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Protein

Thymocyte nuclear protein 1

Gene

Thyn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Thymocyte nuclear protein 1
Alternative name(s):
Thymocyte protein Thy28
Short name:
mThy28
Gene namesi
Name:Thyn1
Synonyms:Thy28
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1925112. Thyn1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • nucleolus Source: MGI
  • nucleus Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226Thymocyte nuclear protein 1PRO_0000262565Add
BLAST

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ91YJ3.
MaxQBiQ91YJ3.
PaxDbiQ91YJ3.
PRIDEiQ91YJ3.

PTM databases

iPTMnetiQ91YJ3.
PhosphoSiteiQ91YJ3.

Expressioni

Tissue specificityi

Expressed in the medulla containing mature thymocytes, but not the cortex having immature thymocytes (at protein level). Abundant expression seen in testis, liver, brain and kidney with lower levels of the expression in thymus, spleen, heart and stomach.3 Publications

Inductioni

Down-regulated upon induction of apoptosis.2 Publications

Gene expression databases

BgeeiQ91YJ3.
CleanExiMM_THYN1.
GenevisibleiQ91YJ3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037614.

Structurei

3D structure databases

ProteinModelPortaliQ91YJ3.
SMRiQ91YJ3. Positions 56-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi5 – 106Nuclear localization signalBy similarity

Phylogenomic databases

eggNOGiKOG3383. Eukaryota.
COG2947. LUCA.
GeneTreeiENSGT00390000013297.
HOGENOMiHOG000263533.
HOVERGENiHBG054408.
InParanoidiQ91YJ3.
OMAiMTLFTRQ.
OrthoDBiEOG7J70GK.
PhylomeDBiQ91YJ3.
TreeFamiTF332126.

Family and domain databases

Gene3Di3.10.590.10. 1 hit.
InterProiIPR002740. EVE_domain.
IPR015947. PUA-like_domain.
[Graphical view]
PfamiPF01878. EVE. 1 hit.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91YJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRPRKRQTG TAGPDRKKLS GKRTKTENSE STSVKLENSS LEMTTTFKNG
60 70 80 90 100
GKNLSNYWLM KSEPESRLEK GIDMKFSIED LKAQPKQTAC WDGVRNYQAR
110 120 130 140 150
NFLRAMKLED EAFFYHSNCK QPGIVGLMKI VKEAYPDHTQ FEKSNPHYDP
160 170 180 190 200
SSKEDDPKWS MVDVQFVRMM KRFIPLEELK TYHQAHKATG GPLKSMTLFT
210 220
RQRLSVQPLT QEEFDFILSL EETEPS
Length:226
Mass (Da):26,178
Last modified:December 1, 2001 - v1
Checksum:i57D69619D37CDF89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB080370 mRNA. Translation: BAC21100.1.
BC016594 mRNA. Translation: AAH16594.1.
CCDSiCCDS22937.1.
RefSeqiNP_653126.1. NM_144543.2.
UniGeneiMm.16925.

Genome annotation databases

EnsembliENSMUST00000039161; ENSMUSP00000037614; ENSMUSG00000035443.
GeneIDi77862.
KEGGimmu:77862.
UCSCiuc009oqb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB080370 mRNA. Translation: BAC21100.1.
BC016594 mRNA. Translation: AAH16594.1.
CCDSiCCDS22937.1.
RefSeqiNP_653126.1. NM_144543.2.
UniGeneiMm.16925.

3D structure databases

ProteinModelPortaliQ91YJ3.
SMRiQ91YJ3. Positions 56-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037614.

PTM databases

iPTMnetiQ91YJ3.
PhosphoSiteiQ91YJ3.

Proteomic databases

EPDiQ91YJ3.
MaxQBiQ91YJ3.
PaxDbiQ91YJ3.
PRIDEiQ91YJ3.

Protocols and materials databases

DNASUi77862.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039161; ENSMUSP00000037614; ENSMUSG00000035443.
GeneIDi77862.
KEGGimmu:77862.
UCSCiuc009oqb.2. mouse.

Organism-specific databases

CTDi29087.
MGIiMGI:1925112. Thyn1.

Phylogenomic databases

eggNOGiKOG3383. Eukaryota.
COG2947. LUCA.
GeneTreeiENSGT00390000013297.
HOGENOMiHOG000263533.
HOVERGENiHBG054408.
InParanoidiQ91YJ3.
OMAiMTLFTRQ.
OrthoDBiEOG7J70GK.
PhylomeDBiQ91YJ3.
TreeFamiTF332126.

Miscellaneous databases

PROiQ91YJ3.
SOURCEiSearch...

Gene expression databases

BgeeiQ91YJ3.
CleanExiMM_THYN1.
GenevisibleiQ91YJ3. MM.

Family and domain databases

Gene3Di3.10.590.10. 1 hit.
InterProiIPR002740. EVE_domain.
IPR015947. PUA-like_domain.
[Graphical view]
PfamiPF01878. EVE. 1 hit.
[Graphical view]
SUPFAMiSSF88697. SSF88697. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of the mouse thymocyte protein gene."
    Miyaji H., Yoshimoto T., Asakura H., Komachi A., Kamiya S., Takasaki M., Mizuguchi J.
    Gene 297:189-196(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. "Anti-IgM-induced down-regulation of nuclear Thy28 protein expression in Ramos B lymphoma cells."
    Jiang X.Z., Toyota H., Yoshimoto T., Takada E., Asakura H., Mizuguchi J.
    Apoptosis 8:509-519(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  4. "Modulation of mThy28 nuclear protein expression during thymocyte development."
    Jiang X.Z., Toyota H., Takada E., Yoshimoto T., Kitamura T., Yamada J., Mizuguchi J.
    Tissue Cell 35:471-478(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.
  6. Cited for: FUNCTION.

Entry informationi

Entry nameiTHYN1_MOUSE
AccessioniPrimary (citable) accession number: Q91YJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.