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Protein

Uridine-cytidine kinase-like 1

Gene

Uckl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May contribute to UTP accumulation needed for blast transformation and proliferation.By similarity

Catalytic activityi

ATP + uridine = ADP + UMP.

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uridine.
Proteins known to be involved in this subpathway in this organism are:
  1. Uridine-cytidine kinase-like 1 (Uckl1), Uridine-cytidine kinase (Uck1), Uridine-cytidine kinase (Uck2), Uridine-cytidine kinase (Uck2), Uridine-cytidine kinase 1 (Uck1), Uridine-cytidine kinase 2 (Uck2), Uridine-cytidine kinase (Uckl1)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uridine, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi105 – 112ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-73614. Pyrimidine salvage.
UniPathwayiUPA00574; UER00637.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine-cytidine kinase-like 1 (EC:2.7.1.-)
Gene namesi
Name:Uckl1
Synonyms:Urkl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1915806. Uckl1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001644611 – 548Uridine-cytidine kinase-like 1Add BLAST548

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56PhosphoserineBy similarity1
Modified residuei63PhosphoserineCombined sources1
Modified residuei539PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated by RNF19B; which induces proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ91YL3.
MaxQBiQ91YL3.
PaxDbiQ91YL3.
PeptideAtlasiQ91YL3.
PRIDEiQ91YL3.

PTM databases

iPTMnetiQ91YL3.
PhosphoSitePlusiQ91YL3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000089917.
CleanExiMM_UCKL1.
ExpressionAtlasiQ91YL3. baseline and differential.
GenevisibleiQ91YL3. MM.

Interactioni

Subunit structurei

Interacts with RNF19B.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050398.

Structurei

3D structure databases

ProteinModelPortaliQ91YL3.
SMRiQ91YL3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uridine kinase family.Curated

Phylogenomic databases

eggNOGiKOG4203. Eukaryota.
COG0035. LUCA.
COG0572. LUCA.
GeneTreeiENSGT00390000015696.
HOGENOMiHOG000262757.
HOVERGENiHBG055146.
InParanoidiQ91YL3.
KOiK00876.
OMAiCYAGKQI.
OrthoDBiEOG091G04SI.
PhylomeDBiQ91YL3.
TreeFamiTF105902.

Family and domain databases

CDDicd06223. PRTases_typeI. 1 hit.
cd02023. UMPK. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR000836. PRibTrfase_dom.
IPR006083. PRK/URK.
IPR029057. PRTase-like.
IPR029933. UCKL1.
IPR000764. Uridine_kinase-like.
PANTHERiPTHR10285:SF98. PTHR10285:SF98. 1 hit.
PfamiView protein in Pfam
PF00485. PRK. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR00235. udk. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91YL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPPASMSA APSPLQSAVA PDVPGRQAEQ NETACEDRSN AGTLDRLLPP
60 70 80 90 100
VGTGRSPRKR TTSQCKSEPP LLRTSKRTIY TAGRPPWYNE HGTQSKEAFA
110 120 130 140 150
IGLGGGSASG KTTVARMIIE ALDVPWVVLL SMDSFYKVLT QQQQEQAACN
160 170 180 190 200
NFNFDHPDAF DFDLIISTLK KLKQGRSVQV PIYDFTTHSR KKDWKTLYGA
210 220 230 240 250
NVIIFEGIMA FADKTLLELL DMKIFVDTDS DIRLVRRLRR DISERGRDIE
260 270 280 290 300
GVIKQYNKFV KPAFDQYIQP TMRLADIVVP RGSGNTVAID LIVQHVHSQL
310 320 330 340 350
EERELSVRAA LASAHQCHPL PQTLSVLKST PQVRGMHTII RDKETSRDEF
360 370 380 390 400
IFYSKRLMRL LIEHALSFLP FQDCTVQTPQ GQDYVGKCYA GKQITGVSIL
410 420 430 440 450
RAGETMEPAL RAVCKDVRIG TILIQTNQLT GEPELHYLRL PKDISDDHVI
460 470 480 490 500
LMDCTVSTGA AAMMAVRVLL DHDVPEDKIF LLSLLMAEMG VHSVAYAFPR
510 520 530 540
VRIITTAVDK RVNDLFRIIP GIGNFGDRYF GTDAVPDGSD DDEAATVG
Length:548
Mass (Da):60,842
Last modified:December 1, 2001 - v1
Checksum:i99A5CA23E9BD8525
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016535 mRNA. Translation: AAH16535.1.
CCDSiCCDS17216.1.
RefSeqiNP_081041.2. NM_026765.3.
UniGeneiMm.232400.

Genome annotation databases

EnsembliENSMUST00000057816; ENSMUSP00000050398; ENSMUSG00000089917.
GeneIDi68556.
KEGGimmu:68556.
UCSCiuc008oms.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiUCKL1_MOUSE
AccessioniPrimary (citable) accession number: Q91YL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: December 1, 2001
Last modified: August 30, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families