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Protein

L-2-hydroxyglutarate dehydrogenase, mitochondrial

Gene

L2hgdh

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor.

Cofactori

FADBy similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

ReactomeiR-MMU-880009 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate

Names & Taxonomyi

Protein namesi
Recommended name:
L-2-hydroxyglutarate dehydrogenase, mitochondrial (EC:1.1.99.2)
Alternative name(s):
Duranin
Gene namesi
Name:L2hgdh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2384968 L2hgdh

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 52MitochondrionSequence analysisAdd BLAST52
ChainiPRO_000022813053 – 464L-2-hydroxyglutarate dehydrogenase, mitochondrialAdd BLAST412

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei105N6-acetyllysineCombined sources1
Modified residuei174N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ91YP0
MaxQBiQ91YP0
PaxDbiQ91YP0
PeptideAtlasiQ91YP0
PRIDEiQ91YP0

PTM databases

iPTMnetiQ91YP0
PhosphoSitePlusiQ91YP0

Expressioni

Gene expression databases

BgeeiENSMUSG00000020988
CleanExiMM_L2HGDH
GenevisibleiQ91YP0 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021370

Structurei

3D structure databases

ProteinModelPortaliQ91YP0
SMRiQ91YP0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L2HGDH family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2665 Eukaryota
COG0579 LUCA
GeneTreeiENSGT00490000043421
HOGENOMiHOG000245180
HOVERGENiHBG081883
InParanoidiQ91YP0
KOiK00109
OMAiGVHFTRM
OrthoDBiEOG091G06OM
PhylomeDBiQ91YP0
TreeFamiTF105922

Family and domain databases

InterProiView protein in InterPro
IPR006076 FAD-dep_OxRdtase
IPR036188 FAD/NAD-bd_sf
PfamiView protein in Pfam
PF01266 DAO, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91YP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWPTLRYVGG VCGLARYCVA GGFLRASGPA SGVPGLLCGG GRRSSSTSSF
60 70 80 90 100
DIVIVGGGIV GLASARTLIL KHPGLSIGVV EKEKDLALHQ TGHNSGVIHS
110 120 130 140 150
GIYYKPESLK AKLCVEGAAL IYEYCNLKGI PYRQCGKLIV AVEQEEIPRL
160 170 180 190 200
QALYERGLQN GVEGLRLIQQ EDIKKKEPYC RGLMAIDCPY TGIVNYQQVA
210 220 230 240 250
LSFAQDFQEA GGSILRDFEV KGIEIAKENS SRSKDGMNYP IAVKNSKGKE
260 270 280 290 300
IRCRYVVTCA GLYSDRISEL SGCNPDPQIV PFRGDYLVLK PEKGYLVKGN
310 320 330 340 350
IYPVPDSRFP FLGVHFTPRL DGTIWLGPNA VLAFKREGYR PFDFDARDVM
360 370 380 390 400
EVILKSGFIN LVFQHFSYGV NEMYKACFLS ETVKHLQKFI PEITISDVLR
410 420 430 440 450
GPAGVRAQAL DRDGNLVEDF VFDGGTGEIA DRVLHVRNAP SPAATSSLAI
460
SRMIAEEAQQ RFKL
Length:464
Mass (Da):50,899
Last modified:December 1, 2001 - v1
Checksum:i27270B28FCCC3762
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti184M → I in BAE31229 (PubMed:16141072).Curated1
Sequence conflicti216R → K in BAE26312 (PubMed:16141072).Curated1
Sequence conflicti225I → V in BAE26312 (PubMed:16141072).Curated1
Sequence conflicti228E → G in BAE31229 (PubMed:16141072).Curated1
Sequence conflicti416L → P in BAE40337 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145228 mRNA Translation: BAE26312.1
AK152450 mRNA Translation: BAE31229.1
AK168429 mRNA Translation: BAE40337.1
BC016226 mRNA Translation: AAH16226.1
CCDSiCCDS25953.1
RefSeqiNP_663418.1, NM_145443.2
UniGeneiMm.103362

Genome annotation databases

EnsembliENSMUST00000021370; ENSMUSP00000021370; ENSMUSG00000020988
GeneIDi217666
KEGGimmu:217666
UCSCiuc011ynb.1 mouse

Similar proteinsi

Entry informationi

Entry nameiL2HDH_MOUSE
AccessioniPrimary (citable) accession number: Q91YP0
Secondary accession number(s): Q3TH61, Q3U7Z0, Q3ULY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: December 1, 2001
Last modified: April 25, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health