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Protein

Atlastin-3

Gene

Atl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi67 – 74GTPBy similarity8
Nucleotide bindingi114 – 116GTPBy similarity3
Nucleotide bindingi213 – 214GTPBy similarity2
Nucleotide bindingi272 – 275GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Atlastin-3 (EC:3.6.5.-)
Gene namesi
Name:Atl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1924270. Atl3.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein Sequence analysis

  • Note: Localizes to endoplasmic reticulum tubules and accumulates in punctuate structures corresponding to 3-way junctions, which represent crossing-points at which the tubules build a polygonal network. Localizes to endoplasmic reticulum tubular network.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 445CytoplasmicBy similarityAdd BLAST445
Transmembranei446 – 466HelicalSequence analysisAdd BLAST21
Topological domaini467LumenalSequence analysis1
Transmembranei468 – 488HelicalSequence analysisAdd BLAST21
Topological domaini489 – 541CytoplasmicBy similarityAdd BLAST53

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002871101 – 541Atlastin-3Add BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei391N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ91YH5.
PaxDbiQ91YH5.
PeptideAtlasiQ91YH5.
PRIDEiQ91YH5.

PTM databases

iPTMnetiQ91YH5.
PhosphoSitePlusiQ91YH5.
SwissPalmiQ91YH5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024759.
ExpressionAtlasiQ91YH5. baseline and differential.
GenevisibleiQ91YH5. MM.

Interactioni

Subunit structurei

Interacts with ZFYVE27.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ91YH5. 1 interactor.
MINTiMINT-1863888.
STRINGi10090.ENSMUSP00000025668.

Structurei

3D structure databases

ProteinModelPortaliQ91YH5.
SMRiQ91YH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 305GB1/RHD3-type GAdd BLAST249

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2037. Eukaryota.
ENOG410XR6Z. LUCA.
GeneTreeiENSGT00390000008959.
HOGENOMiHOG000234332.
HOVERGENiHBG062891.
InParanoidiQ91YH5.
KOiK17339.
OMAiWAFIRYS.
OrthoDBiEOG091G053P.
PhylomeDBiQ91YH5.
TreeFamiTF105251.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030386. G_GB1_RHD3_dom.
IPR003191. Guanylate-bd_C.
IPR015894. Guanylate-bd_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02263. GBP. 1 hit.
PF02841. GBP_C. 1 hit.
[Graphical view]
SUPFAMiSSF48340. SSF48340. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51715. G_GB1_RHD3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91YH5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSPQRTAAV ASRGAGDAME NGKPGPVQVV LVHKEQHSFE LEERALASVL
60 70 80 90 100
LQDHIRDLDV VVVSVAGAFR KGKSFILDFM LRYLYSQKEG GHSDWLGDPE
110 120 130 140 150
EPLTGFSWRG GSDPETTGIQ IWSEVFTVKK PCGKKVAVVL MDTQGAFDSQ
160 170 180 190 200
STVKDCATIF ALSTMTSSVQ IYNLSQNIQE DDLQQLQLFT EYGRLAMDEI
210 220 230 240 250
FQKPFQTLMF LIRDWSFPYE YNYGLQGGMA FLDKRLHVKE HQHEEIQNVR
260 270 280 290 300
NHIHSCFSDV TCFLLPHPGL QVATSPNFDG KLKDIASEFK EQLQALIPYV
310 320 330 340 350
LNPSKLMEKE INGSKVTCRG LLEYFKAYIK IYQGEDLPHP KSMLQATAEA
360 370 380 390 400
NNLAAAASAK DIYYNNMEEI CGGEKPYLSP DILEEKHLEF KQLALDHFKK
410 420 430 440 450
IKKMGGKDFS FRYQQELEEE IKELYENFCK HNGSKNVFST FRTPAVLFTG
460 470 480 490 500
IAALYIASGF TGFIGLEVVA QLFNCMVGLL LIALLTWGYI RYSGQYRELG
510 520 530 540
GAIDSGAAYV LEQASSHIGN STQAAVRDAV VGRPPADKKS Q
Length:541
Mass (Da):60,575
Last modified:December 1, 2001 - v1
Checksum:i8D183335EAF88542
GO
Isoform 2 (identifier: Q91YH5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-164: Missing.

