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Q91YD3

- DCP1A_MOUSE

UniProt

Q91YD3 - DCP1A_MOUSE

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Protein
mRNA-decapping enzyme 1A
Gene
Dcp1a, Mitc1, Smif
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1 By similarity.

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
  2. transcription factor binding Source: MGI

GO - Biological processi

  1. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB-KW
  2. positive regulation of transcription, DNA-templated Source: MGI
  3. transforming growth factor beta receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nonsense-mediated mRNA decay

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA-decapping enzyme 1A (EC:3.-.-.-)
Alternative name(s):
MAD homolog 4-interacting transcription coactivator 1
Smad4-interacting transcriptional co-activator
Transcription factor SMIF
Gene namesi
Name:Dcp1a
Synonyms:Mitc1, Smif
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1923151. Dcp1a.

Subcellular locationi

CytoplasmP-body. Nucleus By similarity
Note: Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4 By similarity. Colocalizes with NANOS3 in the processing bodies.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytoplasmic mRNA processing body Source: UniProtKB
  3. nucleus Source: UniProtKB-SubCell
  4. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 602602mRNA-decapping enzyme 1A
PRO_0000189633Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei162 – 1621Phosphoserine By similarity
Modified residuei200 – 2001Phosphoserine By similarity
Modified residuei335 – 3351Phosphoserine By similarity
Modified residuei339 – 3391Phosphoserine By similarity
Modified residuei372 – 3721Phosphoserine By similarity
Modified residuei420 – 4201Phosphothreonine By similarity
Modified residuei441 – 4411Phosphoserine By similarity
Modified residuei542 – 5421Phosphoserine By similarity
Modified residuei543 – 5431Phosphoserine1 Publication
Modified residuei545 – 5451Phosphoserine1 Publication
Modified residuei551 – 5511Phosphothreonine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91YD3.
PaxDbiQ91YD3.
PRIDEiQ91YD3.

PTM databases

PhosphoSiteiQ91YD3.

Expressioni

Gene expression databases

ArrayExpressiQ91YD3.
BgeeiQ91YD3.
CleanExiMM_DCP1A.
GenevestigatoriQ91YD3.

Interactioni

Subunit structurei

Forms a complex with EDC3, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC3. Binds DCP1B, UPF1 and SMAD4. Part of a cytoplasmic complex containing proteins involved in mRNA decay, including XRN1 and LSM1. Interacts with PNRC2 By similarity. Interacts with DDX17 in an RNA-independent manner By similarity. Interacts with ZC3HAV1 By similarity.

Protein-protein interaction databases

BioGridi217832. 1 interaction.
IntActiQ91YD3. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ91YD3.
SMRiQ91YD3. Positions 21-149, 559-602.

Family & Domainsi

Sequence similaritiesi

Belongs to the DCP1 family.

Phylogenomic databases

eggNOGiNOG314415.
GeneTreeiENSGT00390000014855.
HOGENOMiHOG000090228.
HOVERGENiHBG051320.
InParanoidiQ91YD3.
KOiK12610.
OMAiLTPQHDQ.
OrthoDBiEOG75QR3K.
PhylomeDBiQ91YD3.
TreeFamiTF320504.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR010334. DCP1.
IPR011993. PH_like_dom.
[Graphical view]
PANTHERiPTHR16290. PTHR16290. 1 hit.
PfamiPF06058. DCP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91YD3-1 [UniParc]FASTAAdd to Basket

« Hide

MALSCSTVRP RRRGSALRSK MELLSRAEQE MSLAALKQHD PYITSIADLT    50
GQVALYTFCP KANQWEKTDI EGTLFVYRRS ASPYHGFTIV NRLNMHNLVE 100
PVNKDLEFQL HEPFLLYRNA SLSIYSIWFY DKNDCHRIAK LMADVVEEET 150
RRSQQAARDK QSPSQANGCS DQRPIDILEM LSRAKDEYER NQMGGSNISS 200
PGLQPSTQLS NLGSTETLEE TPSGSQDKSA PSGHKHLTVE ELFGTSLPKE 250
QPTAMGLESE DTDKLLGDAS QKEPSSFLPF PFEQSGGAPQ SENLGIHSAA 300
HHTVQPEVST PVLITPASIA QSGDKHPPSY TLPLSPVLSP TLPAEAPTTQ 350
VPHLPRNSTM IQAVKTTPRQ KSPLLNQPVP ELSHSSLVAS QSPFRAPVSL 400
ANPAGTALPS VDLLQKLRLT PQHDQIQAQP LGKGTMAPSF SSAAGQLATP 450
ESFIEPSSKT AAARAAVSAS LSNMVLAPTL QSMQQNQDPE VFSQPKVLPS 500
AIPIAGSPLV PATTTAVSSV LLSPSVFQQT VPRAADLERK ASSPSPLTVG 550
TAESQRKPSI ILSKSQLQDT LIHLIKNDSS FLSTLHAVYL QVLTKNKDNH 600
NL 602
Length:602
Mass (Da):65,219
Last modified:December 1, 2001 - v1
Checksum:i55BC9C32BCA86CFD
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti481 – 4811Q → R in strain: C57BL/6J. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ344447 mRNA. Translation: CAC69875.1.
BC066173 mRNA. Translation: AAH66173.1.
CCDSiCCDS36848.1.
RefSeqiNP_598522.3. NM_133761.3.
UniGeneiMm.28733.

Genome annotation databases

EnsembliENSMUST00000022535; ENSMUSP00000022535; ENSMUSG00000021962.
GeneIDi75901.
KEGGimmu:75901.
UCSCiuc007sva.1. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ344447 mRNA. Translation: CAC69875.1 .
BC066173 mRNA. Translation: AAH66173.1 .
CCDSi CCDS36848.1.
RefSeqi NP_598522.3. NM_133761.3.
UniGenei Mm.28733.

3D structure databases

ProteinModelPortali Q91YD3.
SMRi Q91YD3. Positions 21-149, 559-602.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 217832. 1 interaction.
IntActi Q91YD3. 4 interactions.

PTM databases

PhosphoSitei Q91YD3.

Proteomic databases

MaxQBi Q91YD3.
PaxDbi Q91YD3.
PRIDEi Q91YD3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000022535 ; ENSMUSP00000022535 ; ENSMUSG00000021962 .
GeneIDi 75901.
KEGGi mmu:75901.
UCSCi uc007sva.1. mouse.

Organism-specific databases

CTDi 55802.
MGIi MGI:1923151. Dcp1a.

Phylogenomic databases

eggNOGi NOG314415.
GeneTreei ENSGT00390000014855.
HOGENOMi HOG000090228.
HOVERGENi HBG051320.
InParanoidi Q91YD3.
KOi K12610.
OMAi LTPQHDQ.
OrthoDBi EOG75QR3K.
PhylomeDBi Q91YD3.
TreeFami TF320504.

Miscellaneous databases

NextBioi 344221.
PROi Q91YD3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q91YD3.
Bgeei Q91YD3.
CleanExi MM_DCP1A.
Genevestigatori Q91YD3.

Family and domain databases

Gene3Di 2.30.29.30. 1 hit.
InterProi IPR010334. DCP1.
IPR011993. PH_like_dom.
[Graphical view ]
PANTHERi PTHR16290. PTHR16290. 1 hit.
Pfami PF06058. DCP1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling."
    Bai R.-Y., Koester C., Ouyang T., Hahn S.A., Hammerschmidt M., Peschel C., Duyster J.
    Nat. Cell Biol. 4:181-190(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-481.
    Strain: C57BL/6J.
    Tissue: Egg.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-543 AND SER-545, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  5. "Functional reconstruction of NANOS3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of NANOS3."
    Yamaji M., Tanaka T., Shigeta M., Chuma S., Saga Y., Saitou M.
    Reproduction 139:381-393(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiDCP1A_MOUSE
AccessioniPrimary (citable) accession number: Q91YD3
Secondary accession number(s): Q6NZE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-21 is the initiator.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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