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Protein

Cold shock domain-containing protein C2

Gene

Csdc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cold shock domain-containing protein C2
Alternative name(s):
RNA-binding protein PIPPin
Gene namesi
Name:Csdc2
Synonyms:Pippin
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2146027. Csdc2.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: PIPPin-RNA complexes are located to the nucleus.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 154154Cold shock domain-containing protein C2PRO_0000100352Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91YQ3.
PaxDbiQ91YQ3.

PTM databases

iPTMnetiQ91YQ3.
PhosphoSiteiQ91YQ3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000042109.
CleanExiMM_CSDC2.
ExpressionAtlasiQ91YQ3. baseline and differential.
GenevisibleiQ91YQ3. MM.

Interactioni

Protein-protein interaction databases

BioGridi222938. 2 interactions.
STRINGi10090.ENSMUSP00000044441.

Structurei

3D structure databases

ProteinModelPortaliQ91YQ3.
SMRiQ91YQ3. Positions 50-148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini69 – 13668CSDAdd
BLAST

Sequence similaritiesi

Contains 1 CSD (cold-shock) domain.Curated

Phylogenomic databases

eggNOGiKOG3070. Eukaryota.
COG1278. LUCA.
GeneTreeiENSGT00390000000022.
HOGENOMiHOG000059524.
HOVERGENiHBG050947.
InParanoidiQ91YQ3.
OMAiTFPFQRE.
OrthoDBiEOG091G0TYX.
TreeFamiTF324381.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR019844. Cold-shock_CS.
IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF00313. CSD. 1 hit.
[Graphical view]
SMARTiSM00357. CSP. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS00352. COLD_SHOCK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91YQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSESTLPPV VPPLHSPKSP VWPTFPFHRE GSRIWERGGG IAPRDLPSPL
60 70 80 90 100
PTKRTRTYSA TARASAGPVF KGVCKQFSRS QGHGFITPEN GSEDIFVHVS
110 120 130 140 150
DIEGEYVPVE GDEVTYKICP IPPKNQKFQA VEVVLTQLAP HTPHETWSGQ

VVGS
Length:154
Mass (Da):16,853
Last modified:October 3, 2012 - v2
Checksum:i85D36118B2775930
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71L → S in AAH16109 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028916 mRNA. Translation: BAC26194.1.
AK132493 mRNA. Translation: BAE21201.1.
AC102103 Genomic DNA. No translation available.
BC016109 mRNA. Translation: AAH16109.1.
CCDSiCCDS27677.1.
RefSeqiNP_663448.2. NM_145473.3.
UniGeneiMm.22524.

Genome annotation databases

EnsembliENSMUST00000038757; ENSMUSP00000044441; ENSMUSG00000042109.
GeneIDi105859.
KEGGimmu:105859.
UCSCiuc007wxs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028916 mRNA. Translation: BAC26194.1.
AK132493 mRNA. Translation: BAE21201.1.
AC102103 Genomic DNA. No translation available.
BC016109 mRNA. Translation: AAH16109.1.
CCDSiCCDS27677.1.
RefSeqiNP_663448.2. NM_145473.3.
UniGeneiMm.22524.

3D structure databases

ProteinModelPortaliQ91YQ3.
SMRiQ91YQ3. Positions 50-148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222938. 2 interactions.
STRINGi10090.ENSMUSP00000044441.

PTM databases

iPTMnetiQ91YQ3.
PhosphoSiteiQ91YQ3.

Proteomic databases

MaxQBiQ91YQ3.
PaxDbiQ91YQ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038757; ENSMUSP00000044441; ENSMUSG00000042109.
GeneIDi105859.
KEGGimmu:105859.
UCSCiuc007wxs.2. mouse.

Organism-specific databases

CTDi27254.
MGIiMGI:2146027. Csdc2.

Phylogenomic databases

eggNOGiKOG3070. Eukaryota.
COG1278. LUCA.
GeneTreeiENSGT00390000000022.
HOGENOMiHOG000059524.
HOVERGENiHBG050947.
InParanoidiQ91YQ3.
OMAiTFPFQRE.
OrthoDBiEOG091G0TYX.
TreeFamiTF324381.

Miscellaneous databases

PROiQ91YQ3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042109.
CleanExiMM_CSDC2.
ExpressionAtlasiQ91YQ3. baseline and differential.
GenevisibleiQ91YQ3. MM.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
InterProiIPR019844. Cold-shock_CS.
IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF00313. CSD. 1 hit.
[Graphical view]
SMARTiSM00357. CSP. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS00352. COLD_SHOCK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSDC2_MOUSE
AccessioniPrimary (citable) accession number: Q91YQ3
Secondary accession number(s): Q3V1F0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: October 3, 2012
Last modified: September 7, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.