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Protein

mRNA-decapping enzyme 1A

Gene

Dcp1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nonsense-mediated mRNA decay

Enzyme and pathway databases

ReactomeiR-MMU-430039. mRNA decay by 5' to 3' exoribonuclease.
R-MMU-450385. Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
mRNA-decapping enzyme 1A (EC:3.-.-.-)
Alternative name(s):
MAD homolog 4-interacting transcription coactivator 1
Smad4-interacting transcriptional co-activator
Transcription factor SMIF
Gene namesi
Name:Dcp1a
Synonyms:Mitc1, Smif
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1923151. Dcp1a.

Subcellular locationi

  • CytoplasmP-body 1 Publication
  • Nucleus By similarity

  • Note: Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4 (By similarity). Colocalizes with NANOS3 in the processing bodies (PubMed:19861488).By similarity1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001896331 – 602mRNA-decapping enzyme 1AAdd BLAST602

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82PhosphoserineCombined sources1
Modified residuei162PhosphoserineCombined sources1
Modified residuei199PhosphoserineCombined sources1
Modified residuei200PhosphoserineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei339PhosphoserineCombined sources1
Modified residuei367PhosphothreonineBy similarity1
Modified residuei372PhosphoserineCombined sources1
Modified residuei395Asymmetric dimethylarginineBy similarity1
Modified residuei420PhosphothreonineCombined sources1
Modified residuei441PhosphoserineBy similarity1
Modified residuei542PhosphoserineCombined sources1
Modified residuei543PhosphoserineCombined sources1
Modified residuei545PhosphoserineCombined sources1
Modified residuei548PhosphothreonineCombined sources1
Modified residuei551PhosphothreonineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ91YD3.
MaxQBiQ91YD3.
PaxDbiQ91YD3.
PeptideAtlasiQ91YD3.
PRIDEiQ91YD3.

PTM databases

iPTMnetiQ91YD3.
PhosphoSitePlusiQ91YD3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021962.
CleanExiMM_DCP1A.
GenevisibleiQ91YD3. MM.

Interactioni

Subunit structurei

Forms a complex with EDC3, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC3. Part of a cytoplasmic complex containing proteins involved in mRNA decay, including XRN1 and LSM1. Interacts with DCP1B. Interacts with DCP2. Interacts with DDX17 in an RNA-independent manner. Interacts with PNRC2. Interacts with SMAD4. Interacts with UPF1. Interacts with ZC3HAV1. Interacts with ZFP36L1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi217832. 1 interactor.
IntActiQ91YD3. 4 interactors.
STRINGi10090.ENSMUSP00000022535.

Structurei

3D structure databases

ProteinModelPortaliQ91YD3.
SMRiQ91YD3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DCP1 family.Curated

Phylogenomic databases

eggNOGiKOG2868. Eukaryota.
ENOG410XRY6. LUCA.
GeneTreeiENSGT00390000014855.
HOGENOMiHOG000090228.
HOVERGENiHBG051320.
InParanoidiQ91YD3.
KOiK12610.
OMAiLTPQHDQ.
OrthoDBiEOG091G0JB7.
PhylomeDBiQ91YD3.
TreeFamiTF320504.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR010334. Dcp1.
IPR031953. mRNA_decap_C.
IPR011993. PH_dom-like.
[Graphical view]
PANTHERiPTHR16290. PTHR16290. 3 hits.
PfamiPF06058. DCP1. 1 hit.
PF16741. mRNA_decap_C. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91YD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSCSTVRP RRRGSALRSK MELLSRAEQE MSLAALKQHD PYITSIADLT
60 70 80 90 100
GQVALYTFCP KANQWEKTDI EGTLFVYRRS ASPYHGFTIV NRLNMHNLVE
110 120 130 140 150
PVNKDLEFQL HEPFLLYRNA SLSIYSIWFY DKNDCHRIAK LMADVVEEET
160 170 180 190 200
RRSQQAARDK QSPSQANGCS DQRPIDILEM LSRAKDEYER NQMGGSNISS
210 220 230 240 250
PGLQPSTQLS NLGSTETLEE TPSGSQDKSA PSGHKHLTVE ELFGTSLPKE
260 270 280 290 300
QPTAMGLESE DTDKLLGDAS QKEPSSFLPF PFEQSGGAPQ SENLGIHSAA
310 320 330 340 350
HHTVQPEVST PVLITPASIA QSGDKHPPSY TLPLSPVLSP TLPAEAPTTQ
360 370 380 390 400
VPHLPRNSTM IQAVKTTPRQ KSPLLNQPVP ELSHSSLVAS QSPFRAPVSL
410 420 430 440 450
ANPAGTALPS VDLLQKLRLT PQHDQIQAQP LGKGTMAPSF SSAAGQLATP
460 470 480 490 500
ESFIEPSSKT AAARAAVSAS LSNMVLAPTL QSMQQNQDPE VFSQPKVLPS
510 520 530 540 550
AIPIAGSPLV PATTTAVSSV LLSPSVFQQT VPRAADLERK ASSPSPLTVG
560 570 580 590 600
TAESQRKPSI ILSKSQLQDT LIHLIKNDSS FLSTLHAVYL QVLTKNKDNH

NL
Length:602
Mass (Da):65,219
Last modified:December 1, 2001 - v1
Checksum:i55BC9C32BCA86CFD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti481Q → R in strain: C57BL/6J. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ344447 mRNA. Translation: CAC69875.1.
BC066173 mRNA. Translation: AAH66173.1.
CCDSiCCDS36848.1.
RefSeqiNP_598522.3. NM_133761.3.
UniGeneiMm.28733.

Genome annotation databases

EnsembliENSMUST00000022535; ENSMUSP00000022535; ENSMUSG00000021962.
GeneIDi75901.
KEGGimmu:75901.
UCSCiuc007sva.1. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ344447 mRNA. Translation: CAC69875.1.
BC066173 mRNA. Translation: AAH66173.1.
CCDSiCCDS36848.1.
RefSeqiNP_598522.3. NM_133761.3.
UniGeneiMm.28733.

3D structure databases

ProteinModelPortaliQ91YD3.
SMRiQ91YD3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi217832. 1 interactor.
IntActiQ91YD3. 4 interactors.
STRINGi10090.ENSMUSP00000022535.

PTM databases

iPTMnetiQ91YD3.
PhosphoSitePlusiQ91YD3.

Proteomic databases

EPDiQ91YD3.
MaxQBiQ91YD3.
PaxDbiQ91YD3.
PeptideAtlasiQ91YD3.
PRIDEiQ91YD3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022535; ENSMUSP00000022535; ENSMUSG00000021962.
GeneIDi75901.
KEGGimmu:75901.
UCSCiuc007sva.1. mouse.

Organism-specific databases

CTDi55802.
MGIiMGI:1923151. Dcp1a.

Phylogenomic databases

eggNOGiKOG2868. Eukaryota.
ENOG410XRY6. LUCA.
GeneTreeiENSGT00390000014855.
HOGENOMiHOG000090228.
HOVERGENiHBG051320.
InParanoidiQ91YD3.
KOiK12610.
OMAiLTPQHDQ.
OrthoDBiEOG091G0JB7.
PhylomeDBiQ91YD3.
TreeFamiTF320504.

Enzyme and pathway databases

ReactomeiR-MMU-430039. mRNA decay by 5' to 3' exoribonuclease.
R-MMU-450385. Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiQ91YD3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021962.
CleanExiMM_DCP1A.
GenevisibleiQ91YD3. MM.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR010334. Dcp1.
IPR031953. mRNA_decap_C.
IPR011993. PH_dom-like.
[Graphical view]
PANTHERiPTHR16290. PTHR16290. 3 hits.
PfamiPF06058. DCP1. 1 hit.
PF16741. mRNA_decap_C. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDCP1A_MOUSE
AccessioniPrimary (citable) accession number: Q91YD3
Secondary accession number(s): Q6NZE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-21 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.