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Protein

CSC1-like protein 1

Gene

Tmem63a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as an osmosensitive calcium-permeable cation channel.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
CSC1-like protein 1
Alternative name(s):
Transmembrane protein 63A
Gene namesi
Name:Tmem63a
Synonyms:Kiaa0792
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2384789. Tmem63a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Transmembranei421 – 441HelicalSequence analysisAdd BLAST21
Transmembranei461 – 481HelicalSequence analysisAdd BLAST21
Transmembranei507 – 527HelicalSequence analysisAdd BLAST21
Transmembranei552 – 572HelicalSequence analysisAdd BLAST21
Transmembranei619 – 639HelicalSequence analysisAdd BLAST21
Transmembranei664 – 684HelicalSequence analysisAdd BLAST21
Transmembranei697 – 717HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002807261 – 804CSC1-like protein 1Add BLAST804

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei738PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91YT8.
PaxDbiQ91YT8.
PeptideAtlasiQ91YT8.
PRIDEiQ91YT8.

PTM databases

iPTMnetiQ91YT8.
PhosphoSitePlusiQ91YT8.
SwissPalmiQ91YT8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026519.
CleanExiMM_TMEM63A.
ExpressionAtlasiQ91YT8. baseline and differential.
GenevisibleiQ91YT8. MM.

Interactioni

Protein-protein interaction databases

BioGridi229015. 1 interactor.
STRINGi10090.ENSMUSP00000027800.

Structurei

3D structure databases

ProteinModelPortaliQ91YT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1134. Eukaryota.
COG5594. LUCA.
GeneTreeiENSGT00390000011855.
HOGENOMiHOG000006559.
HOVERGENiHBG056752.
InParanoidiQ91YT8.
OMAiGLRWWLQ.
OrthoDBiEOG091G02SZ.
PhylomeDBiQ91YT8.
TreeFamiTF324300.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR032880. Csc1_N.
IPR012677. Nucleotide-bd_a/b_plait.
IPR027815. PHM7_cyt.
IPR003864. RSN1_7TM.
IPR026957. TMEM63A.
[Graphical view]
PANTHERiPTHR13018:SF24. PTHR13018:SF24. 1 hit.
PfamiPF14703. PHM7_cyt. 1 hit.
PF02714. RSN1_7TM. 1 hit.
PF13967. RSN1_TM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.

Sequencei

Sequence statusi: Complete.

Q91YT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSPFLDPW PSKAVFVRER LGLGERPNDS YCYNSAKNST VLQGVTFGGI
60 70 80 90 100
PTVLLLDVSC FLFLILVFSI IRRRFWDYGR IALVSEAGSE ARFQRLSSSS
110 120 130 140 150
SGQQDFENEL GCCPWLTAIF RLHDDQILEW CGEDAIHYLS FQRHIIFLLV
160 170 180 190 200
VISFLSLCVI LPVNLSGDLL GKDPYSFGRT TIANLQTDND LLWLHTVFSV
210 220 230 240 250
IYLFLTVGFM WHHTRSIRYK EESLVRQTLF ITGLPREARK ETVESHFRDA
260 270 280 290 300
YPTCEVVDVQ LCYSVAKLIY LCKERKKTEK SLTYYTNLQA KTGRRTLINP
310 320 330 340 350
KPCGQFCCCE VQGCEREDAI SYYTRMNDSL LERITAEESR VQDQPLGMAF
360 370 380 390 400
VTFREKSMAT YILKDFNACK CQGLRCKGEP QPSSYSRELC VSKWTVTFAS
410 420 430 440 450
YPEDICWKNL SIQGVRWWLQ WLGINFSLFV VLFFLTTPSI IMSTMDKFNV
460 470 480 490 500
TKPIHALNNP VISQFFPTLL LWSFSALLPS IVYYSTLLES HWTRSGENRI
510 520 530 540 550
MVSKVYIFLI FMVLILPSLG LTSLDFFFRW LFDKTSSETS IRLECVFLPD
560 570 580 590 600
QGAFFVNYVI ASAFIGSGME LLRLPGLILY TFRMIMAKTA ADRRNVKQNQ
610 620 630 640 650
AFEYEFGAMY AWMLCVFTVI MAYSITCPII VPFGLIYILL KHMVDRHNLY
660 670 680 690 700
FAYLPAKLEK RIHFAAVNQA LAAPILCLFW LFFFSFLRLG LTAPATLFTF
710 720 730 740 750
LVVLLTILAC LLYTCFGCFK HLSPWNYKTE ESASDKGSEA EAHVPPPFTP
760 770 780 790 800
YVPRILNGLA SERTALSPQQ QQTYGAIRNI SGTLPGQPVA QDPSGTAAYA

YQES
Length:804
Mass (Da):91,860
Last modified:December 1, 2001 - v1
Checksum:iA8F024BA82F2AA33
GO

Sequence cautioni

The sequence BAD32305 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE41880 differs from that shown. Reason: Erroneous termination at position 774. Translated as Tyr.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173027 mRNA. Translation: BAD32305.1. Different initiation.
AK144899 mRNA. Translation: BAE26121.1.
AK170559 mRNA. Translation: BAE41880.1. Sequence problems.
BC014795 mRNA. Translation: AAH14795.1.
BC019442 mRNA. Translation: AAH19442.1.
CCDSiCCDS15578.1.
RefSeqiNP_659043.1. NM_144794.2.
XP_006496784.1. XM_006496721.3.
XP_006496785.1. XM_006496722.2.
XP_006496786.1. XM_006496723.3.
UniGeneiMm.185518.

Genome annotation databases

EnsembliENSMUST00000027800; ENSMUSP00000027800; ENSMUSG00000026519.
ENSMUST00000161523; ENSMUSP00000124021; ENSMUSG00000026519.
GeneIDi208795.
KEGGimmu:208795.
UCSCiuc007dwx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173027 mRNA. Translation: BAD32305.1. Different initiation.
AK144899 mRNA. Translation: BAE26121.1.
AK170559 mRNA. Translation: BAE41880.1. Sequence problems.
BC014795 mRNA. Translation: AAH14795.1.
BC019442 mRNA. Translation: AAH19442.1.
CCDSiCCDS15578.1.
RefSeqiNP_659043.1. NM_144794.2.
XP_006496784.1. XM_006496721.3.
XP_006496785.1. XM_006496722.2.
XP_006496786.1. XM_006496723.3.
UniGeneiMm.185518.

3D structure databases

ProteinModelPortaliQ91YT8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229015. 1 interactor.
STRINGi10090.ENSMUSP00000027800.

PTM databases

iPTMnetiQ91YT8.
PhosphoSitePlusiQ91YT8.
SwissPalmiQ91YT8.

Proteomic databases

MaxQBiQ91YT8.
PaxDbiQ91YT8.
PeptideAtlasiQ91YT8.
PRIDEiQ91YT8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027800; ENSMUSP00000027800; ENSMUSG00000026519.
ENSMUST00000161523; ENSMUSP00000124021; ENSMUSG00000026519.
GeneIDi208795.
KEGGimmu:208795.
UCSCiuc007dwx.1. mouse.

Organism-specific databases

CTDi9725.
MGIiMGI:2384789. Tmem63a.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1134. Eukaryota.
COG5594. LUCA.
GeneTreeiENSGT00390000011855.
HOGENOMiHOG000006559.
HOVERGENiHBG056752.
InParanoidiQ91YT8.
OMAiGLRWWLQ.
OrthoDBiEOG091G02SZ.
PhylomeDBiQ91YT8.
TreeFamiTF324300.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiTmem63a. mouse.
PROiQ91YT8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026519.
CleanExiMM_TMEM63A.
ExpressionAtlasiQ91YT8. baseline and differential.
GenevisibleiQ91YT8. MM.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR032880. Csc1_N.
IPR012677. Nucleotide-bd_a/b_plait.
IPR027815. PHM7_cyt.
IPR003864. RSN1_7TM.
IPR026957. TMEM63A.
[Graphical view]
PANTHERiPTHR13018:SF24. PTHR13018:SF24. 1 hit.
PfamiPF14703. PHM7_cyt. 1 hit.
PF02714. RSN1_7TM. 1 hit.
PF13967. RSN1_TM. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCSCL1_MOUSE
AccessioniPrimary (citable) accession number: Q91YT8
Secondary accession number(s): Q3TCS5, Q69ZZ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.