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Protein

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

Gene

St3gal4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

It may catalyze the formation of the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- or NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc-sequences found in terminal carbohydrate groups of glycoproteins and glycolipids.By similarity

Catalytic activityi

CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.99.4. 3474.
ReactomeiR-MMU-2022854. Keratan sulfate biosynthesis.
R-MMU-4085001. Sialic acid metabolism.
R-MMU-975577. N-Glycan antennae elongation.
R-MMU-977068. Termination of O-glycan biosynthesis.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 (EC:2.4.99.-)
Short name:
Alpha 2,3-ST 4
Short name:
Beta-galactoside alpha-2,3-sialyltransferase 4
Alternative name(s):
Alpha 2,3-sialyltransferase IV
Gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase
ST3Gal IV
Short name:
ST3GalIV
Sialyltransferase 4C
Short name:
SIAT4-C
Gene namesi
Name:St3gal4
Synonyms:Siat4c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1316743. St3gal4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 26Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST18
Topological domaini27 – 333LumenalSequence analysisAdd BLAST307

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001492631 – 333CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4Add BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi61N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi120 ↔ 273By similarity
Glycosylationi131N-linked (GlcNAc...)Sequence analysis1
Glycosylationi310N-linked (GlcNAc...)Sequence analysis1
Glycosylationi329N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ91Y74.
MaxQBiQ91Y74.
PaxDbiQ91Y74.
PRIDEiQ91Y74.

PTM databases

iPTMnetiQ91Y74.
PhosphoSitePlusiQ91Y74.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032038.
GenevisibleiQ91Y74. MM.

Interactioni

Protein-protein interaction databases

MINTiMINT-1858706.
STRINGi10090.ENSMUSP00000034537.

Structurei

3D structure databases

ProteinModelPortaliQ91Y74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
GeneTreeiENSGT00760000119095.
HOGENOMiHOG000000682.
HOVERGENiHBG056676.
InParanoidiQ91Y74.
KOiK03494.
OMAiIHYYEQI.
OrthoDBiEOG091G098L.
PhylomeDBiQ91Y74.
TreeFamiTF354325.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91Y74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSKSHWKLL ALALVLVVVM VWYSISREDR YIEFFYFPIS EKKEPCFQGE
60 70 80 90 100
AERQASKIFG NRSREQPIFL QLKDYFWVKT PSTYELPFGT KGSEDLLLRV
110 120 130 140 150
LAITSYSIPE SIKSLECRRC VVVGNGHRLR NSSLGGVINK YDVVIRLNNA
160 170 180 190 200
PVAGYEGDVG SKTTIRLFYP ESAHFDPKIE NNPDTLLVLV AFKAMDFHWI
210 220 230 240 250
ETILSDKKRV RKGFWKQPPL IWDVNPKQVR ILNPFFMEIA ADKLLSLPIQ
260 270 280 290 300
QPRKIKQKPT TGLLAITLAL HLCDLVHIAG FGYPDASNKK QTIHYYEQIT
310 320 330
LKSMAGSGHN VSQEAIAIKR MLEMGAVKNL TYF
Length:333
Mass (Da):38,058
Last modified:December 1, 2001 - v1
Checksum:i4EAB2F09502B54F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB061305 mRNA. Translation: BAB47508.1.
BC050773 mRNA. Translation: AAH50773.1.
CCDSiCCDS22956.1.
RefSeqiNP_033204.2. NM_009178.3.
XP_011240735.1. XM_011242433.1.
UniGeneiMm.275973.

Genome annotation databases

EnsembliENSMUST00000034537; ENSMUSP00000034537; ENSMUSG00000032038.
GeneIDi20443.
KEGGimmu:20443.
UCSCiuc009osm.1. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

ST3Gal IV

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB061305 mRNA. Translation: BAB47508.1.
BC050773 mRNA. Translation: AAH50773.1.
CCDSiCCDS22956.1.
RefSeqiNP_033204.2. NM_009178.3.
XP_011240735.1. XM_011242433.1.
UniGeneiMm.275973.

3D structure databases

ProteinModelPortaliQ91Y74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1858706.
STRINGi10090.ENSMUSP00000034537.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

PTM databases

iPTMnetiQ91Y74.
PhosphoSitePlusiQ91Y74.

Proteomic databases

EPDiQ91Y74.
MaxQBiQ91Y74.
PaxDbiQ91Y74.
PRIDEiQ91Y74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034537; ENSMUSP00000034537; ENSMUSG00000032038.
GeneIDi20443.
KEGGimmu:20443.
UCSCiuc009osm.1. mouse.

Organism-specific databases

CTDi6484.
MGIiMGI:1316743. St3gal4.

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
GeneTreeiENSGT00760000119095.
HOGENOMiHOG000000682.
HOVERGENiHBG056676.
InParanoidiQ91Y74.
KOiK03494.
OMAiIHYYEQI.
OrthoDBiEOG091G098L.
PhylomeDBiQ91Y74.
TreeFamiTF354325.

Enzyme and pathway databases

UniPathwayiUPA00378.
BRENDAi2.4.99.4. 3474.
ReactomeiR-MMU-2022854. Keratan sulfate biosynthesis.
R-MMU-4085001. Sialic acid metabolism.
R-MMU-975577. N-Glycan antennae elongation.
R-MMU-977068. Termination of O-glycan biosynthesis.

Miscellaneous databases

ChiTaRSiSt3gal4. mouse.
PROiQ91Y74.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032038.
GenevisibleiQ91Y74. MM.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSIA4C_MOUSE
AccessioniPrimary (citable) accession number: Q91Y74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.