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Protein

Sorting nexin-4

Gene

Snx4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei108Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei132Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei154Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-4
Gene namesi
Name:Snx4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1916400. Snx4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002361971 – 450Sorting nexin-4Add BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ91YJ2.
MaxQBiQ91YJ2.
PaxDbiQ91YJ2.
PeptideAtlasiQ91YJ2.
PRIDEiQ91YJ2.

PTM databases

iPTMnetiQ91YJ2.
PhosphoSitePlusiQ91YJ2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022808.
CleanExiMM_SNX4.
GenevisibleiQ91YJ2. MM.

Interactioni

Subunit structurei

Interacts with WWC1/KIBRA. Identified in a complex with WWC1/KIBRA and dynein components DYNLL1 and DYNC1I2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ91YJ2. 2 interactors.
MINTiMINT-4121914.
STRINGi10090.ENSMUSP00000023502.

Structurei

3D structure databases

ProteinModelPortaliQ91YJ2.
SMRiQ91YJ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 187PXPROSITE-ProRule annotationAdd BLAST127

Domaini

The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IQ89. Eukaryota.
ENOG4110G6D. LUCA.
GeneTreeiENSGT00840000129805.
HOGENOMiHOG000007933.
HOVERGENiHBG017826.
InParanoidiQ91YJ2.
KOiK17919.
OMAiKSAWADI.
OrthoDBiEOG091G0CLA.
PhylomeDBiQ91YJ2.
TreeFamiTF328543.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91YJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQAPPDPEK LLQPGPLEPL GGPGAVLEAA VGEENEGTRE DGSGVDTMTG
60 70 80 90 100
NNFWLKKIEI SVSEAEKRTG RNAVNMQETY TAYLIETRSV EHADGQSVLT
110 120 130 140 150
DSLWRRYSEF ELLRNYLLVY YPHVVVPPLP EKRAEFVWHK LSADNMDPDF
160 170 180 190 200
VERRRVGLEN FLLRVASHPV LCRDKIFYSF LTQEGNWKET VNETGFQLKA
210 220 230 240 250
DSRLKALNAT FRVKNPDKRF TELRHYSDEL QSVISHLLRV RARVADRLYG
260 270 280 290 300
VYKVHGNYGR VFSEWSAIEK EMGDGLQSAG HHMDVYASSI DDILEDEEHY
310 320 330 340 350
ADQLKEYLFY AEALRAVCRK HELMQYDLET AAQDLAAKKQ QCEELATGTV
360 370 380 390 400
RTFSLKGMTT KLFGQETPEQ REARIKVLEE QINEGEQQLK SKNLEGREFV
410 420 430 440 450
KNAWADIERF KEQKNRDLKE ALISYAVMQI SMCKKGIQVW TNAKECFSKM
Length:450
Mass (Da):51,778
Last modified:December 1, 2001 - v1
Checksum:i533F8305BFE077EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK135356 mRNA. Translation: BAE22501.1.
BC016599 mRNA. Translation: AAH16599.1.
CCDSiCCDS28129.1.
RefSeqiNP_542124.1. NM_080557.2.
UniGeneiMm.28196.
Mm.396285.

Genome annotation databases

EnsembliENSMUST00000023502; ENSMUSP00000023502; ENSMUSG00000022808.
GeneIDi69150.
KEGGimmu:69150.
UCSCiuc007yzz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK135356 mRNA. Translation: BAE22501.1.
BC016599 mRNA. Translation: AAH16599.1.
CCDSiCCDS28129.1.
RefSeqiNP_542124.1. NM_080557.2.
UniGeneiMm.28196.
Mm.396285.

3D structure databases

ProteinModelPortaliQ91YJ2.
SMRiQ91YJ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91YJ2. 2 interactors.
MINTiMINT-4121914.
STRINGi10090.ENSMUSP00000023502.

PTM databases

iPTMnetiQ91YJ2.
PhosphoSitePlusiQ91YJ2.

Proteomic databases

EPDiQ91YJ2.
MaxQBiQ91YJ2.
PaxDbiQ91YJ2.
PeptideAtlasiQ91YJ2.
PRIDEiQ91YJ2.

Protocols and materials databases

DNASUi69150.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023502; ENSMUSP00000023502; ENSMUSG00000022808.
GeneIDi69150.
KEGGimmu:69150.
UCSCiuc007yzz.1. mouse.

Organism-specific databases

CTDi8723.
MGIiMGI:1916400. Snx4.

Phylogenomic databases

eggNOGiENOG410IQ89. Eukaryota.
ENOG4110G6D. LUCA.
GeneTreeiENSGT00840000129805.
HOGENOMiHOG000007933.
HOVERGENiHBG017826.
InParanoidiQ91YJ2.
KOiK17919.
OMAiKSAWADI.
OrthoDBiEOG091G0CLA.
PhylomeDBiQ91YJ2.
TreeFamiTF328543.

Miscellaneous databases

PROiQ91YJ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022808.
CleanExiMM_SNX4.
GenevisibleiQ91YJ2. MM.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNX4_MOUSE
AccessioniPrimary (citable) accession number: Q91YJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.