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Q91YD1

- CXD3_MOUSE

UniProt

Q91YD1 - CXD3_MOUSE

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Protein
Gap junction delta-3 protein
Gene
Gjd3, Gja11, Gjc1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell By similarity.

GO - Molecular functioni

  1. ion channel activity Source: MGI
Complete GO annotation...

GO - Biological processi

  1. cell communication Source: InterPro
  2. gap junction assembly Source: UniProtKB
  3. ion transmembrane transport Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction delta-3 protein
Alternative name(s):
Connexin-30.2
Short name:
Cx30.2
Gap junction alpha-11 protein
Gap junction chi-1 protein
Gene namesi
Name:Gjd3
Synonyms:Gja11, Gjc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2384150. Gjd3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei25 – 4521Helical; Reviewed prediction
Add
BLAST
Topological domaini46 – 7631Extracellular Reviewed prediction
Add
BLAST
Transmembranei77 – 9721Helical; Reviewed prediction
Add
BLAST
Topological domaini98 – 13639Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei137 – 15721Helical; Reviewed prediction
Add
BLAST
Topological domaini158 – 18831Extracellular Reviewed prediction
Add
BLAST
Transmembranei189 – 20921Helical; Reviewed prediction
Add
BLAST
Topological domaini210 – 27869Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. connexon complex Source: UniProtKB
  3. gap junction Source: MGI
  4. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Gap junction delta-3 protein
PRO_0000313009Add
BLAST

Proteomic databases

PRIDEiQ91YD1.

Expressioni

Gene expression databases

BgeeiQ91YD1.
CleanExiMM_GJC1.
MM_GJD3.
GenevestigatoriQ91YD1.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins By similarity.

Protein-protein interaction databases

BioGridi237256. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ91YD1.
SMRiQ91YD1. Positions 3-213.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41593.
GeneTreeiENSGT00750000117663.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiQ91YD1.
KOiK07627.
OMAiRRARRCY.
OrthoDBiEOG7BCNCV.
PhylomeDBiQ91YD1.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91YD1-1 [UniParc]FASTAAdd to Basket

« Hide

MGEWAFLGSL LDAVQLQSPL VGRLWLVIML IFRILVLATV GGAVFEDEQE    50
EFVCNTLQPG CRQTCYDRAF PVSHYRFWLF HILLLSAPPV LFVIYSMHQA 100
SKEAGGAQLA PPCARGRAEA PCSPCALRAR RARRCYLLSV ALRLLAELAF 150
LGGQALLYGF RVDPHYACAG PPCPHTVDCF VSRPTEKTVF VVFYFAVGLL 200
SALLSVAELG HLLWKGRQRA KLLPPPPPSP SLPSQRGDPD PFGPPAYAHR 250
SPAGDSEGEG GSGHSKASLA TVRQDLAI 278
Length:278
Mass (Da):30,220
Last modified:December 1, 2001 - v1
Checksum:iA8A3DC827D070DE9
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 164AVQL → PLQV in AAN65188. 1 Publication
Sequence conflicti43 – 431A → S in AAN65188. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ414561 Genomic DNA. Translation: CAC93843.1.
AY166870 Genomic DNA. Translation: AAN65188.1.
AL591067 Genomic DNA. No translation available.
CCDSiCCDS25369.1.
RefSeqiNP_848711.2. NM_178596.2.
UniGeneiMm.453253.

Genome annotation databases

EnsembliENSMUST00000062931; ENSMUSP00000055246; ENSMUSG00000047197.
GeneIDi353155.
KEGGimmu:353155.
UCSCiuc007lib.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ414561 Genomic DNA. Translation: CAC93843.1 .
AY166870 Genomic DNA. Translation: AAN65188.1 .
AL591067 Genomic DNA. No translation available.
CCDSi CCDS25369.1.
RefSeqi NP_848711.2. NM_178596.2.
UniGenei Mm.453253.

3D structure databases

ProteinModelPortali Q91YD1.
SMRi Q91YD1. Positions 3-213.
ModBasei Search...

Protein-protein interaction databases

BioGridi 237256. 1 interaction.

Proteomic databases

PRIDEi Q91YD1.

Protocols and materials databases

DNASUi 353155.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000062931 ; ENSMUSP00000055246 ; ENSMUSG00000047197 .
GeneIDi 353155.
KEGGi mmu:353155.
UCSCi uc007lib.1. mouse.

Organism-specific databases

CTDi 125111.
MGIi MGI:2384150. Gjd3.

Phylogenomic databases

eggNOGi NOG41593.
GeneTreei ENSGT00750000117663.
HOGENOMi HOG000231127.
HOVERGENi HBG009576.
InParanoidi Q91YD1.
KOi K07627.
OMAi RRARRCY.
OrthoDBi EOG7BCNCV.
PhylomeDBi Q91YD1.
TreeFami TF329606.

Miscellaneous databases

NextBioi 400291.
PROi Q91YD1.
SOURCEi Search...

Gene expression databases

Bgeei Q91YD1.
CleanExi MM_GJC1.
MM_GJD3.
Genevestigatori Q91YD1.

Family and domain databases

InterProi IPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view ]
PANTHERi PTHR11984. PTHR11984. 1 hit.
Pfami PF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view ]
PRINTSi PR00206. CONNEXIN.
SMARTi SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view ]
PROSITEi PS00408. CONNEXINS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural and functional diversity of connexin genes in the mouse and human genome."
    Willecke K., Eiberger J., Degen J., Eckardt D., Romualdi A., Guldenagel M., Deutsch U., Soehl G.
    Biol. Chem. 383:725-737(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. "Differences in expression patterns between mouse connexin-30.2 (Cx30.2) and its putative human orthologue, connexin-31.9."
    Nielsen P.A., Kumar N.M.
    FEBS Lett. 540:151-156(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiCXD3_MOUSE
AccessioniPrimary (citable) accession number: Q91YD1
Secondary accession number(s): Q80ZH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi