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Q91YR7

- PRP6_MOUSE

UniProt

Q91YR7 - PRP6_MOUSE

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Protein
Pre-mRNA-processing factor 6
Gene
Prpf6
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome By similarity. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation By similarity.

GO - Molecular functioni

  1. RNA binding Source: Ensembl
  2. androgen receptor binding Source: MGI
  3. ribonucleoprotein complex binding Source: Ensembl
  4. transcription coactivator activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. RNA localization Source: Ensembl
  2. mRNA splicing, via spliceosome Source: InterPro
  3. positive regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Pre-mRNA-processing factor 6
Alternative name(s):
PRP6 homolog
U5 snRNP-associated 102 kDa protein
Short name:
U5-102 kDa protein
Gene namesi
Name:Prpf6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1922946. Prpf6.

Subcellular locationi

Nucleusnucleoplasm By similarity. Nucleus speckle By similarity
Note: Localized in splicing speckles By similarity.

GO - Cellular componenti

  1. U4/U6 snRNP Source: Ensembl
  2. U4/U6 x U5 tri-snRNP complex Source: Ensembl
  3. U5 snRNP Source: Ensembl
  4. catalytic step 2 spliceosome Source: Ensembl
  5. nuclear speck Source: UniProtKB-SubCell
  6. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 941941Pre-mRNA-processing factor 6
PRO_0000205760Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei266 – 2661Phosphothreonine By similarity
Modified residuei275 – 2751Phosphothreonine By similarity
Modified residuei279 – 2791Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91YR7.
PaxDbiQ91YR7.
PRIDEiQ91YR7.

PTM databases

PhosphoSiteiQ91YR7.

Expressioni

Gene expression databases

ArrayExpressiQ91YR7.
BgeeiQ91YR7.
CleanExiMM_PRPF6.
GenevestigatoriQ91YR7.

Interactioni

Subunit structurei

Associates with the U5 snRNP particle. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39, LSm proteins LSm2-8 and Sm proteins. Interacts with ARAF1. Identified in the spliceosome C complex By similarity. Interacts with AR and NR3C1, but not ESR1, independently of the presence of hormones By similarity.

Protein-protein interaction databases

BioGridi213097. 2 interactions.
IntActiQ91YR7. 2 interactions.
MINTiMINT-4108694.

Structurei

3D structure databases

ProteinModelPortaliQ91YR7.
SMRiQ91YR7. Positions 293-346, 444-478, 726-789.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati384 – 41633HAT 1
Add
BLAST
Repeati418 – 44427HAT 2
Add
BLAST
Repeati445 – 47632HAT 3
Add
BLAST
Repeati554 – 58633HAT 4
Add
BLAST
Repeati588 – 62033HAT 5
Add
BLAST
Repeati622 – 65433HAT 6
Add
BLAST
Repeati689 – 72133HAT 7
Add
BLAST
Repeati723 – 75533HAT 8
Add
BLAST
Repeati855 – 88733HAT 9
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi67 – 726Poly-Asp

Sequence similaritiesi

Contains 9 HAT repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0457.
GeneTreeiENSGT00550000075016.
HOGENOMiHOG000116247.
HOVERGENiHBG023330.
InParanoidiQ3ULJ7.
KOiK12855.
OMAiRQRFYAV.
OrthoDBiEOG7RV9FB.
PhylomeDBiQ91YR7.
TreeFamiTF105743.

Family and domain databases

Gene3Di1.25.40.10. 4 hits.
InterProiIPR003107. HAT.
IPR010491. PRP1_N.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF06424. PRP1_N. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view]
SMARTiSM00386. HAT. 13 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q91YR7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNKKKKPFLG MPAPLGYVPG LGRGATGFTT RSDIGPARDA NDPVDDRHAP    50
PGKRTVGDQM KKNQAADDDD EDLNDTNYDE FNGYAGSLFS SGPYEKDDEE 100
ADAIYAALDK RMDERRKERR EQREKEEIEK YRMERPKIQQ QFSDLKRKLA 150
EVTEEEWLSI PEVGDARNKR QRNPRYEKLT PVPDSFFAKH LQTGENHTSV 200
DPRQTQFGGL NTPYPGGLNT PYPGGMTPGL MTPGTGELDM RKIGQARNTL 250
MDMRLSQVSD SVSGQTVVDP KGYLTDLNSM IPTHGGDIND IKKARLLLKS 300
VRETNPHHPP AWIASARLEE VTGKLQVARN LIMKGTEMCP KSEDVWLEAA 350
RLQPGDTAKA VVAQAVRHLP QSVRIYIRAA ELETDIRAKK RVLRKALEHV 400
PNSVRLWKAA VELEEPEDAR IMLSRAVECC PTSVELWLAL ARLETYENAR 450
KVLNKARENI PTDRHIWITA AKLEEANGNT QMVEKIIDRA ITSLRANGVE 500
INREQWIQDA EECDRAGSVA TCQAVMRAVI GIGIEEEDRK HTWMEDADSC 550
VAHNALECAR AIYAYALQVF PSKKSVWLRA AYFEKNHGTR ESLEALLQRA 600
VAHCPKAEVL WLMGAKSKWL AGDVPAARSI LALAFQANPN SEEIWLAAVK 650
LESENNEYER ARRLLAKARS SAPTARVFMK SVKLEWVLGN ISAAQELCEE 700
ALRHYEDFPK LWMMKGQIEE QGELMEKARE AYNQGLKKCP HSTPLWLLLS 750
RLEEKIGQLT RARAILEKSR LKNPKNPGLW LESVRLEYRA GLKNIANTLM 800
AKALQECPNS GILWSEAVFL EARPQRKTKS VDALKKCEHD PHVLLAVAKL 850
FWSERKITKA REWFHRTVKI DSDLGDAWAF FYKFELQHGT EEQQEEVRKR 900
CENAEPRHGE LWCAVSKDIT NWQRKIGEIL VLVAARIKNT F 941
Length:941
Mass (Da):106,722
Last modified:December 1, 2001 - v1
Checksum:iA08C3AC49AE1B9E9
GO
Isoform 2 (identifier: Q91YR7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     550-570: CVAHNALECARAIYAYALQVF → VSFLACFPACSLDRNSGPINL
     571-941: Missing.

