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Q91YR7

- PRP6_MOUSE

UniProt

Q91YR7 - PRP6_MOUSE

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Protein

Pre-mRNA-processing factor 6

Gene

Prpf6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.By similarity

GO - Molecular functioni

  1. androgen receptor binding Source: MGI
  2. poly(A) RNA binding Source: Ensembl
  3. ribonucleoprotein complex binding Source: Ensembl
  4. transcription coactivator activity Source: MGI

GO - Biological processi

  1. mRNA splicing, via spliceosome Source: InterPro
  2. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  3. RNA localization Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-processing factor 6
Alternative name(s):
PRP6 homolog
U5 snRNP-associated 102 kDa protein
Short name:
U5-102 kDa protein
Gene namesi
Name:Prpf6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1922946. Prpf6.

Subcellular locationi

Nucleusnucleoplasm By similarity. Nucleus speckle By similarity
Note: Localized in splicing speckles.By similarity

GO - Cellular componenti

  1. catalytic step 2 spliceosome Source: Ensembl
  2. nucleus Source: MGI
  3. U4/U6 snRNP Source: Ensembl
  4. U4/U6 x U5 tri-snRNP complex Source: Ensembl
  5. U5 snRNP Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 941941Pre-mRNA-processing factor 6PRO_0000205760Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei266 – 2661PhosphothreonineBy similarity
Modified residuei275 – 2751PhosphothreonineBy similarity
Modified residuei279 – 2791PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91YR7.
PaxDbiQ91YR7.
PRIDEiQ91YR7.

PTM databases

PhosphoSiteiQ91YR7.

Expressioni

Gene expression databases

BgeeiQ91YR7.
CleanExiMM_PRPF6.
ExpressionAtlasiQ91YR7. baseline and differential.
GenevestigatoriQ91YR7.

Interactioni

Subunit structurei

Associates with the U5 snRNP particle. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39, LSm proteins LSm2-8 and Sm proteins. Interacts with ARAF1. Identified in the spliceosome C complex (By similarity). Interacts with AR and NR3C1, but not ESR1, independently of the presence of hormones (By similarity).By similarity

Protein-protein interaction databases

BioGridi213097. 2 interactions.
IntActiQ91YR7. 2 interactions.
MINTiMINT-4108694.

Structurei

3D structure databases

ProteinModelPortaliQ91YR7.
SMRiQ91YR7. Positions 549-577.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati384 – 41633HAT 1Add
BLAST
Repeati418 – 44427HAT 2Add
BLAST
Repeati445 – 47632HAT 3Add
BLAST
Repeati554 – 58633HAT 4Add
BLAST
Repeati588 – 62033HAT 5Add
BLAST
Repeati622 – 65433HAT 6Add
BLAST
Repeati689 – 72133HAT 7Add
BLAST
Repeati723 – 75533HAT 8Add
BLAST
Repeati855 – 88733HAT 9Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi67 – 726Poly-Asp

Sequence similaritiesi

Contains 9 HAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0457.
GeneTreeiENSGT00550000075016.
HOGENOMiHOG000116247.
HOVERGENiHBG023330.
InParanoidiQ91YR7.
KOiK12855.
OMAiRQRFYAV.
OrthoDBiEOG7RV9FB.
PhylomeDBiQ91YR7.
TreeFamiTF105743.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR003107. HAT.
IPR010491. PRP1_N.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF06424. PRP1_N. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00386. HAT. 13 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q91YR7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNKKKKPFLG MPAPLGYVPG LGRGATGFTT RSDIGPARDA NDPVDDRHAP
60 70 80 90 100
PGKRTVGDQM KKNQAADDDD EDLNDTNYDE FNGYAGSLFS SGPYEKDDEE
110 120 130 140 150
ADAIYAALDK RMDERRKERR EQREKEEIEK YRMERPKIQQ QFSDLKRKLA
160 170 180 190 200
EVTEEEWLSI PEVGDARNKR QRNPRYEKLT PVPDSFFAKH LQTGENHTSV
210 220 230 240 250
DPRQTQFGGL NTPYPGGLNT PYPGGMTPGL MTPGTGELDM RKIGQARNTL
260 270 280 290 300
MDMRLSQVSD SVSGQTVVDP KGYLTDLNSM IPTHGGDIND IKKARLLLKS
310 320 330 340 350
VRETNPHHPP AWIASARLEE VTGKLQVARN LIMKGTEMCP KSEDVWLEAA
360 370 380 390 400
RLQPGDTAKA VVAQAVRHLP QSVRIYIRAA ELETDIRAKK RVLRKALEHV
410 420 430 440 450
PNSVRLWKAA VELEEPEDAR IMLSRAVECC PTSVELWLAL ARLETYENAR
460 470 480 490 500
KVLNKARENI PTDRHIWITA AKLEEANGNT QMVEKIIDRA ITSLRANGVE
510 520 530 540 550
INREQWIQDA EECDRAGSVA TCQAVMRAVI GIGIEEEDRK HTWMEDADSC
560 570 580 590 600
VAHNALECAR AIYAYALQVF PSKKSVWLRA AYFEKNHGTR ESLEALLQRA
610 620 630 640 650
VAHCPKAEVL WLMGAKSKWL AGDVPAARSI LALAFQANPN SEEIWLAAVK
660 670 680 690 700
LESENNEYER ARRLLAKARS SAPTARVFMK SVKLEWVLGN ISAAQELCEE
710 720 730 740 750
ALRHYEDFPK LWMMKGQIEE QGELMEKARE AYNQGLKKCP HSTPLWLLLS
760 770 780 790 800
RLEEKIGQLT RARAILEKSR LKNPKNPGLW LESVRLEYRA GLKNIANTLM
810 820 830 840 850
AKALQECPNS GILWSEAVFL EARPQRKTKS VDALKKCEHD PHVLLAVAKL
860 870 880 890 900
FWSERKITKA REWFHRTVKI DSDLGDAWAF FYKFELQHGT EEQQEEVRKR
910 920 930 940
CENAEPRHGE LWCAVSKDIT NWQRKIGEIL VLVAARIKNT F
Length:941
Mass (Da):106,722
Last modified:December 1, 2001 - v1
Checksum:iA08C3AC49AE1B9E9
GO
Isoform 2 (identifier: Q91YR7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     550-570: CVAHNALECARAIYAYALQVF → VSFLACFPACSLDRNSGPINL
     571-941: Missing.

