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Q91YE9 (5NT1B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytosolic 5'-nucleotidase 1B

Short name=cN1B
EC=3.1.3.5
Alternative name(s):
Autoimmune infertility-related protein
Cytosolic 5'-nucleotidase IB
Short name=cN-IB
Gene names
Name:Nt5c1b
Synonyms:Airp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length573 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels. Ref.1

Catalytic activity

A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.

Cofactor

Magnesium.

Enzyme regulation

Activated by ADP.

Subcellular location

Cytoplasm.

Tissue specificity

Highly expressed in testis and brain. Detected at lower levels in skeletal muscle, heart and kidney. Ref.1

Sequence similarities

Belongs to the 5'-nucleotidase type 3 family.

Sequence caution

The sequence AAK39109.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q91YE9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q91YE9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     88-89: Missing.
     247-262: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 573573Cytosolic 5'-nucleotidase 1B
PRO_0000144797

Sites

Active site4281Nucleophile By similarity

Natural variations

Alternative sequence88 – 892Missing in isoform 2.
VSP_010204
Alternative sequence247 – 26216Missing in isoform 2.
VSP_010205

Experimental info

Sequence conflict1031S → F in AAK39109. Ref.2
Sequence conflict1211I → T in CAC44364. Ref.1
Sequence conflict1211I → T in AAK39109. Ref.2
Sequence conflict1621A → V in CAC44364. Ref.1
Sequence conflict1851E → Q in CAC44364. Ref.1
Sequence conflict2281Q → H in CAC44364. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 28, 2011. Version 2.
Checksum: 948868F505D6B965

FASTA57365,002
        10         20         30         40         50         60 
MSQTSLKHKK KNEPGMRYSK ESLDAEKRKD SDKTGARLST QGSQELPLHN TDSRGYVVRN 

        70         80         90        100        110        120 
QWSRTSRSPS TGAPSVDEPR SRNTAIKVEA PNSSTTSRTS SASPSQHETS PPPQTSEKSS 

       130        140        150        160        170        180 
IQQTPQNRPI TQLESQPPTP PETEPNSRRT SAKMYTGSDP WAHRENREPR DLQLRDYAYS 

       190        200        210        220        230        240 
CDSREGMPKT REYPRTPPTE WKPYAQRRLQ YGTSVDMEPE YISDGPQQRQ RQQTEEDEVD 

       250        260        270        280        290        300 
EAYWTSVSML YEKIPSCARP RPPKPKHAIT IAVSSRALFN MVDDRKIYEE EGLEKYMEYQ 

       310        320        330        340        350        360 
LTNENVILTP GPAFRFVKAL QHVNSRLRDL YPDEQDLFDI VLMTNNHAQV GVRLINSVNH 

       370        380        390        400        410        420 
YGLLIDRFCL TGGKSPIGYL KAYLTNLYLS ADSEKVQEAI KEGIASATMY AGAKDMAYCD 

       430        440        450        460        470        480 
TQLRVAFDGD AVLFSDESEH IAKDHGLDKF FQHETLFENK PLAQGPLKSF LEDLGKLQKK 

       490        500        510        520        530        540 
FYAKDERLLC PIRTYLVTAR SAASSGARVL KTLRRWGLEI DEALFLAGAP KGPILVKIRP 

       550        560        570 
HIFFDDQMFH IESAQKFGTI TAHVPYGIAQ KRN 

« Hide

Isoform 2 [UniParc].

Checksum: 99417F747816E36C
Show »

FASTA55562,945

References

« Hide 'large scale' references
[1]"Cloning of a mouse cytosolic 5'-nucleotidase-I identifies a new gene related to human autoimmune infertility-related protein."
Sala-Newby G.B., Newby A.C.
Biochim. Biophys. Acta 1521:12-18(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
Tissue: Testis.
[2]"Isolation of a novel human testis cDNA encoding a polypeptide related to autoimmune infertility."
Setiady Y.Y., Pujianto D.A., Ekowati A.L., Harahap A., Marzuki S.
Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Strain: CD-1.
Tissue: Testis.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ295253 mRNA. Translation: CAC44364.1.
AF356186 mRNA. Translation: AAK39109.1. Different initiation.
AC157570 Genomic DNA. No translation available.
RefSeqNP_081864.2. NM_027588.3.
UniGeneMm.272843.

3D structure databases

ProteinModelPortalQ91YE9.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ91YE9.

Proteomic databases

PRIDEQ91YE9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000002456; ENSMUSP00000002456; ENSMUSG00000020622. [Q91YE9-1]
ENSMUST00000118657; ENSMUSP00000112694; ENSMUSG00000020622. [Q91YE9-2]
GeneID70881.
KEGGmmu:70881.
UCSCuc007nap.2. mouse. [Q91YE9-1]

Organism-specific databases

CTD93034.
MGIMGI:1918131. Nt5c1b.

Phylogenomic databases

eggNOGNOG46880.
GeneTreeENSGT00390000017767.
HOGENOMHOG000243802.
HOVERGENHBG050426.
InParanoidQ91YE9.
KOK01081.
OMAPKHAITI.
OrthoDBEOG79KPF1.
TreeFamTF329831.

Enzyme and pathway databases

BRENDA3.1.3.5. 244.
SABIO-RKQ91YE9.

Gene expression databases

BgeeQ91YE9.
CleanExMM_NT5C1B.
GenevestigatorQ91YE9.

Family and domain databases

InterProIPR010394. 5-nucleotidase.
[Graphical view]
PfamPF06189. 5-nucleotidase. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNT5C1B. mouse.
NextBio332486.
PROQ91YE9.
SOURCESearch...

Entry information

Entry name5NT1B_MOUSE
AccessionPrimary (citable) accession number: Q91YE9
Secondary accession number(s): E9QNH2, Q91Y48
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: June 28, 2011
Last modified: April 16, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot