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Protein

Prostaglandin reductase 1

Gene

Ptgr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4 (By similarity).By similarity

Catalytic activityi

A n-alkanal + NAD(P)+ = an alk-2-enal + NAD(P)H.
11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)+ = (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei178NADPBy similarity1
Binding sitei193NADPBy similarity1
Binding sitei217NADPBy similarity1
Binding sitei321NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi152 – 155NADPBy similarity4
Nucleotide bindingi239 – 245NADPBy similarity7
Nucleotide bindingi270 – 272NADPBy similarity3

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin reductase 1 (EC:1.3.1.-)
Short name:
PRG-1
Alternative name(s):
15-oxoprostaglandin 13-reductase (EC:1.3.1.48)
NADP-dependent leukotriene B4 12-hydroxydehydrogenase (EC:1.3.1.74)
Gene namesi
Name:Ptgr1
Synonyms:Ltb4dh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1914353. Ptgr1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002180661 – 329Prostaglandin reductase 1Add BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphothreonineBy similarity1
Modified residuei178N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ91YR9.
MaxQBiQ91YR9.
PaxDbiQ91YR9.
PeptideAtlasiQ91YR9.
PRIDEiQ91YR9.

2D gel databases

REPRODUCTION-2DPAGEQ91YR9.

PTM databases

PhosphoSitePlusiQ91YR9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028378.
GenevisibleiQ91YR9. MM.

Interactioni

Subunit structurei

Monomer or homodimer.By similarity

Protein-protein interaction databases

IntActiQ91YR9. 1 interactor.
MINTiMINT-4122050.
STRINGi10090.ENSMUSP00000030069.

Structurei

3D structure databases

ProteinModelPortaliQ91YR9.
SMRiQ91YR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1196. Eukaryota.
COG2130. LUCA.
GeneTreeiENSGT00390000009335.
HOGENOMiHOG000294663.
HOVERGENiHBG055024.
InParanoidiQ91YR9.
KOiK13948.
OMAiTHFAGWR.
OrthoDBiEOG091G0F5B.
PhylomeDBiQ91YR9.
TreeFamiTF324201.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR002085. ADH_SF_Zn-type.
IPR014190. B4_12hDH.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR02825. B4_12hDH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91YR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQAKSWTLK KHFEGFPTDG NFELKTTELP PLNNGEVLLE ALFLSVDPYM
60 70 80 90 100
RVAAKKLKEG DRMMGEQVAR VVESKNSAFP KGTIVAALLG WTSHSISDGN
110 120 130 140 150
GLTKLPVEWP DKLPLSLALG TVGMPGLTAY FGLLDICGVK GGETVMVSAA
160 170 180 190 200
AGAVGSVVGQ IAKLKGCKVV GTAGSDEKVA YLKKLGFDVA FNYKTVKSLE
210 220 230 240 250
EALRTASPDG YDCYFDNVGG EFSNAVILQM KTFGRIAICG AISQYNRTGP
260 270 280 290 300
CPQGPAPEVV IYQQLRMEGF IVNRWQGEVR QKALTELMNW VSEGKVQCHE
310 320
YVTEGFEKMP AAFMGMLKGE NLGKTIVKA
Length:329
Mass (Da):35,560
Last modified:August 16, 2005 - v2
Checksum:iFD0CA4682DB493D8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti298C → Y in AAH14865 (PubMed:15489334).Curated1
Sequence conflicti301Y → H in AAH14865 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010888 mRNA. Translation: BAB27248.1.
AK011962 mRNA. Translation: BAB27941.1.
AK035425 mRNA. Translation: BAC29060.1.
AK134440 mRNA. Translation: BAE22145.1.
AK166835 mRNA. Translation: BAE39057.1.
BC014865 mRNA. Translation: AAH14865.1.
CCDSiCCDS18215.1.
RefSeqiNP_080244.1. NM_025968.3.
UniGeneiMm.34497.

Genome annotation databases

EnsembliENSMUST00000030069; ENSMUSP00000030069; ENSMUSG00000028378.
GeneIDi67103.
KEGGimmu:67103.
UCSCiuc008szm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010888 mRNA. Translation: BAB27248.1.
AK011962 mRNA. Translation: BAB27941.1.
AK035425 mRNA. Translation: BAC29060.1.
AK134440 mRNA. Translation: BAE22145.1.
AK166835 mRNA. Translation: BAE39057.1.
BC014865 mRNA. Translation: AAH14865.1.
CCDSiCCDS18215.1.
RefSeqiNP_080244.1. NM_025968.3.
UniGeneiMm.34497.

3D structure databases

ProteinModelPortaliQ91YR9.
SMRiQ91YR9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91YR9. 1 interactor.
MINTiMINT-4122050.
STRINGi10090.ENSMUSP00000030069.

PTM databases

PhosphoSitePlusiQ91YR9.

2D gel databases

REPRODUCTION-2DPAGEQ91YR9.

Proteomic databases

EPDiQ91YR9.
MaxQBiQ91YR9.
PaxDbiQ91YR9.
PeptideAtlasiQ91YR9.
PRIDEiQ91YR9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030069; ENSMUSP00000030069; ENSMUSG00000028378.
GeneIDi67103.
KEGGimmu:67103.
UCSCiuc008szm.1. mouse.

Organism-specific databases

CTDi22949.
MGIiMGI:1914353. Ptgr1.

Phylogenomic databases

eggNOGiKOG1196. Eukaryota.
COG2130. LUCA.
GeneTreeiENSGT00390000009335.
HOGENOMiHOG000294663.
HOVERGENiHBG055024.
InParanoidiQ91YR9.
KOiK13948.
OMAiTHFAGWR.
OrthoDBiEOG091G0F5B.
PhylomeDBiQ91YR9.
TreeFamiTF324201.

Miscellaneous databases

PROiQ91YR9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028378.
GenevisibleiQ91YR9. MM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR002085. ADH_SF_Zn-type.
IPR014190. B4_12hDH.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR02825. B4_12hDH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPTGR1_MOUSE
AccessioniPrimary (citable) accession number: Q91YR9
Secondary accession number(s): Q3TKT6, Q9CPS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: November 2, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.