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Protein

Fructose-bisphosphate aldolase B

Gene

Aldob

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (Gpi), Glucose-6-phosphate isomerase (Gpi1), Glucose-6-phosphate isomerase (Gpi1), Glucose-6-phosphate isomerase (Gpi1)
  3. ATP-dependent 6-phosphofructokinase, liver type (Pfkl), ATP-dependent 6-phosphofructokinase (Pfkp), ATP-dependent 6-phosphofructokinase (Pfkm), ATP-dependent 6-phosphofructokinase, platelet type (Pfkp), ATP-dependent 6-phosphofructokinase, muscle type (Pfkm)
  4. Fructose-bisphosphate aldolase (Aldoa), Fructose-bisphosphate aldolase (Aldoart1), Fructose-bisphosphate aldolase (Aldoa), Fructose-bisphosphate aldolase (Aldoart2), Fructose-bisphosphate aldolase (Aldoart1), Fructose-bisphosphate aldolase (Aldoa), Fructose-bisphosphate aldolase (Aldoa), Fructose-bisphosphate aldolase (Aldob), Fructose-bisphosphate aldolase C (Aldoc), Fructose-bisphosphate aldolase A (Aldoa), Fructose-bisphosphate aldolase B (Aldob), Fructose-bisphosphate aldolase (Aldob)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei56Substrate1
Binding sitei147Substrate1
Active sitei188Proton acceptorBy similarity1
Active sitei230Schiff-base intermediate with dihydroxyacetone-P1
Sitei364Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate1

GO - Molecular functioni

  • ATPase binding Source: MGI
  • cytoskeletal protein binding Source: MGI
  • fructose-1-phosphate aldolase activity Source: MGI
  • fructose binding Source: MGI
  • fructose-bisphosphate aldolase activity Source: MGI
  • identical protein binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

ReactomeiR-MMU-70171. Glycolysis.
R-MMU-70263. Gluconeogenesis.
R-MMU-70350. Fructose catabolism.
UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-bisphosphate aldolase B (EC:4.1.2.13)
Alternative name(s):
Aldolase 2
Liver-type aldolase
Gene namesi
Name:Aldob
Synonyms:Aldo2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:87995. Aldob.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002169412 – 364Fructose-bisphosphate aldolase BAdd BLAST363

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei13N6-succinyllysineCombined sources1
Modified residuei36PhosphoserineCombined sources1
Modified residuei39PhosphothreonineCombined sources1
Modified residuei89PhosphoserineBy similarity1
Modified residuei119PhosphothreonineBy similarity1
Modified residuei121N6-succinyllysineCombined sources1
Modified residuei132PhosphoserineBy similarity1
Modified residuei206PhosphoserineCombined sources1
Modified residuei272PhosphoserineBy similarity1
Modified residuei276PhosphoserineBy similarity1
Modified residuei299PhosphoserineBy similarity1
Modified residuei301PhosphoserineBy similarity1
Modified residuei309PhosphoserineBy similarity1
Modified residuei317N6-succinyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ91Y97.
PaxDbiQ91Y97.
PeptideAtlasiQ91Y97.
PRIDEiQ91Y97.

PTM databases

iPTMnetiQ91Y97.
PhosphoSitePlusiQ91Y97.
SwissPalmiQ91Y97.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028307.
CleanExiMM_ALDOB.
ExpressionAtlasiQ91Y97. baseline and differential.
GenevisibleiQ91Y97. MM.

Interactioni

Subunit structurei

Homotetramer. Interacts with BBS1, BBS2, BBS4 and BBS7.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ91Y97. 5 interactors.
MINTiMINT-1862169.
STRINGi10090.ENSMUSP00000029987.

