Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q91Y63 (S13A3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 13 member 3
Alternative name(s):
Na(+)/dicarboxylate cotransporter 3
Short name=NaDC-3
Short name=mNaDC3
Sodium-dependent high-affinity dicarboxylate transporter 2
Gene names
Name:Slc13a3
Synonyms:Nadc3, Sdct2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length600 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms. The stoichiometry is probably 3 Na+ for 1 divalent succinate.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Highly expressed in kidney, and at much lower levels in brain.

Sequence similarities

Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 600600Solute carrier family 13 member 3
PRO_0000172493

Regions

Topological domain1 – 1616Cytoplasmic Potential
Transmembrane17 – 3721Helical; Potential
Topological domain38 – 5518Extracellular Potential
Transmembrane56 – 7621Helical; Potential
Topological domain77 – 826Cytoplasmic Potential
Transmembrane83 – 10321Helical; Potential
Topological domain104 – 13734Extracellular Potential
Transmembrane138 – 15821Helical; Potential
Topological domain159 – 22971Cytoplasmic Potential
Transmembrane230 – 25021Helical; Potential
Topological domain251 – 27828Extracellular Potential
Transmembrane279 – 29921Helical; Potential
Topological domain300 – 33637Cytoplasmic Potential
Transmembrane337 – 35721Helical; Potential
Topological domain358 – 37215Extracellular Potential
Transmembrane373 – 39321Helical; Potential
Topological domain394 – 42229Cytoplasmic Potential
Intramembrane423 – 44321Helical; Potential
Topological domain444 – 46118Cytoplasmic Potential
Transmembrane462 – 48221Helical; Potential
Topological domain483 – 50523Extracellular Potential
Transmembrane506 – 52621Helical; Potential
Topological domain527 – 54620Cytoplasmic Potential
Transmembrane547 – 56721Helical; Potential
Topological domain568 – 60033Extracellular Potential

Amino acid modifications

Glycosylation5841N-linked (GlcNAc...) Potential
Glycosylation5941N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q91Y63 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 8665D6BAA59AAB51

FASTA60066,143
        10         20         30         40         50         60 
MAALAALAKK VWSARRLLVL LLVPLALLPI LFALPPKEGR CLYVILLMAV YWCTEALPLS 

        70         80         90        100        110        120 
VTALLPIILF PFMGILPSSK VCPQYFLDTN FLFLSGLIMA SAIEEWNLHR RIALKVLMLV 

       130        140        150        160        170        180 
GVQPARLILG MMVTTSFLSM WLSNTASTAM MLPIASAILK SLFGQREARK DLPREGDEST 

       190        200        210        220        230        240 
AAVQGNGLRT VPTEMQFLAS SEGGHTEDAE APMELPDDSK EEEHRRNIWK GFLISIPYSA 

       250        260        270        280        290        300 
SIGGTATLTG TAPNLILLGQ LKSFFPQCDV VNFGSWFIFA FPLMLLFLLV GWLWISFLYG 

       310        320        330        340        350        360 
GMSWRSWRKK KSKIRADAED QAKAVIQEEF QNLGPIKFAE QAVFILFCTF AILLFSRDPK 

       370        380        390        400        410        420 
FIPGWASLFA PGFVSDAVTG VAIVTILFFF PSQKPSLKWW FDFKAPNSET EPLLSWKKAQ 

       430        440        450        460        470        480 
ETVPWNIILL LGGGFAMAKG CEESGLSAWI GGQLHPLEHV PPLLAVLLIT VVIAFFTEFA 

       490        500        510        520        530        540 
SNTATIIIFL PVLAELAIRL HVHPLYLMIP GTVGCSYAFM LPVSTPPNSI AFSTGHLLVK 

       550        560        570        580        590        600 
DMVRTGLLMN LMGVLLLSLA MNTWAQTIFQ LGTFPDWANT HAANATALPP ALTNNTVQTF 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and functional characterization of a high-affinity Na(+)/dicarboxylate cotransporter from mouse brain."
Pajor A.M., Gangula R., Yao X.
Am. J. Physiol. 280:C1215-C1223(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF306491 mRNA. Translation: AAK49898.1.
BC026803 mRNA. Translation: AAH26803.1.
RefSeqNP_473396.1. NM_054055.2.
UniGeneMm.250738.

3D structure databases

ProteinModelPortalQ91Y63.
SMRQ91Y63. Positions 16-566.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ91Y63.

Proteomic databases

PaxDbQ91Y63.
PRIDEQ91Y63.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029208; ENSMUSP00000029208; ENSMUSG00000018459.
GeneID114644.
KEGGmmu:114644.
UCSCuc008nxs.1. mouse.

Organism-specific databases

CTD64849.
MGIMGI:2149635. Slc13a3.

Phylogenomic databases

eggNOGCOG0471.
GeneTreeENSGT00550000074480.
HOGENOMHOG000278432.
HOVERGENHBG055339.
InParanoidQ91Y63.
KOK14445.
OMAVWKGFLI.
OrthoDBEOG7G1V5S.
PhylomeDBQ91Y63.
TreeFamTF312913.

Gene expression databases

ArrayExpressQ91Y63.
BgeeQ91Y63.
GenevestigatorQ91Y63.

Family and domain databases

InterProIPR001898. Na/sul_symport.
[Graphical view]
PfamPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio368604.
PROQ91Y63.
SOURCESearch...

Entry information

Entry nameS13A3_MOUSE
AccessionPrimary (citable) accession number: Q91Y63
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot