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Protein

Transient receptor potential cation channel subfamily M member 2

Gene

Trpm2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD+), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Has ADP-ribose pyrophosphatase activity (By similarity).By similarity1 Publication

Catalytic activityi

ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1387 – 140923NADBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • manganese ion transport Source: MGI
  • response to hydroperoxide Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Hydrolase, Ion channel, Sodium channel

Keywords - Biological processi

Calcium transport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Calcium, NAD, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily M member 2 (EC:3.6.1.13)
Alternative name(s):
Long transient receptor potential channel 2
Short name:
LTrpC-2
Short name:
LTrpC2
Transient receptor potential channel 7
Short name:
TrpC7
Gene namesi
Name:Trpm2
Synonyms:Ltrpc2, Trpc7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1351901. Trpm2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 750750CytoplasmicSequence analysisAdd
BLAST
Transmembranei751 – 77121HelicalSequence analysisAdd
BLAST
Topological domaini772 – 79221ExtracellularSequence analysisAdd
BLAST
Transmembranei793 – 81321HelicalSequence analysisAdd
BLAST
Topological domaini814 – 87057CytoplasmicSequence analysisAdd
BLAST
Transmembranei871 – 89121HelicalSequence analysisAdd
BLAST
Topological domaini892 – 8943ExtracellularSequence analysis
Transmembranei895 – 91521HelicalSequence analysisAdd
BLAST
Topological domaini916 – 93419CytoplasmicSequence analysisAdd
BLAST
Transmembranei935 – 95521HelicalSequence analysisAdd
BLAST
Topological domaini956 – 102570ExtracellularSequence analysisAdd
BLAST
Transmembranei1026 – 104621HelicalSequence analysisAdd
BLAST
Topological domaini1047 – 1507461CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15071507Transient receptor potential cation channel subfamily M member 2PRO_0000215327Add
BLAST

Proteomic databases

EPDiQ91YD4.
PaxDbiQ91YD4.
PRIDEiQ91YD4.

PTM databases

iPTMnetiQ91YD4.
PhosphoSiteiQ91YD4.

Expressioni

Tissue specificityi

Widely expressed, with highest levels in lung, spleen, eye and brain.1 Publication

Inductioni

NAD+.

Gene expression databases

BgeeiQ91YD4.

Interactioni

Protein-protein interaction databases

MINTiMINT-4997883.
STRINGi10090.ENSMUSP00000101040.

Structurei

3D structure databases

ProteinModelPortaliQ91YD4.
SMRiQ91YD4. Positions 1237-1507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1351 – 1502152Nudix hydrolasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 nudix hydrolase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3614. Eukaryota.
KOG4195. Eukaryota.
ENOG410XR5B. LUCA.
HOGENOMiHOG000236350.
HOVERGENiHBG055825.
InParanoidiQ91YD4.
PhylomeDBiQ91YD4.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR005821. Ion_trans_dom.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR029594. TRPM2.
[Graphical view]
PANTHERiPTHR13800:SF2. PTHR13800:SF2. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91YD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESLDRRRTG SEQEEGFGVQ SRRATDLGMV PNLRRSNSSL CKSRRFLCSF
60 70 80 90 100
SSEKQENLSS WIPENIKKKE CVYFVESSKL SDAGKVVCAC GYTHEQHLEV
110 120 130 140 150
AIKPHTFQGK EWDPKKHVQE MPTDAFGDIV FTDLSQKVGK YVRVSQDTPS
160 170 180 190 200
SVIYQLMTQH WGLDVPNLLI SVTGGAKNFN MKLRLKSIFR RGLVKVAQTT
210 220 230 240 250
GAWIITGGSH TGVMKQVGEA VRDFSLSSSC KEGEVITIGV ATWGTIHNRE
260 270 280 290 300
GLIHPMGGFP AEYMLDEEGQ GNLTCLDSNH SHFILVDDGT HGQYGVEIPL
310 320 330 340 350
RTKLEKFISE QTKERGGVAI KIPIVCVVLE GGPGTLHTIY NAINNGTPCV
360 370 380 390 400
IVEGSGRVAD VIAQVATLPV SEITISLIQQ KLSIFFQEMF ETFTENQIVE
410 420 430 440 450
WTKKIQDIVR RRQLLTIFRE GKDGQQDVDV AILQALLKAS RSQDHFGHEN
460 470 480 490 500
WDHQLKLAVA WNRVDIARSE IFTDEWQWKP ADLHPMMTAA LISNKPEFVR
510 520 530 540 550
LFLENGVRLK EFVTWDTLLC LYENLEPSCL FHSKLQKVLA EEQRLAYASA
560 570 580 590 600
TPRLHMHHVA QVLRELLGDS TQLLYPRPRY TDRPRLSMTV PHIKLNVQGV
610 620 630 640 650
SLRSLYKRST GHVTFTIDPV RDLLIWAVIQ NHRELAGIIW AQSQDCTAAA
660 670 680 690 700
LACSKILKEL SKEEEDTDSS EEMLALADEF EHRAIGVFTE CYRKDEERAQ
710 720 730 740 750
KLLVRVSEAW GKTTCLQLAL EAKDMKFVSH GGIQAFLTKV WWGQLCVDNG
760 770 780 790 800
LWRIILCMLA FPLLFTGFIS FREKRLQALC RPARVRAFFN APVVIFHMNI
810 820 830 840 850
LSYFAFLCLF AYVLMVDFQP SPSWCEYLIY LWLFSLVCEE TRQYLFYDPD
860 870 880 890 900
GCGLMKMASL YFSDFWNKLD VGAILLFIVG LTCRLIPATL YPGRIILSLD
910 920 930 940 950
FIMFCLRLMH IFTISKTLGP KIIIVKRMMK DVFFFLFLLA VWVVSFGVAK
960 970 980 990 1000
QAILIHNESR VDWIFRGVVY HSYLTIFGQI PTYIDGVNFS MDQCSPNGTD
1010 1020 1030 1040 1050
PYKPKCPESD WTGQAPAFPE WLTVTLLCLY LLFANILLLN LLIAMFNYTF
1060 1070 1080 1090 1100
QEVQEHTDQI WKFQRHDLIE EYHGRPPAPP PLILLSHLQL LIKRIVLKIP
1110 1120 1130 1140 1150
AKRHKQLKNK LEKNEETALL SWELYLKENY LQNQQYQQKQ RPEQKIQDIS
1160 1170 1180 1190 1200
EKVDTMVDLL DMDQVKRSGS TEQRLASLEE QVTQVTRALH WIVTTLKDSG
1210 1220 1230 1240 1250
FGSGAGALTL APQRAFDEPD AELSIRRKVE EPGDGYHVSA RHLLYPNARI
1260 1270 1280 1290 1300
MRFPVPNEKV PWAAEFLIYD PPFYTAEKDV ALTDPVGDTA EPLSKISYNV
1310 1320 1330 1340 1350
VDGPTDRRSF HGVYVVEYGF PLNPMGRTGL RGRGSLSWFG PNHTLQPVVT
1360 1370 1380 1390 1400
RWKRNQGGAI CRKSVRKMLE VLVMKLPRSE HWALPGGSRE PGEMLPRKLK
1410 1420 1430 1440 1450
RVLRQEFWVA FETLLMQGTE VYKGYVDDPR NTDNAWIETV AVSIHFQDQN
1460 1470 1480 1490 1500
DMELKRLEEN LHTHDPKELT RDLKLSTEWQ VVDRRIPLYA NHKTILQKVA

SLFGAHF
Length:1,507
Mass (Da):172,365
Last modified:December 1, 2001 - v1
Checksum:i86E552DE25939785
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ344343 mRNA. Translation: CAC69081.1.
UniGeneiMm.276762.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ344343 mRNA. Translation: CAC69081.1.
UniGeneiMm.276762.

3D structure databases

ProteinModelPortaliQ91YD4.
SMRiQ91YD4. Positions 1237-1507.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4997883.
STRINGi10090.ENSMUSP00000101040.

PTM databases

iPTMnetiQ91YD4.
PhosphoSiteiQ91YD4.

Proteomic databases

EPDiQ91YD4.
PaxDbiQ91YD4.
PRIDEiQ91YD4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1351901. Trpm2.

Phylogenomic databases

eggNOGiKOG3614. Eukaryota.
KOG4195. Eukaryota.
ENOG410XR5B. LUCA.
HOGENOMiHOG000236350.
HOVERGENiHBG055825.
InParanoidiQ91YD4.
PhylomeDBiQ91YD4.

Miscellaneous databases

PROiQ91YD4.
SOURCEiSearch...

Gene expression databases

BgeeiQ91YD4.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR005821. Ion_trans_dom.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR029594. TRPM2.
[Graphical view]
PANTHERiPTHR13800:SF2. PTHR13800:SF2. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Kashuba V.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
  2. "LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death."
    Hara Y., Wakamori M., Ishii M., Maeno E., Nishida M., Yoshida T., Yamada H., Shimizu S., Mori E., Kudoh J., Shimizu N., Kurose H., Okada Y., Imoto K., Mori Y.
    Mol. Cell 9:163-173(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiTRPM2_MOUSE
AccessioniPrimary (citable) accession number: Q91YD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.