Note: No experimental confirmation available.

Show »
Length:570
Mass (Da):63,960
Checksum:i16E5B26A91A0C60B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei550 – 57021CVAHN…ALQVF → VSFLACFPACSLDRNSGPIN L in isoform 2.
VSP_002063Add
BLAST
Alternative sequencei571 – 941371Missing in isoform 2.
VSP_002064Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti232 – 2321T → A in BAE26451. 1 Publication
Sequence conflicti390 – 3901K → R in BAE26451. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC005801 mRNA. Translation: AAH05801.1.
BC014869 mRNA. Translation: AAH14869.1.
BC023691 mRNA. Translation: AAH23691.2.
BC025030 mRNA. Translation: AAH25030.1.
AK011639 mRNA. Translation: BAB27751.1.
AK145461 mRNA. Translation: BAE26451.1.
AK081998 mRNA. Translation: BAC38390.1.
AL844529 Genomic DNA. Translation: CAX15563.1.
CH466626 Genomic DNA. Translation: EDL07438.1.
CCDSiCCDS38381.1. [Q91YR7-1]
RefSeqiNP_598462.1. NM_133701.2. [Q91YR7-1]
UniGeneiMm.292001.

Genome annotation databases

EnsembliENSMUST00000002529; ENSMUSP00000002529; ENSMUSG00000002455. [Q91YR7-1]
ENSMUST00000136481; ENSMUSP00000121340; ENSMUSG00000002455. [Q91YR7-1]
GeneIDi68879.
KEGGimmu:68879.
UCSCiuc008omy.1. mouse. [Q91YR7-2]
uc008omz.1. mouse. [Q91YR7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC005801 mRNA. Translation: AAH05801.1 .
BC014869 mRNA. Translation: AAH14869.1 .
BC023691 mRNA. Translation: AAH23691.2 .
BC025030 mRNA. Translation: AAH25030.1 .
AK011639 mRNA. Translation: BAB27751.1 .
AK145461 mRNA. Translation: BAE26451.1 .
AK081998 mRNA. Translation: BAC38390.1 .
AL844529 Genomic DNA. Translation: CAX15563.1 .
CH466626 Genomic DNA. Translation: EDL07438.1 .
CCDSi CCDS38381.1. [Q91YR7-1 ]
RefSeqi NP_598462.1. NM_133701.2. [Q91YR7-1 ]
UniGenei Mm.292001.

3D structure databases

ProteinModelPortali Q91YR7.
SMRi Q91YR7. Positions 293-346, 444-478, 726-789.
ModBasei Search...

Protein-protein interaction databases

BioGridi 213097. 2 interactions.
IntActi Q91YR7. 2 interactions.
MINTi MINT-4108694.

PTM databases

PhosphoSitei Q91YR7.

Proteomic databases

MaxQBi Q91YR7.
PaxDbi Q91YR7.
PRIDEi Q91YR7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000002529 ; ENSMUSP00000002529 ; ENSMUSG00000002455 . [Q91YR7-1 ]
ENSMUST00000136481 ; ENSMUSP00000121340 ; ENSMUSG00000002455 . [Q91YR7-1 ]
GeneIDi 68879.
KEGGi mmu:68879.
UCSCi uc008omy.1. mouse. [Q91YR7-2 ]
uc008omz.1. mouse. [Q91YR7-1 ]

Organism-specific databases

CTDi 24148.
MGIi MGI:1922946. Prpf6.

Phylogenomic databases

eggNOGi COG0457.
GeneTreei ENSGT00550000075016.
HOGENOMi HOG000116247.
HOVERGENi HBG023330.
InParanoidi Q3ULJ7.
KOi K12855.
OMAi RQRFYAV.
OrthoDBi EOG7RV9FB.
PhylomeDBi Q91YR7.
TreeFami TF105743.

Miscellaneous databases

ChiTaRSi PRPF6. mouse.
NextBioi 328105.
PROi Q91YR7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q91YR7.
Bgeei Q91YR7.
CleanExi MM_PRPF6.
Genevestigatori Q91YR7.

Family and domain databases

Gene3Di 1.25.40.10. 4 hits.
InterProi IPR003107. HAT.
IPR010491. PRP1_N.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR019734. TPR_repeat.
[Graphical view ]
Pfami PF06424. PRP1_N. 1 hit.
PF13181. TPR_8. 1 hit.
[Graphical view ]
SMARTi SM00386. HAT. 13 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Embryonic head.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiPRP6_MOUSE
AccessioniPrimary (citable) accession number: Q91YR7
Secondary accession number(s): Q3ULJ7
, Q542P0, Q8CIK9, Q8R3M8, Q99JN1, Q9CSZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi