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Q91YR7

- PRP6_MOUSE

UniProt

Q91YR7 - PRP6_MOUSE

Protein

Pre-mRNA-processing factor 6

Gene

Prpf6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.By similarity

    GO - Molecular functioni

    1. androgen receptor binding Source: MGI
    2. ribonucleoprotein complex binding Source: Ensembl
    3. RNA binding Source: Ensembl
    4. transcription coactivator activity Source: MGI

    GO - Biological processi

    1. mRNA splicing, via spliceosome Source: InterPro
    2. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    3. RNA localization Source: Ensembl

    Keywords - Biological processi

    mRNA processing, mRNA splicing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pre-mRNA-processing factor 6
    Alternative name(s):
    PRP6 homolog
    U5 snRNP-associated 102 kDa protein
    Short name:
    U5-102 kDa protein
    Gene namesi
    Name:Prpf6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1922946. Prpf6.

    Subcellular locationi

    Nucleusnucleoplasm By similarity. Nucleus speckle By similarity
    Note: Localized in splicing speckles.By similarity

    GO - Cellular componenti

    1. catalytic step 2 spliceosome Source: Ensembl
    2. nuclear speck Source: UniProtKB-SubCell
    3. nucleus Source: MGI
    4. U4/U6 snRNP Source: Ensembl
    5. U4/U6 x U5 tri-snRNP complex Source: Ensembl
    6. U5 snRNP Source: Ensembl

    Keywords - Cellular componenti

    Nucleus, Spliceosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 941941Pre-mRNA-processing factor 6PRO_0000205760Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei266 – 2661PhosphothreonineBy similarity
    Modified residuei275 – 2751PhosphothreonineBy similarity
    Modified residuei279 – 2791PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ91YR7.
    PaxDbiQ91YR7.
    PRIDEiQ91YR7.

    PTM databases

    PhosphoSiteiQ91YR7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ91YR7.
    BgeeiQ91YR7.
    CleanExiMM_PRPF6.
    GenevestigatoriQ91YR7.

    Interactioni

    Subunit structurei

    Associates with the U5 snRNP particle. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, NHP2L1, EFTUD2, SART1 and USP39, LSm proteins LSm2-8 and Sm proteins. Interacts with ARAF1. Identified in the spliceosome C complex By similarity. Interacts with AR and NR3C1, but not ESR1, independently of the presence of hormones By similarity.By similarity

    Protein-protein interaction databases

    BioGridi213097. 2 interactions.
    IntActiQ91YR7. 2 interactions.
    MINTiMINT-4108694.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91YR7.
    SMRiQ91YR7. Positions 293-346, 444-478, 726-789.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati384 – 41633HAT 1Add
    BLAST
    Repeati418 – 44427HAT 2Add
    BLAST
    Repeati445 – 47632HAT 3Add
    BLAST
    Repeati554 – 58633HAT 4Add
    BLAST
    Repeati588 – 62033HAT 5Add
    BLAST
    Repeati622 – 65433HAT 6Add
    BLAST
    Repeati689 – 72133HAT 7Add
    BLAST
    Repeati723 – 75533HAT 8Add
    BLAST
    Repeati855 – 88733HAT 9Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi67 – 726Poly-Asp

    Sequence similaritiesi

    Contains 9 HAT repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0457.
    GeneTreeiENSGT00550000075016.
    HOGENOMiHOG000116247.
    HOVERGENiHBG023330.
    InParanoidiQ3ULJ7.
    KOiK12855.
    OMAiRQRFYAV.
    OrthoDBiEOG7RV9FB.
    PhylomeDBiQ91YR7.
    TreeFamiTF105743.

    Family and domain databases

    Gene3Di1.25.40.10. 4 hits.
    InterProiIPR003107. HAT.
    IPR010491. PRP1_N.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR019734. TPR_repeat.
    [Graphical view]
    PfamiPF06424. PRP1_N. 1 hit.
    PF13181. TPR_8. 1 hit.
    [Graphical view]
    SMARTiSM00386. HAT. 13 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q91YR7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNKKKKPFLG MPAPLGYVPG LGRGATGFTT RSDIGPARDA NDPVDDRHAP    50
    PGKRTVGDQM KKNQAADDDD EDLNDTNYDE FNGYAGSLFS SGPYEKDDEE 100
    ADAIYAALDK RMDERRKERR EQREKEEIEK YRMERPKIQQ QFSDLKRKLA 150
    EVTEEEWLSI PEVGDARNKR QRNPRYEKLT PVPDSFFAKH LQTGENHTSV 200
    DPRQTQFGGL NTPYPGGLNT PYPGGMTPGL MTPGTGELDM RKIGQARNTL 250
    MDMRLSQVSD SVSGQTVVDP KGYLTDLNSM IPTHGGDIND IKKARLLLKS 300
    VRETNPHHPP AWIASARLEE VTGKLQVARN LIMKGTEMCP KSEDVWLEAA 350
    RLQPGDTAKA VVAQAVRHLP QSVRIYIRAA ELETDIRAKK RVLRKALEHV 400
    PNSVRLWKAA VELEEPEDAR IMLSRAVECC PTSVELWLAL ARLETYENAR 450
    KVLNKARENI PTDRHIWITA AKLEEANGNT QMVEKIIDRA ITSLRANGVE 500
    INREQWIQDA EECDRAGSVA TCQAVMRAVI GIGIEEEDRK HTWMEDADSC 550
    VAHNALECAR AIYAYALQVF PSKKSVWLRA AYFEKNHGTR ESLEALLQRA 600
    VAHCPKAEVL WLMGAKSKWL AGDVPAARSI LALAFQANPN SEEIWLAAVK 650
    LESENNEYER ARRLLAKARS SAPTARVFMK SVKLEWVLGN ISAAQELCEE 700
    ALRHYEDFPK LWMMKGQIEE QGELMEKARE AYNQGLKKCP HSTPLWLLLS 750
    RLEEKIGQLT RARAILEKSR LKNPKNPGLW LESVRLEYRA GLKNIANTLM 800
    AKALQECPNS GILWSEAVFL EARPQRKTKS VDALKKCEHD PHVLLAVAKL 850
    FWSERKITKA REWFHRTVKI DSDLGDAWAF FYKFELQHGT EEQQEEVRKR 900
    CENAEPRHGE LWCAVSKDIT NWQRKIGEIL VLVAARIKNT F 941
    Length:941
    Mass (Da):106,722
    Last modified:December 1, 2001 - v1
    Checksum:iA08C3AC49AE1B9E9
    GO
    Isoform 2 (identifier: Q91YR7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         550-570: CVAHNALECARAIYAYALQVF → VSFLACFPACSLDRNSGPINL
         571-941: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:570
    Mass (Da):63,960
    Checksum:i16E5B26A91A0C60B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti232 – 2321T → A in BAE26451. (PubMed:16141072)Curated
    Sequence conflicti390 – 3901K → R in BAE26451. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei550 – 57021CVAHN…ALQVF → VSFLACFPACSLDRNSGPIN L in isoform 2. 1 PublicationVSP_002063Add
    BLAST
    Alternative sequencei571 – 941371Missing in isoform 2. 1 PublicationVSP_002064Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC005801 mRNA. Translation: AAH05801.1.
    BC014869 mRNA. Translation: AAH14869.1.
    BC023691 mRNA. Translation: AAH23691.2.
    BC025030 mRNA. Translation: AAH25030.1.
    AK011639 mRNA. Translation: BAB27751.1.
    AK145461 mRNA. Translation: BAE26451.1.
    AK081998 mRNA. Translation: BAC38390.1.
    AL844529 Genomic DNA. Translation: CAX15563.1.
    CH466626 Genomic DNA. Translation: EDL07438.1.
    CCDSiCCDS38381.1. [Q91YR7-1]
    RefSeqiNP_598462.1. NM_133701.2. [Q91YR7-1]
    UniGeneiMm.292001.

