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Q91YD3

- DCP1A_MOUSE

UniProt

Q91YD3 - DCP1A_MOUSE

Protein

mRNA-decapping enzyme 1A

Gene

Dcp1a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1 By similarity.By similarity

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW
    2. transcription factor binding Source: MGI

    GO - Biological processi

    1. nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB-KW
    2. positive regulation of transcription, DNA-templated Source: MGI
    3. transforming growth factor beta receptor signaling pathway Source: MGI

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nonsense-mediated mRNA decay

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    mRNA-decapping enzyme 1A (EC:3.-.-.-)
    Alternative name(s):
    MAD homolog 4-interacting transcription coactivator 1
    Smad4-interacting transcriptional co-activator
    Transcription factor SMIF
    Gene namesi
    Name:Dcp1a
    Synonyms:Mitc1, Smif
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1923151. Dcp1a.

    Subcellular locationi

    CytoplasmP-body 1 Publication. Nucleus By similarity
    Note: Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4 By similarity. Colocalizes with NANOS3 in the processing bodies.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytoplasmic mRNA processing body Source: UniProtKB
    3. nucleus Source: UniProtKB-SubCell
    4. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 602602mRNA-decapping enzyme 1APRO_0000189633Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei162 – 1621PhosphoserineBy similarity
    Modified residuei200 – 2001PhosphoserineBy similarity
    Modified residuei335 – 3351PhosphoserineBy similarity
    Modified residuei339 – 3391PhosphoserineBy similarity
    Modified residuei372 – 3721PhosphoserineBy similarity
    Modified residuei420 – 4201PhosphothreonineBy similarity
    Modified residuei441 – 4411PhosphoserineBy similarity
    Modified residuei542 – 5421PhosphoserineBy similarity
    Modified residuei543 – 5431Phosphoserine1 Publication
    Modified residuei545 – 5451Phosphoserine1 Publication
    Modified residuei551 – 5511PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ91YD3.
    PaxDbiQ91YD3.
    PRIDEiQ91YD3.

    PTM databases

    PhosphoSiteiQ91YD3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ91YD3.
    BgeeiQ91YD3.
    CleanExiMM_DCP1A.
    GenevestigatoriQ91YD3.

    Interactioni

    Subunit structurei

    Forms a complex with EDC3, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC3. Binds DCP1B, UPF1 and SMAD4. Part of a cytoplasmic complex containing proteins involved in mRNA decay, including XRN1 and LSM1. Interacts with PNRC2 By similarity. Interacts with DDX17 in an RNA-independent manner By similarity. Interacts with ZC3HAV1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi217832. 1 interaction.
    IntActiQ91YD3. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91YD3.
    SMRiQ91YD3. Positions 21-149, 559-602.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DCP1 family.Curated

    Phylogenomic databases

    eggNOGiNOG314415.
    GeneTreeiENSGT00390000014855.
    HOGENOMiHOG000090228.
    HOVERGENiHBG051320.
    InParanoidiQ91YD3.
    KOiK12610.
    OMAiLTPQHDQ.
    OrthoDBiEOG75QR3K.
    PhylomeDBiQ91YD3.
    TreeFamiTF320504.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR010334. DCP1.
    IPR011993. PH_like_dom.
    [Graphical view]
    PANTHERiPTHR16290. PTHR16290. 1 hit.
    PfamiPF06058. DCP1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91YD3-1 [UniParc]FASTAAdd to Basket

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    MALSCSTVRP RRRGSALRSK MELLSRAEQE MSLAALKQHD PYITSIADLT    50
    GQVALYTFCP KANQWEKTDI EGTLFVYRRS ASPYHGFTIV NRLNMHNLVE 100
    PVNKDLEFQL HEPFLLYRNA SLSIYSIWFY DKNDCHRIAK LMADVVEEET 150
    RRSQQAARDK QSPSQANGCS DQRPIDILEM LSRAKDEYER NQMGGSNISS 200
    PGLQPSTQLS NLGSTETLEE TPSGSQDKSA PSGHKHLTVE ELFGTSLPKE 250
    QPTAMGLESE DTDKLLGDAS QKEPSSFLPF PFEQSGGAPQ SENLGIHSAA 300
    HHTVQPEVST PVLITPASIA QSGDKHPPSY TLPLSPVLSP TLPAEAPTTQ 350
    VPHLPRNSTM IQAVKTTPRQ KSPLLNQPVP ELSHSSLVAS QSPFRAPVSL 400
    ANPAGTALPS VDLLQKLRLT PQHDQIQAQP LGKGTMAPSF SSAAGQLATP 450
    ESFIEPSSKT AAARAAVSAS LSNMVLAPTL QSMQQNQDPE VFSQPKVLPS 500
    AIPIAGSPLV PATTTAVSSV LLSPSVFQQT VPRAADLERK ASSPSPLTVG 550
    TAESQRKPSI ILSKSQLQDT LIHLIKNDSS FLSTLHAVYL QVLTKNKDNH 600
    NL 602
    Length:602
    Mass (Da):65,219
    Last modified:December 1, 2001 - v1
    Checksum:i55BC9C32BCA86CFD
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti481 – 4811Q → R in strain: C57BL/6J. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ344447 mRNA. Translation: CAC69875.1.
    BC066173 mRNA. Translation: AAH66173.1.
    CCDSiCCDS36848.1.
    RefSeqiNP_598522.3. NM_133761.3.
    UniGeneiMm.28733.

    Genome annotation databases

    EnsembliENSMUST00000022535; ENSMUSP00000022535; ENSMUSG00000021962.
    GeneIDi75901.
    KEGGimmu:75901.
    UCSCiuc007sva.1. mouse.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ344447 mRNA. Translation: CAC69875.1 .
    BC066173 mRNA. Translation: AAH66173.1 .
    CCDSi CCDS36848.1.
    RefSeqi NP_598522.3. NM_133761.3.
    UniGenei Mm.28733.

    3D structure databases

    ProteinModelPortali Q91YD3.
    SMRi Q91YD3. Positions 21-149, 559-602.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 217832. 1 interaction.
    IntActi Q91YD3. 4 interactions.

    PTM databases

    PhosphoSitei Q91YD3.

    Proteomic databases

    MaxQBi Q91YD3.
    PaxDbi Q91YD3.
    PRIDEi Q91YD3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000022535 ; ENSMUSP00000022535 ; ENSMUSG00000021962 .
    GeneIDi 75901.
    KEGGi mmu:75901.
    UCSCi uc007sva.1. mouse.

    Organism-specific databases

    CTDi 55802.
    MGIi MGI:1923151. Dcp1a.

    Phylogenomic databases

    eggNOGi NOG314415.
    GeneTreei ENSGT00390000014855.
    HOGENOMi HOG000090228.
    HOVERGENi HBG051320.
    InParanoidi Q91YD3.
    KOi K12610.
    OMAi LTPQHDQ.
    OrthoDBi EOG75QR3K.
    PhylomeDBi Q91YD3.
    TreeFami TF320504.

    Miscellaneous databases

    NextBioi 344221.
    PROi Q91YD3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91YD3.
    Bgeei Q91YD3.
    CleanExi MM_DCP1A.
    Genevestigatori Q91YD3.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR010334. DCP1.
    IPR011993. PH_like_dom.
    [Graphical view ]
    PANTHERi PTHR16290. PTHR16290. 1 hit.
    Pfami PF06058. DCP1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling."
      Bai R.-Y., Koester C., Ouyang T., Hahn S.A., Hammerschmidt M., Peschel C., Duyster J.
      Nat. Cell Biol. 4:181-190(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Swiss Webster.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-481.
      Strain: C57BL/6J.
      Tissue: Egg.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-543 AND SER-545, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    4. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.
    5. "Functional reconstruction of NANOS3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of NANOS3."
      Yamaji M., Tanaka T., Shigeta M., Chuma S., Saga Y., Saitou M.
      Reproduction 139:381-393(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiDCP1A_MOUSE
    AccessioniPrimary (citable) accession number: Q91YD3
    Secondary accession number(s): Q6NZE3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-21 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3