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Protein

Villin-like protein

Gene

Vill

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Possible tumor suppressor.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Actin capping

Keywords - Ligandi

Actin-binding, Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Villin-like protein
Alternative name(s):
EF-6
Gene namesi
Name:VillImported
Synonyms:VillpImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1201781. Vill.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002187391 – 859Villin-like proteinAdd BLAST859

Proteomic databases

PaxDbiQ91YD6.
PRIDEiQ91YD6.

PTM databases

iPTMnetiQ91YD6.
PhosphoSitePlusiQ91YD6.

Expressioni

Developmental stagei

Not detected in adult tissues. Expressed at low levels in early embryogenesis.1 Publication

Gene expression databases

BgeeiENSMUSG00000038775.
CleanExiMM_VILL.
ExpressionAtlasiQ91YD6. baseline and differential.
GenevisibleiQ91YD6. MM.

Interactioni

Protein-protein interaction databases

BioGridi204523. 1 interactor.
IntActiQ91YD6. 2 interactors.
MINTiMINT-4121830.
STRINGi10090.ENSMUSP00000061731.

Structurei

3D structure databases

ProteinModelPortaliQ91YD6.
SMRiQ91YD6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 76Gelsolin-like 1Sequence analysisAdd BLAST53
Repeati148 – 188Gelsolin-like 2Sequence analysisAdd BLAST41
Repeati264 – 308Gelsolin-like 3Sequence analysisAdd BLAST45
Repeati401 – 450Gelsolin-like 4Sequence analysisAdd BLAST50
Repeati521 – 561Gelsolin-like 5Sequence analysisAdd BLAST41
Repeati624 – 665Gelsolin-like 6Sequence analysisAdd BLAST42
Domaini793 – 859HPPROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Belongs to the villin/gelsolin family.Sequence analysis
Contains 6 gelsolin-like repeats.Sequence analysis
Contains 1 HP (headpiece) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0443. Eukaryota.
ENOG410XR0A. LUCA.
GeneTreeiENSGT00760000119111.
HOGENOMiHOG000233630.
HOVERGENiHBG004183.
InParanoidiQ91YD6.
PhylomeDBiQ91YD6.

Family and domain databases

Gene3Di1.10.950.10. 1 hit.
3.40.20.10. 6 hits.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR015626. Villin-like.
IPR007122. Villin/Gelsolin.
IPR003128. Villin_headpiece.
[Graphical view]
PANTHERiPTHR11977. PTHR11977. 2 hits.
PTHR11977:SF30. PTHR11977:SF30. 2 hits.
PfamiPF00626. Gelsolin. 5 hits.
PF02209. VHP. 1 hit.
[Graphical view]
PRINTSiPR00597. GELSOLIN.
SMARTiSM00262. GEL. 6 hits.
SM00153. VHP. 1 hit.
[Graphical view]
SUPFAMiSSF47050. SSF47050. 1 hit.
SSF82754. SSF82754. 2 hits.
PROSITEiPS51089. HP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91YD6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDINQDLPAI DSHRALQIWI TENLKMLPLP ERAHGNFFEE CCYVVLHVPQ
60 70 80 90 100
SPKATQGGSS DLHYWIGKDA SAEAREAAVS FVQCLQEDLG DQTVLHRESQ
110 120 130 140 150
GHESDCFHSY FHPGVIYRKG GRDSALKFAE TNMYNVQRLL HIKGRKHVSA
160 170 180 190 200
TEVALSWNSF NKGDIFLLDL GKVMIQWNGP KASISEKARA LTLTCNLRDR
210 220 230 240 250
ERGGRAQIAV VDAENEATNL LRIMEAVLGC RSGSLCPSVP SNSVSQLQKA
260 270 280 290 300
NVRLYHVCEK GTDLVVQELA TRPLTQDLLQ EDGCYLLDQG GFKIYMWQGR
310 320 330 340 350
KSSPQEKKAA LSRAVGFIQA KGYPNYTNVE VVNDGAESTA FQQLFWSWSK
360 370 380 390 400
ELDRKKHPEK SKLVQGNLEV GKLHTQPELA AQLRMVDDGS GKVEVWYIQD
410 420 430 440 450
LQRQPVHPKY YGQLCSGNCY LVLYTYQKLG CVQYLLYLWQ GHQSTVEDTK
460 470 480 490 500
ALNCSAEELD LMHQGALAQG HVTMGSEPPH FLAIFQGRLV VFQGNAGNKG
510 520 530 540 550
ERPPVSDTRL FHVQGTESHN TRTMEVPARA SSLTSGDVFF LITSHVCYLW
560 570 580 590 600
FGKGCHGDQR EMARTVVSVF PGNNKETVLE GQEPLYFWEA LGGRAPYPSN
610 620 630 640 650
KRLPEEVWSI QPRLFECSSH AGCLVLTEVL FFGQEDLDKY DIMLLDTCQE
660 670 680 690 700
IFLWLGEAAG EWKKEAVAWG LEYLRTHPAE RSLATPIFVV KQGHEPATFT
710 720 730 740 750
GWFVTWDPYK WMNSQSYEEM VGNSLGPGSA ISEMTAEVHN FQLTPRLSDN
760 770 780 790 800
KAGHPALQAF KGSQDSPENE LGLDLRVDGA NPSMNHTSSC SDSMVNGSLP
810 820 830 840 850
RERLMHQALE DLPPGVDPAR KEFYLSDSDF QDIFGKSKEE FYSMAKWKQQ

