Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein TBRG4

Gene

Tbrg4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in cell cycle progression.By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular respiration Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TBRG4
Alternative name(s):
Transforming growth factor beta regulator 4
Gene namesi
Name:Tbrg4
Synonyms:Kiaa0948
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1100868. Tbrg4.

Subcellular locationi

  • Mitochondrion By similarity

GO - Cellular componenti

  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000273027? – 630Protein TBRG4
Transit peptidei1 – ?MitochondrionCurated

Proteomic databases

PaxDbiQ91YM4.
PeptideAtlasiQ91YM4.
PRIDEiQ91YM4.

PTM databases

iPTMnetiQ91YM4.
PhosphoSitePlusiQ91YM4.

Expressioni

Tissue specificityi

Expression detected in spleen, testis, colon, heart, smooth muscle, kidney, brain, lung, liver, brown and white adipose tissue with highest expression in testis, heart, smooth muscle and brown adipose tissue.1 Publication

Gene expression databases

BgeeiENSMUSG00000000384.
CleanExiMM_TBRG4.
ExpressionAtlasiQ91YM4. baseline and differential.
GenevisibleiQ91YM4. MM.

Interactioni

Protein-protein interaction databases

IntActiQ91YM4. 6 interactors.
MINTiMINT-4121960.
STRINGi10090.ENSMUSP00000000394.

Structurei

3D structure databases

ProteinModelPortaliQ91YM4.
SMRiQ91YM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini560 – 618RAPPROSITE-ProRule annotationAdd BLAST59

Sequence similaritiesi

Belongs to the FAST kinase family.Curated
Contains 1 RAP domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IEJA. Eukaryota.
ENOG4111EYX. LUCA.
GeneTreeiENSGT00530000063266.
HOGENOMiHOG000253019.
HOVERGENiHBG094028.
InParanoidiQ91YM4.
OMAiKVGHLSE.
OrthoDBiEOG091G0WV6.
PhylomeDBiQ91YM4.
TreeFamiTF324885.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR013579. FAST_2.
IPR010622. FAST_Leu-rich.
IPR013584. RAP.
[Graphical view]
PfamiPF06743. FAST_1. 1 hit.
PF08368. FAST_2. 1 hit.
PF08373. RAP. 1 hit.
[Graphical view]
SMARTiSM00952. RAP. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS51286. RAP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91YM4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVRLMKRCT CLLREATRLV PTVAPVGRLR LAGVSCKTLT SSVSSPSSGS
60 70 80 90 100
LAELLGKEQV FTPYPEHQEL DFLIEKASRP EQLLELLGSD HSLHHNHAAL
110 120 130 140 150
ILIRLSYLLS EKPKEKALLA EDARFQRLVK LVDSQITCVW HGTLVKLLRS
160 170 180 190 200
LYTLVLPQIS KELQSVEQEV RWRLRRLKYK HLVFLAESCA SFMKEQHSQE
210 220 230 240 250
LLAELLMHLE RRWTEINDSR TLVTMMTMAG HLSESLMNHL EDKCLELVEQ
260 270 280 290 300
FGPDELRKVL VTLAAQSRRS VPLLRAISYH LVQKPFPMTK GMLLDLAYAY
310 320 330 340 350
GKLSFHQTQV SQRLAADLLP FIPSMTPGEV ARCAKSFAFL KWLNLPLFEA
360 370 380 390 400
FTQHLLSRVQ DVSLSHVCSV LLAFARLNFH PEQEEDQFFS MVHEKLDPVL
410 420 430 440 450
GSLEPALQVD LVWALCVLQH VHETELHTVL HPGLHARFLE SKSPKDQSTF
460 470 480 490 500
QKLVHINTTA LLEHPEYKGP FLPASAVAPI PSPSNKKMTP LQKELQETLK
510 520 530 540 550
ALLGNTDKGS LEVATQYGWV LDAEVLLDAD GHFLPLRNFV APHLAQPVGN
560 570 580 590 600
QPLPPGAKRI AFLRWEFPNF NSRSKDLLGR FVLARRHVLA AGFLVVDVPY
610 620 630
YEWLDLKSEW QKSAYLKDKM RKAMAEELAK
Length:630
Mass (Da):71,513
Last modified:December 1, 2001 - v1
Checksum:i22BD82426988C195
GO
Isoform 2 (identifier: Q91YM4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-107: ASRPEQLLELLGSDHSLHHNHAALILIRLSY → D

Note: No experimental confirmation available.
Show »
Length:600
Mass (Da):68,142
Checksum:i4829AD7321B26127
GO

