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Q91YY5

- SO1A5_MOUSE

UniProt

Q91YY5 - SO1A5_MOUSE

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Protein
Solute carrier organic anion transporter family member 1A5
Gene
Slco1a5, Oatp1a5, Oatp3, Slc21a7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Mediates the Na+-independent transport of organic anions such as taurocholate and thyroid hormones By similarity.

GO - Molecular functioni

  1. bile acid transmembrane transporter activity Source: MGI
  2. thyroid hormone transmembrane transporter activity Source: Ensembl

GO - Biological processi

  1. intestinal absorption Source: Ensembl
  2. organ regeneration Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_210189. Transport of organic anions.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 1A5
Alternative name(s):
Organic anion-transporting polypeptide 3
Short name:
OATP-3
Sodium-independent organic anion transporter 3
Solute carrier family 21 member 7
Gene namesi
Name:Slco1a5
Synonyms:Oatp1a5, Oatp3, Slc21a7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1351865. Slco1a5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei21 – 4020Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini41 – 5919Extracellular Reviewed prediction
Add
BLAST
Transmembranei60 – 8021Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini81 – 866Cytoplasmic Reviewed prediction
Transmembranei87 – 11125Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini112 – 15544Extracellular Reviewed prediction
Add
BLAST
Transmembranei156 – 18429Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini185 – 20319Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei204 – 22421Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini225 – 24218Extracellular Reviewed prediction
Add
BLAST
Transmembranei243 – 26725Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini268 – 31144Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei312 – 33322Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini334 – 35320Extracellular Reviewed prediction
Add
BLAST
Transmembranei354 – 37724Helical; Name=8; Reviewed prediction
Add
BLAST
Topological domaini378 – 3814Cytoplasmic Reviewed prediction
Transmembranei382 – 40524Helical; Name=9; Reviewed prediction
Add
BLAST
Topological domaini406 – 513108Extracellular Reviewed prediction
Add
BLAST
Transmembranei514 – 53623Helical; Name=10; Reviewed prediction
Add
BLAST
Topological domaini537 – 5459Cytoplasmic Reviewed prediction
Transmembranei546 – 57126Helical; Name=11; Reviewed prediction
Add
BLAST
Topological domaini572 – 60534Extracellular Reviewed prediction
Add
BLAST
Transmembranei606 – 62318Helical; Name=12; Reviewed prediction
Add
BLAST
Topological domaini624 – 67047Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. brush border membrane Source: Ensembl
  2. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 670670Solute carrier organic anion transporter family member 1A5
PRO_0000191043Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi124 – 1241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi135 – 1351N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi439 ↔ 465 By similarity
Disulfide bondi443 ↔ 454 By similarity
Disulfide bondi445 ↔ 469 By similarity
Glycosylationi483 – 4831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi492 – 4921N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ91YY5.
PRIDEiQ91YY5.

Expressioni

Gene expression databases

GenevestigatoriQ91YY5.

Interactioni

Protein-protein interaction databases

MINTiMINT-4997889.
STRINGi10090.ENSMUSP00000107456.

Structurei

3D structure databases

ProteinModelPortaliQ91YY5.
SMRiQ91YY5. Positions 437-468.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini433 – 48856Kazal-like
Add
BLAST

Sequence similaritiesi

Contains 1 Kazal-like domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG256971.
GeneTreeiENSGT00740000115555.
HOGENOMiHOG000231269.
HOVERGENiHBG063896.
InParanoidiQ91YY5.
KOiK03460.
OrthoDBiEOG7GFB4C.
PhylomeDBiQ91YY5.
TreeFamiTF317540.

Family and domain databases

InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SMARTiSM00280. KAZAL. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91YY5-1 [UniParc]FASTAAdd to Basket