QAKKKLGFF
Length:859
Mass (Da):96,509
Last modified:December 1, 2001 - v1
Checksum:iDA126D0FD75FCA75
GO
Isoform 2Curated (identifier: Q91YD6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     651-712: Missing.
     737-758: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:775
Mass (Da):86,821
Checksum:iF329CA28ABC3C60D
GO
Isoform 3Curated (identifier: Q91YD6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-384: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:475
Mass (Da):53,508
Checksum:i82490C2124AC20EF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59S → F in BAC25828 (PubMed:16141072).Curated1
Sequence conflicti73E → K in BAC25828 (PubMed:16141072).Curated1
Sequence conflicti84C → S in AAH21808 (PubMed:15489334).Curated1
Sequence conflicti128F → L in AAH21808 (PubMed:15489334).Curated1
Sequence conflicti143K → R in BAC25828 (PubMed:16141072).Curated1
Sequence conflicti167L → V in AAH21808 (PubMed:15489334).Curated1
Sequence conflicti304P → S in AAH21808 (PubMed:15489334).Curated1
Sequence conflicti375T → N in BAC25828 (PubMed:16141072).Curated1
Sequence conflicti407H → D in AAH21808 (PubMed:15489334).Curated1
Sequence conflicti410Y → H in AAH21808 (PubMed:15489334).Curated1
Sequence conflicti568S → T in AAH21808 (PubMed:15489334).Curated1
Sequence conflicti621A → T in AAH21808 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0516901 – 384Missing in isoform 3. 1 PublicationAdd BLAST384
Alternative sequenceiVSP_051691651 – 712Missing in isoform 2. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_051692737 – 758Missing in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ344341 mRNA. Translation: CAC69079.1.
AK028229 mRNA. Translation: BAC25828.1.
BC021808 mRNA. Translation: AAH21808.1.
BC022664 mRNA. Translation: AAH22664.1.
U72681 mRNA. Translation: AAB51041.1.
CCDSiCCDS23606.1. [Q91YD6-2]
CCDS52962.1. [Q91YD6-1]
RefSeqiNP_001158039.1. NM_001164567.1.
NP_035830.2. NM_011700.2.
UniGeneiMm.83817.

Genome annotation databases

EnsembliENSMUST00000141185; ENSMUSP00000116546; ENSMUSG00000038775. [Q91YD6-3]
GeneIDi22351.
KEGGimmu:22351.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ344341 mRNA. Translation: CAC69079.1.
AK028229 mRNA. Translation: BAC25828.1.
BC021808 mRNA. Translation: AAH21808.1.
BC022664 mRNA. Translation: AAH22664.1.
U72681 mRNA. Translation: AAB51041.1.
CCDSiCCDS23606.1. [Q91YD6-2]
CCDS52962.1. [Q91YD6-1]
RefSeqiNP_001158039.1. NM_001164567.1.
NP_035830.2. NM_011700.2.
UniGeneiMm.83817.

3D structure databases

ProteinModelPortaliQ91YD6.
SMRiQ91YD6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204523. 1 interactor.
IntActiQ91YD6. 2 interactors.
MINTiMINT-4121830.
STRINGi10090.ENSMUSP00000061731.

PTM databases

iPTMnetiQ91YD6.
PhosphoSitePlusiQ91YD6.

Proteomic databases

PaxDbiQ91YD6.
PRIDEiQ91YD6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000141185; ENSMUSP00000116546; ENSMUSG00000038775. [Q91YD6-3]
GeneIDi22351.
KEGGimmu:22351.

Organism-specific databases

CTDi50853.
MGIiMGI:1201781. Vill.

Phylogenomic databases

eggNOGiKOG0443. Eukaryota.
ENOG410XR0A. LUCA.
GeneTreeiENSGT00760000119111.
HOGENOMiHOG000233630.
HOVERGENiHBG004183.
InParanoidiQ91YD6.
PhylomeDBiQ91YD6.

Miscellaneous databases

PROiQ91YD6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038775.
CleanExiMM_VILL.
ExpressionAtlasiQ91YD6. baseline and differential.
GenevisibleiQ91YD6. MM.

Family and domain databases

Gene3Di1.10.950.10. 1 hit.
3.40.20.10. 6 hits.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR015626. Villin-like.
IPR007122. Villin/Gelsolin.
IPR003128. Villin_headpiece.
[Graphical view]
PANTHERiPTHR11977. PTHR11977. 2 hits.
PTHR11977:SF30. PTHR11977:SF30. 2 hits.
PfamiPF00626. Gelsolin. 5 hits.
PF02209. VHP. 1 hit.
[Graphical view]
PRINTSiPR00597. GELSOLIN.
SMARTiSM00262. GEL. 6 hits.
SM00153. VHP. 1 hit.
[Graphical view]
SUPFAMiSSF47050. SSF47050. 1 hit.
SSF82754. SSF82754. 2 hits.
PROSITEiPS51089. HP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVILL_MOUSE
AccessioniPrimary (citable) accession number: Q91YD6
Secondary accession number(s): P97809
, Q8BIS5, Q8R211, Q8VDI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.