Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q91Y97

- ALDOB_MOUSE

UniProt

Q91Y97 - ALDOB_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Fructose-bisphosphate aldolase B

Gene

Aldob

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561Substrate
Binding sitei147 – 1471Substrate
Active sitei188 – 1881Proton acceptorBy similarity
Active sitei230 – 2301Schiff-base intermediate with dihydroxyacetone-P
Sitei364 – 3641Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

GO - Molecular functioni

  1. fructose binding Source: Ensembl
  2. fructose-bisphosphate aldolase activity Source: MGI

GO - Biological processi

  1. fructose 1,6-bisphosphate metabolic process Source: Ensembl
  2. fructose metabolic process Source: Ensembl
  3. glycolytic process Source: UniProtKB-UniPathway
  4. NADH oxidation Source: Ensembl
  5. positive regulation of ATPase activity Source: Ensembl
  6. vacuolar proton-transporting V-type ATPase complex assembly Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

ReactomeiREACT_230419. Fructose catabolism.
REACT_232322. Glycolysis.
REACT_263230. Gluconeogenesis.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase B (EC:4.1.2.13)
Alternative name(s):
Aldolase 2
Liver-type aldolase
Gene namesi
Name:Aldob
Synonyms:Aldo2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:87995. Aldob.

Subcellular locationi

GO - Cellular componenti

  1. centriolar satellite Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 364363Fructose-bisphosphate aldolase BPRO_0000216941Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei13 – 131N6-succinyllysine1 Publication
Modified residuei36 – 361Phosphoserine1 Publication
Modified residuei39 – 391Phosphothreonine1 Publication
Modified residuei121 – 1211N6-succinyllysine1 Publication
Modified residuei317 – 3171N6-succinyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ91Y97.
PaxDbiQ91Y97.
PRIDEiQ91Y97.

PTM databases

PhosphoSiteiQ91Y97.

Expressioni

Gene expression databases

BgeeiQ91Y97.
CleanExiMM_ALDOB.
ExpressionAtlasiQ91Y97. baseline and differential.
GenevestigatoriQ91Y97.

Interactioni

Subunit structurei

Homotetramer. Interacts with BBS1, BBS2, BBS4 and BBS7.By similarity

Protein-protein interaction databases

IntActiQ91Y97. 5 interactions.
MINTiMINT-1862169.
STRINGi10090.ENSMUSP00000029987.

Structurei

3D structure databases

ProteinModelPortaliQ91Y97.
SMRiQ91Y97. Positions 2-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3588.
GeneTreeiENSGT00390000010235.
HOGENOMiHOG000220876.
HOVERGENiHBG002386.
InParanoidiQ91Y97.
KOiK01623.
OMAiDMEHCQY.
OrthoDBiEOG744T94.
PhylomeDBiQ91Y97.
TreeFamiTF314203.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view]
PANTHERiPTHR11627. PTHR11627. 1 hit.
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91Y97-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAHRFPALTP EQKKELSEIA QRIVANGKGI LAADESVGTM GNRLQRIKVE
60 70 80 90 100
NTEENRRQFR ELLFSVDNSI SQSIGGVILF HETLYQKDSQ GNLFRNVLKE
110 120 130 140 150
KGIVVGIKLD QGGAPLAGTN KETTIQGLDG LSERCAQYKK DGVDFGKWRA
160 170 180 190 200
VLRIADQCPS SLAIQENANA LARYASICQQ NGLVPIVEPE VLPDGDHDLE
210 220 230 240 250
HCQYVSEKVL AAVYKALNDH HVYLEGTLLK PNMVTAGHAC TKKYTPEQVA
260 270 280 290 300
MATVTALHRT VPAAVPGICF LSGGMSEEDA TLNLNAINRC PLPRPWKLSF
310 320 330 340 350
SYGRALQASA LAAWGGKAAN KKATQEAFMK RAMANCQAAQ GQYVHTGSSG
360
AAATQSLFTA SYTY
Length:364
Mass (Da):39,507
Last modified:January 23, 2007 - v3
Checksum:iE6CD995D0073ED47
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811H → Y in AAH34173. (PubMed:15489334)Curated
Sequence conflicti155 – 1562AD → DH in AAL06323. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403567, AF403565, AF403566 Genomic DNA. Translation: AAL06323.1.
BC016435 mRNA. Translation: AAH16435.1.
BC022113 mRNA. Translation: AAH22113.1.
BC024056 mRNA. Translation: AAH24056.1.
BC024112 mRNA. Translation: AAH24112.1.
BC026577 mRNA. Translation: AAH26577.1.
BC030724 mRNA. Translation: AAH30724.1.
BC030725 mRNA. Translation: AAH30725.1.
BC034169 mRNA. Translation: AAH34169.1.
BC034171 mRNA. Translation: AAH34171.1.
BC034172 mRNA. Translation: AAH34172.1.
BC034173 mRNA. Translation: AAH34173.1.
BC036130 mRNA. Translation: AAH36130.1.
BC036131 mRNA. Translation: AAH36131.1.
BC036132 mRNA. Translation: AAH36132.1.
BC036133 mRNA. Translation: AAH36133.1.
CCDSiCCDS18176.1.
RefSeqiNP_659152.1. NM_144903.2.
UniGeneiMm.482116.

Genome annotation databases

EnsembliENSMUST00000029987; ENSMUSP00000029987; ENSMUSG00000028307.
GeneIDi230163.
KEGGimmu:230163.
UCSCiuc008svw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403567 , AF403565 , AF403566 Genomic DNA. Translation: AAL06323.1 .
BC016435 mRNA. Translation: AAH16435.1 .
BC022113 mRNA. Translation: AAH22113.1 .
BC024056 mRNA. Translation: AAH24056.1 .
BC024112 mRNA. Translation: AAH24112.1 .
BC026577 mRNA. Translation: AAH26577.1 .
BC030724 mRNA. Translation: AAH30724.1 .
BC030725 mRNA. Translation: AAH30725.1 .
BC034169 mRNA. Translation: AAH34169.1 .
BC034171 mRNA. Translation: AAH34171.1 .
BC034172 mRNA. Translation: AAH34172.1 .
BC034173 mRNA. Translation: AAH34173.1 .
BC036130 mRNA. Translation: AAH36130.1 .
BC036131 mRNA. Translation: AAH36131.1 .
BC036132 mRNA. Translation: AAH36132.1 .
BC036133 mRNA. Translation: AAH36133.1 .
CCDSi CCDS18176.1.
RefSeqi NP_659152.1. NM_144903.2.
UniGenei Mm.482116.

3D structure databases

ProteinModelPortali Q91Y97.
SMRi Q91Y97. Positions 2-349.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q91Y97. 5 interactions.
MINTi MINT-1862169.
STRINGi 10090.ENSMUSP00000029987.

PTM databases

PhosphoSitei Q91Y97.

Proteomic databases

MaxQBi Q91Y97.
PaxDbi Q91Y97.
PRIDEi Q91Y97.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029987 ; ENSMUSP00000029987 ; ENSMUSG00000028307 .
GeneIDi 230163.
KEGGi mmu:230163.
UCSCi uc008svw.1. mouse.

Organism-specific databases

CTDi 229.
MGIi MGI:87995. Aldob.

Phylogenomic databases

eggNOGi COG3588.
GeneTreei ENSGT00390000010235.
HOGENOMi HOG000220876.
HOVERGENi HBG002386.
InParanoidi Q91Y97.
KOi K01623.
OMAi DMEHCQY.
OrthoDBi EOG744T94.
PhylomeDBi Q91Y97.
TreeFami TF314203.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .
Reactomei REACT_230419. Fructose catabolism.
REACT_232322. Glycolysis.
REACT_263230. Gluconeogenesis.

Miscellaneous databases

ChiTaRSi Aldob. mouse.
NextBioi 379836.
PROi Q91Y97.
SOURCEi Search...

Gene expression databases

Bgeei Q91Y97.
CleanExi MM_ALDOB.
ExpressionAtlasi Q91Y97. baseline and differential.
Genevestigatori Q91Y97.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR029769. FBA_euk-type.
IPR000741. FBA_I.
[Graphical view ]
PANTHERi PTHR11627. PTHR11627. 1 hit.
Pfami PF00274. Glycolytic. 1 hit.
[Graphical view ]
PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse aldolase B (aldo2) genomic sequence of the open reading frame including first poly A site and signals."
    Funari V.A., Tolan D.R.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon, Kidney and Liver.
  3. Kanor S., Quadroni M., Bienvenut W.V.
    Submitted (MAR-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-12 AND 108-120, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Skeletal muscle.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36 AND THR-39, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-13; LYS-121 AND LYS-317, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiALDOB_MOUSE
AccessioniPrimary (citable) accession number: Q91Y97
Secondary accession number(s): Q8K034, Q91W73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In vertebrates, 3 forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3