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Protein

Ribosomal RNA processing protein 1 homolog B

Gene

Rrp1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (By similarity). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (By similarity). Involved in regulation of mRNA splicing (PubMed:23604122). Inhibits SIPA1 GTPase activity (PubMed:18081427). Involved in regulating expression of extracellular matrix genes (PubMed:18081427). Associates with chromatin and may play a role in modulating chromatin structure (By similarity).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processApoptosis, mRNA processing, mRNA splicing, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA processing protein 1 homolog B
Alternative name(s):
RRP1-like protein B
Gene namesi
Name:Rrp1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1919712 Rrp1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003401161 – 724Ribosomal RNA processing protein 1 homolog BAdd BLAST724

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei336PhosphoserineBy similarity1
Modified residuei370PhosphoserineBy similarity1
Modified residuei432PhosphoserineBy similarity1
Modified residuei438PhosphoserineBy similarity1
Modified residuei494PhosphoserineBy similarity1
Modified residuei618N6-acetyllysineBy similarity1
Modified residuei668PhosphoserineBy similarity1
Modified residuei672PhosphoserineBy similarity1
Modified residuei678Citrulline1 Publication1
Modified residuei694PhosphothreonineBy similarity1
Modified residuei698PhosphoserineBy similarity1
Modified residuei701PhosphoserineBy similarity1

Post-translational modificationi

Citrullinated by PADI4.1 Publication

Keywords - PTMi

Acetylation, Citrullination, Phosphoprotein

Proteomic databases

EPDiQ91YK2
MaxQBiQ91YK2
PaxDbiQ91YK2
PeptideAtlasiQ91YK2
PRIDEiQ91YK2

PTM databases

iPTMnetiQ91YK2
PhosphoSitePlusiQ91YK2

Expressioni

Gene expression databases

BgeeiENSMUSG00000058392
ExpressionAtlasiQ91YK2 baseline and differential
GenevisibleiQ91YK2 MM

Interactioni

Subunit structurei

Interacts with the transcriptional activator E2F1 (By similarity). Interacts with serine/threonine-protein phosphatase PP1 subunits PPP1CB and PPP1CC but not with PPP1CA (By similarity). Interacts with 60S ribosomal proteins RPL5 and RPL27, ribosomal processing protein RRP1/NNP1 and other nucleolar proteins including NOP2/NOL1 and FBL (By similarity). Also interacts with nucleolar protein NPM1/B23 (By similarity). Interacts with splicing factor SRSF1 and LUC7L3/CROP (By similarity). Interacts with GTPase activator SIPA1 (PubMed:18081427). Interacts with H1FX, NCL, PARP1, TRIM28 and YBX3 (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi215383, 46 interactors
IntActiQ91YK2, 2 interactors
MINTiQ91YK2
STRINGi10090.ENSMUSP00000080085

Structurei

3D structure databases

ProteinModelPortaliQ91YK2
SMRiQ91YK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RRP1 family.Curated

Phylogenomic databases

eggNOGiKOG3911 Eukaryota
ENOG4111GJ6 LUCA
GeneTreeiENSGT00390000011821
HOGENOMiHOG000070179
HOVERGENiHBG098014
InParanoidiQ91YK2
KOiK14849
OMAiQKPLHGV
OrthoDBiEOG091G0AX5
PhylomeDBiQ91YK2
TreeFamiTF315294

Family and domain databases

InterProiView protein in InterPro
IPR010301 Nop52
PANTHERiPTHR13026 PTHR13026, 1 hit
PfamiView protein in Pfam
PF05997 Nop52, 1 hit

Sequencei

Sequence statusi: Complete.

Q91YK2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALAMQSSEF QFAQRLASSE KGVRDRAVRK LRQYLSARTQ SDTGSFSQEE
60 70 80 90 100
LLKIWKGLFY CMWVQDEPLL QEELANIISQ LIHVVNSLEA QYLFIQTFWQ
110 120 130 140 150
TMNREWQGID KLQLDKYYML IRLVLRQSFE VLKRNAWEES QITLFLDILM
160 170 180 190 200
KEILSPESQS PNGVRTHLID VYLEELTTVG GAELLADQNL KLIDPFCRIA
210 220 230 240 250
AKTKDHTLVQ TVARGVFEVI VDQSACVPQE SVEERKTKED GSGFPTKALA
260 270 280 290 300
CRKAVSGKKA ALDECLRDGV IGSRERDICA ALKDSGSPLQ FDYKAVADRL
310 320 330 340 350
LEIANSKSTP PFNRKRLCRL VRKFQDLCEG NGAPLSSAED NGQRRHKRKR
360 370 380 390 400
KKLLESEKGD TVSPAAEEDS GGHIHKKKRK KRKRSHFQPD TQNLDAVAVP
410 420 430 440 450
KVPDSESEPD TAQRQAPCGQ ACVTEPTAEA VSSIGENSSK PTPVMPIHNK
460 470 480 490 500
RKRPRKKKLR AHKEICKSTT LPQEDMSKND AVSGHSQSSA AHISSSEGVQ
510 520 530 540 550
AQKRKRKLGA LPDSSSDLPV QKSGTPTSPV EGKDGQTTLP RCKRSQKKTA
560 570 580 590 600
SSTLDPCDPS SQKPAISKKK KKTMKLMSNG VLESNPGQIQ ALGSNRTLKK
610 620 630 640 650
PLKTEDDFVK FDTRFLPKPL FFRKAKNSSA TRPQGPAGQL NKTPSSSKKV
660 670 680 690 700
TFGLNRNMTA EFKKTDKSIL VSPTGLSRVA FNPEQRPLHG VLKTATSSPA
710 720
STPLSPMRLP ATTPKRRPRA ADFF
Length:724
Mass (Da):80,582
Last modified:June 10, 2008 - v2
Checksum:i4DEFC78AADBA38F1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti209V → A in AAH16569 (PubMed:15489334).Curated1
Sequence conflicti229Q → E in AAH16569 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT033797 Genomic DNA No translation available.
BC016569 mRNA Translation: AAH16569.1
CCDSiCCDS28613.1
RefSeqiNP_082520.2, NM_028244.2
UniGeneiMm.102761

Genome annotation databases

EnsembliENSMUST00000081339; ENSMUSP00000080085; ENSMUSG00000058392
GeneIDi72462
KEGGimmu:72462
UCSCiuc008bvt.2 mouse

Entry informationi

Entry nameiRRP1B_MOUSE
AccessioniPrimary (citable) accession number: Q91YK2
Secondary accession number(s): B0V2W7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: March 28, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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