Gap junction delta-3 protein - Mus musculus (Mouse)

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Q91YD1 (CXD3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 73. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Gap junction delta-3 protein

Alternative name(s):
Connexin-30.2
Short name=Cx30.2
Gap junction alpha-11 protein
Gap junction chi-1 protein

Gene names

Name:	Gjd3
Synonyms:	Gja11, Gjc1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	278 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell By similarity.
Subunit structure	A connexon is composed of a hexamer of connexins By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity. Cell junction › gap junction By similarity.
Sequence similarities	Belongs to the connexin family. Delta-type subfamily.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Gap junction Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell communication Inferred from electronic annotation. Source: InterPro gap junction assembly Inferred from sequence or structural similarity PubMed 12154091. Source: UniProtKB
Cellular_component	cell surface Inferred from sequence or structural similarity PubMed 12154091. Source: UniProtKB connexon complex Inferred from sequence or structural similarity PubMed 12154091. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ion channel activity Inferred from direct assay PubMed 15879306. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 278

278

Gap junction delta-3 protein

PRO_0000313009

Regions

Topological domain

1 – 24

Cytoplasmic Potential

Transmembrane

25 – 45

Helical; Potential

Topological domain

46 – 76

Extracellular Potential

Transmembrane

77 – 97

Helical; Potential

Topological domain

98 – 136

Cytoplasmic Potential

Transmembrane

137 – 157

Helical; Potential

Topological domain

158 – 188

Extracellular Potential

Transmembrane

189 – 209

Helical; Potential

Topological domain

210 – 278

Cytoplasmic Potential

Experimental info

Sequence conflict

13 – 16

AVQL → PLQV in AAN65188. Ref.2

Sequence conflict

A → S in AAN65188. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

Q91YD1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: A8A3DC827D070DE9
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FASTA

278

30,220

        10         20         30         40         50         60 
MGEWAFLGSL LDAVQLQSPL VGRLWLVIML IFRILVLATV GGAVFEDEQE EFVCNTLQPG 

        70         80         90        100        110        120 
CRQTCYDRAF PVSHYRFWLF HILLLSAPPV LFVIYSMHQA SKEAGGAQLA PPCARGRAEA 

       130        140        150        160        170        180 
PCSPCALRAR RARRCYLLSV ALRLLAELAF LGGQALLYGF RVDPHYACAG PPCPHTVDCF 

       190        200        210        220        230        240 
VSRPTEKTVF VVFYFAVGLL SALLSVAELG HLLWKGRQRA KLLPPPPPSP SLPSQRGDPD 

       250        260        270 
PFGPPAYAHR SPAGDSEGEG GSGHSKASLA TVRQDLAI

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural and functional diversity of connexin genes in the mouse and human genome." Willecke K., Eiberger J., Degen J., Eckardt D., Romualdi A., Guldenagel M., Deutsch U., Soehl G. Biol. Chem. 383:725-737(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv.
[2]	"Differences in expression patterns between mouse connexin-30.2 (Cx30.2) and its putative human orthologue, connexin-31.9." Nielsen P.A., Kumar N.M. FEBS Lett. 540:151-156(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/Sv.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ414561 Genomic DNA. Translation: CAC93843.1. AY166870 Genomic DNA. Translation: AAN65188.1. AL591067 Genomic DNA. No translation available.
IPI	IPI00330948.
RefSeq	NP_848711.2. NM_178596.2.
UniGene	Mm.453253.
3D structure databases
ProteinModelPortal	Q91YD1.
SMR	Q91YD1. Positions 3-213.
ModBase	Search...
Proteomic databases
PRIDE	Q91YD1.
Protocols and materials databases
DNASU	353155.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000062931; ENSMUSP00000055246; ENSMUSG00000047197.
GeneID	353155.
KEGG	mmu:353155.
UCSC	uc007lib.1. mouse.
Organism-specific databases
CTD	125111.
MGI	MGI:2384150. Gjd3.
Phylogenomic databases
eggNOG	NOG41593.
GeneTree	ENSGT00700000104079.
HOGENOM	HOG000231127.
HOVERGEN	HBG009576.
InParanoid	Q91YD1.
KO	K07627.
OMA	ACAGPPC.
OrthoDB	EOG4XWFZR.
Gene expression databases
Bgee	Q91YD1.
CleanEx	MM_GJC1. MM_GJD3.
Genevestigator	Q91YD1.
Family and domain databases
InterPro	IPR000500. Connexin. IPR019570. Connexin_CCC. IPR017990. Connexin_CS. IPR013092. Connexin_N. [Graphical view]
PANTHER	PTHR11984. PTHR11984. 1 hit.
Pfam	PF00029. Connexin. 1 hit. PF10582. Connexin_CCC. 1 hit. [Graphical view]
PRINTS	PR00206. CONNEXIN.
SMART	SM00037. CNX. 1 hit. SM01089. Connexin_CCC. 1 hit. [Graphical view]
PROSITE	PS00408. CONNEXINS_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	400291.
SOURCE	Search...

Entry information

Entry name

CXD3_MOUSE

Accession

Primary (citable) accession number: Q91YD1
Secondary accession number(s): Q80ZH0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents