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Q91YD4 (TRPM2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transient receptor potential cation channel subfamily M member 2
EC=3.6.1.13
Alternative name(s):
Long transient receptor potential channel 2
Short name=LTrpC-2
Short name=LTrpC2
Transient receptor potential channel 7
Short name=TrpC7
Gene names
Name:Trpm2
Synonyms:Ltrpc2, Trpc7
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length1507 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD+), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Has ADP-ribose pyrophosphatase activity By similarity. Ref.2

Catalytic activity

ADP-ribose + H2O = AMP + D-ribose 5-phosphate.

Subcellular location

Membrane; Multi-pass membrane protein Ref.2.

Tissue specificity

Widely expressed, with highest levels in lung, spleen, eye and brain. Ref.2

Induction

NAD+.

Sequence similarities

Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily. [View classification]

Contains 1 nudix hydrolase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15071507Transient receptor potential cation channel subfamily M member 2
PRO_0000215327

Regions

Topological domain1 – 750750Cytoplasmic Potential
Transmembrane751 – 77121Helical; Potential
Topological domain772 – 79221Extracellular Potential
Transmembrane793 – 81321Helical; Potential
Topological domain814 – 87057Cytoplasmic Potential
Transmembrane871 – 89121Helical; Potential
Topological domain892 – 8943Extracellular Potential
Transmembrane895 – 91521Helical; Potential
Topological domain916 – 93419Cytoplasmic Potential
Transmembrane935 – 95521Helical; Potential
Topological domain956 – 102570Extracellular Potential
Transmembrane1026 – 104621Helical; Potential
Topological domain1047 – 1507461Cytoplasmic Potential
Domain1351 – 1502152Nudix hydrolase
Nucleotide binding1387 – 140923NAD By similarity

Amino acid modifications

Modified residue4041N6-acetyllysine By similarity
Modified residue11021N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q91YD4 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 86E552DE25939785

FASTA1,507172,365
        10         20         30         40         50         60 
MESLDRRRTG SEQEEGFGVQ SRRATDLGMV PNLRRSNSSL CKSRRFLCSF SSEKQENLSS 

        70         80         90        100        110        120 
WIPENIKKKE CVYFVESSKL SDAGKVVCAC GYTHEQHLEV AIKPHTFQGK EWDPKKHVQE 

       130        140        150        160        170        180 
MPTDAFGDIV FTDLSQKVGK YVRVSQDTPS SVIYQLMTQH WGLDVPNLLI SVTGGAKNFN 

       190        200        210        220        230        240 
MKLRLKSIFR RGLVKVAQTT GAWIITGGSH TGVMKQVGEA VRDFSLSSSC KEGEVITIGV 

       250        260        270        280        290        300 
ATWGTIHNRE GLIHPMGGFP AEYMLDEEGQ GNLTCLDSNH SHFILVDDGT HGQYGVEIPL 

       310        320        330        340        350        360 
RTKLEKFISE QTKERGGVAI KIPIVCVVLE GGPGTLHTIY NAINNGTPCV IVEGSGRVAD 

       370        380        390        400        410        420 
VIAQVATLPV SEITISLIQQ KLSIFFQEMF ETFTENQIVE WTKKIQDIVR RRQLLTIFRE 

       430        440        450        460        470        480 
GKDGQQDVDV AILQALLKAS RSQDHFGHEN WDHQLKLAVA WNRVDIARSE IFTDEWQWKP 

       490        500        510        520        530        540 
ADLHPMMTAA LISNKPEFVR LFLENGVRLK EFVTWDTLLC LYENLEPSCL FHSKLQKVLA 

       550        560        570        580        590        600 
EEQRLAYASA TPRLHMHHVA QVLRELLGDS TQLLYPRPRY TDRPRLSMTV PHIKLNVQGV 

       610        620        630        640        650        660 
SLRSLYKRST GHVTFTIDPV RDLLIWAVIQ NHRELAGIIW AQSQDCTAAA LACSKILKEL 

       670        680        690        700        710        720 
SKEEEDTDSS EEMLALADEF EHRAIGVFTE CYRKDEERAQ KLLVRVSEAW GKTTCLQLAL 

       730        740        750        760        770        780 
EAKDMKFVSH GGIQAFLTKV WWGQLCVDNG LWRIILCMLA FPLLFTGFIS FREKRLQALC 

       790        800        810        820        830        840 
RPARVRAFFN APVVIFHMNI LSYFAFLCLF AYVLMVDFQP SPSWCEYLIY LWLFSLVCEE 

       850        860        870        880        890        900 
TRQYLFYDPD GCGLMKMASL YFSDFWNKLD VGAILLFIVG LTCRLIPATL YPGRIILSLD 

       910        920        930        940        950        960 
FIMFCLRLMH IFTISKTLGP KIIIVKRMMK DVFFFLFLLA VWVVSFGVAK QAILIHNESR 

       970        980        990       1000       1010       1020 
VDWIFRGVVY HSYLTIFGQI PTYIDGVNFS MDQCSPNGTD PYKPKCPESD WTGQAPAFPE 

      1030       1040       1050       1060       1070       1080 
WLTVTLLCLY LLFANILLLN LLIAMFNYTF QEVQEHTDQI WKFQRHDLIE EYHGRPPAPP 

      1090       1100       1110       1120       1130       1140 
PLILLSHLQL LIKRIVLKIP AKRHKQLKNK LEKNEETALL SWELYLKENY LQNQQYQQKQ 

      1150       1160       1170       1180       1190       1200 
RPEQKIQDIS EKVDTMVDLL DMDQVKRSGS TEQRLASLEE QVTQVTRALH WIVTTLKDSG 

      1210       1220       1230       1240       1250       1260 
FGSGAGALTL APQRAFDEPD AELSIRRKVE EPGDGYHVSA RHLLYPNARI MRFPVPNEKV 

      1270       1280       1290       1300       1310       1320 
PWAAEFLIYD PPFYTAEKDV ALTDPVGDTA EPLSKISYNV VDGPTDRRSF HGVYVVEYGF 

      1330       1340       1350       1360       1370       1380 
PLNPMGRTGL RGRGSLSWFG PNHTLQPVVT RWKRNQGGAI CRKSVRKMLE VLVMKLPRSE 

      1390       1400       1410       1420       1430       1440 
HWALPGGSRE PGEMLPRKLK RVLRQEFWVA FETLLMQGTE VYKGYVDDPR NTDNAWIETV 

      1450       1460       1470       1480       1490       1500 
AVSIHFQDQN DMELKRLEEN LHTHDPKELT RDLKLSTEWQ VVDRRIPLYA NHKTILQKVA 


SLFGAHF

« Hide

References

[1]Kashuba V.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death."
Hara Y., Wakamori M., Ishii M., Maeno E., Nishida M., Yoshida T., Yamada H., Shimizu S., Mori E., Kudoh J., Shimizu N., Kurose H., Okada Y., Imoto K., Mori Y.
Mol. Cell 9:163-173(2002) [PubMed: 11804595] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ344343 mRNA. Translation: CAC69081.1.
IPIIPI00130116.
UniGeneMm.276762.

3D structure databases

ProteinModelPortalQ91YD4.
SMRQ91YD4. Positions 1236-1507.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ91YD4.

PTM databases

PhosphoSiteQ91YD4.

Proteomic databases

PRIDEQ91YD4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020505; ENSMUSP00000020505; ENSMUSG00000009292.
ENSMUST00000105400; ENSMUSP00000101039; ENSMUSG00000009292.

Organism-specific databases

MGIMGI:1351901. Trpm2.

Phylogenomic databases

GeneTreeENSGT00550000074246.
HOGENOMHBG715055.
HOVERGENHBG055825.
InParanoidQ91YD4.
OMATGVMKQV.
PhylomeDBQ91YD4.

Gene expression databases

ArrayExpressQ91YD4.
BgeeQ91YD4.
GenevestigatorQ91YD4.
GermOnlineENSMUSG00000009292. Mus musculus.

Family and domain databases

InterProIPR005821. Ion_trans.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
Gene3DG3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit.
PfamPF00520. Ion_trans. 1 hit.
[Graphical view]
SUPFAMSSF55811. NUDIX_hydrolase. 1 hit.
PROSITEPS51462. NUDIX. 1 hit.
PS00893. NUDIX_BOX. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio306826.
SOURCESearch...

Entry information

Entry nameTRPM2_MOUSE
AccessionPrimary (citable) accession number: Q91YD4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: December 1, 2001
Last modified: September 21, 2011
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents