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Protein

Sorting nexin-4

Gene

Snx4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei108Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei132Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei154Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-4
Gene namesi
Name:Snx4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1916400 Snx4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002361971 – 450Sorting nexin-4Add BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ91YJ2
MaxQBiQ91YJ2
PaxDbiQ91YJ2
PeptideAtlasiQ91YJ2
PRIDEiQ91YJ2

PTM databases

iPTMnetiQ91YJ2
PhosphoSitePlusiQ91YJ2

Expressioni

Gene expression databases

BgeeiENSMUSG00000022808
CleanExiMM_SNX4
GenevisibleiQ91YJ2 MM

Interactioni

Subunit structurei

Interacts with WWC1/KIBRA. Identified in a complex with WWC1/KIBRA and dynein components DYNLL1 and DYNC1I2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ91YJ2, 2 interactors
MINTiQ91YJ2
STRINGi10090.ENSMUSP00000023502

Structurei

3D structure databases

ProteinModelPortaliQ91YJ2
SMRiQ91YJ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 187PXPROSITE-ProRule annotationAdd BLAST127

Domaini

The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

eggNOGiENOG410IQ89 Eukaryota
ENOG4110G6D LUCA
GeneTreeiENSGT00910000144107
HOGENOMiHOG000007933
HOVERGENiHBG017826
InParanoidiQ91YJ2
KOiK17919
OMAiRYTEFEL
OrthoDBiEOG091G0CLA
PhylomeDBiQ91YJ2
TreeFamiTF328543

Family and domain databases

CDDicd07622 BAR_SNX4, 1 hit
cd06864 PX_SNX4, 1 hit
Gene3Di1.20.1270.60, 1 hit
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR027267 AH/BAR_dom_sf
IPR001683 Phox
IPR036871 PX_dom_sf
IPR034902 PX_SNX4
IPR034783 SNX4
IPR037430 SNX4_BAR
PANTHERiPTHR10555:SF139 PTHR10555:SF139, 1 hit
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit

Sequencei

Sequence statusi: Complete.

Q91YJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQAPPDPEK LLQPGPLEPL GGPGAVLEAA VGEENEGTRE DGSGVDTMTG
60 70 80 90 100
NNFWLKKIEI SVSEAEKRTG RNAVNMQETY TAYLIETRSV EHADGQSVLT
110 120 130 140 150
DSLWRRYSEF ELLRNYLLVY YPHVVVPPLP EKRAEFVWHK LSADNMDPDF
160 170 180 190 200
VERRRVGLEN FLLRVASHPV LCRDKIFYSF LTQEGNWKET VNETGFQLKA
210 220 230 240 250
DSRLKALNAT FRVKNPDKRF TELRHYSDEL QSVISHLLRV RARVADRLYG
260 270 280 290 300
VYKVHGNYGR VFSEWSAIEK EMGDGLQSAG HHMDVYASSI DDILEDEEHY
310 320 330 340 350
ADQLKEYLFY AEALRAVCRK HELMQYDLET AAQDLAAKKQ QCEELATGTV
360 370 380 390 400
RTFSLKGMTT KLFGQETPEQ REARIKVLEE QINEGEQQLK SKNLEGREFV
410 420 430 440 450
KNAWADIERF KEQKNRDLKE ALISYAVMQI SMCKKGIQVW TNAKECFSKM
Length:450
Mass (Da):51,778
Last modified:December 1, 2001 - v1
Checksum:i533F8305BFE077EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK135356 mRNA Translation: BAE22501.1
BC016599 mRNA Translation: AAH16599.1
CCDSiCCDS28129.1
RefSeqiNP_542124.1, NM_080557.2
UniGeneiMm.28196
Mm.396285

Genome annotation databases

EnsembliENSMUST00000023502; ENSMUSP00000023502; ENSMUSG00000022808
GeneIDi69150
KEGGimmu:69150
UCSCiuc007yzz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSNX4_MOUSE
AccessioniPrimary (citable) accession number: Q91YJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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