SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q91YJ2

- SNX4_MOUSE

UniProt

Q91YJ2 - SNX4_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Sorting nexin-4
Gene
Snx4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei106 – 1061Phosphatidylinositol 3-phosphate By similarity
Binding sitei108 – 1081Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei132 – 1321Phosphatidylinositol 3-phosphate By similarity
Binding sitei154 – 1541Phosphatidylinositol 3-phosphate By similarity

GO - Molecular functioni

  1. phosphatidylinositol binding Source: UniProtKB

GO - Biological processi

  1. endocytic recycling Source: UniProtKB
  2. intracellular protein transport Source: RefGenome
  3. protein transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-4
Gene namesi
Name:Snx4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1916400. Snx4.

Subcellular locationi

Early endosome membrane; Peripheral membrane protein; Cytoplasmic side By similarity
Note: Also detected on a juxtanuclear endocytic recycling compartment (ERC) By similarity.

GO - Cellular componenti

  1. cytoplasmic dynein complex Source: UniProtKB
  2. early endosome membrane Source: UniProtKB
  3. endosome Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Sorting nexin-4
PRO_0000236197Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ91YJ2.
PaxDbiQ91YJ2.
PRIDEiQ91YJ2.

PTM databases

PhosphoSiteiQ91YJ2.

Expressioni

Gene expression databases

ArrayExpressiQ91YJ2.
BgeeiQ91YJ2.
CleanExiMM_SNX4.
GenevestigatoriQ91YJ2.

Interactioni

Subunit structurei

Interacts with WWC1/KIBRA. Identified in a complex with WWC1/KIBRA and dynein components DYNLL1 and DYNC1I2 By similarity.

Protein-protein interaction databases

IntActiQ91YJ2. 2 interactions.
MINTiMINT-4121914.

Structurei

3D structure databases

ProteinModelPortaliQ91YJ2.
SMRiQ91YJ2. Positions 55-185.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 187127PX
Add
BLAST

Domaini

The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization By similarity.

Sequence similaritiesi

Belongs to the sorting nexin family.

Phylogenomic databases

eggNOGiCOG5391.
GeneTreeiENSGT00740000114933.
HOGENOMiHOG000007933.
HOVERGENiHBG017826.
InParanoidiQ91YJ2.
KOiK17919.
OMAiMDVYAAS.
OrthoDBiEOG76HQ1H.
PhylomeDBiQ91YJ2.
TreeFamiTF328543.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91YJ2-1 [UniParc]FASTAAdd to Basket

« Hide

MEQAPPDPEK LLQPGPLEPL GGPGAVLEAA VGEENEGTRE DGSGVDTMTG    50
NNFWLKKIEI SVSEAEKRTG RNAVNMQETY TAYLIETRSV EHADGQSVLT 100
DSLWRRYSEF ELLRNYLLVY YPHVVVPPLP EKRAEFVWHK LSADNMDPDF 150
VERRRVGLEN FLLRVASHPV LCRDKIFYSF LTQEGNWKET VNETGFQLKA 200
DSRLKALNAT FRVKNPDKRF TELRHYSDEL QSVISHLLRV RARVADRLYG 250
VYKVHGNYGR VFSEWSAIEK EMGDGLQSAG HHMDVYASSI DDILEDEEHY 300
ADQLKEYLFY AEALRAVCRK HELMQYDLET AAQDLAAKKQ QCEELATGTV 350
RTFSLKGMTT KLFGQETPEQ REARIKVLEE QINEGEQQLK SKNLEGREFV 400
KNAWADIERF KEQKNRDLKE ALISYAVMQI SMCKKGIQVW TNAKECFSKM 450
Length:450
Mass (Da):51,778
Last modified:December 1, 2001 - v1
Checksum:i533F8305BFE077EE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK135356 mRNA. Translation: BAE22501.1.
BC016599 mRNA. Translation: AAH16599.1.
CCDSiCCDS28129.1.
RefSeqiNP_542124.1. NM_080557.2.
UniGeneiMm.28196.
Mm.396285.

Genome annotation databases

EnsembliENSMUST00000023502; ENSMUSP00000023502; ENSMUSG00000022808.
GeneIDi69150.
KEGGimmu:69150.
UCSCiuc007yzz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK135356 mRNA. Translation: BAE22501.1 .
BC016599 mRNA. Translation: AAH16599.1 .
CCDSi CCDS28129.1.
RefSeqi NP_542124.1. NM_080557.2.
UniGenei Mm.28196.
Mm.396285.

3D structure databases

ProteinModelPortali Q91YJ2.
SMRi Q91YJ2. Positions 55-185.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q91YJ2. 2 interactions.
MINTi MINT-4121914.

PTM databases

PhosphoSitei Q91YJ2.

Proteomic databases

MaxQBi Q91YJ2.
PaxDbi Q91YJ2.
PRIDEi Q91YJ2.

Protocols and materials databases

DNASUi 69150.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023502 ; ENSMUSP00000023502 ; ENSMUSG00000022808 .
GeneIDi 69150.
KEGGi mmu:69150.
UCSCi uc007yzz.1. mouse.

Organism-specific databases

CTDi 8723.
MGIi MGI:1916400. Snx4.

Phylogenomic databases

eggNOGi COG5391.
GeneTreei ENSGT00740000114933.
HOGENOMi HOG000007933.
HOVERGENi HBG017826.
InParanoidi Q91YJ2.
KOi K17919.
OMAi MDVYAAS.
OrthoDBi EOG76HQ1H.
PhylomeDBi Q91YJ2.
TreeFami TF328543.

Miscellaneous databases

NextBioi 328712.
PROi Q91YJ2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q91YJ2.
Bgeei Q91YJ2.
CleanExi MM_SNX4.
Genevestigatori Q91YJ2.

Family and domain databases

Gene3Di 3.30.1520.10. 1 hit.
InterProi IPR001683. Phox.
[Graphical view ]
Pfami PF00787. PX. 1 hit.
[Graphical view ]
SMARTi SM00312. PX. 1 hit.
[Graphical view ]
SUPFAMi SSF64268. SSF64268. 1 hit.
PROSITEi PS50195. PX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiSNX4_MOUSE
AccessioniPrimary (citable) accession number: Q91YJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi