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Protein

Atlastin-3

Gene

Atl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi67 – 748GTPBy similarity
Nucleotide bindingi114 – 1163GTPBy similarity
Nucleotide bindingi213 – 2142GTPBy similarity
Nucleotide bindingi272 – 2754GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Atlastin-3 (EC:3.6.5.-)
Gene namesi
Name:Atl3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1924270. Atl3.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity

  • Note: Localizes to endoplasmic reticulum tubules and accumulates in punctuate structures corresponding to 3-way junctions, which represent crossing-points at which the tubules build a polygonal network.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 445445CytoplasmicBy similarityAdd
BLAST
Transmembranei446 – 46621HelicalSequence analysisAdd
BLAST
Topological domaini467 – 4671LumenalSequence analysis
Transmembranei468 – 48821HelicalSequence analysisAdd
BLAST
Topological domaini489 – 54153CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 541541Atlastin-3PRO_0000287110Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei391 – 3911N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ91YH5.
MaxQBiQ91YH5.
PaxDbiQ91YH5.
PeptideAtlasiQ91YH5.
PRIDEiQ91YH5.

PTM databases

iPTMnetiQ91YH5.
PhosphoSiteiQ91YH5.
SwissPalmiQ91YH5.

Expressioni

Gene expression databases

BgeeiQ91YH5.
ExpressionAtlasiQ91YH5. baseline and differential.
GenevisibleiQ91YH5. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ91YH5. 1 interaction.
MINTiMINT-1863888.
STRINGi10090.ENSMUSP00000025668.

Structurei

3D structure databases

ProteinModelPortaliQ91YH5.
SMRiQ91YH5. Positions 23-436.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini57 – 305249GB1/RHD3-type GAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2037. Eukaryota.
ENOG410XR6Z. LUCA.
GeneTreeiENSGT00390000008959.
HOGENOMiHOG000234332.
HOVERGENiHBG062891.
InParanoidiQ91YH5.
KOiK17339.
OMAiWAFIRYS.
OrthoDBiEOG7H4DTH.
PhylomeDBiQ91YH5.
TreeFamiTF105251.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030386. G_GB1_RHD3_dom.
IPR003191. Guanylate-bd_C.
IPR015894. Guanylate-bd_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02263. GBP. 1 hit.
PF02841. GBP_C. 1 hit.
[Graphical view]
SUPFAMiSSF48340. SSF48340. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51715. G_GB1_RHD3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91YH5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLSPQRTAAV ASRGAGDAME NGKPGPVQVV LVHKEQHSFE LEERALASVL
60 70 80 90 100
LQDHIRDLDV VVVSVAGAFR KGKSFILDFM LRYLYSQKEG GHSDWLGDPE
110 120 130 140 150
EPLTGFSWRG GSDPETTGIQ IWSEVFTVKK PCGKKVAVVL MDTQGAFDSQ
160 170 180 190 200
STVKDCATIF ALSTMTSSVQ IYNLSQNIQE DDLQQLQLFT EYGRLAMDEI
210 220 230 240 250
FQKPFQTLMF LIRDWSFPYE YNYGLQGGMA FLDKRLHVKE HQHEEIQNVR
260 270 280 290 300
NHIHSCFSDV TCFLLPHPGL QVATSPNFDG KLKDIASEFK EQLQALIPYV
310 320 330 340 350
LNPSKLMEKE INGSKVTCRG LLEYFKAYIK IYQGEDLPHP KSMLQATAEA
360 370 380 390 400
NNLAAAASAK DIYYNNMEEI CGGEKPYLSP DILEEKHLEF KQLALDHFKK
410 420 430 440 450
IKKMGGKDFS FRYQQELEEE IKELYENFCK HNGSKNVFST FRTPAVLFTG
460 470 480 490 500
IAALYIASGF TGFIGLEVVA QLFNCMVGLL LIALLTWGYI RYSGQYRELG
510 520 530 540
GAIDSGAAYV LEQASSHIGN STQAAVRDAV VGRPPADKKS Q
Length:541
Mass (Da):60,575
Last modified:December 1, 2001 - v1
Checksum:i8D183335EAF88542
GO
Isoform 2 (identifier: Q91YH5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-164: Missing.

