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Protein

Uridine-cytidine kinase-like 1

Gene

Uckl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May contribute to UTP accumulation needed for blast transformation and proliferation.By similarity

Catalytic activityi

ATP + uridine = ADP + UMP.

Pathwayi: UMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from uridine.
Proteins known to be involved in this subpathway in this organism are:
  1. Uridine-cytidine kinase-like 1 (Uckl1), Uridine kinase (Uck1), Uridine kinase (Uck2), Uridine kinase (Uck2), Uridine-cytidine kinase 1 (Uck1), Uridine-cytidine kinase 2 (Uck2), Uridine kinase (Uckl1)
This subpathway is part of the pathway UMP biosynthesis via salvage pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from uridine, the pathway UMP biosynthesis via salvage pathway and in Pyrimidine metabolism.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi105 – 1128ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00574; UER00637.

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine-cytidine kinase-like 1 (EC:2.7.1.-)
Gene namesi
Name:Uckl1
Synonyms:Urkl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1915806. Uckl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548Uridine-cytidine kinase-like 1PRO_0000164461Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei56 – 561PhosphoserineBy similarity
Modified residuei63 – 631PhosphoserineCombined sources
Modified residuei539 – 5391PhosphoserineBy similarity

Post-translational modificationi

Ubiquitinated by RNF19B; which induces proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ91YL3.
MaxQBiQ91YL3.
PaxDbiQ91YL3.
PeptideAtlasiQ91YL3.
PRIDEiQ91YL3.

PTM databases

iPTMnetiQ91YL3.
PhosphoSiteiQ91YL3.

Expressioni

Gene expression databases

BgeeiQ91YL3.
CleanExiMM_UCKL1.
ExpressionAtlasiQ91YL3. baseline and differential.
GenevisibleiQ91YL3. MM.

Interactioni

Subunit structurei

Interacts with RNF19B.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050398.

Structurei

3D structure databases

ProteinModelPortaliQ91YL3.
SMRiQ91YL3. Positions 97-300, 326-532.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uridine kinase family.Curated

Phylogenomic databases

eggNOGiKOG4203. Eukaryota.
COG0035. LUCA.
COG0572. LUCA.
GeneTreeiENSGT00390000015696.
HOGENOMiHOG000262757.
HOVERGENiHBG055146.
InParanoidiQ91YL3.
KOiK00876.
OMAiMDCFYKI.
OrthoDBiEOG76T9QV.
PhylomeDBiQ91YL3.
TreeFamiTF105902.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR006083. PRK/URK.
IPR029057. PRTase-like.
IPR029933. UCKL1.
IPR000764. Uridine_kinase-like.
[Graphical view]
PANTHERiPTHR10285:SF68. PTHR10285:SF68. 2 hits.
PfamiPF00485. PRK. 1 hit.
PF14681. UPRTase. 1 hit.
[Graphical view]
PRINTSiPR00988. URIDINKINASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR00235. udk. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91YL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPPASMSA APSPLQSAVA PDVPGRQAEQ NETACEDRSN AGTLDRLLPP
60 70 80 90 100
VGTGRSPRKR TTSQCKSEPP LLRTSKRTIY TAGRPPWYNE HGTQSKEAFA
110 120 130 140 150
IGLGGGSASG KTTVARMIIE ALDVPWVVLL SMDSFYKVLT QQQQEQAACN
160 170 180 190 200
NFNFDHPDAF DFDLIISTLK KLKQGRSVQV PIYDFTTHSR KKDWKTLYGA
210 220 230 240 250
NVIIFEGIMA FADKTLLELL DMKIFVDTDS DIRLVRRLRR DISERGRDIE
260 270 280 290 300
GVIKQYNKFV KPAFDQYIQP TMRLADIVVP RGSGNTVAID LIVQHVHSQL
310 320 330 340 350
EERELSVRAA LASAHQCHPL PQTLSVLKST PQVRGMHTII RDKETSRDEF
360 370 380 390 400
IFYSKRLMRL LIEHALSFLP FQDCTVQTPQ GQDYVGKCYA GKQITGVSIL
410 420 430 440 450
RAGETMEPAL RAVCKDVRIG TILIQTNQLT GEPELHYLRL PKDISDDHVI
460 470 480 490 500
LMDCTVSTGA AAMMAVRVLL DHDVPEDKIF LLSLLMAEMG VHSVAYAFPR
510 520 530 540
VRIITTAVDK RVNDLFRIIP GIGNFGDRYF GTDAVPDGSD DDEAATVG
Length:548
Mass (Da):60,842
Last modified:December 1, 2001 - v1
Checksum:i99A5CA23E9BD8525
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016535 mRNA. Translation: AAH16535.1.
CCDSiCCDS17216.1.
RefSeqiNP_081041.2. NM_026765.3.
UniGeneiMm.232400.

Genome annotation databases

EnsembliENSMUST00000057816; ENSMUSP00000050398; ENSMUSG00000089917.
GeneIDi68556.
KEGGimmu:68556.
UCSCiuc008oms.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC016535 mRNA. Translation: AAH16535.1.
CCDSiCCDS17216.1.
RefSeqiNP_081041.2. NM_026765.3.
UniGeneiMm.232400.

3D structure databases

ProteinModelPortaliQ91YL3.
SMRiQ91YL3. Positions 97-300, 326-532.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050398.

PTM databases

iPTMnetiQ91YL3.
PhosphoSiteiQ91YL3.

Proteomic databases

EPDiQ91YL3.
MaxQBiQ91YL3.
PaxDbiQ91YL3.
PeptideAtlasiQ91YL3.
PRIDEiQ91YL3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057816; ENSMUSP00000050398; ENSMUSG00000089917.
GeneIDi68556.
KEGGimmu:68556.
UCSCiuc008oms.2. mouse.

Organism-specific databases

CTDi54963.
MGIiMGI:1915806. Uckl1.

Phylogenomic databases

eggNOGiKOG4203. Eukaryota.
COG0035. LUCA.
COG0572. LUCA.
GeneTreeiENSGT00390000015696.
HOGENOMiHOG000262757.
HOVERGENiHBG055146.
InParanoidiQ91YL3.
KOiK00876.
OMAiMDCFYKI.
OrthoDBiEOG76T9QV.
PhylomeDBiQ91YL3.
TreeFamiTF105902.

Enzyme and pathway databases

UniPathwayiUPA00574; UER00637.

Miscellaneous databases

ChiTaRSiUckl1. mouse.
PROiQ91YL3.
SOURCEiSearch...

Gene expression databases

BgeeiQ91YL3.
CleanExiMM_UCKL1.
ExpressionAtlasiQ91YL3. baseline and differential.
GenevisibleiQ91YL3. MM.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR006083. PRK/URK.
IPR029057. PRTase-like.
IPR029933. UCKL1.
IPR000764. Uridine_kinase-like.
[Graphical view]
PANTHERiPTHR10285:SF68. PTHR10285:SF68. 2 hits.
PfamiPF00485. PRK. 1 hit.
PF14681. UPRTase. 1 hit.
[Graphical view]
PRINTSiPR00988. URIDINKINASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR00235. udk. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Lung, Pancreas and Spleen.

Entry informationi

Entry nameiUCKL1_MOUSE
AccessioniPrimary (citable) accession number: Q91YL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.