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Protein

Cytochrome c oxidase subunit 4 isoform 2, mitochondrial

Gene

Cox4i2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 4 isoform 2, mitochondrial
Alternative name(s):
Cytochrome c oxidase subunit IV isoform 2
Short name:
COX IV-2
Gene namesi
Name:Cox4i2
Synonyms:Cox4b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi69422. Cox4i2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial respiratory chain complex IV Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 172Cytochrome c oxidase subunit 4 isoform 2, mitochondrialPRO_0000006091
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi41 ↔ 55Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ91Y94.
PRIDEiQ91Y94.

Expressioni

Tissue specificityi

Highly expressed in lung.

Gene expression databases

GenevisibleiQ91Y94. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010418.

Structurei

3D structure databases

ProteinModelPortaliQ91Y94.
SMRiQ91Y94. Positions 37-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase IV family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4075. Eukaryota.
ENOG4111T97. LUCA.
GeneTreeiENSGT00390000002407.
HOGENOMiHOG000231486.
HOVERGENiHBG051087.
InParanoidiQ91Y94.
KOiK02263.
OMAiDYERKEW.
OrthoDBiEOG7BKCWF.
PhylomeDBiQ91Y94.
TreeFamiTF105061.

Family and domain databases

Gene3Di1.10.442.10. 1 hit.
InterProiIPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PANTHERiPTHR10707. PTHR10707. 1 hit.
PfamiPF02936. COX4. 1 hit.
[Graphical view]
PRINTSiPR01873. CYTCOXIDASE4.
SUPFAMiSSF81406. SSF81406. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91Y94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSRATRSLV MKTGGLRTQG THSPGSAASS SQRRMTPYVD CYAQRSYPMP
60 70 80 90 100
DEPYCTELSE EQRALKEKEK GSWAQLSQAE KVALYRLQFH ETFAEMNHRS
110 120 130 140 150
NEWKTVMGCV FFFIGFTALV IWWQRVYVFP KKVVTLTEER KAQQLQRLLD
160 170
MKSNPIQGLS AHWDYEKKEW KK
Length:172
Mass (Da):20,170
Last modified:December 1, 2001 - v1
Checksum:iFBBF5527F83E7EF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255347 mRNA. Translation: AAK49191.1.
RefSeqiNP_445924.1. NM_053472.1.
XP_006235342.1. XM_006235280.2.
UniGeneiRn.7214.

Genome annotation databases

EnsembliENSRNOT00000010418; ENSRNOP00000010418; ENSRNOG00000007827.
GeneIDi84683.
KEGGirno:84683.
UCSCiRGD:69422. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255347 mRNA. Translation: AAK49191.1.
RefSeqiNP_445924.1. NM_053472.1.
XP_006235342.1. XM_006235280.2.
UniGeneiRn.7214.

3D structure databases

ProteinModelPortaliQ91Y94.
SMRiQ91Y94. Positions 37-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010418.

Proteomic databases

PaxDbiQ91Y94.
PRIDEiQ91Y94.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010418; ENSRNOP00000010418; ENSRNOG00000007827.
GeneIDi84683.
KEGGirno:84683.
UCSCiRGD:69422. rat.

Organism-specific databases

CTDi84701.
RGDi69422. Cox4i2.

Phylogenomic databases

eggNOGiKOG4075. Eukaryota.
ENOG4111T97. LUCA.
GeneTreeiENSGT00390000002407.
HOGENOMiHOG000231486.
HOVERGENiHBG051087.
InParanoidiQ91Y94.
KOiK02263.
OMAiDYERKEW.
OrthoDBiEOG7BKCWF.
PhylomeDBiQ91Y94.
TreeFamiTF105061.

Miscellaneous databases

NextBioi617266.
PROiQ91Y94.

Gene expression databases

GenevisibleiQ91Y94. RN.

Family and domain databases

Gene3Di1.10.442.10. 1 hit.
InterProiIPR013288. Cyt_c_oxidase_su4.
IPR004203. Cyt_c_oxidase_su4_fam.
[Graphical view]
PANTHERiPTHR10707. PTHR10707. 1 hit.
PfamiPF02936. COX4. 1 hit.
[Graphical view]
PRINTSiPR01873. CYTCOXIDASE4.
SUPFAMiSSF81406. SSF81406. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Mammalian subunit IV isoforms of cytochrome c oxidase."
    Huettemann M., Kadenbach B., Grossman L.I.
    Gene 267:111-123(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCOX42_RAT
AccessioniPrimary (citable) accession number: Q91Y94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.