Structurei

3D structure databases

ProteinModelPortaliQ91Y97.
SMRiQ91Y97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1557. Eukaryota.
COG3588. LUCA.
GeneTreeiENSGT00390000010235.
HOGENOMiHOG000220876.
HOVERGENiHBG002386.
InParanoidiQ91Y97.
KOiK01623.
OMAiANCQAAQ.
OrthoDBiEOG091G0A9T.
PhylomeDBiQ91Y97.
TreeFamiTF314203.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91Y97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHRFPALTP EQKKELSEIA QRIVANGKGI LAADESVGTM GNRLQRIKVE
60 70 80 90 100
NTEENRRQFR ELLFSVDNSI SQSIGGVILF HETLYQKDSQ GNLFRNVLKE
110 120 130 140 150
KGIVVGIKLD QGGAPLAGTN KETTIQGLDG LSERCAQYKK DGVDFGKWRA
160 170 180 190 200
VLRIADQCPS SLAIQENANA LARYASICQQ NGLVPIVEPE VLPDGDHDLE
210 220 230 240 250
HCQYVSEKVL AAVYKALNDH HVYLEGTLLK PNMVTAGHAC TKKYTPEQVA
260 270 280 290 300
MATVTALHRT VPAAVPGICF LSGGMSEEDA TLNLNAINRC PLPRPWKLSF
310 320 330 340 350
SYGRALQASA LAAWGGKAAN KKATQEAFMK RAMANCQAAQ GQYVHTGSSG
360
AAATQSLFTA SYTY
Length:364
Mass (Da):39,507
Last modified:January 23, 2007 - v3
Checksum:iE6CD995D0073ED47
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81H → Y in AAH34173 (PubMed:15489334).Curated1
Sequence conflicti155 – 156AD → DH in AAL06323 (Ref. 1) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403567, AF403565, AF403566 Genomic DNA. Translation: AAL06323.1.
BC016435 mRNA. Translation: AAH16435.1.
BC022113 mRNA. Translation: AAH22113.1.
BC024056 mRNA. Translation: AAH24056.1.
BC024112 mRNA. Translation: AAH24112.1.
BC026577 mRNA. Translation: AAH26577.1.
BC030724 mRNA. Translation: AAH30724.1.
BC030725 mRNA. Translation: AAH30725.1.
BC034169 mRNA. Translation: AAH34169.1.
BC034171 mRNA. Translation: AAH34171.1.
BC034172 mRNA. Translation: AAH34172.1.
BC034173 mRNA. Translation: AAH34173.1.
BC036130 mRNA. Translation: AAH36130.1.
BC036131 mRNA. Translation: AAH36131.1.
BC036132 mRNA. Translation: AAH36132.1.
BC036133 mRNA. Translation: AAH36133.1.
CCDSiCCDS18176.1.
RefSeqiNP_659152.1. NM_144903.3.
UniGeneiMm.482116.

Genome annotation databases

EnsembliENSMUST00000029987; ENSMUSP00000029987; ENSMUSG00000028307.
GeneIDi230163.
KEGGimmu:230163.
UCSCiuc008svw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403567, AF403565, AF403566 Genomic DNA. Translation: AAL06323.1.
BC016435 mRNA. Translation: AAH16435.1.
BC022113 mRNA. Translation: AAH22113.1.
BC024056 mRNA. Translation: AAH24056.1.
BC024112 mRNA. Translation: AAH24112.1.
BC026577 mRNA. Translation: AAH26577.1.
BC030724 mRNA. Translation: AAH30724.1.
BC030725 mRNA. Translation: AAH30725.1.
BC034169 mRNA. Translation: AAH34169.1.
BC034171 mRNA. Translation: AAH34171.1.
BC034172 mRNA. Translation: AAH34172.1.
BC034173 mRNA. Translation: AAH34173.1.
BC036130 mRNA. Translation: AAH36130.1.
BC036131 mRNA. Translation: AAH36131.1.
BC036132 mRNA. Translation: AAH36132.1.
BC036133 mRNA. Translation: AAH36133.1.
CCDSiCCDS18176.1.
RefSeqiNP_659152.1. NM_144903.3.
UniGeneiMm.482116.

3D structure databases

ProteinModelPortaliQ91Y97.
SMRiQ91Y97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91Y97. 5 interactors.
MINTiMINT-1862169.
STRINGi10090.ENSMUSP00000029987.

PTM databases

iPTMnetiQ91Y97.
PhosphoSitePlusiQ91Y97.
SwissPalmiQ91Y97.

Proteomic databases

MaxQBiQ91Y97.
PaxDbiQ91Y97.
PeptideAtlasiQ91Y97.
PRIDEiQ91Y97.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029987; ENSMUSP00000029987; ENSMUSG00000028307.
GeneIDi230163.
KEGGimmu:230163.
UCSCiuc008svw.1. mouse.

Organism-specific databases

CTDi229.
MGIiMGI:87995. Aldob.

Phylogenomic databases

eggNOGiKOG1557. Eukaryota.
COG3588. LUCA.
GeneTreeiENSGT00390000010235.
HOGENOMiHOG000220876.
HOVERGENiHBG002386.
InParanoidiQ91Y97.
KOiK01623.
OMAiANCQAAQ.
OrthoDBiEOG091G0A9T.
PhylomeDBiQ91Y97.
TreeFamiTF314203.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.
ReactomeiR-MMU-70171. Glycolysis.
R-MMU-70263. Gluconeogenesis.
R-MMU-70350. Fructose catabolism.

Miscellaneous databases

ChiTaRSiAldob. mouse.
PROiQ91Y97.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028307.
CleanExiMM_ALDOB.
ExpressionAtlasiQ91Y97. baseline and differential.
GenevisibleiQ91Y97. MM.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR029768. Aldolase_I_AS.
IPR013785. Aldolase_TIM.
IPR000741. FBA_I.
[Graphical view]
PfamiPF00274. Glycolytic. 1 hit.
[Graphical view]
PROSITEiPS00158. ALDOLASE_CLASS_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALDOB_MOUSE
AccessioniPrimary (citable) accession number: Q91Y97
Secondary accession number(s): Q8K034, Q91W73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In vertebrates, 3 forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.