    Genome annotation databases

    EnsembliENSMUST00000002529; ENSMUSP00000002529; ENSMUSG00000002455. [Q91YR7-1]
    ENSMUST00000136481; ENSMUSP00000121340; ENSMUSG00000002455. [Q91YR7-1]
    GeneIDi68879.
    KEGGimmu:68879.
    UCSCiuc008omy.1. mouse. [Q91YR7-2]
    uc008omz.1. mouse. [Q91YR7-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC005801 mRNA. Translation: AAH05801.1 .
    BC014869 mRNA. Translation: AAH14869.1 .
    BC023691 mRNA. Translation: AAH23691.2 .
    BC025030 mRNA. Translation: AAH25030.1 .
    AK011639 mRNA. Translation: BAB27751.1 .
    AK145461 mRNA. Translation: BAE26451.1 .
    AK081998 mRNA. Translation: BAC38390.1 .
    AL844529 Genomic DNA. Translation: CAX15563.1 .
    CH466626 Genomic DNA. Translation: EDL07438.1 .
    CCDSi CCDS38381.1. [Q91YR7-1 ]
    RefSeqi NP_598462.1. NM_133701.2. [Q91YR7-1 ]
    UniGenei Mm.292001.

    3D structure databases

    ProteinModelPortali Q91YR7.
    SMRi Q91YR7. Positions 293-346, 444-478, 726-789.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 213097. 2 interactions.
    IntActi Q91YR7. 2 interactions.
    MINTi MINT-4108694.

    PTM databases

    PhosphoSitei Q91YR7.

    Proteomic databases

    MaxQBi Q91YR7.
    PaxDbi Q91YR7.
    PRIDEi Q91YR7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000002529 ; ENSMUSP00000002529 ; ENSMUSG00000002455 . [Q91YR7-1 ]
    ENSMUST00000136481 ; ENSMUSP00000121340 ; ENSMUSG00000002455 . [Q91YR7-1 ]
    GeneIDi 68879.
    KEGGi mmu:68879.
    UCSCi uc008omy.1. mouse. [Q91YR7-2 ]
    uc008omz.1. mouse. [Q91YR7-1 ]

    Organism-specific databases

    CTDi 24148.
    MGIi MGI:1922946. Prpf6.

    Phylogenomic databases

    eggNOGi COG0457.
    GeneTreei ENSGT00550000075016.
    HOGENOMi HOG000116247.
    HOVERGENi HBG023330.
    InParanoidi Q3ULJ7.
    KOi K12855.
    OMAi RQRFYAV.
    OrthoDBi EOG7RV9FB.
    PhylomeDBi Q91YR7.
    TreeFami TF105743.

    Miscellaneous databases

    ChiTaRSi PRPF6. mouse.
    NextBioi 328105.
    PROi Q91YR7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91YR7.
    Bgeei Q91YR7.
    CleanExi MM_PRPF6.
    Genevestigatori Q91YR7.

    Family and domain databases

    Gene3Di 1.25.40.10. 4 hits.
    InterProi IPR003107. HAT.
    IPR010491. PRP1_N.
    IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR019734. TPR_repeat.
    [Graphical view ]
    Pfami PF06424. PRP1_N. 1 hit.
    PF13181. TPR_8. 1 hit.
    [Graphical view ]
    SMARTi SM00386. HAT. 13 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo and Embryonic head.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: FVB/N.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiPRP6_MOUSE
    AccessioniPrimary (citable) accession number: Q91YR7
    Secondary accession number(s): Q3ULJ7
    , Q542P0, Q8CIK9, Q8R3M8, Q99JN1, Q9CSZ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3