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Protein

Monocarboxylate transporter 10

Gene

Slc16a10

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-independent transporter that mediates the uptake of aromatic acids. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.1.13.2. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 10
Short name:
MCT 10
Alternative name(s):
Aromatic amino acid transporter 1
Solute carrier family 16 member 10
T-type amino acid transporter 1
Gene namesi
Name:Slc16a10
Synonyms:Mct10, Tat1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69197. Slc16a10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6565CytoplasmicSequence analysisAdd
BLAST
Transmembranei66 – 8621HelicalSequence analysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence analysisAdd
BLAST
Transmembranei144 – 16421HelicalSequence analysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence analysisAdd
BLAST
Transmembranei200 – 22021HelicalSequence analysisAdd
BLAST
Transmembranei228 – 24821HelicalSequence analysisAdd
BLAST
Transmembranei291 – 31121HelicalSequence analysisAdd
BLAST
Transmembranei329 – 34921HelicalSequence analysisAdd
BLAST
Transmembranei351 – 37121HelicalSequence analysisAdd
BLAST
Transmembranei396 – 41621HelicalSequence analysisAdd
BLAST
Transmembranei419 – 43921HelicalSequence analysisAdd
BLAST
Transmembranei451 – 47121HelicalSequence analysisAdd
BLAST
Topological domaini472 – 51443CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2073717.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Monocarboxylate transporter 10PRO_0000314255Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei262 – 2621PhosphoserineCombined sources
Modified residuei497 – 4971PhosphoserineCombined sources
Modified residuei500 – 5001PhosphoserineBy similarity
Modified residuei502 – 5021PhosphoserineBy similarity
Modified residuei503 – 5031PhosphoserineCombined sources

Post-translational modificationi

Not N-glycosylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ91Y77.
PRIDEiQ91Y77.

PTM databases

iPTMnetiQ91Y77.

Expressioni

Tissue specificityi

Strongly expressed in intestine, placenta and liver. In small intestine is detected in the basolateral membrane (at protein level).1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000718.

Chemistry

BindingDBiQ91Y77.

Structurei

3D structure databases

ProteinModelPortaliQ91Y77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IMVX. Eukaryota.
ENOG410XRHC. LUCA.
HOGENOMiHOG000046644.
HOVERGENiHBG006387.
InParanoidiQ91Y77.
KOiK08187.
PhylomeDBiQ91Y77.

Family and domain databases

InterProiIPR030762. MCT10.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF119. PTHR11360:SF119. 1 hit.
PfamiPF07690. MFS_1. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91Y77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPSLEEPAA AERETNEAQP PGPAPSDDAP LPVPGPSDVS DGSVEKVEVE
60 70 80 90 100
LTRSTGNQEP PEPPEGGWGW LVMLAAMWCN GSVFGIQNAY GVLFVSMLET
110 120 130 140 150
FGAKDDDNMA FKAAWVGSLS MGMIFFCCPI VSVFTDMFGC RRTAVLGAAV
160 170 180 190 200
GFVGLMSSSF VSSIEPLYFT YGVVFACGCS FAYQPSLVIL GHYFKKRLGL
210 220 230 240 250
VNGIVTAGSS VFTILLPLLL GNLTSTVGLC YTLRILCIFM FVLFLAGFTY
260 270 280 290 300
RPLVPSSKEK ESEDSRSSFF SRRKLSPPKK IFNFALFKET AYAVWAAGIP
310 320 330 340 350
LALFGYFVPY VHLMNHVKER FKDVNNKEVL FMCIGVTSGV GRLLFGRIAD
360 370 380 390 400
YLPGVKKVYL QVLSFFFIGL TSMMIPLCSV FGALIALCLI MGLFDGCFIS
410 420 430 440 450
IMAPIAFELV GPQDASQAIG FLLGFMSIPM TVGPPVAGLL HDKLGSYDLA
460 470 480 490 500
FYLAGIPPFI GGAVLCLIPW IHSKKQREIS KNTGGEKMEK MLANQSSLLS
510
SSSGIFKKES DSII
Length:514
Mass (Da):55,663
Last modified:December 1, 2001 - v1
Checksum:i3AB082C0AE3B80A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047324 mRNA. Translation: BAB55595.1.
RefSeqiNP_620186.1. NM_138831.1.
UniGeneiRn.21992.

Genome annotation databases

GeneIDi170566.
KEGGirno:170566.
UCSCiRGD:69197. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047324 mRNA. Translation: BAB55595.1.
RefSeqiNP_620186.1. NM_138831.1.
UniGeneiRn.21992.

3D structure databases

ProteinModelPortaliQ91Y77.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000718.

Chemistry

BindingDBiQ91Y77.
ChEMBLiCHEMBL2073717.

Protein family/group databases

TCDBi2.A.1.13.2. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiQ91Y77.

Proteomic databases

PaxDbiQ91Y77.
PRIDEiQ91Y77.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi170566.
KEGGirno:170566.
UCSCiRGD:69197. rat.

Organism-specific databases

CTDi117247.
RGDi69197. Slc16a10.

Phylogenomic databases

eggNOGiENOG410IMVX. Eukaryota.
ENOG410XRHC. LUCA.
HOGENOMiHOG000046644.
HOVERGENiHBG006387.
InParanoidiQ91Y77.
KOiK08187.
PhylomeDBiQ91Y77.

Miscellaneous databases

PROiQ91Y77.

Family and domain databases

InterProiIPR030762. MCT10.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF119. PTHR11360:SF119. 1 hit.
PfamiPF07690. MFS_1. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters."
    Kim D.K., Kanai Y., Chairoungdua A., Matsuo H., Cha S.H., Endou H.
    J. Biol. Chem. 276:17221-17228(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Small intestine.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-262; SER-497 AND SER-503, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMOT10_RAT
AccessioniPrimary (citable) accession number: Q91Y77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.