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Q91YD1 (CXD3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gap junction delta-3 protein
Alternative name(s):
Connexin-30.2
Short name=Cx30.2
Gap junction alpha-11 protein
Gap junction chi-1 protein
Gene names
Name:Gjd3
Synonyms:Gja11, Gjc1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell By similarity.

Subunit structure

A connexon is composed of a hexamer of connexins By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Cell junctiongap junction By similarity.

Sequence similarities

Belongs to the connexin family. Delta-type subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 278278Gap junction delta-3 protein
PRO_0000313009

Regions

Topological domain1 – 2424Cytoplasmic Potential
Transmembrane25 – 4521Helical; Potential
Topological domain46 – 7631Extracellular Potential
Transmembrane77 – 9721Helical; Potential
Topological domain98 – 13639Cytoplasmic Potential
Transmembrane137 – 15721Helical; Potential
Topological domain158 – 18831Extracellular Potential
Transmembrane189 – 20921Helical; Potential
Topological domain210 – 27869Cytoplasmic Potential

Experimental info

Sequence conflict13 – 164AVQL → PLQV in AAN65188. Ref.2
Sequence conflict431A → S in AAN65188. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q91YD1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: A8A3DC827D070DE9

FASTA27830,220
        10         20         30         40         50         60 
MGEWAFLGSL LDAVQLQSPL VGRLWLVIML IFRILVLATV GGAVFEDEQE EFVCNTLQPG 

        70         80         90        100        110        120 
CRQTCYDRAF PVSHYRFWLF HILLLSAPPV LFVIYSMHQA SKEAGGAQLA PPCARGRAEA 

       130        140        150        160        170        180 
PCSPCALRAR RARRCYLLSV ALRLLAELAF LGGQALLYGF RVDPHYACAG PPCPHTVDCF 

       190        200        210        220        230        240 
VSRPTEKTVF VVFYFAVGLL SALLSVAELG HLLWKGRQRA KLLPPPPPSP SLPSQRGDPD 

       250        260        270 
PFGPPAYAHR SPAGDSEGEG GSGHSKASLA TVRQDLAI 

« Hide

References

« Hide 'large scale' references
[1]"Structural and functional diversity of connexin genes in the mouse and human genome."
Willecke K., Eiberger J., Degen J., Eckardt D., Romualdi A., Guldenagel M., Deutsch U., Soehl G.
Biol. Chem. 383:725-737(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[2]"Differences in expression patterns between mouse connexin-30.2 (Cx30.2) and its putative human orthologue, connexin-31.9."
Nielsen P.A., Kumar N.M.
FEBS Lett. 540:151-156(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ414561 Genomic DNA. Translation: CAC93843.1.
AY166870 Genomic DNA. Translation: AAN65188.1.
AL591067 Genomic DNA. No translation available.
RefSeqNP_848711.2. NM_178596.2.
UniGeneMm.453253.

3D structure databases

ProteinModelPortalQ91YD1.
SMRQ91YD1. Positions 3-213.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid237256. 1 interaction.

Proteomic databases

PRIDEQ91YD1.

Protocols and materials databases

DNASU353155.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000062931; ENSMUSP00000055246; ENSMUSG00000047197.
GeneID353155.
KEGGmmu:353155.
UCSCuc007lib.1. mouse.

Organism-specific databases

CTD125111.
MGIMGI:2384150. Gjd3.

Phylogenomic databases

eggNOGNOG41593.
GeneTreeENSGT00750000117663.
HOGENOMHOG000231127.
HOVERGENHBG009576.
InParanoidQ91YD1.
KOK07627.
OMARRARRCY.
OrthoDBEOG7BCNCV.
PhylomeDBQ91YD1.
TreeFamTF329606.

Gene expression databases

BgeeQ91YD1.
CleanExMM_GJC1.
MM_GJD3.
GenevestigatorQ91YD1.

Family and domain databases

InterProIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERPTHR11984. PTHR11984. 1 hit.
PfamPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSPR00206. CONNEXIN.
SMARTSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEPS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio400291.
PROQ91YD1.
SOURCESearch...

Entry information

Entry nameCXD3_MOUSE
AccessionPrimary (citable) accession number: Q91YD1
Secondary accession number(s): Q80ZH0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot