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Q91YD1

- CXD3_MOUSE

UniProt

Q91YD1 - CXD3_MOUSE

Protein

Gap junction delta-3 protein

Gene

Gjd3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

    GO - Molecular functioni

    1. ion channel activity Source: MGI

    GO - Biological processi

    1. cell communication Source: InterPro
    2. gap junction assembly Source: UniProtKB
    3. ion transmembrane transport Source: GOC

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gap junction delta-3 protein
    Alternative name(s):
    Connexin-30.2
    Short name:
    Cx30.2
    Gap junction alpha-11 protein
    Gap junction chi-1 protein
    Gene namesi
    Name:Gjd3
    Synonyms:Gja11, Gjc1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2384150. Gjd3.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Cell junctiongap junction By similarity

    GO - Cellular componenti

    1. cell surface Source: UniProtKB
    2. connexon complex Source: UniProtKB
    3. gap junction Source: MGI
    4. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Gap junction, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 278278Gap junction delta-3 proteinPRO_0000313009Add
    BLAST

    Proteomic databases

    PRIDEiQ91YD1.

    Expressioni

    Gene expression databases

    BgeeiQ91YD1.
    CleanExiMM_GJC1.
    MM_GJD3.
    GenevestigatoriQ91YD1.

    Interactioni

    Subunit structurei

    A connexon is composed of a hexamer of connexins.By similarity

    Protein-protein interaction databases

    BioGridi237256. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91YD1.
    SMRiQ91YD1. Positions 3-213.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2424CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini46 – 7631ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini98 – 13639CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini158 – 18831ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini210 – 27869CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei77 – 9721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei137 – 15721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei189 – 20921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the connexin family. Delta-type subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41593.
    GeneTreeiENSGT00750000117663.
    HOGENOMiHOG000231127.
    HOVERGENiHBG009576.
    InParanoidiQ91YD1.
    KOiK07627.
    OMAiRRARRCY.
    OrthoDBiEOG7BCNCV.
    PhylomeDBiQ91YD1.
    TreeFamiTF329606.

    Family and domain databases

    InterProiIPR000500. Connexin.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view]
    PANTHERiPTHR11984. PTHR11984. 1 hit.
    PfamiPF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view]
    PRINTSiPR00206. CONNEXIN.
    SMARTiSM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view]
    PROSITEiPS00408. CONNEXINS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91YD1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEWAFLGSL LDAVQLQSPL VGRLWLVIML IFRILVLATV GGAVFEDEQE    50
    EFVCNTLQPG CRQTCYDRAF PVSHYRFWLF HILLLSAPPV LFVIYSMHQA 100
    SKEAGGAQLA PPCARGRAEA PCSPCALRAR RARRCYLLSV ALRLLAELAF 150
    LGGQALLYGF RVDPHYACAG PPCPHTVDCF VSRPTEKTVF VVFYFAVGLL 200
    SALLSVAELG HLLWKGRQRA KLLPPPPPSP SLPSQRGDPD PFGPPAYAHR 250
    SPAGDSEGEG GSGHSKASLA TVRQDLAI 278
    Length:278
    Mass (Da):30,220
    Last modified:December 1, 2001 - v1
    Checksum:iA8A3DC827D070DE9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti13 – 164AVQL → PLQV in AAN65188. (PubMed:12681499)Curated
    Sequence conflicti43 – 431A → S in AAN65188. (PubMed:12681499)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ414561 Genomic DNA. Translation: CAC93843.1.
    AY166870 Genomic DNA. Translation: AAN65188.1.
    AL591067 Genomic DNA. No translation available.
    CCDSiCCDS25369.1.
    RefSeqiNP_848711.2. NM_178596.2.
    UniGeneiMm.453253.

    Genome annotation databases

    EnsembliENSMUST00000062931; ENSMUSP00000055246; ENSMUSG00000047197.
    GeneIDi353155.
    KEGGimmu:353155.
    UCSCiuc007lib.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ414561 Genomic DNA. Translation: CAC93843.1 .
    AY166870 Genomic DNA. Translation: AAN65188.1 .
    AL591067 Genomic DNA. No translation available.
    CCDSi CCDS25369.1.
    RefSeqi NP_848711.2. NM_178596.2.
    UniGenei Mm.453253.

    3D structure databases

    ProteinModelPortali Q91YD1.
    SMRi Q91YD1. Positions 3-213.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 237256. 1 interaction.

    Proteomic databases

    PRIDEi Q91YD1.

    Protocols and materials databases

    DNASUi 353155.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000062931 ; ENSMUSP00000055246 ; ENSMUSG00000047197 .
    GeneIDi 353155.
    KEGGi mmu:353155.
    UCSCi uc007lib.1. mouse.

    Organism-specific databases

    CTDi 125111.
    MGIi MGI:2384150. Gjd3.

    Phylogenomic databases

    eggNOGi NOG41593.
    GeneTreei ENSGT00750000117663.
    HOGENOMi HOG000231127.
    HOVERGENi HBG009576.
    InParanoidi Q91YD1.
    KOi K07627.
    OMAi RRARRCY.
    OrthoDBi EOG7BCNCV.
    PhylomeDBi Q91YD1.
    TreeFami TF329606.

    Miscellaneous databases

    NextBioi 400291.
    PROi Q91YD1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91YD1.
    CleanExi MM_GJC1.
    MM_GJD3.
    Genevestigatori Q91YD1.

    Family and domain databases

    InterProi IPR000500. Connexin.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view ]
    PANTHERi PTHR11984. PTHR11984. 1 hit.
    Pfami PF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view ]
    PRINTSi PR00206. CONNEXIN.
    SMARTi SM00037. CNX. 1 hit.
    SM01089. Connexin_CCC. 1 hit.
    [Graphical view ]
    PROSITEi PS00408. CONNEXINS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural and functional diversity of connexin genes in the mouse and human genome."
      Willecke K., Eiberger J., Degen J., Eckardt D., Romualdi A., Guldenagel M., Deutsch U., Soehl G.
      Biol. Chem. 383:725-737(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    2. "Differences in expression patterns between mouse connexin-30.2 (Cx30.2) and its putative human orthologue, connexin-31.9."
      Nielsen P.A., Kumar N.M.
      FEBS Lett. 540:151-156(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiCXD3_MOUSE
    AccessioniPrimary (citable) accession number: Q91YD1
    Secondary accession number(s): Q80ZH0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3