Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q91YJ2 (SNX4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sorting nexin-4
Gene names
Name:Snx4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation By similarity.

Subunit structure

Interacts with WWC1/KIBRA. Identified in a complex with WWC1/KIBRA and dynein components DYNLL1 and DYNC1I2 By similarity.

Subcellular location

Early endosome membrane; Peripheral membrane protein; Cytoplasmic side By similarity. Note: Also detected on a juxtanuclear endocytic recycling compartment (ERC) By similarity.

Domain

The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization By similarity.

Sequence similarities

Belongs to the sorting nexin family.

Contains 1 PX (phox homology) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 450450Sorting nexin-4
PRO_0000236197

Regions

Domain61 – 187127PX

Sites

Binding site1061Phosphatidylinositol 3-phosphate By similarity
Binding site1081Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygen By similarity
Binding site1321Phosphatidylinositol 3-phosphate By similarity
Binding site1541Phosphatidylinositol 3-phosphate By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q91YJ2 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 533F8305BFE077EE

FASTA45051,778
        10         20         30         40         50         60 
MEQAPPDPEK LLQPGPLEPL GGPGAVLEAA VGEENEGTRE DGSGVDTMTG NNFWLKKIEI 

        70         80         90        100        110        120 
SVSEAEKRTG RNAVNMQETY TAYLIETRSV EHADGQSVLT DSLWRRYSEF ELLRNYLLVY 

       130        140        150        160        170        180 
YPHVVVPPLP EKRAEFVWHK LSADNMDPDF VERRRVGLEN FLLRVASHPV LCRDKIFYSF 

       190        200        210        220        230        240 
LTQEGNWKET VNETGFQLKA DSRLKALNAT FRVKNPDKRF TELRHYSDEL QSVISHLLRV 

       250        260        270        280        290        300 
RARVADRLYG VYKVHGNYGR VFSEWSAIEK EMGDGLQSAG HHMDVYASSI DDILEDEEHY 

       310        320        330        340        350        360 
ADQLKEYLFY AEALRAVCRK HELMQYDLET AAQDLAAKKQ QCEELATGTV RTFSLKGMTT 

       370        380        390        400        410        420 
KLFGQETPEQ REARIKVLEE QINEGEQQLK SKNLEGREFV KNAWADIERF KEQKNRDLKE 

       430        440        450 
ALISYAVMQI SMCKKGIQVW TNAKECFSKM 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK135356 mRNA. Translation: BAE22501.1.
BC016599 mRNA. Translation: AAH16599.1.
CCDSCCDS28129.1.
RefSeqNP_542124.1. NM_080557.2.
UniGeneMm.28196.
Mm.396285.

3D structure databases

ProteinModelPortalQ91YJ2.
SMRQ91YJ2. Positions 55-185.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ91YJ2. 2 interactions.
MINTMINT-4121914.

PTM databases

PhosphoSiteQ91YJ2.

Proteomic databases

MaxQBQ91YJ2.
PaxDbQ91YJ2.
PRIDEQ91YJ2.

Protocols and materials databases

DNASU69150.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023502; ENSMUSP00000023502; ENSMUSG00000022808.
GeneID69150.
KEGGmmu:69150.
UCSCuc007yzz.1. mouse.

Organism-specific databases

CTD8723.
MGIMGI:1916400. Snx4.

Phylogenomic databases

eggNOGCOG5391.
GeneTreeENSGT00740000114933.
HOGENOMHOG000007933.
HOVERGENHBG017826.
InParanoidQ91YJ2.
KOK17919.
OMAMDVYAAS.
OrthoDBEOG76HQ1H.
PhylomeDBQ91YJ2.
TreeFamTF328543.

Gene expression databases

ArrayExpressQ91YJ2.
BgeeQ91YJ2.
CleanExMM_SNX4.
GenevestigatorQ91YJ2.

Family and domain databases

Gene3D3.30.1520.10. 1 hit.
InterProIPR001683. Phox.
[Graphical view]
PfamPF00787. PX. 1 hit.
[Graphical view]
SMARTSM00312. PX. 1 hit.
[Graphical view]
SUPFAMSSF64268. SSF64268. 1 hit.
PROSITEPS50195. PX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio328712.
PROQ91YJ2.
SOURCESearch...

Entry information

Entry nameSNX4_MOUSE
AccessionPrimary (citable) accession number: Q91YJ2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot