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Protein
Submitted name:

ATPase, H+ transporting, lysosomal V1 subunit B1

Gene

Atp6v1b1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • ATP hydrolysis coupled proton transport Source: InterPro
  • ATP metabolic process Source: InterPro
  • calcium ion homeostasis Source: UniProtKB
  • excretion Source: UniProtKB
  • ossification Source: UniProtKB
  • pH reduction Source: UniProtKB
  • proton transport Source: UniProtKB
  • regulation of pH Source: UniProtKB
  • sensory perception of sound Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-1222556. ROS, RNS production in response to bacteria.
R-MMU-77387. Insulin receptor recycling.
R-MMU-917977. Transferrin endocytosis and recycling.
R-MMU-983712. Ion channel transport.

Protein family/group databases

TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Submitted name:
ATPase, H+ transporting, lysosomal V1 subunit B1Imported
Submitted name:
ATPase, H+ transporting, lysosomal V1 subunit B1, isoform CRA_aImported
Submitted name:
Protein Atp6v1b1Imported
Submitted name:
Vacuolar proton translocating ATPase B1 isoformImported
Gene namesi
Name:Atp6v1b1Imported
ORF Names:mCG_142376Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:103285. Atp6v1b1.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • basolateral plasma membrane Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB
  • extracellular exosome Source: MGI
  • lateral plasma membrane Source: UniProtKB
  • membrane Source: MGI
  • microvillus Source: UniProtKB
  • proton-transporting V-type ATPase, V1 domain Source: InterPro
  • vacuolar proton-transporting V-type ATPase complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

PTM databases

PhosphoSiteiQ91YH6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000006269.

Interactioni

Protein-protein interaction databases

MINTiMINT-4121894.
STRINGi10090.ENSMUSP00000006431.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 11067ATP-synt_ab_NInterPro annotationAdd
BLAST
Domaini167 – 393227ATP-synt_abInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG1351. Eukaryota.
COG1156. LUCA.
GeneTreeiENSGT00550000074724.
HOVERGENiHBG002176.
KOiK02147.
OMAiGIDSQKT.
OrthoDBiEOG091G04TR.
TreeFamiTF300313.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00310. ATP_synth_B_arch. 1 hit.
InterProiIPR020003. ATPase_a/bsu_AS.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR005723. ATPase_V1-cplx_bsu.
IPR027417. P-loop_NTPase.
IPR022879. V-ATPase_su_B/beta.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
PIRSFiPIRSF039114. V-ATPsynth_beta/V-ATPase_B. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01040. V-ATPase_V1_B. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91YH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTVDSRSS GFTGNSCDPG TAQEHVQAVT RNYITHPRVT YRTVCSVNGP
60 70 80 90 100
LVVLDQVKFA QYAEIVNFTL PDGTQRSGQV LEVAGTKAIV QVFEGTSGID
110 120 130 140 150
SQKTTCEFTG DILRTPVSED MLGRIFNGSG KPIDKGPAVM AEEFLDINGQ
160 170 180 190 200
PINPHDRIYP EEMIQTGISP IDVMNSIARG QKIPIFSAAG LPHNEIAAQI
210 220 230 240 250
CRQAGLVKKS KAVLDYHEDN FAIVFAAMGV NMETARFFKS DFEQNGTMGN
260 270 280 290 300
VCLFLNLAND PTIERIITPR LALTTAEFLA YQCEKHVLVI LTDMSSYAEA
310 320 330 340 350
LREVSAAREE VPGRRGFPGY MYTDLATIYE RAGRVEGRGG SITQIPILTM
360 370 380 390 400
PNDDITHPIP DLTGFITEGQ IYVDRQLHNR QVYPPINVLP SLSRLMKSAI
410 420 430 440 450
GEGMTRKDHG DVSNQLYACY AIGKDVQAMK AVVGEEALTS EDLLYLEFLQ
460 470 480 490 500
KFEKNFITQG PYENRTVFES LDLGWKLLRI FPKEMLKRIP QSMTDEFYSR
510
QGAQQDPASD TAL
Length:513
Mass (Da):56,791
Last modified:December 1, 2001 - v1
Checksum:i43EE1D236D4F6406
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090647 Genomic DNA. No translation available.
BC017127 mRNA. Translation: AAH17127.1.
AF435091 mRNA. Translation: AAN45856.1.
AK052604 mRNA. Translation: BAC35059.1.
AK052707 mRNA. Translation: BAC35108.1.
AK078810 mRNA. Translation: BAC37404.1.
AK168980 mRNA. Translation: BAE40781.1.
CH466523 Genomic DNA. Translation: EDK99099.1.
RefSeqiNP_598918.1. NM_134157.2.
UniGeneiMm.220823.

Genome annotation databases

EnsembliENSMUST00000006431; ENSMUSP00000006431; ENSMUSG00000006269.
GeneIDi110935.
KEGGimmu:110935.
UCSCiuc009coc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC090647 Genomic DNA. No translation available.
BC017127 mRNA. Translation: AAH17127.1.
AF435091 mRNA. Translation: AAN45856.1.
AK052604 mRNA. Translation: BAC35059.1.
AK052707 mRNA. Translation: BAC35108.1.
AK078810 mRNA. Translation: BAC37404.1.
AK168980 mRNA. Translation: BAE40781.1.
CH466523 Genomic DNA. Translation: EDK99099.1.
RefSeqiNP_598918.1. NM_134157.2.
UniGeneiMm.220823.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4121894.
STRINGi10090.ENSMUSP00000006431.

Protein family/group databases

TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

PTM databases

PhosphoSiteiQ91YH6.

Protocols and materials databases

DNASUi110935.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006431; ENSMUSP00000006431; ENSMUSG00000006269.
GeneIDi110935.
KEGGimmu:110935.
UCSCiuc009coc.1. mouse.

Organism-specific databases

CTDi525.
MGIiMGI:103285. Atp6v1b1.

Phylogenomic databases

eggNOGiKOG1351. Eukaryota.
COG1156. LUCA.
GeneTreeiENSGT00550000074724.
HOVERGENiHBG002176.
KOiK02147.
OMAiGIDSQKT.
OrthoDBiEOG091G04TR.
TreeFamiTF300313.

Enzyme and pathway databases

ReactomeiR-MMU-1222556. ROS, RNS production in response to bacteria.
R-MMU-77387. Insulin receptor recycling.
R-MMU-917977. Transferrin endocytosis and recycling.
R-MMU-983712. Ion channel transport.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006269.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00310. ATP_synth_B_arch. 1 hit.
InterProiIPR020003. ATPase_a/bsu_AS.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR005723. ATPase_V1-cplx_bsu.
IPR027417. P-loop_NTPase.
IPR022879. V-ATPase_su_B/beta.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
PIRSFiPIRSF039114. V-ATPsynth_beta/V-ATPase_B. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01040. V-ATPase_V1_B. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ91YH6_MOUSE
AccessioniPrimary (citable) accession number: Q91YH6
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.