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Protein

Gap junction delta-3 protein

Gene

Gjd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

GO - Molecular functioni

  • gap junction channel activity Source: Ensembl
  • ion channel activity Source: MGI

GO - Biological processi

  • cell communication Source: InterPro
  • gap junction assembly Source: UniProtKB
  • response to glucose Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction delta-3 protein
Alternative name(s):
Connexin-30.2
Short name:
Cx30.2
Gap junction alpha-11 protein
Gap junction chi-1 protein
Gene namesi
Name:Gjd3
Synonyms:Gja11, Gjc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2384150. Gjd3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24CytoplasmicSequence analysisAdd BLAST24
Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Topological domaini46 – 76ExtracellularSequence analysisAdd BLAST31
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 136CytoplasmicSequence analysisAdd BLAST39
Transmembranei137 – 157HelicalSequence analysisAdd BLAST21
Topological domaini158 – 188ExtracellularSequence analysisAdd BLAST31
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 278CytoplasmicSequence analysisAdd BLAST69

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • connexin complex Source: UniProtKB
  • gap junction Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003130091 – 278Gap junction delta-3 proteinAdd BLAST278

Proteomic databases

PaxDbiQ91YD1.
PRIDEiQ91YD1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000047197.
CleanExiMM_GJC1.
MM_GJD3.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.By similarity

Protein-protein interaction databases

BioGridi237256. 1 interactor.
STRINGi10090.ENSMUSP00000055246.

Structurei

3D structure databases

ProteinModelPortaliQ91YD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the connexin family. Delta-type subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEGI. Eukaryota.
ENOG4111HI4. LUCA.
GeneTreeiENSGT00840000129674.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiQ91YD1.
KOiK07627.
OMAiACAGPPC.
OrthoDBiEOG091G0KR7.
PhylomeDBiQ91YD1.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91YD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEWAFLGSL LDAVQLQSPL VGRLWLVIML IFRILVLATV GGAVFEDEQE
60 70 80 90 100
EFVCNTLQPG CRQTCYDRAF PVSHYRFWLF HILLLSAPPV LFVIYSMHQA
110 120 130 140 150
SKEAGGAQLA PPCARGRAEA PCSPCALRAR RARRCYLLSV ALRLLAELAF
160 170 180 190 200
LGGQALLYGF RVDPHYACAG PPCPHTVDCF VSRPTEKTVF VVFYFAVGLL
210 220 230 240 250
SALLSVAELG HLLWKGRQRA KLLPPPPPSP SLPSQRGDPD PFGPPAYAHR
260 270
SPAGDSEGEG GSGHSKASLA TVRQDLAI
Length:278
Mass (Da):30,220
Last modified:December 1, 2001 - v1
Checksum:iA8A3DC827D070DE9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13 – 16AVQL → PLQV in AAN65188 (PubMed:12681499).Curated4
Sequence conflicti43A → S in AAN65188 (PubMed:12681499).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ414561 Genomic DNA. Translation: CAC93843.1.
AY166870 Genomic DNA. Translation: AAN65188.1.
AL591067 Genomic DNA. No translation available.
CCDSiCCDS25369.1.
RefSeqiNP_848711.2. NM_178596.2.
UniGeneiMm.453253.

Genome annotation databases

EnsembliENSMUST00000062931; ENSMUSP00000055246; ENSMUSG00000047197.
GeneIDi353155.
KEGGimmu:353155.
UCSCiuc007lib.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ414561 Genomic DNA. Translation: CAC93843.1.
AY166870 Genomic DNA. Translation: AAN65188.1.
AL591067 Genomic DNA. No translation available.
CCDSiCCDS25369.1.
RefSeqiNP_848711.2. NM_178596.2.
UniGeneiMm.453253.

3D structure databases

ProteinModelPortaliQ91YD1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi237256. 1 interactor.
STRINGi10090.ENSMUSP00000055246.

Proteomic databases

PaxDbiQ91YD1.
PRIDEiQ91YD1.

Protocols and materials databases

DNASUi353155.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062931; ENSMUSP00000055246; ENSMUSG00000047197.
GeneIDi353155.
KEGGimmu:353155.
UCSCiuc007lib.1. mouse.

Organism-specific databases

CTDi125111.
MGIiMGI:2384150. Gjd3.

Phylogenomic databases

eggNOGiENOG410IEGI. Eukaryota.
ENOG4111HI4. LUCA.
GeneTreeiENSGT00840000129674.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiQ91YD1.
KOiK07627.
OMAiACAGPPC.
OrthoDBiEOG091G0KR7.
PhylomeDBiQ91YD1.
TreeFamiTF329606.

Miscellaneous databases

PROiQ91YD1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047197.
CleanExiMM_GJC1.
MM_GJD3.

Family and domain databases

InterProiIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXD3_MOUSE
AccessioniPrimary (citable) accession number: Q91YD1
Secondary accession number(s): Q80ZH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.