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Protein

Coagulation factor XI

Gene

F11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.By similarity

Catalytic activityi

Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.

Enzyme regulationi

Inhibited by SERPINA5.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei430 – 4301Charge relay systemBy similarity
Active sitei479 – 4791Charge relay systemBy similarity
Active sitei574 – 5741Charge relay systemBy similarity

GO - Molecular functioni

GO - Biological processi

  • blood coagulation Source: UniProtKB-KW
  • plasminogen activation Source: MGI
  • positive regulation of fibrinolysis Source: MGI
  • regulation of blood coagulation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Blood coagulation, Hemostasis

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiR-MMU-140837. Intrinsic Pathway of Fibrin Clot Formation.

Protein family/group databases

MEROPSiS01.213.

Names & Taxonomyi

Protein namesi
Recommended name:
Coagulation factor XI (EC:3.4.21.27)
Short name:
FXI
Alternative name(s):
Plasma thromboplastin antecedent
Short name:
PTA
Cleaved into the following 2 chains:
Gene namesi
Name:F11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:99481. F11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Chaini19 – 389371Coagulation factor XIa heavy chainBy similarityPRO_0000027827Add
BLAST
Chaini390 – 624235Coagulation factor XIa light chainBy similarityPRO_0000027828Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi20 ↔ 103Sequence analysis
Disulfide bondi46 ↔ 76By similarity
Disulfide bondi50 ↔ 56By similarity
Glycosylationi90 – 901N-linked (GlcNAc...)By similarity
Disulfide bondi110 ↔ 193By similarity
Glycosylationi126 – 1261N-linked (GlcNAc...)By similarity
Disulfide bondi136 ↔ 165By similarity
Disulfide bondi140 ↔ 146By similarity
Disulfide bondi200 ↔ 283By similarity
Disulfide bondi226 ↔ 255By similarity
Disulfide bondi230 ↔ 236By similarity
Disulfide bondi291 ↔ 376By similarity
Glycosylationi297 – 2971N-linked (GlcNAc...)Sequence analysis
Disulfide bondi317 ↔ 348By similarity
Disulfide bondi321 ↔ 327By similarity
Disulfide bondi339 – 339InterchainSequence analysis
Disulfide bondi382 ↔ 499Interchain (between heavy and light chains)PROSITE-ProRule annotation
Disulfide bondi415 ↔ 431By similarity
Glycosylationi449 – 4491N-linked (GlcNAc...)By similarity
Glycosylationi490 – 4901N-linked (GlcNAc...)By similarity
Disulfide bondi513 ↔ 580By similarity
Disulfide bondi544 ↔ 559By similarity
Disulfide bondi570 ↔ 598By similarity

Post-translational modificationi

Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-389 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen.By similarity
N-glycosylated on both chains. N-glycosylated sites mainly consist of nonfucosylated sialylated biantennary (in high abundance) and/or triantennary (in low abundance) complex structures.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ91Y47.
PaxDbiQ91Y47.
PRIDEiQ91Y47.

PTM databases

iPTMnetiQ91Y47.
PhosphoSiteiQ91Y47.
SwissPalmiQ91Y47.

Expressioni

Gene expression databases

BgeeiQ91Y47.
CleanExiMM_F11.
GenevisibleiQ91Y47. MM.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Forms a heterodimer with SERPINA5. After activation the heavy and light chains are also linked by a disulfide bond (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034064.

Structurei

3D structure databases

ProteinModelPortaliQ91Y47.
SMRiQ91Y47. Positions 20-622.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 10384Apple 1PROSITE-ProRule annotationAdd
BLAST
Domaini110 – 19384Apple 2PROSITE-ProRule annotationAdd
BLAST
Domaini200 – 28384Apple 3PROSITE-ProRule annotationAdd
BLAST
Domaini291 – 37686Apple 4PROSITE-ProRule annotationAdd
BLAST
Domaini390 – 622233Peptidase S1PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni547 – 5504Heparin-bindingBy similarity

Sequence similaritiesi

Belongs to the peptidase S1 family. Plasma kallikrein subfamily.PROSITE-ProRule annotation
Contains 4 apple domains.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118962.
HOGENOMiHOG000112467.
HOVERGENiHBG000399.
InParanoidiQ91Y47.
KOiK01323.
OMAiVWHLVGI.
OrthoDBiEOG75B84T.
TreeFamiTF343687.

Family and domain databases

InterProiIPR000177. Apple.
IPR003609. Pan_app.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00024. PAN_1. 4 hits.
PF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00005. APPLEDOMAIN.
PR00722. CHYMOTRYPSIN.
SMARTiSM00223. APPLE. 4 hits.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS00495. APPLE. 3 hits.
PS50948. PAN. 4 hits.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91Y47-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSLHQVLYF IFFASVSSEC VTKVFKDISF QGGDLSTVFT PSATYCRLVC
60 70 80 90 100
THHPRCLLFT FMAESSSDDP TKWFACILKD SVTEILPMVN MTGAISGYSF
110 120 130 140 150
KQCPQQLSTC SKDVYVNLDM KGMNYNSSVV KNARECQERC TDDAHCQFFT
160 170 180 190 200
YATGYFPSVD HRKMCLLKYT RTGTPTTITK LNGVVSGFSL KSCGLSNLAC
210 220 230 240 250
IRDIFPNTVL ADLNIDSVVA PDAFVCRRIC THHPTCLFFT FFSQAWPKES
260 270 280 290 300
QRHLCLLKTS ESGLPSTRIT KSHALSGFSL QHCRHSVPVF CHPSFYNDTD
310 320 330 340 350
FLGEELDIVD VKGQETCQKT CTNNARCQFF TYYPSHRLCN ERNRRGRCYL
360 370 380 390 400
KLSSNGSPTR ILHGRGGISG YSLRLCKMDN VCTTKINPRV VGGAASVHGE
410 420 430 440 450
WPWQVTLHIS QGHLCGGSII GNQWILTAAH CFSGIETPKK LRVYGGIVNQ
460 470 480 490 500
SEINEGTAFF RVQEMIIHDQ YTTAESGYDI ALLKLESAMN YTDFQRPICL
510 520 530 540 550
PSKGDRNAVH TECWVTGWGY TALRGEVQST LQKAKVPLVS NEECQTRYRR
560 570 580 590 600
HKITNKMICA GYKEGGKDTC KGDSGGPLSC KYNGVWHLVG ITSWGEGCGQ
610 620
KERPGVYTNV AKYVDWILEK TQTV
Length:624
Mass (Da):69,789
Last modified:July 27, 2011 - v2
Checksum:i0EEDDEBC56009E97
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti114 – 1141V → E in AAK40233 (PubMed:9242536).Curated
Sequence conflicti272 – 2721S → I in AAK40233 (PubMed:9242536).Curated
Sequence conflicti368 – 3681I → L in AAK40233 (PubMed:9242536).Curated
Sequence conflicti462 – 4621V → E in AAK40233 (PubMed:9242536).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF356627 mRNA. Translation: AAK40233.1.
AK005546 mRNA. Translation: BAB24114.1.
CH466554 Genomic DNA. Translation: EDL35542.1.
BC019485 mRNA. Translation: AAH19485.1.
CCDSiCCDS22274.1.
RefSeqiNP_082342.1. NM_028066.2.
UniGeneiMm.33326.

Genome annotation databases

EnsembliENSMUST00000034064; ENSMUSP00000034064; ENSMUSG00000031645.
GeneIDi109821.
KEGGimmu:109821.
UCSCiuc009los.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF356627 mRNA. Translation: AAK40233.1.
AK005546 mRNA. Translation: BAB24114.1.
CH466554 Genomic DNA. Translation: EDL35542.1.
BC019485 mRNA. Translation: AAH19485.1.
CCDSiCCDS22274.1.
RefSeqiNP_082342.1. NM_028066.2.
UniGeneiMm.33326.

3D structure databases

ProteinModelPortaliQ91Y47.
SMRiQ91Y47. Positions 20-622.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034064.

Protein family/group databases

MEROPSiS01.213.

PTM databases

iPTMnetiQ91Y47.
PhosphoSiteiQ91Y47.
SwissPalmiQ91Y47.

Proteomic databases

MaxQBiQ91Y47.
PaxDbiQ91Y47.
PRIDEiQ91Y47.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034064; ENSMUSP00000034064; ENSMUSG00000031645.
GeneIDi109821.
KEGGimmu:109821.
UCSCiuc009los.2. mouse.

Organism-specific databases

CTDi2160.
MGIiMGI:99481. F11.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118962.
HOGENOMiHOG000112467.
HOVERGENiHBG000399.
InParanoidiQ91Y47.
KOiK01323.
OMAiVWHLVGI.
OrthoDBiEOG75B84T.
TreeFamiTF343687.

Enzyme and pathway databases

ReactomeiR-MMU-140837. Intrinsic Pathway of Fibrin Clot Formation.

Miscellaneous databases

NextBioi362825.
PROiQ91Y47.
SOURCEiSearch...

Gene expression databases

BgeeiQ91Y47.
CleanExiMM_F11.
GenevisibleiQ91Y47. MM.

Family and domain databases

InterProiIPR000177. Apple.
IPR003609. Pan_app.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00024. PAN_1. 4 hits.
PF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00005. APPLEDOMAIN.
PR00722. CHYMOTRYPSIN.
SMARTiSM00223. APPLE. 4 hits.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS00495. APPLE. 3 hits.
PS50948. PAN. 4 hits.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of murine and human factor XI."
    Gailani D., Sun M.F., Sun Y.
    Blood 90:1055-1064(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: B10.WR.
    Tissue: Liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Placenta.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiFA11_MOUSE
AccessioniPrimary (citable) accession number: Q91Y47
Secondary accession number(s): Q9DAT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: July 27, 2011
Last modified: May 11, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.