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Protein

Gap junction delta-3 protein

Gene

Gjd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

GO - Molecular functioni

  • gap junction channel activity Source: Ensembl
  • ion channel activity Source: MGI

GO - Biological processi

  • cell communication Source: InterPro
  • gap junction assembly Source: UniProtKB
  • ion transmembrane transport Source: GOC
  • response to glucose Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction delta-3 protein
Alternative name(s):
Connexin-30.2
Short name:
Cx30.2
Gap junction alpha-11 protein
Gap junction chi-1 protein
Gene namesi
Name:Gjd3
Synonyms:Gja11, Gjc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2384150. Gjd3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei25 – 4521HelicalSequence AnalysisAdd
BLAST
Topological domaini46 – 7631ExtracellularSequence AnalysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence AnalysisAdd
BLAST
Topological domaini98 – 13639CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei137 – 15721HelicalSequence AnalysisAdd
BLAST
Topological domaini158 – 18831ExtracellularSequence AnalysisAdd
BLAST
Transmembranei189 – 20921HelicalSequence AnalysisAdd
BLAST
Topological domaini210 – 27869CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • connexon complex Source: UniProtKB
  • gap junction Source: MGI
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Gap junction delta-3 proteinPRO_0000313009Add
BLAST

Proteomic databases

PRIDEiQ91YD1.

Expressioni

Gene expression databases

BgeeiQ91YD1.
CleanExiMM_GJC1.
MM_GJD3.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.By similarity

Protein-protein interaction databases

BioGridi237256. 1 interaction.
STRINGi10090.ENSMUSP00000055246.

Structurei

3D structure databases

ProteinModelPortaliQ91YD1.
SMRiQ91YD1. Positions 3-213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the connexin family. Delta-type subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41593.
GeneTreeiENSGT00800000124029.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiQ91YD1.
KOiK07627.
OMAiACAGPPC.
OrthoDBiEOG7BCNCV.
PhylomeDBiQ91YD1.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91YD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEWAFLGSL LDAVQLQSPL VGRLWLVIML IFRILVLATV GGAVFEDEQE
60 70 80 90 100
EFVCNTLQPG CRQTCYDRAF PVSHYRFWLF HILLLSAPPV LFVIYSMHQA
110 120 130 140 150
SKEAGGAQLA PPCARGRAEA PCSPCALRAR RARRCYLLSV ALRLLAELAF
160 170 180 190 200
LGGQALLYGF RVDPHYACAG PPCPHTVDCF VSRPTEKTVF VVFYFAVGLL
210 220 230 240 250
SALLSVAELG HLLWKGRQRA KLLPPPPPSP SLPSQRGDPD PFGPPAYAHR
260 270
SPAGDSEGEG GSGHSKASLA TVRQDLAI
Length:278
Mass (Da):30,220
Last modified:December 1, 2001 - v1
Checksum:iA8A3DC827D070DE9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 164AVQL → PLQV in AAN65188 (PubMed:12681499).Curated
Sequence conflicti43 – 431A → S in AAN65188 (PubMed:12681499).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ414561 Genomic DNA. Translation: CAC93843.1.
AY166870 Genomic DNA. Translation: AAN65188.1.
AL591067 Genomic DNA. No translation available.
CCDSiCCDS25369.1.
RefSeqiNP_848711.2. NM_178596.2.
UniGeneiMm.453253.

Genome annotation databases

EnsembliENSMUST00000062931; ENSMUSP00000055246; ENSMUSG00000047197.
GeneIDi353155.
KEGGimmu:353155.
UCSCiuc007lib.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ414561 Genomic DNA. Translation: CAC93843.1.
AY166870 Genomic DNA. Translation: AAN65188.1.
AL591067 Genomic DNA. No translation available.
CCDSiCCDS25369.1.
RefSeqiNP_848711.2. NM_178596.2.
UniGeneiMm.453253.

3D structure databases

ProteinModelPortaliQ91YD1.
SMRiQ91YD1. Positions 3-213.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi237256. 1 interaction.
STRINGi10090.ENSMUSP00000055246.

Proteomic databases

PRIDEiQ91YD1.

Protocols and materials databases

DNASUi353155.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062931; ENSMUSP00000055246; ENSMUSG00000047197.
GeneIDi353155.
KEGGimmu:353155.
UCSCiuc007lib.1. mouse.

Organism-specific databases

CTDi125111.
MGIiMGI:2384150. Gjd3.

Phylogenomic databases

eggNOGiNOG41593.
GeneTreeiENSGT00800000124029.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiQ91YD1.
KOiK07627.
OMAiACAGPPC.
OrthoDBiEOG7BCNCV.
PhylomeDBiQ91YD1.
TreeFamiTF329606.

Miscellaneous databases

NextBioi400291.
PROiQ91YD1.
SOURCEiSearch...

Gene expression databases

BgeeiQ91YD1.
CleanExiMM_GJC1.
MM_GJD3.

Family and domain databases

InterProiIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural and functional diversity of connexin genes in the mouse and human genome."
    Willecke K., Eiberger J., Degen J., Eckardt D., Romualdi A., Guldenagel M., Deutsch U., Soehl G.
    Biol. Chem. 383:725-737(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. "Differences in expression patterns between mouse connexin-30.2 (Cx30.2) and its putative human orthologue, connexin-31.9."
    Nielsen P.A., Kumar N.M.
    FEBS Lett. 540:151-156(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiCXD3_MOUSE
AccessioniPrimary (citable) accession number: Q91YD1
Secondary accession number(s): Q80ZH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 1, 2001
Last modified: July 22, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.