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Protein

Cytochrome c oxidase subunit 4 isoform 2, mitochondrial

Gene

Cox4i2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: RGD

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial
Alternative name(s):
Cytochrome c oxidase subunit IV isoform 2
Short name:
COX IV-2
Gene namesi
Name:Cox4i2
Synonyms:Cox4b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi69422 Cox4i2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000006091? – 172Cytochrome c oxidase subunit 4 isoform 2, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 55Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ91Y94
PRIDEiQ91Y94

PTM databases

iPTMnetiQ91Y94
PhosphoSitePlusiQ91Y94

Expressioni

Tissue specificityi

Highly expressed in lung.

Gene expression databases

BgeeiENSRNOG00000007827
GenevisibleiQ91Y94 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010418

Structurei

3D structure databases

ProteinModelPortaliQ91Y94
SMRiQ91Y94
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase IV family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4075 Eukaryota
ENOG4111T97 LUCA
GeneTreeiENSGT00390000002407
HOGENOMiHOG000231486
HOVERGENiHBG051087
InParanoidiQ91Y94
KOiK02263
OMAiLVIWWQR
OrthoDBiEOG091G0XDH
PhylomeDBiQ91Y94
TreeFamiTF105061

Family and domain databases

CDDicd00922 Cyt_c_Oxidase_IV, 1 hit
Gene3Di1.10.442.10, 1 hit
InterProiView protein in InterPro
IPR013288 Cyt_c_oxidase_su4
IPR004203 Cyt_c_oxidase_su4_fam
IPR036639 Cyt_c_oxidase_su4_sf
PANTHERiPTHR10707 PTHR10707, 1 hit
PfamiView protein in Pfam
PF02936 COX4, 1 hit
PRINTSiPR01873 CYTCOXIDASE4
SUPFAMiSSF81406 SSF81406, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91Y94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSRATRSLV MKTGGLRTQG THSPGSAASS SQRRMTPYVD CYAQRSYPMP
60 70 80 90 100
DEPYCTELSE EQRALKEKEK GSWAQLSQAE KVALYRLQFH ETFAEMNHRS
110 120 130 140 150
NEWKTVMGCV FFFIGFTALV IWWQRVYVFP KKVVTLTEER KAQQLQRLLD
160 170
MKSNPIQGLS AHWDYEKKEW KK
Length:172
Mass (Da):20,170
Last modified:December 1, 2001 - v1
Checksum:iFBBF5527F83E7EF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255347 mRNA Translation: AAK49191.1
RefSeqiNP_445924.1, NM_053472.1
XP_006235342.1, XM_006235280.3
XP_017447569.1, XM_017592080.1
UniGeneiRn.7214

Genome annotation databases

EnsembliENSRNOT00000010418; ENSRNOP00000010418; ENSRNOG00000007827
GeneIDi84683
KEGGirno:84683
UCSCiRGD:69422 rat

Similar proteinsi

Entry informationi

Entry nameiCOX42_RAT
AccessioniPrimary (citable) accession number: Q91Y94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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