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Protein

Solute carrier family 13 member 3

Gene

Slc13a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms. The stoichiometry is probably 3 Na+ for 1 divalent succinate.

GO - Molecular functioni

GO - Biological processi

  • citrate transport Source: GO_Central
  • dicarboxylic acid transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-MMU-433137. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 13 member 3
Alternative name(s):
Na(+)/dicarboxylate cotransporter 3
Short name:
NaDC-3
Short name:
mNaDC3
Sodium-dependent high-affinity dicarboxylate transporter 2
Gene namesi
Name:Slc13a3
Synonyms:Nadc3, Sdct2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2149635. Slc13a3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 55ExtracellularSequence analysisAdd BLAST18
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Topological domaini77 – 82CytoplasmicSequence analysis6
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 137ExtracellularSequence analysisAdd BLAST34
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 229CytoplasmicSequence analysisAdd BLAST71
Transmembranei230 – 250HelicalSequence analysisAdd BLAST21
Topological domaini251 – 278ExtracellularSequence analysisAdd BLAST28
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Topological domaini300 – 336CytoplasmicSequence analysisAdd BLAST37
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21
Topological domaini358 – 372ExtracellularSequence analysisAdd BLAST15
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 422CytoplasmicSequence analysisAdd BLAST29
Intramembranei423 – 443HelicalSequence analysisAdd BLAST21
Topological domaini444 – 461CytoplasmicSequence analysisAdd BLAST18
Transmembranei462 – 482HelicalSequence analysisAdd BLAST21
Topological domaini483 – 505ExtracellularSequence analysisAdd BLAST23
Transmembranei506 – 526HelicalSequence analysisAdd BLAST21
Topological domaini527 – 546CytoplasmicSequence analysisAdd BLAST20
Transmembranei547 – 567HelicalSequence analysisAdd BLAST21
Topological domaini568 – 600ExtracellularSequence analysisAdd BLAST33

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • integral component of plasma membrane Source: GO_Central
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001724931 – 600Solute carrier family 13 member 3Add BLAST600

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi584N-linked (GlcNAc...)Sequence analysis1
Glycosylationi594N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ91Y63.
PaxDbiQ91Y63.
PRIDEiQ91Y63.

PTM databases

iPTMnetiQ91Y63.
PhosphoSitePlusiQ91Y63.

Expressioni

Tissue specificityi

Highly expressed in kidney, and at much lower levels in brain.

Gene expression databases

BgeeiENSMUSG00000018459.
ExpressionAtlasiQ91Y63. baseline and differential.
GenevisibleiQ91Y63. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029208.

Structurei

3D structure databases

ProteinModelPortaliQ91Y63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1281. Eukaryota.
COG0471. LUCA.
GeneTreeiENSGT00550000074480.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ91Y63.
KOiK14445.
OMAiVKPAWLI.
OrthoDBiEOG091G092X.
PhylomeDBiQ91Y63.
TreeFamiTF312913.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91Y63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALAALAKK VWSARRLLVL LLVPLALLPI LFALPPKEGR CLYVILLMAV
60 70 80 90 100
YWCTEALPLS VTALLPIILF PFMGILPSSK VCPQYFLDTN FLFLSGLIMA
110 120 130 140 150
SAIEEWNLHR RIALKVLMLV GVQPARLILG MMVTTSFLSM WLSNTASTAM
160 170 180 190 200
MLPIASAILK SLFGQREARK DLPREGDEST AAVQGNGLRT VPTEMQFLAS
210 220 230 240 250
SEGGHTEDAE APMELPDDSK EEEHRRNIWK GFLISIPYSA SIGGTATLTG
260 270 280 290 300
TAPNLILLGQ LKSFFPQCDV VNFGSWFIFA FPLMLLFLLV GWLWISFLYG
310 320 330 340 350
GMSWRSWRKK KSKIRADAED QAKAVIQEEF QNLGPIKFAE QAVFILFCTF
360 370 380 390 400
AILLFSRDPK FIPGWASLFA PGFVSDAVTG VAIVTILFFF PSQKPSLKWW
410 420 430 440 450
FDFKAPNSET EPLLSWKKAQ ETVPWNIILL LGGGFAMAKG CEESGLSAWI
460 470 480 490 500
GGQLHPLEHV PPLLAVLLIT VVIAFFTEFA SNTATIIIFL PVLAELAIRL
510 520 530 540 550
HVHPLYLMIP GTVGCSYAFM LPVSTPPNSI AFSTGHLLVK DMVRTGLLMN
560 570 580 590 600
LMGVLLLSLA MNTWAQTIFQ LGTFPDWANT HAANATALPP ALTNNTVQTF
Length:600
Mass (Da):66,143
Last modified:December 1, 2001 - v1
Checksum:i8665D6BAA59AAB51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF306491 mRNA. Translation: AAK49898.1.
BC026803 mRNA. Translation: AAH26803.1.
CCDSiCCDS17081.1.
RefSeqiNP_473396.1. NM_054055.2.
UniGeneiMm.250738.

Genome annotation databases

EnsembliENSMUST00000029208; ENSMUSP00000029208; ENSMUSG00000018459.
GeneIDi114644.
KEGGimmu:114644.
UCSCiuc008nxs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF306491 mRNA. Translation: AAK49898.1.
BC026803 mRNA. Translation: AAH26803.1.
CCDSiCCDS17081.1.
RefSeqiNP_473396.1. NM_054055.2.
UniGeneiMm.250738.

3D structure databases

ProteinModelPortaliQ91Y63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029208.

PTM databases

iPTMnetiQ91Y63.
PhosphoSitePlusiQ91Y63.

Proteomic databases

MaxQBiQ91Y63.
PaxDbiQ91Y63.
PRIDEiQ91Y63.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029208; ENSMUSP00000029208; ENSMUSG00000018459.
GeneIDi114644.
KEGGimmu:114644.
UCSCiuc008nxs.1. mouse.

Organism-specific databases

CTDi64849.
MGIiMGI:2149635. Slc13a3.

Phylogenomic databases

eggNOGiKOG1281. Eukaryota.
COG0471. LUCA.
GeneTreeiENSGT00550000074480.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ91Y63.
KOiK14445.
OMAiVKPAWLI.
OrthoDBiEOG091G092X.
PhylomeDBiQ91Y63.
TreeFamiTF312913.

Enzyme and pathway databases

ReactomeiR-MMU-433137. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Miscellaneous databases

PROiQ91Y63.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018459.
ExpressionAtlasiQ91Y63. baseline and differential.
GenevisibleiQ91Y63. MM.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS13A3_MOUSE
AccessioniPrimary (citable) accession number: Q91Y63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.