Q91YT0NDUV1_MOUSENADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialNDUFV17.1.1.2Complex I-51kDCI-51kDNADH-ubiquinone oxidoreductase 51 kDa subunitNdufv1Mus musculusMouseEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMusThe transcriptional landscape of the mammalian genome.NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]Proteome analysis of mouse brain: two-dimensional electrophoresis profiles of tissue proteins during the course of aging.PROTEIN SEQUENCE OF 21-29PROTEIN SEQUENCE OF 29-48; 72-81; 89-126; 138-147; 153-219; 258-267; 275-297; 303-329; 370-375; 387-394 AND 402-449IDENTIFICATION BY MASS SPECTROMETRYA tissue-specific atlas of mouse protein phosphorylation and expression.IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-81IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-81; LYS-104 AND LYS-375IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.METHYLATION [LARGE SCALE ANALYSIS] AT ARG-257IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.INTERACTION WITH RAB5IFCryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states.STRUCTURE BY ELECTRON MICROSCOPY (3.30 ANGSTROMS) OF 30-457FUNCTIONCATALYTIC ACTIVITYCOFACTORSUBUNITCore subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Part of the peripheral arm of the enzyme, where the electrons from NADH are accepted by flavin mononucleotide (FMN) and then passed along a chain of iron-sulfur clusters by electron tunnelling to the final acceptor ubiquinone. Contains FMN, which is the initial electron acceptor as well as one iron-sulfur cluster.a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+)FMNBinds 1 FMN.[4Fe-4S] clusterBinds 1 [4Fe-4S] cluster.Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (PubMed:29915388). This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme (PubMed:29915388). Interacts with RAB5IF (PubMed:31536960).Mitochondrion inner membranePeripheral membrane proteinMatrix sideBelongs to the complex I 51 kDa subunit family.3D-structure4Fe-4SAcetylationDirect protein sequencingElectron transportFlavoproteinFMNIronIron-sulfurMembraneMetal-bindingMethylationMitochondrionMitochondrion inner membraneNADOxidoreductaseReference proteomeRespiratory chainTransit peptideTranslocaseTransportUbiquinoneNADHFMN[4Fe-4S] cluster[4Fe-4S] cluster[4Fe-4S] cluster[4Fe-4S] clusterMLAARHFLGGLVPVRVSVRFSSGTTAPKKTSFGSLKDEDRIFTNLYGRHDWRLKGALRRGDWYKTKEILLKGPDWILGEMKTSGLRGRGGAGFPTGLKWSFMNKPSDGRPKYLVVNADEGEPGTCKDREIMRHDPHKLVEGCLVGGRAMGARAAYIYIRGEFYNEASNLQVAIREAYEAGLIGKNACGSDYDFDVFVVRGAGAYICGEETALIESIEGKQGKPRLKPPFPADVGVFGCPTTVANVETVAVSPTICRRGGTWFAGFGRERNSGTKLFNISGHVNHPCTVEEEMSVPLKELIEKHAGGVTGGWDNLLAVIPGGSSTPLIPKSVCETVLMDFDALVQAQTGLGTAAVIVMDRSTDIVKAIARLIEFYKHESCGQCTPCREGVDWMNKVMARFVKGDARPAEIDSLWEISKQIEGHTICALGDGAAWPVQGLIRHFRPELEDRMQRFAQQHRAWQAAS
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