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Q91Y97

- ALDOB_MOUSE

UniProt

Q91Y97 - ALDOB_MOUSE

Protein

Fructose-bisphosphate aldolase B

Gene

Aldob

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei56 – 561Substrate
    Binding sitei147 – 1471Substrate
    Active sitei188 – 1881Proton acceptorBy similarity
    Active sitei230 – 2301Schiff-base intermediate with dihydroxyacetone-P
    Sitei364 – 3641Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate

    GO - Molecular functioni

    1. fructose binding Source: Ensembl
    2. fructose-bisphosphate aldolase activity Source: MGI

    GO - Biological processi

    1. fructose 1,6-bisphosphate metabolic process Source: Ensembl
    2. fructose metabolic process Source: Ensembl
    3. glycolytic process Source: UniProtKB-UniPathway
    4. NADH oxidation Source: Ensembl
    5. positive regulation of ATPase activity Source: Ensembl
    6. vacuolar proton-transporting V-type ATPase complex assembly Source: Ensembl

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00183.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fructose-bisphosphate aldolase B (EC:4.1.2.13)
    Alternative name(s):
    Aldolase 2
    Liver-type aldolase
    Gene namesi
    Name:Aldob
    Synonyms:Aldo2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:87995. Aldob.

    Subcellular locationi

    GO - Cellular componenti

    1. centriolar satellite Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 364363Fructose-bisphosphate aldolase BPRO_0000216941Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei13 – 131N6-succinyllysine1 Publication
    Modified residuei36 – 361Phosphoserine1 Publication
    Modified residuei39 – 391Phosphothreonine1 Publication
    Modified residuei121 – 1211N6-succinyllysine1 Publication
    Modified residuei317 – 3171N6-succinyllysine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ91Y97.
    PaxDbiQ91Y97.
    PRIDEiQ91Y97.

    PTM databases

    PhosphoSiteiQ91Y97.

    Expressioni

    Gene expression databases

    BgeeiQ91Y97.
    CleanExiMM_ALDOB.
    GenevestigatoriQ91Y97.

    Interactioni

    Subunit structurei

    Homotetramer. Interacts with BBS1, BBS2, BBS4 and BBS7.By similarity

    Protein-protein interaction databases

    IntActiQ91Y97. 5 interactions.
    MINTiMINT-1862169.
    STRINGi10090.ENSMUSP00000029987.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91Y97.
    SMRiQ91Y97. Positions 2-349.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG3588.
    GeneTreeiENSGT00390000010235.
    HOGENOMiHOG000220876.
    HOVERGENiHBG002386.
    InParanoidiQ91Y97.
    KOiK01623.
    OMAiDMEHCQY.
    OrthoDBiEOG744T94.
    PhylomeDBiQ91Y97.
    TreeFamiTF314203.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view]
    PfamiPF00274. Glycolytic. 1 hit.
    [Graphical view]
    PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q91Y97-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHRFPALTP EQKKELSEIA QRIVANGKGI LAADESVGTM GNRLQRIKVE    50
    NTEENRRQFR ELLFSVDNSI SQSIGGVILF HETLYQKDSQ GNLFRNVLKE 100
    KGIVVGIKLD QGGAPLAGTN KETTIQGLDG LSERCAQYKK DGVDFGKWRA 150
    VLRIADQCPS SLAIQENANA LARYASICQQ NGLVPIVEPE VLPDGDHDLE 200
    HCQYVSEKVL AAVYKALNDH HVYLEGTLLK PNMVTAGHAC TKKYTPEQVA 250
    MATVTALHRT VPAAVPGICF LSGGMSEEDA TLNLNAINRC PLPRPWKLSF 300
    SYGRALQASA LAAWGGKAAN KKATQEAFMK RAMANCQAAQ GQYVHTGSSG 350
    AAATQSLFTA SYTY 364
    Length:364
    Mass (Da):39,507
    Last modified:January 23, 2007 - v3
    Checksum:iE6CD995D0073ED47
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti81 – 811H → Y in AAH34173. (PubMed:15489334)Curated
    Sequence conflicti155 – 1562AD → DH in AAL06323. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF403567, AF403565, AF403566 Genomic DNA. Translation: AAL06323.1.
    BC016435 mRNA. Translation: AAH16435.1.
    BC022113 mRNA. Translation: AAH22113.1.
    BC024056 mRNA. Translation: AAH24056.1.
    BC024112 mRNA. Translation: AAH24112.1.
    BC026577 mRNA. Translation: AAH26577.1.
    BC030724 mRNA. Translation: AAH30724.1.
    BC030725 mRNA. Translation: AAH30725.1.
    BC034169 mRNA. Translation: AAH34169.1.
    BC034171 mRNA. Translation: AAH34171.1.
    BC034172 mRNA. Translation: AAH34172.1.
    BC034173 mRNA. Translation: AAH34173.1.
    BC036130 mRNA. Translation: AAH36130.1.
    BC036131 mRNA. Translation: AAH36131.1.
    BC036132 mRNA. Translation: AAH36132.1.
    BC036133 mRNA. Translation: AAH36133.1.
    CCDSiCCDS18176.1.
    RefSeqiNP_659152.1. NM_144903.2.
    UniGeneiMm.482116.

