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Q91YJ2

- SNX4_MOUSE

UniProt

Q91YJ2 - SNX4_MOUSE

Protein

Sorting nexin-4

Gene

Snx4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei106 – 1061Phosphatidylinositol 3-phosphateBy similarity
    Binding sitei108 – 1081Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei132 – 1321Phosphatidylinositol 3-phosphateBy similarity
    Binding sitei154 – 1541Phosphatidylinositol 3-phosphateBy similarity

    GO - Molecular functioni

    1. phosphatidylinositol binding Source: UniProtKB

    GO - Biological processi

    1. endocytic recycling Source: UniProtKB
    2. intracellular protein transport Source: RefGenome
    3. protein transport Source: UniProtKB

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sorting nexin-4
    Gene namesi
    Name:Snx4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1916400. Snx4.

    Subcellular locationi

    Early endosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
    Note: Also detected on a juxtanuclear endocytic recycling compartment (ERC).By similarity

    GO - Cellular componenti

    1. cytoplasmic dynein complex Source: UniProtKB
    2. early endosome membrane Source: UniProtKB
    3. endosome Source: RefGenome

    Keywords - Cellular componenti

    Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 450450Sorting nexin-4PRO_0000236197Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ91YJ2.
    PaxDbiQ91YJ2.
    PRIDEiQ91YJ2.

    PTM databases

    PhosphoSiteiQ91YJ2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ91YJ2.
    BgeeiQ91YJ2.
    CleanExiMM_SNX4.
    GenevestigatoriQ91YJ2.

    Interactioni

    Subunit structurei

    Interacts with WWC1/KIBRA. Identified in a complex with WWC1/KIBRA and dynein components DYNLL1 and DYNC1I2 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ91YJ2. 2 interactions.
    MINTiMINT-4121914.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91YJ2.
    SMRiQ91YJ2. Positions 55-185.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini61 – 187127PXPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.By similarity

    Sequence similaritiesi

    Belongs to the sorting nexin family.Curated
    Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5391.
    GeneTreeiENSGT00740000114933.
    HOGENOMiHOG000007933.
    HOVERGENiHBG017826.
    InParanoidiQ91YJ2.
    KOiK17919.
    OMAiMDVYAAS.
    OrthoDBiEOG76HQ1H.
    PhylomeDBiQ91YJ2.
    TreeFamiTF328543.

    Family and domain databases

    Gene3Di3.30.1520.10. 1 hit.
    InterProiIPR001683. Phox.
    [Graphical view]
    PfamiPF00787. PX. 1 hit.
    [Graphical view]
    SMARTiSM00312. PX. 1 hit.
    [Graphical view]
    SUPFAMiSSF64268. SSF64268. 1 hit.
    PROSITEiPS50195. PX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91YJ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQAPPDPEK LLQPGPLEPL GGPGAVLEAA VGEENEGTRE DGSGVDTMTG    50
    NNFWLKKIEI SVSEAEKRTG RNAVNMQETY TAYLIETRSV EHADGQSVLT 100
    DSLWRRYSEF ELLRNYLLVY YPHVVVPPLP EKRAEFVWHK LSADNMDPDF 150
    VERRRVGLEN FLLRVASHPV LCRDKIFYSF LTQEGNWKET VNETGFQLKA 200
    DSRLKALNAT FRVKNPDKRF TELRHYSDEL QSVISHLLRV RARVADRLYG 250
    VYKVHGNYGR VFSEWSAIEK EMGDGLQSAG HHMDVYASSI DDILEDEEHY 300
    ADQLKEYLFY AEALRAVCRK HELMQYDLET AAQDLAAKKQ QCEELATGTV 350
    RTFSLKGMTT KLFGQETPEQ REARIKVLEE QINEGEQQLK SKNLEGREFV 400
    KNAWADIERF KEQKNRDLKE ALISYAVMQI SMCKKGIQVW TNAKECFSKM 450
    Length:450
    Mass (Da):51,778
    Last modified:December 1, 2001 - v1
    Checksum:i533F8305BFE077EE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK135356 mRNA. Translation: BAE22501.1.
    BC016599 mRNA. Translation: AAH16599.1.
    CCDSiCCDS28129.1.
    RefSeqiNP_542124.1. NM_080557.2.
    UniGeneiMm.28196.
    Mm.396285.

    Genome annotation databases

    EnsembliENSMUST00000023502; ENSMUSP00000023502; ENSMUSG00000022808.
    GeneIDi69150.
    KEGGimmu:69150.
    UCSCiuc007yzz.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK135356 mRNA. Translation: BAE22501.1 .
    BC016599 mRNA. Translation: AAH16599.1 .
    CCDSi CCDS28129.1.
    RefSeqi NP_542124.1. NM_080557.2.
    UniGenei Mm.28196.
    Mm.396285.

    3D structure databases

    ProteinModelPortali Q91YJ2.
    SMRi Q91YJ2. Positions 55-185.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q91YJ2. 2 interactions.
    MINTi MINT-4121914.

    PTM databases

    PhosphoSitei Q91YJ2.

    Proteomic databases

    MaxQBi Q91YJ2.
    PaxDbi Q91YJ2.
    PRIDEi Q91YJ2.

    Protocols and materials databases

    DNASUi 69150.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023502 ; ENSMUSP00000023502 ; ENSMUSG00000022808 .
    GeneIDi 69150.
    KEGGi mmu:69150.
    UCSCi uc007yzz.1. mouse.

    Organism-specific databases

    CTDi 8723.
    MGIi MGI:1916400. Snx4.

    Phylogenomic databases

    eggNOGi COG5391.
    GeneTreei ENSGT00740000114933.
    HOGENOMi HOG000007933.
    HOVERGENi HBG017826.
    InParanoidi Q91YJ2.
    KOi K17919.
    OMAi MDVYAAS.
    OrthoDBi EOG76HQ1H.
    PhylomeDBi Q91YJ2.
    TreeFami TF328543.

    Miscellaneous databases

    NextBioi 328712.
    PROi Q91YJ2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91YJ2.
    Bgeei Q91YJ2.
    CleanExi MM_SNX4.
    Genevestigatori Q91YJ2.

    Family and domain databases

    Gene3Di 3.30.1520.10. 1 hit.
    InterProi IPR001683. Phox.
    [Graphical view ]
    Pfami PF00787. PX. 1 hit.
    [Graphical view ]
    SMARTi SM00312. PX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64268. SSF64268. 1 hit.
    PROSITEi PS50195. PX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiSNX4_MOUSE
    AccessioniPrimary (citable) accession number: Q91YJ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3