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Protein

BAG family molecular chaperone regulator 2

Gene

Bag2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

ReactomeiR-MMU-3371453. Regulation of HSF1-mediated heat shock response.

Names & Taxonomyi

Protein namesi
Recommended name:
BAG family molecular chaperone regulator 2
Short name:
BAG-2
Alternative name(s):
Bcl-2-associated athanogene 2
Gene namesi
Name:Bag2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1891254. Bag2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 210209BAG family molecular chaperone regulator 2PRO_0000088867Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei20 – 201PhosphoserineBy similarity
Modified residuei73 – 731PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ91YN9.
MaxQBiQ91YN9.
PaxDbiQ91YN9.
PRIDEiQ91YN9.
TopDownProteomicsiQ91YN9.

PTM databases

iPTMnetiQ91YN9.
PhosphoSiteiQ91YN9.

Expressioni

Gene expression databases

BgeeiQ91YN9.
CleanExiMM_BAG2.
ExpressionAtlasiQ91YN9. baseline and differential.
GenevisibleiQ91YN9. MM.

Interactioni

Subunit structurei

Binds to the ATPase domain of HSP/HSC70 chaperones. May interact with NWD1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229449. 68 interactions.
IntActiQ91YN9. 73 interactions.
MINTiMINT-4122025.
STRINGi10090.ENSMUSP00000042009.

Structurei

Secondary structure

1
210
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi109 – 14234Combined sources
Helixi153 – 1608Combined sources
Helixi164 – 18623Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CQXX-ray2.30C/D107-188[»]
3D0TX-ray2.55A/B/C/D107-189[»]
ProteinModelPortaliQ91YN9.
SMRiQ91YN9. Positions 107-189.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ91YN9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini109 – 18981BAGPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili20 – 6041Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 BAG domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3633. Eukaryota.
ENOG410XRW0. LUCA.
GeneTreeiENSGT00390000017590.
HOGENOMiHOG000073529.
HOVERGENiHBG004808.
InParanoidiQ91YN9.
KOiK09556.
OMAiKIQAKMN.
OrthoDBiEOG7HTHJ7.
PhylomeDBiQ91YN9.
TreeFamiTF102012.

Family and domain databases

InterProiIPR003103. BAG_domain.
[Graphical view]
SMARTiSM00264. BAG. 1 hit.
[Graphical view]
PROSITEiPS51035. BAG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91YN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQAKISAKA HEGRFCRSSS MADRSSRLLE SLDQLELRVE ALRDAATAVE
60 70 80 90 100
QEKEILLEMI HSIQNSQDMR QISDGEREEL NLTANRLMGR TLTVEVSVET
110 120 130 140 150
IRNPQQEESL KHATRIIDEV VSKFLDDLGN AKSHLMSLYS ACSSEVPPGP
160 170 180 190 200
VDQKFQSIVI GCALEDQKKI KRRLETLLRN IDNSDKAIKL LEHAKGAGSK
210
SLQNTDGKFN
Length:210
Mass (Da):23,474
Last modified:December 1, 2001 - v1
Checksum:i96D693F88A1D35D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK083600 mRNA. Translation: BAC38967.1.
AK144720 mRNA. Translation: BAE26031.1.
BC016230 mRNA. Translation: AAH16230.1.
BC028944 mRNA. Translation: AAH28944.1.
CCDSiCCDS14864.1.
RefSeqiNP_663367.1. NM_145392.2.
UniGeneiMm.247037.

Genome annotation databases

EnsembliENSMUST00000044691; ENSMUSP00000042009; ENSMUSG00000042215.
GeneIDi213539.
KEGGimmu:213539.
UCSCiuc007any.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK083600 mRNA. Translation: BAC38967.1.
AK144720 mRNA. Translation: BAE26031.1.
BC016230 mRNA. Translation: AAH16230.1.
BC028944 mRNA. Translation: AAH28944.1.
CCDSiCCDS14864.1.
RefSeqiNP_663367.1. NM_145392.2.
UniGeneiMm.247037.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CQXX-ray2.30C/D107-188[»]
3D0TX-ray2.55A/B/C/D107-189[»]
ProteinModelPortaliQ91YN9.
SMRiQ91YN9. Positions 107-189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229449. 68 interactions.
IntActiQ91YN9. 73 interactions.
MINTiMINT-4122025.
STRINGi10090.ENSMUSP00000042009.

PTM databases

iPTMnetiQ91YN9.
PhosphoSiteiQ91YN9.

Proteomic databases

EPDiQ91YN9.
MaxQBiQ91YN9.
PaxDbiQ91YN9.
PRIDEiQ91YN9.
TopDownProteomicsiQ91YN9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044691; ENSMUSP00000042009; ENSMUSG00000042215.
GeneIDi213539.
KEGGimmu:213539.
UCSCiuc007any.1. mouse.

Organism-specific databases

CTDi9532.
MGIiMGI:1891254. Bag2.

Phylogenomic databases

eggNOGiKOG3633. Eukaryota.
ENOG410XRW0. LUCA.
GeneTreeiENSGT00390000017590.
HOGENOMiHOG000073529.
HOVERGENiHBG004808.
InParanoidiQ91YN9.
KOiK09556.
OMAiKIQAKMN.
OrthoDBiEOG7HTHJ7.
PhylomeDBiQ91YN9.
TreeFamiTF102012.

Enzyme and pathway databases

ReactomeiR-MMU-3371453. Regulation of HSF1-mediated heat shock response.

Miscellaneous databases

EvolutionaryTraceiQ91YN9.
PROiQ91YN9.
SOURCEiSearch...

Gene expression databases

BgeeiQ91YN9.
CleanExiMM_BAG2.
ExpressionAtlasiQ91YN9. baseline and differential.
GenevisibleiQ91YN9. MM.

Family and domain databases

InterProiIPR003103. BAG_domain.
[Graphical view]
SMARTiSM00264. BAG. 1 hit.
[Graphical view]
PROSITEiPS51035. BAG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N and FVB/N-3.
    Tissue: Mammary tumor.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart, Kidney, Lung, Spleen and Testis.

Entry informationi

Entry nameiBAG2_MOUSE
AccessioniPrimary (citable) accession number: Q91YN9
Secondary accession number(s): Q3UMR7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.