    Genome annotation databases

    EnsembliENSMUST00000029987; ENSMUSP00000029987; ENSMUSG00000028307.
    GeneIDi230163.
    KEGGimmu:230163.
    UCSCiuc008svw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF403567 , AF403565 , AF403566 Genomic DNA. Translation: AAL06323.1 .
    BC016435 mRNA. Translation: AAH16435.1 .
    BC022113 mRNA. Translation: AAH22113.1 .
    BC024056 mRNA. Translation: AAH24056.1 .
    BC024112 mRNA. Translation: AAH24112.1 .
    BC026577 mRNA. Translation: AAH26577.1 .
    BC030724 mRNA. Translation: AAH30724.1 .
    BC030725 mRNA. Translation: AAH30725.1 .
    BC034169 mRNA. Translation: AAH34169.1 .
    BC034171 mRNA. Translation: AAH34171.1 .
    BC034172 mRNA. Translation: AAH34172.1 .
    BC034173 mRNA. Translation: AAH34173.1 .
    BC036130 mRNA. Translation: AAH36130.1 .
    BC036131 mRNA. Translation: AAH36131.1 .
    BC036132 mRNA. Translation: AAH36132.1 .
    BC036133 mRNA. Translation: AAH36133.1 .
    CCDSi CCDS18176.1.
    RefSeqi NP_659152.1. NM_144903.2.
    UniGenei Mm.482116.

    3D structure databases

    ProteinModelPortali Q91Y97.
    SMRi Q91Y97. Positions 2-349.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q91Y97. 5 interactions.
    MINTi MINT-1862169.
    STRINGi 10090.ENSMUSP00000029987.

    PTM databases

    PhosphoSitei Q91Y97.

    Proteomic databases

    MaxQBi Q91Y97.
    PaxDbi Q91Y97.
    PRIDEi Q91Y97.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029987 ; ENSMUSP00000029987 ; ENSMUSG00000028307 .
    GeneIDi 230163.
    KEGGi mmu:230163.
    UCSCi uc008svw.1. mouse.

    Organism-specific databases

    CTDi 229.
    MGIi MGI:87995. Aldob.

    Phylogenomic databases

    eggNOGi COG3588.
    GeneTreei ENSGT00390000010235.
    HOGENOMi HOG000220876.
    HOVERGENi HBG002386.
    InParanoidi Q91Y97.
    KOi K01623.
    OMAi DMEHCQY.
    OrthoDBi EOG744T94.
    PhylomeDBi Q91Y97.
    TreeFami TF314203.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00183 .

    Miscellaneous databases

    ChiTaRSi ALDOB. mouse.
    NextBioi 379836.
    PROi Q91Y97.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q91Y97.
    CleanExi MM_ALDOB.
    Genevestigatori Q91Y97.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR000741. FBA_I.
    [Graphical view ]
    Pfami PF00274. Glycolytic. 1 hit.
    [Graphical view ]
    PROSITEi PS00158. ALDOLASE_CLASS_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse aldolase B (aldo2) genomic sequence of the open reading frame including first poly A site and signals."
      Funari V.A., Tolan D.R.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon, Kidney and Liver.
    3. Kanor S., Quadroni M., Bienvenut W.V.
      Submitted (MAR-2006) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-12 AND 108-120, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6J.
      Tissue: Skeletal muscle.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36 AND THR-39, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-13; LYS-121 AND LYS-317, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiALDOB_MOUSE
    AccessioniPrimary (citable) accession number: Q91Y97
    Secondary accession number(s): Q8K034, Q91W73
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 23, 2003
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 113 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    In vertebrates, 3 forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3