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Protein

Claudin-16

Gene

Cldn16

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-16
Alternative name(s):
Paracellin-1
Gene namesi
Name:Cldn16
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620322. Cldn16.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33CytoplasmicSequence analysis
Transmembranei4 – 2421HelicalSequence analysisAdd
BLAST
Topological domaini25 – 7955ExtracellularSequence analysisAdd
BLAST
Transmembranei80 – 10021HelicalSequence analysisAdd
BLAST
Topological domaini101 – 11515CytoplasmicSequence analysisAdd
BLAST
Transmembranei116 – 13621HelicalSequence analysisAdd
BLAST
Topological domaini137 – 16933ExtracellularSequence analysisAdd
BLAST
Transmembranei170 – 19021HelicalSequence analysisAdd
BLAST
Topological domaini191 – 23545CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Claudin-16PRO_0000144776Add
BLAST

Proteomic databases

PaxDbiQ91Y55.
PRIDEiQ91Y55.

PTM databases

PhosphoSiteiQ91Y55.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044832.

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEIE. Eukaryota.
ENOG410XP0E. LUCA.
HOVERGENiHBG050987.
InParanoidiQ91Y55.
PhylomeDBiQ91Y55.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003927. Claudin16.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF56. PTHR12002:SF56. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01447. CLAUDIN16.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91Y55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDLLQYAAC FLAIFSTGFL IVATRTDCWM VNADDSLEVS TKCRGLWWEC
60 70 80 90 100
VTNAFDGIRT CDEYDSIYAE HPLKLVVTRA LMITADILAG FGFITLLLGL
110 120 130 140 150
DCVKFLPDEP HIKVRLCFVA GTVLLIAGTP GIIGSVWYAV DVYVERSSLV
160 170 180 190 200
LHNIFLGIQY KFGWSCWLGM AGSLGCFLAG ALLTCCLYLF KDVGPERNYP
210 220 230
YAMRKPYSTA GVSMAKSYKA PRTETAKMYA VDTRV
Length:235
Mass (Da):26,091
Last modified:December 1, 2001 - v1
Checksum:i357E658C317050C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333099 mRNA. Translation: AAK52459.1.
UniGeneiRn.43852.

Genome annotation databases

UCSCiRGD:620322. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333099 mRNA. Translation: AAK52459.1.
UniGeneiRn.43852.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044832.

PTM databases

PhosphoSiteiQ91Y55.

Proteomic databases

PaxDbiQ91Y55.
PRIDEiQ91Y55.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:620322. rat.

Organism-specific databases

RGDi620322. Cldn16.

Phylogenomic databases

eggNOGiENOG410IEIE. Eukaryota.
ENOG410XP0E. LUCA.
HOVERGENiHBG050987.
InParanoidiQ91Y55.
PhylomeDBiQ91Y55.

Miscellaneous databases

NextBioi620903.
PROiQ91Y55.

Family and domain databases

InterProiIPR006187. Claudin.
IPR003927. Claudin16.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PTHR12002:SF56. PTHR12002:SF56. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01447. CLAUDIN16.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Primary gene structure and expression studies of rodent paracellin-1."
    Weber S., Schlingmann K.P., Peters M., Nejsum L.N., Nielsen S., Engel H., Grzeschik K.H., Seyberth H.W., Grone H.J., Nusing R., Konrad M.
    J. Am. Soc. Nephrol. 12:2664-2672(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Kidney.

Entry informationi

Entry nameiCLD16_RAT
AccessioniPrimary (citable) accession number: Q91Y55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: December 1, 2001
Last modified: December 9, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.