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Protein

SH3 domain-binding protein 5

Gene

Sh3bp5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death (By similarity).By similarity

GO - Molecular functioni

  • protein kinase inhibitor activity Source: GO_Central
  • SH3 domain binding Source: RGD

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 domain-binding protein 5
Short name:
SH3BP-5
Alternative name(s):
Vascular endothelial cell-specific protein 18
Gene namesi
Name:Sh3bp5
Synonyms:Sab, Vesp18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi620220. Sh3bp5.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi353 – 3531S → A: Large decrease in phosphorylation by SAPK3. 1 Publication
Mutagenesisi423 – 4231S → A: Slight decrease in phosphorylation by SAPK3. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457SH3 domain-binding protein 5PRO_0000064370Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei353 – 3531Phosphoserine; by MAPK12 and MAPK91 Publication
Modified residuei377 – 3771PhosphoserineBy similarity
Modified residuei378 – 3781PhosphoserineBy similarity
Modified residuei420 – 4201PhosphoserineCombined sources
Modified residuei423 – 4231Phosphoserine; by MAPK12Combined sources1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ91Y80.
PRIDEiQ91Y80.

PTM databases

iPTMnetiQ91Y80.
PhosphoSiteiQ91Y80.

Expressioni

Gene expression databases

GenevisibleiQ91Y80. RN.

Interactioni

Subunit structurei

Interacts with BTK (PubMed:15158451). Interacts with all isoforms of MAPK8, MAPK9, MAPK10 and MAPK12 (PubMed:15158451). Interacts with GDP-bound and nucleotide-free forms of RAB11A (By similarity).By similarity1 Publication

GO - Molecular functioni

  • SH3 domain binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026389.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi11 – 6959Glu-richAdd
BLAST
Compositional biasi38 – 425Poly-Glu

Sequence similaritiesi

Belongs to the SH3BP5 family.Curated

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiKOG2008. Eukaryota.
ENOG410ZK48. LUCA.
GeneTreeiENSGT00390000018500.
HOGENOMiHOG000212681.
HOVERGENiHBG018168.
InParanoidiQ91Y80.
OMAiPECEAER.
OrthoDBiEOG75F4FK.
PhylomeDBiQ91Y80.
TreeFamiTF105573.

Family and domain databases

InterProiIPR007940. SH3BP5.
[Graphical view]
PANTHERiPTHR19423. PTHR19423. 1 hit.
PfamiPF05276. SH3BP5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91Y80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTALKRSRS EEPVELPPPA REAEEKEEEE ERMEQGLEEE EEVDPRIQGE
60 70 80 90 100
LEKLNQSTDD INRRETELED ARQKFRSVLV EATVKLDELA KKIGKAVEDS
110 120 130 140 150
KPYWEARRVA RQAQLEAQKA TQDFQRATEV LRAAKETISL AEQRLLEDDK
160 170 180 190 200
RQFDSAWQEM LNHATQRVME AEQTKTRSEL VHKETAARYN AAMGRMRQLE
210 220 230 240 250
KKLKRAINKS KPYFELKAKY YVQLEQLKKT VDDLQAKLAL AKGEYKAALK
260 270 280 290 300
SLERISDEIH ERRRSNAMGP RGCGVGAEGS ITSVENLPAS KPEPDAISVA
310 320 330 340 350
SEAFEDDNCG NLVSEDDSET QSVSSFSSGP TSPSEMPDQF PAVARPGSLD
360 370 380 390 400
LPSPVSLSEF GMMFPILGPR SECSGASSPE CEVERGDRAE GAENKMSDKA
410 420 430 440 450
NNNRVLSSTS AGGGRSRSQS STSLEGQALE TRMKQLSLQC SKGREGIIAD

IKTVQIG
Length:457
Mass (Da):50,829
Last modified:January 23, 2007 - v2
Checksum:i68339F6993950B7C
GO

Sequence cautioni

The sequence BAB47152.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027562 mRNA. Translation: BAB47152.1. Different initiation.
RefSeqiNP_446463.2. NM_054011.1.
UniGeneiRn.163321.

Genome annotation databases

EnsembliENSRNOT00000082172; ENSRNOP00000071111; ENSRNOG00000052391.
GeneIDi117186.
KEGGirno:117186.
UCSCiRGD:620220. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB027562 mRNA. Translation: BAB47152.1. Different initiation.
RefSeqiNP_446463.2. NM_054011.1.
UniGeneiRn.163321.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026389.

PTM databases

iPTMnetiQ91Y80.
PhosphoSiteiQ91Y80.

Proteomic databases

PaxDbiQ91Y80.
PRIDEiQ91Y80.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000082172; ENSRNOP00000071111; ENSRNOG00000052391.
GeneIDi117186.
KEGGirno:117186.
UCSCiRGD:620220. rat.

Organism-specific databases

CTDi9467.
RGDi620220. Sh3bp5.

Phylogenomic databases

eggNOGiKOG2008. Eukaryota.
ENOG410ZK48. LUCA.
GeneTreeiENSGT00390000018500.
HOGENOMiHOG000212681.
HOVERGENiHBG018168.
InParanoidiQ91Y80.
OMAiPECEAER.
OrthoDBiEOG75F4FK.
PhylomeDBiQ91Y80.
TreeFamiTF105573.

Miscellaneous databases

PROiQ91Y80.

Gene expression databases

GenevisibleiQ91Y80. RN.

Family and domain databases

InterProiIPR007940. SH3BP5.
[Graphical view]
PANTHERiPTHR19423. PTHR19423. 1 hit.
PfamiPF05276. SH3BP5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of VESP18, a vascular endothelial cell specific protein."
    Aoki T., Toyoda H., Nishimoto S., Tawara J., Komurasaki T.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "Phosphorylation of the mitochondrial protein Sab by stress-activated protein kinase 3."
    Court N.W., Kuo I., Quigley O., Bogoyevitch M.A.
    Biochem. Biophys. Res. Commun. 319:130-137(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MAPK9 AND MAPK12, PHOSPHORYLATION AT SER-353 AND SER-423, SUBCELLULAR LOCATION, MUTAGENESIS OF SER-353 AND SER-423.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-420 AND SER-423, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry namei3BP5_RAT
AccessioniPrimary (citable) accession number: Q91Y80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.