Reviewed, UniProtKB/Swiss-Prot Q91YP0 (L2HDH_MOUSE)

Names and origin

Protein names

Recommended name:
    L-2-hydroxyglutarate dehydrogenase, mitochondrial
      Short name=Duranin
    EC=1.1.99.2

Gene names

Name:

L2hgdh

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	464 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	(S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.
Cofactor	FAD By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the L2HGDH family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	cellular protein metabolic process Inferred from sequence or structural similarity. Source: HGNC oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from sequence or structural similarity. Source: HGNC mitochondrion Inferred from sequence or structural similarity. Source: HGNC
Molecular function	2-hydroxyglutarate dehydrogenase activity Inferred from sequence or structural similarity. Source: HGNC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 52	52	Mitochondrion Potential
	Chain	53 – 464	412	L-2-hydroxyglutarate dehydrogenase, mitochondrial		PRO_0000228130
Experimental info
	Sequence conflict	184	1	M → I in BAE31229. Ref.1
	Sequence conflict	216	1	R → K in BAE26312. Ref.1
	Sequence conflict	225	1	I → V in BAE26312. Ref.1
	Sequence conflict	228	1	E → G in BAE31229. Ref.1
	Sequence conflict	416	1	L → P in BAE40337. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q91YP0-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 27270B28FCCC3762	FASTA	464	50,899
	10 20 30 40 50 60 MWPTLRYVGG VCGLARYCVA GGFLRASGPA SGVPGLLCGG GRRSSSTSSF DIVIVGGGIV 70 80 90 100 110 120 GLASARTLIL KHPGLSIGVV EKEKDLALHQ TGHNSGVIHS GIYYKPESLK AKLCVEGAAL 130 140 150 160 170 180 IYEYCNLKGI PYRQCGKLIV AVEQEEIPRL QALYERGLQN GVEGLRLIQQ EDIKKKEPYC 190 200 210 220 230 240 RGLMAIDCPY TGIVNYQQVA LSFAQDFQEA GGSILRDFEV KGIEIAKENS SRSKDGMNYP 250 260 270 280 290 300 IAVKNSKGKE IRCRYVVTCA GLYSDRISEL SGCNPDPQIV PFRGDYLVLK PEKGYLVKGN 310 320 330 340 350 360 IYPVPDSRFP FLGVHFTPRL DGTIWLGPNA VLAFKREGYR PFDFDARDVM EVILKSGFIN 370 380 390 400 410 420 LVFQHFSYGV NEMYKACFLS ETVKHLQKFI PEITISDVLR GPAGVRAQAL DRDGNLVEDF 430 440 450 460 VFDGGTGEIA DRVLHVRNAP SPAATSSLAI SRMIAEEAQQ RFKL

References

[1]

"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Amnion, Bone marrow and Mammary gland.

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK145228 mRNA. Translation: BAE26312.1. AK152450 mRNA. Translation: BAE31229.1. AK168429 mRNA. Translation: BAE40337.1. BC016226 mRNA. Translation: AAH16226.1.
IPI	IPI00130331.
RefSeq	NP_663418.1.
UniGene	Mm.103362
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q91YP0.
Genome annotation databases
Ensembl	ENSMUSG00000020988. Mus musculus. [Contig view]
GeneID	217666.
KEGG	mmu:217666.
NMPDR	fig|10090.3.peg.26626.
Organism-specific databases
MGI	MGI:2384968. L2hgdh.
Phylogenomic databases
HOGENOM	Q91YP0.
HOVERGEN	Q91YP0.
OMA	Q91YP0. KIVPFRG.
Enzyme and pathway databases
BRENDA	1.1.99.2. 244.
Gene expression databases
ArrayExpress	Q91YP0.
Bgee	Q91YP0.
CleanEx	MM_L2HGDH.
GermOnline	ENSMUSG00000020988. Mus musculus.
Family and domain databases
InterPro	IPR006076. FAD-dep_OxRdtase. [Graphical view]
Pfam	PF01266. DAO. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	375942.
SOURCE	Search...

Entry information

Entry name

L2HDH_MOUSE

Accession

Primary (citable) accession number: Q91YP0
Secondary accession number(s): Q3TH61, Q3U7Z0, Q3ULY6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	December 1, 2001
Last modified:	June 16, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)