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Protein

Acyl-CoA:lysophosphatidylglycerol acyltransferase 1

Gene

Lpgat1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Lysophosphatidylglycerol (LPG) specific acyltransferase that recognizes various acyl-CoAs and LPGs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-CoAs and oleoyl-CoA as acyl donors. Prefers oleoyl-LPG over palmitoyl-LPG as an acyl receptor and oleoyl-CoA over lauroyl-CoA as an acyl donor (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiR-MMU-1482925. Acyl chain remodelling of PG.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 (EC:2.3.1.-)
Gene namesi
Name:Lpgat1
Synonyms:Fam34a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2446186. Lpgat1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002082051 – 370Acyl-CoA:lysophosphatidylglycerol acyltransferase 1Add BLAST370

Proteomic databases

EPDiQ91YX5.
MaxQBiQ91YX5.
PaxDbiQ91YX5.
PRIDEiQ91YX5.

PTM databases

iPTMnetiQ91YX5.
PhosphoSitePlusiQ91YX5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026623.
CleanExiMM_LPGAT1.
ExpressionAtlasiQ91YX5. baseline and differential.
GenevisibleiQ91YX5. MM.

Interactioni

Protein-protein interaction databases

IntActiQ91YX5. 1 interactor.
MINTiMINT-4094868.
STRINGi10090.ENSMUSP00000106480.

Structurei

3D structure databases

ProteinModelPortaliQ91YX5.
SMRiQ91YX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi101 – 106HXXXXD motif6

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1505. Eukaryota.
COG0204. LUCA.
GeneTreeiENSGT00390000012157.
HOGENOMiHOG000261637.
HOVERGENiHBG051533.
InParanoidiQ91YX5.
KOiK13514.
PhylomeDBiQ91YX5.

Family and domain databases

InterProiView protein in InterPro
IPR032098. Acyltransf_C.
IPR002123. Plipid/glycerol_acylTrfase.
PfamiView protein in Pfam
PF16076. Acyltransf_C. 1 hit.
PF01553. Acyltransferase. 1 hit.
SMARTiView protein in SMART
SM00563. PlsC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91YX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVTVEEAPW LGWIVAKALM RFAFMVANNL VAIPSYICYV IILQPLRVLD
60 70 80 90 100
SKRFWYIEGL MYKWLLGMVA SWGWYAGYTV MEWGEDIKAI AKDEAVMLVN
110 120 130 140 150
HQATGDVCTL MMCLQDKGPV VAQMMWLMDH IFKYTNFGIV SLIHGDFFIR
160 170 180 190 200
QGRAYRDQQL LVLKKHLEHN YRSRDRKWIV LFPEGGFLRK RRETSQAFAK
210 220 230 240 250
KNNLPFLTHV TLPRFGATNI ILKALVARQE NGSPAGGDAR GLECKSRGLQ
260 270 280 290 300
WIIDTTIAYP KAEPIDIQTW ILGYRKPTVT HVHYRIFPIG DVPLETEDLT
310 320 330 340 350
SWLYQRFIEK EDLLSHFYKT GAFPPPQGQK EAVCREMTLS NMWIFLIQSF
360 370
AFLSGYLWYH IIQYFYHCLF
Length:370
Mass (Da):43,088
Last modified:December 1, 2001 - v1
Checksum:iEE746F9AAD3073EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC013667 mRNA. Translation: AAH13667.1.
CCDSiCCDS15622.1.
RefSeqiNP_758470.1. NM_172266.3.
XP_006497218.1. XM_006497155.3.
XP_006497219.1. XM_006497156.3.
UniGeneiMm.277958.

Genome annotation databases

EnsembliENSMUST00000110855; ENSMUSP00000106479; ENSMUSG00000026623.
GeneIDi226856.
KEGGimmu:226856.
UCSCiuc007ecs.3. mouse.

Similar proteinsi

Entry informationi

Entry nameiLGAT1_MOUSE
AccessioniPrimary (citable) accession number: Q91YX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: December 1, 2001
Last modified: August 30, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families