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Protein

Importin-9

Gene

Ipo9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS7, RPL18A and H2B histone. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import RPL4, RPL6 H2A, H3 and H4 histones.By similarity1 Publication

GO - Molecular functioni

  • histone binding Source: MGI
  • protein transporter activity Source: UniProtKB
  • Ran GTPase binding Source: MGI

GO - Biological processi

  • protein import into nucleus Source: MGI
  • protein stabilization Source: MGI
  • ribosome biogenesis Source: MGI

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Importin-9
Short name:
Imp9
Alternative name(s):
Importin-9a
Short name:
Imp9a
Importin-9b
Short name:
Imp9b
Ran-binding protein 9
Short name:
RanBP9
Gene namesi
Name:Ipo9
Synonyms:Imp9, Ranbp9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1918944 Ipo9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001207552 – 1041Importin-9Add BLAST1040

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ91YE6
MaxQBiQ91YE6
PaxDbiQ91YE6
PRIDEiQ91YE6

PTM databases

iPTMnetiQ91YE6
PhosphoSitePlusiQ91YE6
SwissPalmiQ91YE6

Expressioni

Gene expression databases

CleanExiMM_IPO9
MM_RANBP9

Interactioni

Subunit structurei

Interacts with PPP2R1A and PPP2R1B (By similarity). Binds with high affinity to RPS7, RPL18A and H2B histone. The binding is coupled to RanGTP cycles. May bind RPL4, RPL6, H2A, H3 and H4 histones with low affinity.By similarity2 Publications

GO - Molecular functioni

  • histone binding Source: MGI
  • Ran GTPase binding Source: MGI

Protein-protein interaction databases

DIPiDIP-34268N
IntActiQ91YE6, 5 interactors
MINTiQ91YE6
STRINGi10090.ENSMUSP00000036093

Structurei

3D structure databases

ProteinModelPortaliQ91YE6
SMRiQ91YE6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 119Importin N-terminalPROSITE-ProRule annotationAdd BLAST77

Sequence similaritiesi

Belongs to the importin beta family.Curated

Phylogenomic databases

eggNOGiKOG2274 Eukaryota
COG5657 LUCA
HOGENOMiHOG000237316
HOVERGENiHBG049054
InParanoidiQ91YE6
PhylomeDBiQ91YE6

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR001494 Importin-beta_N
PfamiView protein in Pfam
PF03810 IBN_N, 1 hit
SMARTiView protein in SMART
SM00913 IBN_N, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50166 IMPORTIN_B_NT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91YE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAAAAGAA SGLPGPVAQG LKEALVDTLT GILSPVQEVR AAAEEQIKVL
60 70 80 90 100
EVTEEFGVHL AELTVDPQGA LAIRQLASVI LKQYVETHWC AQSEKFRPPE
110 120 130 140 150
TTERAKIVIR ELLPNGLRES ISKVRSSVAY AVSAIAHWDW PEAWPQLFNL
160 170 180 190 200
LMEMLVSGDL NAVHGAMRVL TEFTREVTDT QMPLVAPVIL PEMYKIFTMA
210 220 230 240 250
EVYGIRTRSR AVEIFTTCAH MICNMEELEK GAAKVLIFPV VQQFTEAFVQ
260 270 280 290 300
ALQMPDGPTS DSGFKMEVLK AVTALVKNFP KHMVSSMQQI LPIVWNTLTE
310 320 330 340 350
SAAFYVRTEV NYTEEVEDPV DSDGEVLGFE NLVFSIFEFV HALLENSKFK
360 370 380 390 400
STVKKALPEL IYYIILYMQI TEEQIKVWTA NPQQFVEDED DDTFSYTVRI
410 420 430 440 450
AAQDLLLAVA TDFQNESAVA LATAATRHLQ EAEQTKASGT EHWWKIHEAC
460 470 480 490 500
MLALGSVKSI ITDSVKNGRI HFDMHGFLTN VILADLNLSA SPFLLGRALW
510 520 530 540 550
AASRFTVAMS PELIQQFLQA TVSGLHETQP PSVRISAVRA IWGYCDQLKV
560 570 580 590 600
SESTHVLQPF LPSILDGLIH LAAQFSSEVL NLVMETLCIV CTVDPEFTAS
610 620 630 640 650
VENKICPFTI AIFLKYSNDP VVASLAQDIF KELSQIEACQ GPMQMRLIPT
660 670 680 690 700
LVSIMQAPAD KIPAGLCATA IDILTTVVRN TKPPLSQLLI CQAFPAVAQC
710 720 730 740 750
TLHTDDNATM QNGGECLRAY VSVTLEQVAQ WHDEQGHNGL WYVMQVVSQL
760 770 780 790 800
LDPRTSEFTA AFVGRLVSTL ISKAGRELGE NLDQILRAIL SKMQQAETLS
810 820 830 840 850
VMQSLIMVFA HLVHTQLEPL LEFLCSLPGP TGKPALEFVM AEWTSRQHLF
860 870 880 890 900
YGQYEGKVSS VALCKLLQHG INADDKRLQD IRVKGEEIYS MDEGIRTRSK
910 920 930 940 950
SAKNPERWTN IPLLVKILKL IINELSNVME ANAARQATPA EWNQDDSNDM
960 970 980 990 1000
WEDQEEEEEE EEDGLAGQLL SDILATSKYE EDYYEDDEED DPDALKDPLY
1010 1020 1030 1040
QIDLQAYLTD FLCQFAQQPC YIMFSCHLND NERRVLQTIG I
Length:1,041
Mass (Da):116,052
Last modified:January 23, 2007 - v3
Checksum:i2307E00D0AEABEA4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti166A → V in AAK91127 (PubMed:11823430).Curated1
Sequence conflicti277K → E in AAK91127 (PubMed:11823430).Curated1
Sequence conflicti782L → P in AAK91127 (PubMed:11823430).Curated1
Sequence conflicti793M → V in AAK91128 (PubMed:11823430).Curated1
Sequence conflicti801V → A in AAK91127 (PubMed:11823430).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ309238 mRNA Translation: CAC69407.1
AF273672 mRNA Translation: AAK91127.1
AF273673 mRNA Translation: AAK91128.1
UniGeneiMm.271642

Similar proteinsi

Entry informationi

Entry nameiIPO9_MOUSE
AccessioniPrimary (citable) accession number: Q91YE6
Secondary accession number(s): Q924M3, Q924M4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 118 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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