        510        520        530        540 
FQNCSCIQSS GNSSAVLGLC KKGPECANKL QYFLIMSVIG SFIYSITAIP GYMVLLRCIK 

       550        560        570        580        590        600 
SEEKSLGIGL HAFCTRIFAG IPAPIYFGAL IDRTCLHWGT LKCGEPGACR IYNINNFRRI 

       610        620        630        640        650        660 
YLVLPAALRG SSYLPAFFIL ILMRKFQLPG EMYSSETELA DMKQTVKKSE CTDVHGIPKV 

       670 
ENDGELKTKL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression, transport properties, and chromosomal location of organic anion transporter subtype 3." Walters H.C., Craddock A.L., Fusegawa H., Willingham M.C., Dawson P.A. Am. J. Physiol. 279:G1188-G1200(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary tumor.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF240694 mRNA. Translation: AAK39416.1. BC013594 mRNA. Translation: AAH13594.1.
IPI	IPI00135701.
RefSeq	NP_001254636.1. NM_001267707.1. NP_570931.1. NM_130861.3.
UniGene	Mm.206599.
3D structure databases
ProteinModelPortal	Q91YY5.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000107456.
Proteomic databases
PaxDb	Q91YY5.
PRIDE	Q91YY5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000081380; ENSMUSP00000080116; ENSMUSG00000063975. ENSMUST00000111825; ENSMUSP00000137607; ENSMUSG00000063975.
GeneID	108096.
KEGG	mmu:108096.
UCSC	uc009eoz.1. mouse.
Organism-specific databases
CTD	108096.
MGI	MGI:1351865. Slco1a5.
Phylogenomic databases
eggNOG	NOG256971.
GeneTree	ENSGT00690000102038.
HOGENOM	HOG000231269.
HOVERGEN	HBG063896.
InParanoid	Q91YY5.
KO	K03460.
OrthoDB	EOG45B1F2.
Gene expression databases
Genevestigator	Q91YY5.
GermOnline	ENSMUSG00000063975. Mus musculus.
Family and domain databases
InterPro	IPR002350. Kazal_dom. IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. IPR004156. OA_transporter. [Graphical view]
PANTHER	PTHR11388. PTHR11388. 1 hit.
Pfam	PF07648. Kazal_2. 1 hit. PF03137. OATP. 1 hit. [Graphical view]
SMART	SM00280. KAZAL. 1 hit. [Graphical view]
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMs	TIGR00805. oat. 1 hit.
PROSITE	PS51465. KAZAL_2. 1 hit. PS50850. MFS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	Slco1a5. mouse.
NextBio	360050.
SOURCE	Search...

Entry information

Entry name

SO1A5_MOUSE

Accession

Primary (citable) accession number: Q91YY5
Secondary accession number(s): Q91XS2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2003
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents