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Protein
Submitted name:

Kinesin light chain 2

Gene

Klc2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.
R-MMU-5625970. RHO GTPases activate KTN1.
R-MMU-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-MMU-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Submitted name:
Kinesin light chain 2Imported
Submitted name:
Klc2 proteinImported
Gene namesi
Name:Klc2Imported
ORF Names:mCG_8395Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:107953. Klc2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi441 ↔ 474Combined sources

Expressioni

Gene expression databases

BgeeiENSMUSG00000024862.

Interactioni

Protein-protein interaction databases

DIPiDIP-61735N.
MINTiMINT-4122066.
STRINGi10090.ENSMUSP00000112262.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZFWX-ray2.90A/B218-480[»]
5FJYX-ray4.00A/B/C161-480[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini198 – 399202TPR_REGIONInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili85 – 14056Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG1840. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00390000006393.
HOGENOMiHOG000261663.
HOVERGENiHBG006217.
KOiK10407.
OMAiNNDNKPI.
OrthoDBiEOG091G05DM.
TreeFamiTF314010.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR002151. Kinesin_light.
IPR015792. Kinesin_light_repeat.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13374. TPR_10. 1 hit.
[Graphical view]
PRINTSiPR00381. KINESINLIGHT.
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiPS01160. KINESIN_LIGHT. 2 hits.
PS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91YS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATMVLPREE KLSQDEIVLG TKAVIQGLET LRGEHRALLA PLASHEAGEA
60 70 80 90 100
EPGSQERCLL LRRSLEAIEL GLGEAQVILA LSSHLGAVES EKQKLRAQVR
110 120 130 140 150
RLVQENQWLR EELAGTQQKL QRSEQAVAQL EEEKQHLLFM SQIRKLDEDA
160 170 180 190 200
SPNEEKGDVP KDSLDDLFPN EDEQSPAPSP GGGDVAAQHG GYEIPARLRT
210 220 230 240 250
LHNLVIQYAS QGRYEVAVPL CKQALEDLEK TSGHDHPDVA TMLNILALVY
260 270 280 290 300
RDQNKYKDAA HLLNDALAIR EKTLGKDHPA VAATLNNLAV LYGKRGKYKE
310 320 330 340 350
AEPLCKRALE IREKVLGKFH PDVAKQLSNL ALLCQNQGKA EEVEYYYRRA
360 370 380 390 400
LEIYATRLGP DDPNVAKTKN NLASCYLKQG KYQDAETLYK EILTRAHEKE
410 420 430 440 450
FGSVNGENKP IWMHAEEREE SKDKRRDSAP YGEYGSWYKA CKVDSPTVNT
460 470 480 490 500
TLRSLGALYR RQGKLEAAHT LEDCASRSRK QGLDPASQTK VVELLKDGSG
510 520 530 540 550
GRGHRRGSRD VAGPQSESDL EESGPAAEWS GDGSGSLRRS GSFGKLRDAL
560 570 580 590 600
RRSSEMLVRK LQGGGPQEPP NSRMKRASSL NFLNKSVEEP VQPGGTGLSD
610
SRTLSSSSMD LSRRSSLVG
Length:619
Mass (Da):68,420
Last modified:December 1, 2001 - v1
Checksum:iA3C2B941BECDB178
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124502 Genomic DNA. No translation available.
BC014845 mRNA. Translation: AAH14845.1.
CH466612 Genomic DNA. Translation: EDL33106.1.
RefSeqiNP_032477.2. NM_008451.2.
XP_011246905.1. XM_011248603.1.
UniGeneiMm.271648.

Genome annotation databases

EnsembliENSMUST00000116563; ENSMUSP00000112262; ENSMUSG00000024862.
GeneIDi16594.
KEGGimmu:16594.
UCSCiuc008gcg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC124502 Genomic DNA. No translation available.
BC014845 mRNA. Translation: AAH14845.1.
CH466612 Genomic DNA. Translation: EDL33106.1.
RefSeqiNP_032477.2. NM_008451.2.
XP_011246905.1. XM_011248603.1.
UniGeneiMm.271648.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZFWX-ray2.90A/B218-480[»]
5FJYX-ray4.00A/B/C161-480[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61735N.
MINTiMINT-4122066.
STRINGi10090.ENSMUSP00000112262.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000116563; ENSMUSP00000112262; ENSMUSG00000024862.
GeneIDi16594.
KEGGimmu:16594.
UCSCiuc008gcg.1. mouse.

Organism-specific databases

CTDi64837.
MGIiMGI:107953. Klc2.

Phylogenomic databases

eggNOGiKOG1840. Eukaryota.
COG0457. LUCA.
GeneTreeiENSGT00390000006393.
HOGENOMiHOG000261663.
HOVERGENiHBG006217.
KOiK10407.
OMAiNNDNKPI.
OrthoDBiEOG091G05DM.
TreeFamiTF314010.

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.
R-MMU-5625970. RHO GTPases activate KTN1.
R-MMU-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-MMU-983189. Kinesins.

Miscellaneous databases

ChiTaRSiKlc2. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024862.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR002151. Kinesin_light.
IPR015792. Kinesin_light_repeat.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13374. TPR_10. 1 hit.
[Graphical view]
PRINTSiPR00381. KINESINLIGHT.
SMARTiSM00028. TPR. 4 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 3 hits.
PROSITEiPS01160. KINESIN_LIGHT. 2 hits.
PS50005. TPR. 5 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ91YS4_MOUSE
AccessioniPrimary (citable) accession number: Q91YS4
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.