Show »
Length:377
Mass (Da):42,738
Checksum:i14ABC3C3F819B836
GO

Sequence cautioni

The sequence AAH02149 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti271Q → K in BAC27066 (PubMed:16141072).Curated1
Sequence conflicti397H → N in BAE28094 (PubMed:16141072).Curated1
Sequence conflicti489Y → C in BAC26148 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0253141 – 164Missing in isoform 2. 1 PublicationAdd BLAST164

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028842 mRNA. Translation: BAC26148.1.
AK030660 mRNA. Translation: BAC27066.1.
AK077752 mRNA. Translation: BAC36992.1.
AK147720 mRNA. Translation: BAE28094.1.
AK169476 mRNA. Translation: BAE41194.1.
BC002149 mRNA. Translation: AAH02149.1. Different initiation.
BC017138 mRNA. Translation: AAH17138.1.
CCDSiCCDS29527.1. [Q91YH5-1]
RefSeqiNP_001156977.1. NM_001163505.1.
NP_666203.3. NM_146091.4. [Q91YH5-1]
UniGeneiMm.264016.

Genome annotation databases

EnsembliENSMUST00000025668; ENSMUSP00000025668; ENSMUSG00000024759. [Q91YH5-1]
GeneIDi109168.
KEGGimmu:109168.
UCSCiuc008glg.2. mouse. [Q91YH5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028842 mRNA. Translation: BAC26148.1.
AK030660 mRNA. Translation: BAC27066.1.
AK077752 mRNA. Translation: BAC36992.1.
AK147720 mRNA. Translation: BAE28094.1.
AK169476 mRNA. Translation: BAE41194.1.
BC002149 mRNA. Translation: AAH02149.1. Different initiation.
BC017138 mRNA. Translation: AAH17138.1.
CCDSiCCDS29527.1. [Q91YH5-1]
RefSeqiNP_001156977.1. NM_001163505.1.
NP_666203.3. NM_146091.4. [Q91YH5-1]
UniGeneiMm.264016.

3D structure databases

ProteinModelPortaliQ91YH5.
SMRiQ91YH5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91YH5. 1 interactor.
MINTiMINT-1863888.
STRINGi10090.ENSMUSP00000025668.

PTM databases

iPTMnetiQ91YH5.
PhosphoSitePlusiQ91YH5.
SwissPalmiQ91YH5.

Proteomic databases

EPDiQ91YH5.
PaxDbiQ91YH5.
PeptideAtlasiQ91YH5.
PRIDEiQ91YH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025668; ENSMUSP00000025668; ENSMUSG00000024759. [Q91YH5-1]
GeneIDi109168.
KEGGimmu:109168.
UCSCiuc008glg.2. mouse. [Q91YH5-1]

Organism-specific databases

CTDi25923.
MGIiMGI:1924270. Atl3.

Phylogenomic databases

eggNOGiKOG2037. Eukaryota.
ENOG410XR6Z. LUCA.
GeneTreeiENSGT00390000008959.
HOGENOMiHOG000234332.
HOVERGENiHBG062891.
InParanoidiQ91YH5.
KOiK17339.
OMAiWAFIRYS.
OrthoDBiEOG091G053P.
PhylomeDBiQ91YH5.
TreeFamiTF105251.

Miscellaneous databases

PROiQ91YH5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024759.
ExpressionAtlasiQ91YH5. baseline and differential.
GenevisibleiQ91YH5. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030386. G_GB1_RHD3_dom.
IPR003191. Guanylate-bd_C.
IPR015894. Guanylate-bd_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02263. GBP. 1 hit.
PF02841. GBP_C. 1 hit.
[Graphical view]
SUPFAMiSSF48340. SSF48340. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51715. G_GB1_RHD3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATLA3_MOUSE
AccessioniPrimary (citable) accession number: Q91YH5
Secondary accession number(s): Q3UGW3
, Q8C0L7, Q8C174, Q99LZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.