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Protein

L-2-hydroxyglutarate dehydrogenase, mitochondrial

Gene

L2hgdh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.

Cofactori

FADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-MMU-880009. Interconversion of 2-oxoglutarate and 2-hydroxyglutarate.

Names & Taxonomyi

Protein namesi
Recommended name:
L-2-hydroxyglutarate dehydrogenase, mitochondrial (EC:1.1.99.2)
Alternative name(s):
Duranin
Gene namesi
Name:L2hgdh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2384968. L2hgdh.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 52MitochondrionSequence analysisAdd BLAST52
ChainiPRO_000022813053 – 464L-2-hydroxyglutarate dehydrogenase, mitochondrialAdd BLAST412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei105N6-acetyllysineCombined sources1
Modified residuei174N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ91YP0.
MaxQBiQ91YP0.
PaxDbiQ91YP0.
PeptideAtlasiQ91YP0.
PRIDEiQ91YP0.

PTM databases

iPTMnetiQ91YP0.
PhosphoSitePlusiQ91YP0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020988.
CleanExiMM_L2HGDH.
GenevisibleiQ91YP0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021370.

Structurei

3D structure databases

ProteinModelPortaliQ91YP0.
SMRiQ91YP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L2HGDH family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2665. Eukaryota.
COG0579. LUCA.
GeneTreeiENSGT00490000043421.
HOGENOMiHOG000245180.
HOVERGENiHBG081883.
InParanoidiQ91YP0.
KOiK00109.
OMAiGVHFTRM.
OrthoDBiEOG091G06OM.
PhylomeDBiQ91YP0.
TreeFamiTF105922.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR006076. FAD-dep_OxRdtase.
IPR023753. FAD/NAD-binding_dom.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91YP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWPTLRYVGG VCGLARYCVA GGFLRASGPA SGVPGLLCGG GRRSSSTSSF
60 70 80 90 100
DIVIVGGGIV GLASARTLIL KHPGLSIGVV EKEKDLALHQ TGHNSGVIHS
110 120 130 140 150
GIYYKPESLK AKLCVEGAAL IYEYCNLKGI PYRQCGKLIV AVEQEEIPRL
160 170 180 190 200
QALYERGLQN GVEGLRLIQQ EDIKKKEPYC RGLMAIDCPY TGIVNYQQVA
210 220 230 240 250
LSFAQDFQEA GGSILRDFEV KGIEIAKENS SRSKDGMNYP IAVKNSKGKE
260 270 280 290 300
IRCRYVVTCA GLYSDRISEL SGCNPDPQIV PFRGDYLVLK PEKGYLVKGN
310 320 330 340 350
IYPVPDSRFP FLGVHFTPRL DGTIWLGPNA VLAFKREGYR PFDFDARDVM
360 370 380 390 400
EVILKSGFIN LVFQHFSYGV NEMYKACFLS ETVKHLQKFI PEITISDVLR
410 420 430 440 450
GPAGVRAQAL DRDGNLVEDF VFDGGTGEIA DRVLHVRNAP SPAATSSLAI
460
SRMIAEEAQQ RFKL
Length:464
Mass (Da):50,899
Last modified:December 1, 2001 - v1
Checksum:i27270B28FCCC3762
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti184M → I in BAE31229 (PubMed:16141072).Curated1
Sequence conflicti216R → K in BAE26312 (PubMed:16141072).Curated1
Sequence conflicti225I → V in BAE26312 (PubMed:16141072).Curated1
Sequence conflicti228E → G in BAE31229 (PubMed:16141072).Curated1
Sequence conflicti416L → P in BAE40337 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145228 mRNA. Translation: BAE26312.1.
AK152450 mRNA. Translation: BAE31229.1.
AK168429 mRNA. Translation: BAE40337.1.
BC016226 mRNA. Translation: AAH16226.1.
CCDSiCCDS25953.1.
RefSeqiNP_663418.1. NM_145443.2.
UniGeneiMm.103362.

Genome annotation databases

EnsembliENSMUST00000021370; ENSMUSP00000021370; ENSMUSG00000020988.
GeneIDi217666.
KEGGimmu:217666.
UCSCiuc011ynb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145228 mRNA. Translation: BAE26312.1.
AK152450 mRNA. Translation: BAE31229.1.
AK168429 mRNA. Translation: BAE40337.1.
BC016226 mRNA. Translation: AAH16226.1.
CCDSiCCDS25953.1.
RefSeqiNP_663418.1. NM_145443.2.
UniGeneiMm.103362.

3D structure databases

ProteinModelPortaliQ91YP0.
SMRiQ91YP0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021370.

PTM databases

iPTMnetiQ91YP0.
PhosphoSitePlusiQ91YP0.

Proteomic databases

EPDiQ91YP0.
MaxQBiQ91YP0.
PaxDbiQ91YP0.
PeptideAtlasiQ91YP0.
PRIDEiQ91YP0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021370; ENSMUSP00000021370; ENSMUSG00000020988.
GeneIDi217666.
KEGGimmu:217666.
UCSCiuc011ynb.1. mouse.

Organism-specific databases

CTDi79944.
MGIiMGI:2384968. L2hgdh.

Phylogenomic databases

eggNOGiKOG2665. Eukaryota.
COG0579. LUCA.
GeneTreeiENSGT00490000043421.
HOGENOMiHOG000245180.
HOVERGENiHBG081883.
InParanoidiQ91YP0.
KOiK00109.
OMAiGVHFTRM.
OrthoDBiEOG091G06OM.
PhylomeDBiQ91YP0.
TreeFamiTF105922.

Enzyme and pathway databases

ReactomeiR-MMU-880009. Interconversion of 2-oxoglutarate and 2-hydroxyglutarate.

Miscellaneous databases

PROiQ91YP0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020988.
CleanExiMM_L2HGDH.
GenevisibleiQ91YP0. MM.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiIPR006076. FAD-dep_OxRdtase.
IPR023753. FAD/NAD-binding_dom.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiL2HDH_MOUSE
AccessioniPrimary (citable) accession number: Q91YP0
Secondary accession number(s): Q3TH61, Q3U7Z0, Q3ULY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.