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Q91YJ2

- SNX4_MOUSE

UniProt

Q91YJ2 - SNX4_MOUSE

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Protein

Sorting nexin-4

Gene

Snx4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei106 – 1061Phosphatidylinositol 3-phosphateBy similarity
Binding sitei108 – 1081Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei132 – 1321Phosphatidylinositol 3-phosphateBy similarity
Binding sitei154 – 1541Phosphatidylinositol 3-phosphateBy similarity

GO - Molecular functioni

  1. phosphatidylinositol binding Source: UniProtKB

GO - Biological processi

  1. endocytic recycling Source: UniProtKB
  2. intracellular protein transport Source: RefGenome
  3. protein transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-4
Gene namesi
Name:Snx4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1916400. Snx4.

Subcellular locationi

Early endosome membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Note: Also detected on a juxtanuclear endocytic recycling compartment (ERC).By similarity

GO - Cellular componenti

  1. cytoplasmic dynein complex Source: UniProtKB
  2. early endosome membrane Source: UniProtKB
  3. endosome Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Sorting nexin-4PRO_0000236197Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ91YJ2.
PaxDbiQ91YJ2.
PRIDEiQ91YJ2.

PTM databases

PhosphoSiteiQ91YJ2.

Expressioni

Gene expression databases

BgeeiQ91YJ2.
CleanExiMM_SNX4.
ExpressionAtlasiQ91YJ2. baseline and differential.
GenevestigatoriQ91YJ2.

Interactioni

Subunit structurei

Interacts with WWC1/KIBRA. Identified in a complex with WWC1/KIBRA and dynein components DYNLL1 and DYNC1I2 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ91YJ2. 2 interactions.
MINTiMINT-4121914.

Structurei

3D structure databases

ProteinModelPortaliQ91YJ2.
SMRiQ91YJ2. Positions 55-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 187127PXPROSITE-ProRule annotationAdd
BLAST

Domaini

The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization.By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5391.
GeneTreeiENSGT00760000119294.
HOGENOMiHOG000007933.
HOVERGENiHBG017826.
InParanoidiQ91YJ2.
KOiK17919.
OMAiMDVYAAS.
OrthoDBiEOG76HQ1H.
PhylomeDBiQ91YJ2.
TreeFamiTF328543.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91YJ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEQAPPDPEK LLQPGPLEPL GGPGAVLEAA VGEENEGTRE DGSGVDTMTG
60 70 80 90 100
NNFWLKKIEI SVSEAEKRTG RNAVNMQETY TAYLIETRSV EHADGQSVLT
110 120 130 140 150
DSLWRRYSEF ELLRNYLLVY YPHVVVPPLP EKRAEFVWHK LSADNMDPDF
160 170 180 190 200
VERRRVGLEN FLLRVASHPV LCRDKIFYSF LTQEGNWKET VNETGFQLKA
210 220 230 240 250
DSRLKALNAT FRVKNPDKRF TELRHYSDEL QSVISHLLRV RARVADRLYG
260 270 280 290 300
VYKVHGNYGR VFSEWSAIEK EMGDGLQSAG HHMDVYASSI DDILEDEEHY
310 320 330 340 350
ADQLKEYLFY AEALRAVCRK HELMQYDLET AAQDLAAKKQ QCEELATGTV
360 370 380 390 400
RTFSLKGMTT KLFGQETPEQ REARIKVLEE QINEGEQQLK SKNLEGREFV
410 420 430 440 450
KNAWADIERF KEQKNRDLKE ALISYAVMQI SMCKKGIQVW TNAKECFSKM
Length:450
Mass (Da):51,778
Last modified:December 1, 2001 - v1
Checksum:i533F8305BFE077EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK135356 mRNA. Translation: BAE22501.1.
BC016599 mRNA. Translation: AAH16599.1.
CCDSiCCDS28129.1.
RefSeqiNP_542124.1. NM_080557.2.
UniGeneiMm.28196.
Mm.396285.

Genome annotation databases

EnsembliENSMUST00000023502; ENSMUSP00000023502; ENSMUSG00000022808.
GeneIDi69150.
KEGGimmu:69150.
UCSCiuc007yzz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK135356 mRNA. Translation: BAE22501.1 .
BC016599 mRNA. Translation: AAH16599.1 .
CCDSi CCDS28129.1.
RefSeqi NP_542124.1. NM_080557.2.
UniGenei Mm.28196.
Mm.396285.

3D structure databases

ProteinModelPortali Q91YJ2.
SMRi Q91YJ2. Positions 55-185.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q91YJ2. 2 interactions.
MINTi MINT-4121914.

PTM databases

PhosphoSitei Q91YJ2.

Proteomic databases

MaxQBi Q91YJ2.
PaxDbi Q91YJ2.
PRIDEi Q91YJ2.

Protocols and materials databases

DNASUi 69150.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023502 ; ENSMUSP00000023502 ; ENSMUSG00000022808 .
GeneIDi 69150.
KEGGi mmu:69150.
UCSCi uc007yzz.1. mouse.

Organism-specific databases

CTDi 8723.
MGIi MGI:1916400. Snx4.

Phylogenomic databases

eggNOGi COG5391.
GeneTreei ENSGT00760000119294.
HOGENOMi HOG000007933.
HOVERGENi HBG017826.
InParanoidi Q91YJ2.
KOi K17919.
OMAi MDVYAAS.
OrthoDBi EOG76HQ1H.
PhylomeDBi Q91YJ2.
TreeFami TF328543.

Miscellaneous databases

NextBioi 328712.
PROi Q91YJ2.
SOURCEi Search...

Gene expression databases

Bgeei Q91YJ2.
CleanExi MM_SNX4.
ExpressionAtlasi Q91YJ2. baseline and differential.
Genevestigatori Q91YJ2.

Family and domain databases

Gene3Di 3.30.1520.10. 1 hit.
InterProi IPR001683. Phox.
[Graphical view ]
Pfami PF00787. PX. 1 hit.
[Graphical view ]
SMARTi SM00312. PX. 1 hit.
[Graphical view ]
SUPFAMi SSF64268. SSF64268. 1 hit.
PROSITEi PS50195. PX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiSNX4_MOUSE
AccessioniPrimary (citable) accession number: Q91YJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3