Sequence cautioni

The sequence AAC36538 differs from that shown. Reason: Erroneous termination at position 309. Translated as Gln.Curated
The sequence BAC36037 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC98055 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti166V → L in BAC36037 (PubMed:16141072).Curated1
Sequence conflicti224T → I in BAC36037 (PubMed:16141072).Curated1
Sequence conflicti286F → S in AAC36538 (PubMed:9798653).Curated1
Sequence conflicti316A → V in AAC36538 (PubMed:9798653).Curated1
Sequence conflicti327P → S in AAC36538 (PubMed:9798653).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02246177 – 107ASRPE…IRLSY → D in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129245 mRNA. Translation: BAC98055.1. Different initiation.
AK075897 mRNA. Translation: BAC36037.1. Different initiation.
AK166760 mRNA. Translation: BAE38999.1.
AK168088 mRNA. Translation: BAE40061.1.
AL603787 Genomic DNA. Translation: CAI24214.1.
BC016483 mRNA. Translation: AAH16483.1.
BC031155 mRNA. Translation: AAH31155.1.
BC031910 mRNA. Translation: AAH31910.1.
U89434 mRNA. Translation: AAC36538.1. Sequence problems.
CCDSiCCDS24423.1. [Q91YM4-1]
RefSeqiNP_001123929.1. NM_001130457.1. [Q91YM4-1]
NP_598772.1. NM_134011.2. [Q91YM4-1]
XP_006514670.1. XM_006514607.3. [Q91YM4-1]
XP_006514671.1. XM_006514608.3. [Q91YM4-1]
UniGeneiMm.247761.

Genome annotation databases

EnsembliENSMUST00000000394; ENSMUSP00000000394; ENSMUSG00000000384. [Q91YM4-1]
ENSMUST00000156969; ENSMUSP00000114256; ENSMUSG00000000384. [Q91YM4-1]
ENSMUST00000189268; ENSMUSP00000140835; ENSMUSG00000000384. [Q91YM4-1]
GeneIDi21379.
KEGGimmu:21379.
UCSCiuc007hyz.2. mouse. [Q91YM4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129245 mRNA. Translation: BAC98055.1. Different initiation.
AK075897 mRNA. Translation: BAC36037.1. Different initiation.
AK166760 mRNA. Translation: BAE38999.1.
AK168088 mRNA. Translation: BAE40061.1.
AL603787 Genomic DNA. Translation: CAI24214.1.
BC016483 mRNA. Translation: AAH16483.1.
BC031155 mRNA. Translation: AAH31155.1.
BC031910 mRNA. Translation: AAH31910.1.
U89434 mRNA. Translation: AAC36538.1. Sequence problems.
CCDSiCCDS24423.1. [Q91YM4-1]
RefSeqiNP_001123929.1. NM_001130457.1. [Q91YM4-1]
NP_598772.1. NM_134011.2. [Q91YM4-1]
XP_006514670.1. XM_006514607.3. [Q91YM4-1]
XP_006514671.1. XM_006514608.3. [Q91YM4-1]
UniGeneiMm.247761.

3D structure databases

ProteinModelPortaliQ91YM4.
SMRiQ91YM4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91YM4. 6 interactors.
MINTiMINT-4121960.
STRINGi10090.ENSMUSP00000000394.

PTM databases

iPTMnetiQ91YM4.
PhosphoSitePlusiQ91YM4.

Proteomic databases

PaxDbiQ91YM4.
PeptideAtlasiQ91YM4.
PRIDEiQ91YM4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000394; ENSMUSP00000000394; ENSMUSG00000000384. [Q91YM4-1]
ENSMUST00000156969; ENSMUSP00000114256; ENSMUSG00000000384. [Q91YM4-1]
ENSMUST00000189268; ENSMUSP00000140835; ENSMUSG00000000384. [Q91YM4-1]
GeneIDi21379.
KEGGimmu:21379.
UCSCiuc007hyz.2. mouse. [Q91YM4-1]

Organism-specific databases

CTDi9238.
MGIiMGI:1100868. Tbrg4.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IEJA. Eukaryota.
ENOG4111EYX. LUCA.
GeneTreeiENSGT00530000063266.
HOGENOMiHOG000253019.
HOVERGENiHBG094028.
InParanoidiQ91YM4.
OMAiKVGHLSE.
OrthoDBiEOG091G0WV6.
PhylomeDBiQ91YM4.
TreeFamiTF324885.

Miscellaneous databases

ChiTaRSiTbrg4. mouse.
PROiQ91YM4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000384.
CleanExiMM_TBRG4.
ExpressionAtlasiQ91YM4. baseline and differential.
GenevisibleiQ91YM4. MM.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR013579. FAST_2.
IPR010622. FAST_Leu-rich.
IPR013584. RAP.
[Graphical view]
PfamiPF06743. FAST_1. 1 hit.
PF08368. FAST_2. 1 hit.
PF08373. RAP. 1 hit.
[Graphical view]
SMARTiSM00952. RAP. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS51286. RAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBRG4_MOUSE
AccessioniPrimary (citable) accession number: Q91YM4
Secondary accession number(s): O89082
, Q3TKZ4, Q6ZQ19, Q8C6D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.