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Protein

Solute carrier family 13 member 3

Gene

Slc13a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms. The stoichiometry is probably 3 Na+ for 1 divalent succinate.

GO - Molecular functioni

GO - Biological processi

  • dicarboxylic acid transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_348160. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 13 member 3
Alternative name(s):
Na(+)/dicarboxylate cotransporter 3
Short name:
NaDC-3
Short name:
mNaDC3
Sodium-dependent high-affinity dicarboxylate transporter 2
Gene namesi
Name:Slc13a3
Synonyms:Nadc3, Sdct2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2149635. Slc13a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei17 – 3721HelicalSequence AnalysisAdd
BLAST
Topological domaini38 – 5518ExtracellularSequence AnalysisAdd
BLAST
Transmembranei56 – 7621HelicalSequence AnalysisAdd
BLAST
Topological domaini77 – 826CytoplasmicSequence Analysis
Transmembranei83 – 10321HelicalSequence AnalysisAdd
BLAST
Topological domaini104 – 13734ExtracellularSequence AnalysisAdd
BLAST
Transmembranei138 – 15821HelicalSequence AnalysisAdd
BLAST
Topological domaini159 – 22971CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei230 – 25021HelicalSequence AnalysisAdd
BLAST
Topological domaini251 – 27828ExtracellularSequence AnalysisAdd
BLAST
Transmembranei279 – 29921HelicalSequence AnalysisAdd
BLAST
Topological domaini300 – 33637CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei337 – 35721HelicalSequence AnalysisAdd
BLAST
Topological domaini358 – 37215ExtracellularSequence AnalysisAdd
BLAST
Transmembranei373 – 39321HelicalSequence AnalysisAdd
BLAST
Topological domaini394 – 42229CytoplasmicSequence AnalysisAdd
BLAST
Intramembranei423 – 44321HelicalSequence AnalysisAdd
BLAST
Topological domaini444 – 46118CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei462 – 48221HelicalSequence AnalysisAdd
BLAST
Topological domaini483 – 50523ExtracellularSequence AnalysisAdd
BLAST
Transmembranei506 – 52621HelicalSequence AnalysisAdd
BLAST
Topological domaini527 – 54620CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei547 – 56721HelicalSequence AnalysisAdd
BLAST
Topological domaini568 – 60033ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 600600Solute carrier family 13 member 3PRO_0000172493Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi584 – 5841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi594 – 5941N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ91Y63.
PaxDbiQ91Y63.
PRIDEiQ91Y63.

PTM databases

PhosphoSiteiQ91Y63.

Expressioni

Tissue specificityi

Highly expressed in kidney, and at much lower levels in brain.

Gene expression databases

BgeeiQ91Y63.
ExpressionAtlasiQ91Y63. baseline and differential.
GenevisibleiQ91Y63. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029208.

Structurei

3D structure databases

ProteinModelPortaliQ91Y63.
SMRiQ91Y63. Positions 19-162, 413-564.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0471.
GeneTreeiENSGT00550000074480.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ91Y63.
KOiK14445.
OMAiLMLVSIM.
OrthoDBiEOG7G1V5S.
PhylomeDBiQ91Y63.
TreeFamiTF312913.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91Y63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALAALAKK VWSARRLLVL LLVPLALLPI LFALPPKEGR CLYVILLMAV
60 70 80 90 100
YWCTEALPLS VTALLPIILF PFMGILPSSK VCPQYFLDTN FLFLSGLIMA
110 120 130 140 150
SAIEEWNLHR RIALKVLMLV GVQPARLILG MMVTTSFLSM WLSNTASTAM
160 170 180 190 200
MLPIASAILK SLFGQREARK DLPREGDEST AAVQGNGLRT VPTEMQFLAS
210 220 230 240 250
SEGGHTEDAE APMELPDDSK EEEHRRNIWK GFLISIPYSA SIGGTATLTG
260 270 280 290 300
TAPNLILLGQ LKSFFPQCDV VNFGSWFIFA FPLMLLFLLV GWLWISFLYG
310 320 330 340 350
GMSWRSWRKK KSKIRADAED QAKAVIQEEF QNLGPIKFAE QAVFILFCTF
360 370 380 390 400
AILLFSRDPK FIPGWASLFA PGFVSDAVTG VAIVTILFFF PSQKPSLKWW
410 420 430 440 450
FDFKAPNSET EPLLSWKKAQ ETVPWNIILL LGGGFAMAKG CEESGLSAWI
460 470 480 490 500
GGQLHPLEHV PPLLAVLLIT VVIAFFTEFA SNTATIIIFL PVLAELAIRL
510 520 530 540 550
HVHPLYLMIP GTVGCSYAFM LPVSTPPNSI AFSTGHLLVK DMVRTGLLMN
560 570 580 590 600
LMGVLLLSLA MNTWAQTIFQ LGTFPDWANT HAANATALPP ALTNNTVQTF
Length:600
Mass (Da):66,143
Last modified:December 1, 2001 - v1
Checksum:i8665D6BAA59AAB51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF306491 mRNA. Translation: AAK49898.1.
BC026803 mRNA. Translation: AAH26803.1.
CCDSiCCDS17081.1.
RefSeqiNP_473396.1. NM_054055.2.
UniGeneiMm.250738.

Genome annotation databases

EnsembliENSMUST00000029208; ENSMUSP00000029208; ENSMUSG00000018459.
GeneIDi114644.
KEGGimmu:114644.
UCSCiuc008nxs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF306491 mRNA. Translation: AAK49898.1.
BC026803 mRNA. Translation: AAH26803.1.
CCDSiCCDS17081.1.
RefSeqiNP_473396.1. NM_054055.2.
UniGeneiMm.250738.

3D structure databases

ProteinModelPortaliQ91Y63.
SMRiQ91Y63. Positions 19-162, 413-564.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029208.

PTM databases

PhosphoSiteiQ91Y63.

Proteomic databases

MaxQBiQ91Y63.
PaxDbiQ91Y63.
PRIDEiQ91Y63.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029208; ENSMUSP00000029208; ENSMUSG00000018459.
GeneIDi114644.
KEGGimmu:114644.
UCSCiuc008nxs.1. mouse.

Organism-specific databases

CTDi64849.
MGIiMGI:2149635. Slc13a3.

Phylogenomic databases

eggNOGiCOG0471.
GeneTreeiENSGT00550000074480.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ91Y63.
KOiK14445.
OMAiLMLVSIM.
OrthoDBiEOG7G1V5S.
PhylomeDBiQ91Y63.
TreeFamiTF312913.

Enzyme and pathway databases

ReactomeiREACT_348160. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Miscellaneous databases

NextBioi368604.
PROiQ91Y63.
SOURCEiSearch...

Gene expression databases

BgeeiQ91Y63.
ExpressionAtlasiQ91Y63. baseline and differential.
GenevisibleiQ91Y63. MM.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional characterization of a high-affinity Na(+)/dicarboxylate cotransporter from mouse brain."
    Pajor A.M., Gangula R., Yao X.
    Am. J. Physiol. 280:C1215-C1223(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiS13A3_MOUSE
AccessioniPrimary (citable) accession number: Q91Y63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: December 1, 2001
Last modified: July 22, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.