Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q91Y63

- S13A3_MOUSE

UniProt

Q91Y63 - S13A3_MOUSE

Protein

Solute carrier family 13 member 3

Gene

Slc13a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms. The stoichiometry is probably 3 Na+ for 1 divalent succinate.

    GO - Molecular functioni

    1. high-affinity sodium:dicarboxylate symporter activity Source: MGI

    GO - Biological processi

    1. dicarboxylic acid transport Source: MGI

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 13 member 3
    Alternative name(s):
    Na(+)/dicarboxylate cotransporter 3
    Short name:
    NaDC-3
    Short name:
    mNaDC3
    Sodium-dependent high-affinity dicarboxylate transporter 2
    Gene namesi
    Name:Slc13a3
    Synonyms:Nadc3, Sdct2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2149635. Slc13a3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: MGI
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 600600Solute carrier family 13 member 3PRO_0000172493Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi584 – 5841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi594 – 5941N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ91Y63.
    PaxDbiQ91Y63.
    PRIDEiQ91Y63.

    PTM databases

    PhosphoSiteiQ91Y63.

    Expressioni

    Tissue specificityi

    Highly expressed in kidney, and at much lower levels in brain.

    Gene expression databases

    ArrayExpressiQ91Y63.
    BgeeiQ91Y63.
    GenevestigatoriQ91Y63.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91Y63.
    SMRiQ91Y63. Positions 19-162, 413-564.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1616CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini38 – 5518ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini77 – 826CytoplasmicSequence Analysis
    Topological domaini104 – 13734ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini159 – 22971CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini251 – 27828ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini300 – 33637CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini358 – 37215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini394 – 42229CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini444 – 46118CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini483 – 50523ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini527 – 54620CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini568 – 60033ExtracellularSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei423 – 44321HelicalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei56 – 7621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei83 – 10321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei230 – 25021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei279 – 29921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei337 – 35721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei373 – 39321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei462 – 48221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei506 – 52621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei547 – 56721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0471.
    GeneTreeiENSGT00550000074480.
    HOGENOMiHOG000278432.
    HOVERGENiHBG055339.
    InParanoidiQ91Y63.
    KOiK14445.
    OMAiTEDKDCP.
    OrthoDBiEOG7G1V5S.
    PhylomeDBiQ91Y63.
    TreeFamiTF312913.

    Family and domain databases

    InterProiIPR001898. Na/sul_symport.
    [Graphical view]
    PfamiPF00939. Na_sulph_symp. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91Y63-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAALAALAKK VWSARRLLVL LLVPLALLPI LFALPPKEGR CLYVILLMAV    50
    YWCTEALPLS VTALLPIILF PFMGILPSSK VCPQYFLDTN FLFLSGLIMA 100
    SAIEEWNLHR RIALKVLMLV GVQPARLILG MMVTTSFLSM WLSNTASTAM 150
    MLPIASAILK SLFGQREARK DLPREGDEST AAVQGNGLRT VPTEMQFLAS 200
    SEGGHTEDAE APMELPDDSK EEEHRRNIWK GFLISIPYSA SIGGTATLTG 250
    TAPNLILLGQ LKSFFPQCDV VNFGSWFIFA FPLMLLFLLV GWLWISFLYG 300
    GMSWRSWRKK KSKIRADAED QAKAVIQEEF QNLGPIKFAE QAVFILFCTF 350
    AILLFSRDPK FIPGWASLFA PGFVSDAVTG VAIVTILFFF PSQKPSLKWW 400
    FDFKAPNSET EPLLSWKKAQ ETVPWNIILL LGGGFAMAKG CEESGLSAWI 450
    GGQLHPLEHV PPLLAVLLIT VVIAFFTEFA SNTATIIIFL PVLAELAIRL 500
    HVHPLYLMIP GTVGCSYAFM LPVSTPPNSI AFSTGHLLVK DMVRTGLLMN 550
    LMGVLLLSLA MNTWAQTIFQ LGTFPDWANT HAANATALPP ALTNNTVQTF 600
    Length:600
    Mass (Da):66,143
    Last modified:December 1, 2001 - v1
    Checksum:i8665D6BAA59AAB51
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF306491 mRNA. Translation: AAK49898.1.
    BC026803 mRNA. Translation: AAH26803.1.
    CCDSiCCDS17081.1.
    RefSeqiNP_473396.1. NM_054055.2.
    UniGeneiMm.250738.

    Genome annotation databases

    EnsembliENSMUST00000029208; ENSMUSP00000029208; ENSMUSG00000018459.
    GeneIDi114644.
    KEGGimmu:114644.
    UCSCiuc008nxs.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF306491 mRNA. Translation: AAK49898.1 .
    BC026803 mRNA. Translation: AAH26803.1 .
    CCDSi CCDS17081.1.
    RefSeqi NP_473396.1. NM_054055.2.
    UniGenei Mm.250738.

    3D structure databases

    ProteinModelPortali Q91Y63.
    SMRi Q91Y63. Positions 19-162, 413-564.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q91Y63.

    Proteomic databases

    MaxQBi Q91Y63.
    PaxDbi Q91Y63.
    PRIDEi Q91Y63.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029208 ; ENSMUSP00000029208 ; ENSMUSG00000018459 .
    GeneIDi 114644.
    KEGGi mmu:114644.
    UCSCi uc008nxs.1. mouse.

    Organism-specific databases

    CTDi 64849.
    MGIi MGI:2149635. Slc13a3.

    Phylogenomic databases

    eggNOGi COG0471.
    GeneTreei ENSGT00550000074480.
    HOGENOMi HOG000278432.
    HOVERGENi HBG055339.
    InParanoidi Q91Y63.
    KOi K14445.
    OMAi TEDKDCP.
    OrthoDBi EOG7G1V5S.
    PhylomeDBi Q91Y63.
    TreeFami TF312913.

    Miscellaneous databases

    NextBioi 368604.
    PROi Q91Y63.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q91Y63.
    Bgeei Q91Y63.
    Genevestigatori Q91Y63.

    Family and domain databases

    InterProi IPR001898. Na/sul_symport.
    [Graphical view ]
    Pfami PF00939. Na_sulph_symp. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional characterization of a high-affinity Na(+)/dicarboxylate cotransporter from mouse brain."
      Pajor A.M., Gangula R., Yao X.
      Am. J. Physiol. 280:C1215-C1223(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiS13A3_MOUSE
    AccessioniPrimary (citable) accession number: Q91Y63
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3