Show »
Length:377
Mass (Da):42,738
Checksum:i14ABC3C3F819B836
GO

Sequence cautioni

The sequence AAH02149.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti271 – 2711Q → K in BAC27066 (PubMed:16141072).Curated
Sequence conflicti397 – 3971H → N in BAE28094 (PubMed:16141072).Curated
Sequence conflicti489 – 4891Y → C in BAC26148 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 164164Missing in isoform 2. 1 PublicationVSP_025314Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028842 mRNA. Translation: BAC26148.1.
AK030660 mRNA. Translation: BAC27066.1.
AK077752 mRNA. Translation: BAC36992.1.
AK147720 mRNA. Translation: BAE28094.1.
AK169476 mRNA. Translation: BAE41194.1.
BC002149 mRNA. Translation: AAH02149.1. Different initiation.
BC017138 mRNA. Translation: AAH17138.1.
CCDSiCCDS29527.1. [Q91YH5-1]
RefSeqiNP_001156977.1. NM_001163505.1.
NP_666203.3. NM_146091.4. [Q91YH5-1]
UniGeneiMm.264016.

Genome annotation databases

EnsembliENSMUST00000025668; ENSMUSP00000025668; ENSMUSG00000024759. [Q91YH5-1]
GeneIDi109168.
KEGGimmu:109168.
UCSCiuc008glg.2. mouse. [Q91YH5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028842 mRNA. Translation: BAC26148.1.
AK030660 mRNA. Translation: BAC27066.1.
AK077752 mRNA. Translation: BAC36992.1.
AK147720 mRNA. Translation: BAE28094.1.
AK169476 mRNA. Translation: BAE41194.1.
BC002149 mRNA. Translation: AAH02149.1. Different initiation.
BC017138 mRNA. Translation: AAH17138.1.
CCDSiCCDS29527.1. [Q91YH5-1]
RefSeqiNP_001156977.1. NM_001163505.1.
NP_666203.3. NM_146091.4. [Q91YH5-1]
UniGeneiMm.264016.

3D structure databases

ProteinModelPortaliQ91YH5.
SMRiQ91YH5. Positions 23-436.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91YH5. 1 interaction.
MINTiMINT-1863888.
STRINGi10090.ENSMUSP00000025668.

PTM databases

iPTMnetiQ91YH5.
PhosphoSiteiQ91YH5.
SwissPalmiQ91YH5.

Proteomic databases

EPDiQ91YH5.
MaxQBiQ91YH5.
PaxDbiQ91YH5.
PeptideAtlasiQ91YH5.
PRIDEiQ91YH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025668; ENSMUSP00000025668; ENSMUSG00000024759. [Q91YH5-1]
GeneIDi109168.
KEGGimmu:109168.
UCSCiuc008glg.2. mouse. [Q91YH5-1]

Organism-specific databases

CTDi25923.
MGIiMGI:1924270. Atl3.

Phylogenomic databases

eggNOGiKOG2037. Eukaryota.
ENOG410XR6Z. LUCA.
GeneTreeiENSGT00390000008959.
HOGENOMiHOG000234332.
HOVERGENiHBG062891.
InParanoidiQ91YH5.
KOiK17339.
OMAiWAFIRYS.
OrthoDBiEOG7H4DTH.
PhylomeDBiQ91YH5.
TreeFamiTF105251.

Miscellaneous databases

PROiQ91YH5.
SOURCEiSearch...

Gene expression databases

BgeeiQ91YH5.
ExpressionAtlasiQ91YH5. baseline and differential.
GenevisibleiQ91YH5. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR030386. G_GB1_RHD3_dom.
IPR003191. Guanylate-bd_C.
IPR015894. Guanylate-bd_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02263. GBP. 1 hit.
PF02841. GBP_C. 1 hit.
[Graphical view]
SUPFAMiSSF48340. SSF48340. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51715. G_GB1_RHD3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Embryo, Head, Skin and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiATLA3_MOUSE
AccessioniPrimary (citable) accession number: Q91YH5
Secondary accession number(s): Q3UGW3
, Q8C0L7, Q8C174, Q99LZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.