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Reviewed, UniProtKB/Swiss-Prot Q91Y47 (FA11_MOUSE)

Last modified June 16, 2009. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Coagulation factor XI
      Short name=FXI
    EC=3.4.21.27
Alternative name(s):
    Plasma thromboplastin antecedent
      Short name=PTA
Cleaved into the following 2 chains:
    1- Recommended name:
            Coagulation factor XIa heavy chain
    2- Recommended name:
            Coagulation factor XIa light chain
Gene names
Name: F11
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length624 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX By similarity.

Catalytic activity

Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.

Subunit structure

Homodimer; disulfide-linked. After activation the heavy and light chains are also linked by a disulfide bond By similarity.

Subcellular location

Secreted.

Post-translational modification

Activated by factor XIIa (or XII), which cleaves each polypeptide after Arg-389 into the light chain, which contains the active site, and the heavy chain, which associates with high molecular weight (HMW) kininogen By similarity.

Sequence similarities

Belongs to the peptidase S1 family. Plasma kallikrein subfamily.

Contains 4 apple domains.

Contains 1 peptidase S1 domain.

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Ontologies

Keywords
   Biological processBlood coagulation
   Cellular componentSecreted
   DomainRepeat
Signal
   LigandHeparin-binding
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
Gene Ontology (GO)
   Biological processblood coagulation

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: InterPro

regulation of blood coagulation

Inferred from mutant phenotype. Source: MGI

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionheparin binding

Inferred from electronic annotation. Source: UniProtKB-KW

serine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 By similarity
Chain19 – 389371Coagulation factor XIa heavy chain By similarity
PRO_0000027827
Chain390 – 624235Coagulation factor XIa light chain By similarity
PRO_0000027828

Regions

Domain20 – 10384Apple 1
Domain110 – 19384Apple 2
Domain200 – 28384Apple 3
Domain291 – 37686Apple 4
Domain390 – 622233Peptidase S1
Region547 – 5504Heparin-binding By similarity

Sites

Active site4301Charge relay system By similarity
Active site4791Charge relay system By similarity
Active site5741Charge relay system By similarity

Amino acid modifications

Modified residue171Phosphoserine By similarity
Modified residue221Phosphothreonine By similarity
Glycosylation901N-linked (GlcNAc...) Potential
Glycosylation1261N-linked (GlcNAc...) Potential
Glycosylation2971N-linked (GlcNAc...) Potential
Glycosylation4491N-linked (GlcNAc...) Potential
Glycosylation4901N-linked (GlcNAc...) Potential
Disulfide bond20 ↔ 103 Potential
Disulfide bond46 ↔ 76 By similarity
Disulfide bond50 ↔ 56 By similarity
Disulfide bond110 ↔ 193 By similarity
Disulfide bond136 ↔ 165 By similarity
Disulfide bond140 ↔ 146 By similarity
Disulfide bond200 ↔ 283 By similarity
Disulfide bond226 ↔ 255 By similarity
Disulfide bond230 ↔ 236 By similarity
Disulfide bond291 ↔ 376 By similarity
Disulfide bond317 ↔ 348 By similarity
Disulfide bond321 ↔ 327 By similarity
Disulfide bond339Interchain Potential
Disulfide bond382 ↔ 499Interchain (between heavy and light chains) By similarity
Disulfide bond415 ↔ 431 By similarity
Disulfide bond513 ↔ 580 Potential
Disulfide bond544 ↔ 559 By similarity
Disulfide bond570 ↔ 598 Potential

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Sequences

Sequence LengthMass (Da)Tools
Q91Y47-1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 49D281BFAEC12A03

FASTA62469,875
        10         20         30         40         50         60 
MTSLHQVLYF IFFASVSSEC VTKVFKDISF QGGDLSTVFT PSATYCRLVC THHPRCLLFT 

        70         80         90        100        110        120 
FMAESSSDDP TKWFACILKD SVTEILPMVN MTGAISGYSF KQCPQQLSTC SKDEYVNLDM 

       130        140        150        160        170        180 
KGMNYNSSVV KNARECQERC TDDAHCQFFT YATGYFPSVD HRKMCLLKYT RTGTPTTITK 

       190        200        210        220        230        240 
LNGVVSGFSL KSCGLSNLAC IRDIFPNTVL ADLNIDSVVA PDAFVCRRIC THHPTCLFFT 

       250        260        270        280        290        300 
FFSQAWPKES QRHLCLLKTS ESGLPSTRIT KIHALSGFSL QHCRHSVPVF CHPSFYNDTD 

       310        320        330        340        350        360 
FLGEELDIVD VKGQETCQKT CTNNARCQFF TYYPSHRLCN ERNRRGRCYL KLSSNGSPTR 

       370        380        390        400        410        420 
ILHGRGGLSG YSLRLCKMDN VCTTKINPRV VGGAASVHGE WPWQVTLHIS QGHLCGGSII 

       430        440        450        460        470        480 
GNQWILTAAH CFSGIETPKK LRVYGGIVNQ SEINEGTAFF REQEMIIHDQ YTTAESGYDI 

       490        500        510        520        530        540 
ALLKLESAMN YTDFQRPICL PSKGDRNAVH TECWVTGWGY TALRGEVQST LQKAKVPLVS 

       550        560        570        580        590        600 
NEECQTRYRR HKITNKMICA GYKEGGKDTC KGDSGGPLSC KYNGVWHLVG ITSWGEGCGQ 

       610        620 
KERPGVYTNV AKYVDWILEK TQTV

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References

[1]"A comparison of murine and human factor XI."
Gailani D., Sun M.F., Sun Y.
Blood 90:1055-1064(1997) [PubMed: 9242536] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: B10.WR.
Tissue: Liver.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AF356627 mRNA. Translation: AAK40233.1.
IPIIPI00416285.
UniGeneMm.33326

3D structure databases

HSSPHSSP built from PDB template 1EZX based on UniProtKB P00760.
SMRQ91Y47. Positions 20-621.
ModBaseSearch...

Protein family/group databases

MEROPSS01.213.

PTM databases

PhosphoSiteQ91Y47.

Genome annotation databases

EnsemblENSMUSG00000031645. Mus musculus. [Contig view]

Organism-specific databases

MGIMGI:99481. F11.

Phylogenomic databases

HOGENOMQ91Y47.
HOVERGENQ91Y47.

Enzyme and pathway databases

BRENDA3.4.21.27. 244.

Gene expression databases

ArrayExpressQ91Y47.
BgeeQ91Y47.
CleanExMM_F11.
GermOnlineENSMUSG00000031645. Mus musculus.

Family and domain databases

InterProIPR000177. Apple.
IPR003014. PAN-1_domain.
IPR003609. Pan_app.
IPR018114. Peptidase_S1/S6_AS.
IPR001254. Peptidase_S1_S6.
IPR001314. Peptidase_S1A.
[Graphical view]
PfamPF00024. PAN_1. 4 hits.
PF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00005. APPLEDOMAIN.
PR00722. CHYMOTRYPSIN.
SMARTSM00223. APPLE. 4 hits.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
PROSITEPS00495. APPLE. 2 hits.
PS50948. PAN. 4 hits.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameFA11_MOUSE
AccessionPrimary (citable) accession number: Q91Y47
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: December 1, 2001
Last modified: June 16, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Peptidase families

Classification of peptidase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents