Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine zipper putative tumor suppressor 2

Gene

Lzts2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.UniRule annotation

GO - Biological processi

  • cytokinesis Source: UniProtKB-HAMAP
  • kidney development Source: MGI
  • microtubule severing Source: UniProtKB-HAMAP
  • mitotic nuclear division Source: UniProtKB-KW
  • negative regulation of canonical Wnt signaling pathway Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of protein localization to nucleus Source: MGI
  • negative regulation of Wnt signaling pathway Source: MGI
  • nuclear export Source: UniProtKB-HAMAP
  • positive regulation of cell death Source: Ensembl
  • renal system development Source: MGI
  • spindle midzone assembly Source: UniProtKB-HAMAP
  • Wnt signaling pathway Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine zipper putative tumor suppressor 2UniRule annotation
Alternative name(s):
Protein LAPSER1UniRule annotation
Gene namesi
Name:Lzts2
Synonyms:Kiaa1813, Lapser1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2385095. Lzts2.

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Cytoplasmcytoskeletonmicrotubule organizing centercentrosome UniRule annotation1 Publication

  • Note: Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis.UniRule annotation

GO - Cellular componenti

  • centrosome Source: UniProtKB-HAMAP
  • cytoplasm Source: MGI
  • microtubule Source: UniProtKB-KW
  • midbody Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 671671Leucine zipper putative tumor suppressor 2PRO_0000182975Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei249 – 2491PhosphoserineCombined sources
Modified residuei296 – 2961PhosphoserineCombined sources
Modified residuei572 – 5721PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ91YU6.
MaxQBiQ91YU6.
PaxDbiQ91YU6.
PRIDEiQ91YU6.

PTM databases

PhosphoSiteiQ91YU6.

Expressioni

Gene expression databases

BgeeiQ91YU6.
CleanExiMM_LZTS2.
GenevisibleiQ91YU6. MM.

Interactioni

Subunit structurei

Interacts with KATNB1. Also interacts with CTNNB1, gamma-tubulin and KIF23.UniRule annotation

Protein-protein interaction databases

BioGridi230483. 4 interactions.
IntActiQ91YU6. 4 interactions.
STRINGi10090.ENSMUSP00000045478.

Structurei

3D structure databases

ProteinModelPortaliQ91YU6.
SMRiQ91YU6. Positions 409-434.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 333333Required for centrosomal localizationBy similarityAdd
BLAST
Regioni449 – 671223Sufficient for interaction with CTNNB1By similarityAdd
BLAST
Regioni452 – 671220Sufficient for interaction with KATNB1 and for inhibition of katanin-mediated microtubule severingBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili329 – 651323UniRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi633 – 64210Nuclear export signalUniRule annotation

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi188 – 306119Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the LZTS2 family.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGJE. Eukaryota.
ENOG4111JZA. LUCA.
GeneTreeiENSGT00510000046769.
HOGENOMiHOG000230889.
HOVERGENiHBG052381.
InParanoidiQ91YU6.
OMAiEPAPCIC.
OrthoDBiEOG7F7W8K.
TreeFamiTF331420.

Family and domain databases

HAMAPiMF_03026. LZTS2.
InterProiIPR028597. LZTS2.
[Graphical view]
PANTHERiPTHR19354:SF4. PTHR19354:SF4. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91YU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIVHTLPVP LEPARETATA PKTPAMGSVS SLISGRPCPG GPAPQRHHGV
60 70 80 90 100
PGPTFFRQQD GLLPGGYEAQ EPLCPAVPPR KAVPGNSFTY VNEDFRTESP
110 120 130 140 150
PSPSSDVEDP REHQAHNAHL RGPPPKLIPV SGKLEKNMEK ILIRPTAFKP
160 170 180 190 200
VLPKPRGAPS LPGFLGPRAA GLSGSQGSLT QLFGGPASSS SSSSSSSAAD
210 220 230 240 250
KPLALSGWAS GCPSGTLSDS GRNSLSSLPT YSTGGAEPTT NSPGGHLPSH
260 270 280 290 300
GPGRGALPGP ARGVPTGPSH SDSGRSSSSK STGSLGGRVA GGLLGSGARA
310 320 330 340 350
SPGSSSGGDR SPPPPPPPPP SDEALLHCVL EGKLRDREAE LQQLRDSMDE
360 370 380 390 400
SEATVCQAFG ARQRRWPRER GEDCAAQAQQ ATQRVQRAQQ LLQLQVFQLQ
410 420 430 440 450
QEKRQLQDDF AQLLQEREQL ERRCATFERE QRELGPRLEE TKWEVCQKSG
460 470 480 490 500
EISLLKQQLK ESQAELVQKG SELVALRVAL REARATLRVS EGRARGLQEA
510 520 530 540 550
ARAREQELEA CSQELQRYRQ EAERLREKAG HLDAEASGLR DPPVPPATTD
560 570 580 590 600
PFLLAESDEA KVQRAAAGAG GSLRAQVERL RQELQREQRR GDEQRDSFEG
610 620 630 640 650
ERLAWQAEKE QVIRYQKQLQ HNYIQMYRRN RQLEQELQQL SLELEARELA
660 670
DLGLAESAPC ICLEEITATE I
Length:671
Mass (Da):72,578
Last modified:July 27, 2011 - v3
Checksum:i5F78644A14B1F1E6
GO

Sequence cautioni

The sequence BAC98256.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti64 – 641P → R in BAC98256 (PubMed:14621295).Curated
Sequence conflicti64 – 641P → R in AAH14695 (PubMed:15489334).Curated
Sequence conflicti64 – 641P → R in AAH92263 (PubMed:15489334).Curated
Sequence conflicti327 – 3271H → Q in AAH14695 (PubMed:15489334).Curated
Sequence conflicti327 – 3271H → Q in AAH92263 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129446 mRNA. Translation: BAC98256.1. Different initiation.
AC132957 Genomic DNA. No translation available.
BC014695 mRNA. Translation: AAH14695.1.
BC092263 mRNA. Translation: AAH92263.1.
CCDSiCCDS29855.1.
RefSeqiNP_001123997.1. NM_001130525.1.
NP_001123998.1. NM_001130526.1.
NP_663478.2. NM_145503.2.
XP_006527067.1. XM_006527004.2.
UniGeneiMm.28204.
Mm.329877.

Genome annotation databases

EnsembliENSMUST00000039016; ENSMUSP00000045478; ENSMUSG00000035342.
ENSMUST00000178087; ENSMUSP00000136405; ENSMUSG00000035342.
ENSMUST00000179108; ENSMUSP00000137571; ENSMUSG00000035342.
GeneIDi226154.
KEGGimmu:226154.
UCSCiuc008hql.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129446 mRNA. Translation: BAC98256.1. Different initiation.
AC132957 Genomic DNA. No translation available.
BC014695 mRNA. Translation: AAH14695.1.
BC092263 mRNA. Translation: AAH92263.1.
CCDSiCCDS29855.1.
RefSeqiNP_001123997.1. NM_001130525.1.
NP_001123998.1. NM_001130526.1.
NP_663478.2. NM_145503.2.
XP_006527067.1. XM_006527004.2.
UniGeneiMm.28204.
Mm.329877.

3D structure databases

ProteinModelPortaliQ91YU6.
SMRiQ91YU6. Positions 409-434.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230483. 4 interactions.
IntActiQ91YU6. 4 interactions.
STRINGi10090.ENSMUSP00000045478.

PTM databases

PhosphoSiteiQ91YU6.

Proteomic databases

EPDiQ91YU6.
MaxQBiQ91YU6.
PaxDbiQ91YU6.
PRIDEiQ91YU6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039016; ENSMUSP00000045478; ENSMUSG00000035342.
ENSMUST00000178087; ENSMUSP00000136405; ENSMUSG00000035342.
ENSMUST00000179108; ENSMUSP00000137571; ENSMUSG00000035342.
GeneIDi226154.
KEGGimmu:226154.
UCSCiuc008hql.2. mouse.

Organism-specific databases

CTDi84445.
MGIiMGI:2385095. Lzts2.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IGJE. Eukaryota.
ENOG4111JZA. LUCA.
GeneTreeiENSGT00510000046769.
HOGENOMiHOG000230889.
HOVERGENiHBG052381.
InParanoidiQ91YU6.
OMAiEPAPCIC.
OrthoDBiEOG7F7W8K.
TreeFamiTF331420.

Miscellaneous databases

ChiTaRSiLzts2. mouse.
NextBioi378036.
PROiQ91YU6.
SOURCEiSearch...

Gene expression databases

BgeeiQ91YU6.
CleanExiMM_LZTS2.
GenevisibleiQ91YU6. MM.

Family and domain databases

HAMAPiMF_03026. LZTS2.
InterProiIPR028597. LZTS2.
[Graphical view]
PANTHERiPTHR19354:SF4. PTHR19354:SF4. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryonic tail.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NMRI.
    Tissue: Mammary tumor.
  4. "LAPSER1/LZTS2: a pluripotent tumor suppressor linked to the inhibition of katanin-mediated microtubule severing."
    Sudo H., Maru Y.
    Hum. Mol. Genet. 17:2524-2540(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-249 AND SER-296, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney.

Entry informationi

Entry nameiLZTS2_MOUSE
AccessioniPrimary (citable) accession number: Q91YU6
Secondary accession number(s): E9QKK6, Q569X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: July 27, 2011
Last modified: April 13, 2016
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.