Note: No experimental confirmation available.

Show »
Length:570
Mass (Da):63,960
Checksum:i16E5B26A91A0C60B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti232 – 2321T → A in BAE26451. (PubMed:16141072)Curated
Sequence conflicti390 – 3901K → R in BAE26451. (PubMed:16141072)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei550 – 57021CVAHN…ALQVF → VSFLACFPACSLDRNSGPIN L in isoform 2. 1 PublicationVSP_002063Add
BLAST
Alternative sequencei571 – 941371Missing in isoform 2. 1 PublicationVSP_002064Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC005801 mRNA. Translation: AAH05801.1.
BC014869 mRNA. Translation: AAH14869.1.
BC023691 mRNA. Translation: AAH23691.2.
BC025030 mRNA. Translation: AAH25030.1.
AK011639 mRNA. Translation: BAB27751.1.
AK145461 mRNA. Translation: BAE26451.1.
AK081998 mRNA. Translation: BAC38390.1.
AL844529 Genomic DNA. Translation: CAX15563.1.
CH466626 Genomic DNA. Translation: EDL07438.1.
CCDSiCCDS38381.1. [Q91YR7-1]
RefSeqiNP_598462.1. NM_133701.2. [Q91YR7-1]
UniGeneiMm.292001.

Genome annotation databases

EnsembliENSMUST00000002529; ENSMUSP00000002529; ENSMUSG00000002455. [Q91YR7-1]
ENSMUST00000136481; ENSMUSP00000121340; ENSMUSG00000002455. [Q91YR7-1]
GeneIDi68879.
KEGGimmu:68879.
UCSCiuc008omy.1. mouse. [Q91YR7-2]
uc008omz.1. mouse. [Q91YR7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC005801 mRNA. Translation: AAH05801.1 .
BC014869 mRNA. Translation: AAH14869.1 .
BC023691 mRNA. Translation: AAH23691.2 .
BC025030 mRNA. Translation: AAH25030.1 .
AK011639 mRNA. Translation: BAB27751.1 .
AK145461 mRNA. Translation: BAE26451.1 .
AK081998 mRNA. Translation: BAC38390.1 .
AL844529 Genomic DNA. Translation: CAX15563.1 .
CH466626 Genomic DNA. Translation: EDL07438.1 .
CCDSi CCDS38381.1. [Q91YR7-1 ]
RefSeqi NP_598462.1. NM_133701.2. [Q91YR7-1 ]
UniGenei Mm.292001.

3D structure databases

ProteinModelPortali Q91YR7.
SMRi Q91YR7. Positions 549-577.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 213097. 2 interactions.
IntActi Q91YR7. 2 interactions.
MINTi MINT-4108694.

PTM databases

PhosphoSitei Q91YR7.

Proteomic databases

MaxQBi Q91YR7.
PaxDbi Q91YR7.
PRIDEi Q91YR7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000002529 ; ENSMUSP00000002529 ; ENSMUSG00000002455 . [Q91YR7-1 ]
ENSMUST00000136481 ; ENSMUSP00000121340 ; ENSMUSG00000002455 . [Q91YR7-1 ]
GeneIDi 68879.
KEGGi mmu:68879.
UCSCi uc008omy.1. mouse. [Q91YR7-2 ]
uc008omz.1. mouse. [Q91YR7-1 ]

Organism-specific databases

CTDi 24148.
MGIi MGI:1922946. Prpf6.

Phylogenomic databases

eggNOGi COG0457.
GeneTreei ENSGT00550000075016.
HOGENOMi HOG000116247.
HOVERGENi HBG023330.
InParanoidi Q91YR7.
KOi K12855.
OMAi RQRFYAV.
OrthoDBi EOG7RV9FB.
PhylomeDBi Q91YR7.
TreeFami TF105743.

Miscellaneous databases

ChiTaRSi PRPF6. mouse.
NextBioi 328105.
PROi Q91YR7.
SOURCEi Search...

Gene expression databases

Bgeei Q91YR7.
CleanExi MM_PRPF6.
ExpressionAtlasi Q91YR7. baseline and differential.
Genevestigatori Q91YR7.

Family and domain databases

Gene3Di 1.25.40.10. 4 hits.
InterProi IPR003107. HAT.
IPR010491. PRP1_N.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view ]
Pfami PF06424. PRP1_N. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view ]
SMARTi SM00386. HAT. 13 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Embryonic head.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiPRP6_MOUSE
AccessioniPrimary (citable) accession number: Q91YR7
Secondary accession number(s): Q3ULJ7
, Q542P0, Q8CIK9, Q8R3M8, Q99JN1, Q9CSZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3