ID   L2HDH_MOUSE             Reviewed;         464 AA.
AC   Q91YP0; Q3TH61; Q3U7Z0; Q3ULY6;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   16-JUN-2009, entry version 55.
DE   RecName: Full=L-2-hydroxyglutarate dehydrogenase, mitochondrial;
DE            Short=Duranin;
DE            EC=1.1.99.2;
DE   Flags: Precursor;
GN   Name=L2hgdh;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Amnion, Bone marrow, and Mammary gland;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- CATALYTIC ACTIVITY: (S)-2-hydroxyglutarate + acceptor = 2-
CC       oxoglutarate + reduced acceptor.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion (By similarity).
CC   -!- SIMILARITY: Belongs to the L2HGDH family.
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DR   EMBL; AK145228; BAE26312.1; -; mRNA.
DR   EMBL; AK152450; BAE31229.1; -; mRNA.
DR   EMBL; AK168429; BAE40337.1; -; mRNA.
DR   EMBL; BC016226; AAH16226.1; -; mRNA.
DR   IPI; IPI00130331; -.
DR   RefSeq; NP_663418.1; -.
DR   UniGene; Mm.103362; -.
DR   PRIDE; Q91YP0; -.
DR   Ensembl; ENSMUSG00000020988; Mus musculus.
DR   GeneID; 217666; -.
DR   KEGG; mmu:217666; -.
DR   NMPDR; fig|10090.3.peg.26626; -.
DR   MGI; MGI:2384968; L2hgdh.
DR   HOGENOM; Q91YP0; -.
DR   HOVERGEN; Q91YP0; -.
DR   OMA; Q91YP0; KIVPFRG.
DR   BRENDA; 1.1.99.2; 244.
DR   NextBio; 375942; -.
DR   ArrayExpress; Q91YP0; -.
DR   Bgee; Q91YP0; -.
DR   CleanEx; MM_L2HGDH; -.
DR   GermOnline; ENSMUSG00000020988; Mus musculus.
DR   GO; GO:0016021; C:integral to membrane; ISS:HGNC.
DR   GO; GO:0005739; C:mitochondrion; ISS:HGNC.
DR   GO; GO:0047545; F:2-hydroxyglutarate dehydrogenase activity; ISS:HGNC.
DR   GO; GO:0044267; P:cellular protein metabolic process; ISS:HGNC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   Pfam; PF01266; DAO; 1.
PE   2: Evidence at transcript level;
KW   FAD; Flavoprotein; Mitochondrion; Oxidoreductase; Transit peptide.
FT   TRANSIT       1     52       Mitochondrion (Potential).
FT   CHAIN        53    464       L-2-hydroxyglutarate dehydrogenase,
FT                                mitochondrial.
FT                                /FTId=PRO_0000228130.
FT   CONFLICT    184    184       M -> I (in Ref. 1; BAE31229).
FT   CONFLICT    216    216       R -> K (in Ref. 1; BAE26312).
FT   CONFLICT    225    225       I -> V (in Ref. 1; BAE26312).
FT   CONFLICT    228    228       E -> G (in Ref. 1; BAE31229).
FT   CONFLICT    416    416       L -> P (in Ref. 1; BAE40337).
SQ   SEQUENCE   464 AA;  50899 MW;  27270B28FCCC3762 CRC64;
     MWPTLRYVGG VCGLARYCVA GGFLRASGPA SGVPGLLCGG GRRSSSTSSF DIVIVGGGIV
     GLASARTLIL KHPGLSIGVV EKEKDLALHQ TGHNSGVIHS GIYYKPESLK AKLCVEGAAL
     IYEYCNLKGI PYRQCGKLIV AVEQEEIPRL QALYERGLQN GVEGLRLIQQ EDIKKKEPYC
     RGLMAIDCPY TGIVNYQQVA LSFAQDFQEA GGSILRDFEV KGIEIAKENS SRSKDGMNYP
     IAVKNSKGKE IRCRYVVTCA GLYSDRISEL SGCNPDPQIV PFRGDYLVLK PEKGYLVKGN
     IYPVPDSRFP FLGVHFTPRL DGTIWLGPNA VLAFKREGYR PFDFDARDVM EVILKSGFIN
     LVFQHFSYGV NEMYKACFLS ETVKHLQKFI PEITISDVLR GPAGVRAQAL DRDGNLVEDF
     VFDGGTGEIA DRVLHVRNAP SPAATSSLAI SRMIAEEAQQ RFKL
//