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Protein

Autophagy-related protein 13

Gene

Atg13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.1 Publication

GO - Molecular functioni

GO - Biological processi

  • autophagosome assembly Source: UniProtKB
  • mitophagy Source: ParkinsonsUK-UCL
  • positive regulation of protein targeting to mitochondrion Source: MGI
  • response to mitochondrial depolarisation Source: BHF-UCL

Keywordsi

Biological processAutophagy

Enzyme and pathway databases

ReactomeiR-MMU-1632852 Macroautophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 13
Gene namesi
Name:Atg13
Synonyms:D2Ertd391e, Kiaa0652
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1196429 Atg13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003451511 – 516Autophagy-related protein 13Add BLAST516

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei354Phosphoserine; by ULK1By similarity1
Modified residuei355PhosphoserineBy similarity1
Modified residuei360PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by ULK1, ULK2 and mTOR. Phosphorylation status depends on nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. ULK1-mediated phosphorylation of ATG13 at Ser-354 is required for efficient clearance of depolarized mitochondria.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PeptideAtlasiQ91YI1
PRIDEiQ91YI1

PTM databases

iPTMnetiQ91YI1
PhosphoSitePlusiQ91YI1

Expressioni

Gene expression databases

BgeeiENSMUSG00000027244
GenevisibleiQ91YI1 MM

Interactioni

Subunit structurei

Part of a complex consisting of ATG13, ULK1 and RB1CC1 (PubMed:19258318, PubMed:19211835). Interacts with ATG101 (By similarity). Interacts with ULK1 (via C-terminus) (By similarity). Interacts with ULK2 (via C-terminus) (By similarity). Interacts (via the LIR motif) with GABARAP, GABARAPL and GABARAPL2 (By similarity). Interacts (via the LIR motif) with MAP1LC3A, MAP1LC3B and MAP1LC3C (By similarity). Interacts with TAB2 and TAB3 (By similarity). Interacts with C9orf72 (By similarity).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ATG101Q9BSB42EBI-8391007,EBI-2946739From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-60542N
IntActiQ91YI1, 4 interactors
MINTiQ91YI1

Structurei

3D structure databases

ProteinModelPortaliQ91YI1
SMRiQ91YI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni127 – 134Important for interaction with ATG101By similarity8

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi443 – 446LIR4

Domaini

The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family proteins GABARAP, GABARAPL, GABARAPL2, and MAP1LC3A.By similarity

Sequence similaritiesi

Belongs to the ATG13 family. Metazoan subfamily.Curated

Phylogenomic databases

GeneTreeiENSGT00390000007055
HOGENOMiHOG000008446
InParanoidiQ91YI1
KOiK08331
OMAiKICTRSS
OrthoDBiEOG091G0TEK
PhylomeDBiQ91YI1
TreeFamiTF321599

Family and domain databases

Gene3Di3.30.900.10, 1 hit
InterProiView protein in InterPro
IPR018731 Atg13
IPR036570 HORMA_dom_sf
PfamiView protein in Pfam
PF10033 ATG13, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91YI1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METELSSQDR KDLDKFIKFF ALKTVQVIVQ ARLGEKICTR SSSSPTGSDW
60 70 80 90 100
FNLAIKDIPE VTHEAKKALS GQLPAVGRSM CVEISLKTSE GDSMELEIWC
110 120 130 140 150
LEMNEKCDKE IKVSYTVYNR LSLLLKSLLA ITRVTPAYRL SRKQGHEYVI
160 170 180 190 200
LYRIYFGEVQ LNGLGEGFQT VRVGTVGTPV GTLTLSCAYR INLAFMSTRQ
210 220 230 240 250
FERTPPIMGI IIDHFVDRPY PSSSPMHPCN YRTAEDAGVA YPSVEDSQEV
260 270 280 290 300
CTTSFSTSPP SQLSSSRLSY QPAVLGLGSA DLAYPVVFTA GLNTTHAHQL
310 320 330 340 350
MVPGKEGGVT LAPSHPTHGA QADPERLVMH MPSDGTHCAA TPSSSEDTET
360 370 380 390 400
VSNSSEGRAS PHDILETIFV RKVGAFVNKP INQVTVTSLD IPFAMFAPKN
410 420 430 440 450
LELEDADPMV NPPESPETTS PLHGSLHSDG SSGGSGGSTH DDFVMIDFKP
460 470 480 490 500
AFSKDDILPM DLGTFYREFQ NPPQLSSLSI DFGAQSMAED LDSLPEKLAV
510
HEKNVREFDA FVETLQ
Length:516
Mass (Da):56,441
Last modified:September 2, 2008 - v2
Checksum:i04B4E49BB19449F2
GO
Isoform 2 (identifier: Q91YI1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     263-299: Missing.

Show »
Length:479
Mass (Da):52,615
Checksum:iC7F080564F28E564
GO

Sequence cautioni

The sequence BAC65621 differs from that shown. The sequence differs from that shown because it seems to be derived from a pre-mRNA.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034922263 – 299Missing in isoform 2. 2 PublicationsAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK149672 mRNA Translation: BAE29016.1
AK171206 mRNA Translation: BAE42312.1
AK171440 mRNA Translation: BAE42453.1
AL714023 Genomic DNA Translation: CAM14512.1
AL714023 Genomic DNA Translation: CAM14513.1
CH466519 Genomic DNA Translation: EDL27574.1
BC016669 mRNA Translation: AAH16669.1
BC023673 mRNA Translation: AAH23673.1
BC023712 mRNA Translation: AAH23712.1
BC033419 mRNA Translation: AAH33419.1
AK122339 Transcribed RNA Translation: BAC65621.3 Sequence problems.
CCDSiCCDS16438.1 [Q91YI1-2]
RefSeqiNP_663503.1, NM_145528.3 [Q91YI1-2]
XP_006499953.1, XM_006499890.3
UniGeneiMm.28492

Genome annotation databases

EnsembliENSMUST00000028678; ENSMUSP00000028678; ENSMUSG00000027244 [Q91YI1-1]
ENSMUST00000076803; ENSMUSP00000076081; ENSMUSG00000027244 [Q91YI1-2]
GeneIDi51897
KEGGimmu:51897
UCSCiuc008kwn.2 mouse [Q91YI1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiATG13_MOUSE
AccessioniPrimary (citable) accession number: Q91YI1
Secondary accession number(s): A2AH18, Q80TU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: March 28, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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