« Hide

MGETEKRIAT HGVRCFSKIK MFLLALTCAY VSKSLSGIYM NSMLTQIERQ    50
FDIPTSIVGL INGSFEIGNL LLIILVSYFG TKLHRPIMIG IGCVIMGLGC 100
FLMSLPHFLM GRYEYETTIS PTSNLSSNSF LCMENRTQTL KPTQDPAECV 150
KEMKSLMWIY VLVGNIIRGI GETPIMPLGI SYIEDFAKSE NSPLYIGILE 200
SGKMIGPIVG LLLGSFCARI YVDTGSVNTD DLTITPTDTR WVGAWWIGFL 250
VCAGVNILTS IPFFFFPKTL PKEGLQDNVA RTENDKEEKH REKAKEENRG 300
ITKDFLPFMK SLSCNPIYML LILTSVLQIN AFINMFTFLP KYLEQQYGKS 350
TSEVVLLIGV CNLPPICIGY LLIGFIMKKF RITVKKAAYM AFCLSLFEYL 400
LSYFHFMISC DNFQVAGLTT SYEGVQHPLY VENKVLADCN TRCSCLTNTW 450
DPVCGDNGLS YMSACLAGCE KSVGMGTHMV FQNCSCIQSS GNSSAVLGLC 500
KKGPECANKL QYFLIMSVIG SFIYSITAIP GYMVLLRCIK SEEKSLGIGL 550
HAFCTRIFAG IPAPIYFGAL IDRTCLHWGT LKCGEPGACR IYNINNFRRI 600
YLVLPAALRG SSYLPAFFIL ILMRKFQLPG EMYSSETELA DMKQTVKKSE 650
CTDVHGIPKV ENDGELKTKL 670
Length:670
Mass (Da):74,663
Last modified:December 1, 2001 - v1
Checksum:iAF802A903FCD457D
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti280 – 2801A → D in AAK39416. 1 Publication
Sequence conflicti591 – 5911I → M in AAK39416. 1 Publication
Sequence conflicti644 – 6441Q → L in AAK39416. 1 Publication
Sequence conflicti656 – 6561G → R in AAK39416. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF240694 mRNA. Translation: AAK39416.1.
BC013594 mRNA. Translation: AAH13594.1.
CCDSiCCDS57464.1.
RefSeqiNP_001254636.1. NM_001267707.1.
NP_570931.1. NM_130861.3.
XP_006506920.1. XM_006506857.1.
UniGeneiMm.206599.

Genome annotation databases

EnsembliENSMUST00000081380; ENSMUSP00000080116; ENSMUSG00000063975.
ENSMUST00000111825; ENSMUSP00000137607; ENSMUSG00000063975.
GeneIDi108096.
KEGGimmu:108096.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF240694 mRNA. Translation: AAK39416.1 .
BC013594 mRNA. Translation: AAH13594.1 .
CCDSi CCDS57464.1.
RefSeqi NP_001254636.1. NM_001267707.1.
NP_570931.1. NM_130861.3.
XP_006506920.1. XM_006506857.1.
UniGenei Mm.206599.

3D structure databases

ProteinModelPortali Q91YY5.
SMRi Q91YY5. Positions 437-468.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4997889.
STRINGi 10090.ENSMUSP00000107456.

Proteomic databases

PaxDbi Q91YY5.
PRIDEi Q91YY5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000081380 ; ENSMUSP00000080116 ; ENSMUSG00000063975 .
ENSMUST00000111825 ; ENSMUSP00000137607 ; ENSMUSG00000063975 .
GeneIDi 108096.
KEGGi mmu:108096.

Organism-specific databases

CTDi 108096.
MGIi MGI:1351865. Slco1a5.

Phylogenomic databases

eggNOGi NOG256971.
GeneTreei ENSGT00740000115555.
HOGENOMi HOG000231269.
HOVERGENi HBG063896.
InParanoidi Q91YY5.
KOi K03460.
OrthoDBi EOG7GFB4C.
PhylomeDBi Q91YY5.
TreeFami TF317540.

Enzyme and pathway databases

Reactomei REACT_210189. Transport of organic anions.

Miscellaneous databases

ChiTaRSi Slco1a5. mouse.
NextBioi 360050.
PROi Q91YY5.
SOURCEi Search...

Gene expression databases

Genevestigatori Q91YY5.

Family and domain databases

InterProi IPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR004156. OA_transporter.
[Graphical view ]
PANTHERi PTHR11388. PTHR11388. 1 hit.
Pfami PF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view ]
SMARTi SM00280. KAZAL. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 3 hits.
TIGRFAMsi TIGR00805. oat. 1 hit.
PROSITEi PS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression, transport properties, and chromosomal location of organic anion transporter subtype 3."
    Walters H.C., Craddock A.L., Fusegawa H., Willingham M.C., Dawson P.A.
    Am. J. Physiol. 279:G1188-G1200(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.

Entry informationi

Entry nameiSO1A5_MOUSE
AccessioniPrimary (citable) accession number: Q91YY5
Secondary accession number(s): Q91XS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi