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Protein

Villin-like protein

Gene

Vill

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Possible tumor suppressor.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Actin capping

Keywords - Ligandi

Actin-binding, Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Villin-like protein
Alternative name(s):
EF-6
Gene namesi
Name:VillImported
Synonyms:VillpImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1201781. Vill.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 859859Villin-like proteinPRO_0000218739Add
BLAST

Proteomic databases

MaxQBiQ91YD6.
PaxDbiQ91YD6.
PRIDEiQ91YD6.

PTM databases

iPTMnetiQ91YD6.
PhosphoSiteiQ91YD6.

Expressioni

Developmental stagei

Not detected in adult tissues. Expressed at low levels in early embryogenesis.1 Publication

Gene expression databases

BgeeiQ91YD6.
CleanExiMM_VILL.
ExpressionAtlasiQ91YD6. baseline and differential.
GenevisibleiQ91YD6. MM.

Interactioni

Protein-protein interaction databases

BioGridi204523. 1 interaction.
IntActiQ91YD6. 2 interactions.
MINTiMINT-4121830.
STRINGi10090.ENSMUSP00000061731.

Structurei

3D structure databases

ProteinModelPortaliQ91YD6.
SMRiQ91YD6. Positions 15-717, 798-859.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati24 – 7653Gelsolin-like 1Sequence analysisAdd
BLAST
Repeati148 – 18841Gelsolin-like 2Sequence analysisAdd
BLAST
Repeati264 – 30845Gelsolin-like 3Sequence analysisAdd
BLAST
Repeati401 – 45050Gelsolin-like 4Sequence analysisAdd
BLAST
Repeati521 – 56141Gelsolin-like 5Sequence analysisAdd
BLAST
Repeati624 – 66542Gelsolin-like 6Sequence analysisAdd
BLAST
Domaini793 – 85967HPPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the villin/gelsolin family.Sequence analysis
Contains 6 gelsolin-like repeats.Sequence analysis
Contains 1 HP (headpiece) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0443. Eukaryota.
ENOG410XR0A. LUCA.
GeneTreeiENSGT00760000119111.
HOGENOMiHOG000233630.
HOVERGENiHBG004183.
InParanoidiQ91YD6.
PhylomeDBiQ91YD6.

Family and domain databases

Gene3Di1.10.950.10. 1 hit.
3.40.20.10. 6 hits.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR015626. Villin-like.
IPR007122. Villin/Gelsolin.
IPR003128. Villin_headpiece.
[Graphical view]
PANTHERiPTHR11977. PTHR11977. 2 hits.
PTHR11977:SF30. PTHR11977:SF30. 2 hits.
PfamiPF00626. Gelsolin. 5 hits.
PF02209. VHP. 1 hit.
[Graphical view]
PRINTSiPR00597. GELSOLIN.
SMARTiSM00262. GEL. 6 hits.
SM00153. VHP. 1 hit.
[Graphical view]
SUPFAMiSSF47050. SSF47050. 1 hit.
SSF82754. SSF82754. 2 hits.
PROSITEiPS51089. HP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91YD6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDINQDLPAI DSHRALQIWI TENLKMLPLP ERAHGNFFEE CCYVVLHVPQ
60 70 80 90 100
SPKATQGGSS DLHYWIGKDA SAEAREAAVS FVQCLQEDLG DQTVLHRESQ
110 120 130 140 150
GHESDCFHSY FHPGVIYRKG GRDSALKFAE TNMYNVQRLL HIKGRKHVSA
160 170 180 190 200
TEVALSWNSF NKGDIFLLDL GKVMIQWNGP KASISEKARA LTLTCNLRDR
210 220 230 240 250
ERGGRAQIAV VDAENEATNL LRIMEAVLGC RSGSLCPSVP SNSVSQLQKA
260 270 280 290 300
NVRLYHVCEK GTDLVVQELA TRPLTQDLLQ EDGCYLLDQG GFKIYMWQGR
310 320 330 340 350
KSSPQEKKAA LSRAVGFIQA KGYPNYTNVE VVNDGAESTA FQQLFWSWSK
360 370 380 390 400
ELDRKKHPEK SKLVQGNLEV GKLHTQPELA AQLRMVDDGS GKVEVWYIQD
410 420 430 440 450
LQRQPVHPKY YGQLCSGNCY LVLYTYQKLG CVQYLLYLWQ GHQSTVEDTK
460 470 480 490 500
ALNCSAEELD LMHQGALAQG HVTMGSEPPH FLAIFQGRLV VFQGNAGNKG
510 520 530 540 550
ERPPVSDTRL FHVQGTESHN TRTMEVPARA SSLTSGDVFF LITSHVCYLW
560 570 580 590 600
FGKGCHGDQR EMARTVVSVF PGNNKETVLE GQEPLYFWEA LGGRAPYPSN
610 620 630 640 650
KRLPEEVWSI QPRLFECSSH AGCLVLTEVL FFGQEDLDKY DIMLLDTCQE
660 670 680 690 700
IFLWLGEAAG EWKKEAVAWG LEYLRTHPAE RSLATPIFVV KQGHEPATFT
710 720 730 740 750
GWFVTWDPYK WMNSQSYEEM VGNSLGPGSA ISEMTAEVHN FQLTPRLSDN
760 770 780 790 800
KAGHPALQAF KGSQDSPENE LGLDLRVDGA NPSMNHTSSC SDSMVNGSLP
810 820 830 840 850
RERLMHQALE DLPPGVDPAR KEFYLSDSDF QDIFGKSKEE FYSMAKWKQQ

QAKKKLGFF
Length:859
Mass (Da):96,509
Last modified:December 1, 2001 - v1
Checksum:iDA126D0FD75FCA75
GO
Isoform 2Curated (identifier: Q91YD6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     651-712: Missing.
     737-758: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:775
Mass (Da):86,821
Checksum:iF329CA28ABC3C60D
GO
Isoform 3Curated (identifier: Q91YD6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-384: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:475
Mass (Da):53,508
Checksum:i82490C2124AC20EF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti59 – 591S → F in BAC25828 (PubMed:16141072).Curated
Sequence conflicti73 – 731E → K in BAC25828 (PubMed:16141072).Curated
Sequence conflicti84 – 841C → S in AAH21808 (PubMed:15489334).Curated
Sequence conflicti128 – 1281F → L in AAH21808 (PubMed:15489334).Curated
Sequence conflicti143 – 1431K → R in BAC25828 (PubMed:16141072).Curated
Sequence conflicti167 – 1671L → V in AAH21808 (PubMed:15489334).Curated
Sequence conflicti304 – 3041P → S in AAH21808 (PubMed:15489334).Curated
Sequence conflicti375 – 3751T → N in BAC25828 (PubMed:16141072).Curated
Sequence conflicti407 – 4071H → D in AAH21808 (PubMed:15489334).Curated
Sequence conflicti410 – 4101Y → H in AAH21808 (PubMed:15489334).Curated
Sequence conflicti568 – 5681S → T in AAH21808 (PubMed:15489334).Curated
Sequence conflicti621 – 6211A → T in AAH21808 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 384384Missing in isoform 3. 1 PublicationVSP_051690Add
BLAST
Alternative sequencei651 – 71262Missing in isoform 2. 1 PublicationVSP_051691Add
BLAST
Alternative sequencei737 – 75822Missing in isoform 2. 1 PublicationVSP_051692Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ344341 mRNA. Translation: CAC69079.1.
AK028229 mRNA. Translation: BAC25828.1.
BC021808 mRNA. Translation: AAH21808.1.
BC022664 mRNA. Translation: AAH22664.1.
U72681 mRNA. Translation: AAB51041.1.
CCDSiCCDS23606.1. [Q91YD6-2]
CCDS52962.1. [Q91YD6-1]
RefSeqiNP_001158039.1. NM_001164567.1.
NP_035830.2. NM_011700.2.
UniGeneiMm.83817.

Genome annotation databases

EnsembliENSMUST00000141185; ENSMUSP00000116546; ENSMUSG00000038775. [Q91YD6-3]
GeneIDi22351.
KEGGimmu:22351.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ344341 mRNA. Translation: CAC69079.1.
AK028229 mRNA. Translation: BAC25828.1.
BC021808 mRNA. Translation: AAH21808.1.
BC022664 mRNA. Translation: AAH22664.1.
U72681 mRNA. Translation: AAB51041.1.
CCDSiCCDS23606.1. [Q91YD6-2]
CCDS52962.1. [Q91YD6-1]
RefSeqiNP_001158039.1. NM_001164567.1.
NP_035830.2. NM_011700.2.
UniGeneiMm.83817.

3D structure databases

ProteinModelPortaliQ91YD6.
SMRiQ91YD6. Positions 15-717, 798-859.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204523. 1 interaction.
IntActiQ91YD6. 2 interactions.
MINTiMINT-4121830.
STRINGi10090.ENSMUSP00000061731.

PTM databases

iPTMnetiQ91YD6.
PhosphoSiteiQ91YD6.

Proteomic databases

MaxQBiQ91YD6.
PaxDbiQ91YD6.
PRIDEiQ91YD6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000141185; ENSMUSP00000116546; ENSMUSG00000038775. [Q91YD6-3]
GeneIDi22351.
KEGGimmu:22351.

Organism-specific databases

CTDi50853.
MGIiMGI:1201781. Vill.

Phylogenomic databases

eggNOGiKOG0443. Eukaryota.
ENOG410XR0A. LUCA.
GeneTreeiENSGT00760000119111.
HOGENOMiHOG000233630.
HOVERGENiHBG004183.
InParanoidiQ91YD6.
PhylomeDBiQ91YD6.

Miscellaneous databases

PROiQ91YD6.
SOURCEiSearch...

Gene expression databases

BgeeiQ91YD6.
CleanExiMM_VILL.
ExpressionAtlasiQ91YD6. baseline and differential.
GenevisibleiQ91YD6. MM.

Family and domain databases

Gene3Di1.10.950.10. 1 hit.
3.40.20.10. 6 hits.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR015626. Villin-like.
IPR007122. Villin/Gelsolin.
IPR003128. Villin_headpiece.
[Graphical view]
PANTHERiPTHR11977. PTHR11977. 2 hits.
PTHR11977:SF30. PTHR11977:SF30. 2 hits.
PfamiPF00626. Gelsolin. 5 hits.
PF02209. VHP. 1 hit.
[Graphical view]
PRINTSiPR00597. GELSOLIN.
SMARTiSM00262. GEL. 6 hits.
SM00153. VHP. 1 hit.
[Graphical view]
SUPFAMiSSF47050. SSF47050. 1 hit.
SSF82754. SSF82754. 2 hits.
PROSITEiPS51089. HP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Protopopov A., Kashuba V., Zabarovsky E.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: BALB/cJImported.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Strain: Czech IIImported and FVB/NImported.
    Tissue: KidneyImported and Mammary tumorImported.
  4. "E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts."
    Fu X., Kamps M.P.
    Mol. Cell. Biol. 17:1503-1512(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 652-727 (ISOFORMS 1/3), DEVELOPMENTAL STAGE.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney.

Entry informationi

Entry nameiVILL_MOUSE
AccessioniPrimary (citable) accession number: Q91YD6
Secondary accession number(s): P97809
, Q8BIS5, Q8R211, Q8VDI8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.