ID   Q91Y04_MOUSE            Unreviewed;       786 AA.
AC   Q91Y04;
DT   01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT   01-DEC-2001, sequence version 1.
DT   27-MAR-2024, entry version 168.
DE   SubName: Full=Protocadherin beta 15 {ECO:0000313|EMBL:AAK26065.1, ECO:0000313|Ensembl:ENSMUSP00000059598.2};
GN   Name=Pcdhb15 {ECO:0000313|Ensembl:ENSMUSP00000059598.2,
GN   ECO:0000313|MGI:MGI:2136750};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAK26065.1};
RN   [1] {ECO:0000313|EMBL:AAK26065.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:AAK26065.1};
RX   PubMed=10380929; DOI=10.1016/S0092-8674(00)80789-8;
RA   Wu Q., Maniatis T.;
RT   "A striking organization of a large family of human neural cadherin-like
RT   cell adhesion genes.";
RL   Cell 97:779-790(1999).
RN   [2] {ECO:0000313|EMBL:BAC30087.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC30087.1};
RC   TISSUE=Hypothalamus {ECO:0000313|EMBL:BAC30087.1};
RX   PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA   Carninci P., Hayashizaki Y.;
RT   "High-efficiency full-length cDNA cloning.";
RL   Methods Enzymol. 303:19-44(1999).
RN   [3] {ECO:0000313|EMBL:BAC30087.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC30087.1};
RC   TISSUE=Hypothalamus {ECO:0000313|EMBL:BAC30087.1};
RX   PubMed=11042159; DOI=10.1101/gr.145100;
RA   Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA   Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT   "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT   full-length cDNA libraries for rapid discovery of new genes.";
RL   Genome Res. 10:1617-1630(2000).
RN   [4] {ECO:0000313|EMBL:BAC30087.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC30087.1};
RC   TISSUE=Hypothalamus {ECO:0000313|EMBL:BAC30087.1};
RX   PubMed=11076861; DOI=10.1101/gr.152600;
RA   Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA   Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA   Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA   Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA   Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA   Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA   Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT   "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT   pipeline with 384 multicapillary sequencer.";
RL   Genome Res. 10:1757-1771(2000).
RN   [5] {ECO:0000313|EMBL:AAK26065.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:AAK26065.1};
RX   PubMed=10716726; DOI=10.1073/pnas.060027397;
RA   Wu Q., Maniatis T.;
RT   "Large exons encoding multiple ectodomains are a characteristic feature of
RT   protocadherin genes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:3124-3129(2000).
RN   [6] {ECO:0000313|EMBL:AAK26065.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:AAK26065.1};
RX   PubMed=11230163; DOI=10.1101/gr.167301;
RA   Wu Q., Zhang T., Cheng J.-F., Kim Y., Grimwood J., Schmutz J., Dickson M.,
RA   Noonan J.P., Zhang M.Q., Myers R.M., Maniatis T.;
RT   "Comparative DNA sequence analysis of mouse and human protocadherin gene
RT   clusters.";
RL   Genome Res. 11:389-404(2001).
RN   [7] {ECO:0000313|EMBL:BAC30087.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC30087.1};
RC   TISSUE=Hypothalamus {ECO:0000313|EMBL:BAC30087.1};
RX   PubMed=11217851; DOI=10.1038/35055500;
RG   The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT   "Functional annotation of a full-length mouse cDNA collection.";
RL   Nature 409:685-690(2001).
RN   [8] {ECO:0000313|EMBL:BAC30087.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC30087.1};
RC   TISSUE=Hypothalamus {ECO:0000313|EMBL:BAC30087.1};
RA   Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P.,
RA   Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K.,
RA   Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K.,
RA   Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y.,
RA   Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T.,
RA   Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R.,
RA   Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K.,
RA   Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T.,
RA   Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S.,
RA   Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M.,
RA   Hayashizaki Y.;
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:BAC30087.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC30087.1};
RC   TISSUE=Hypothalamus {ECO:0000313|EMBL:BAC30087.1};
RX   PubMed=12466851; DOI=10.1038/nature01266;
RG   The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT   "Analysis of the mouse transcriptome based on functional annotation of
RT   60,770 full-length cDNAs.";
RL   Nature 420:563-573(2002).
RN   [10] {ECO:0000313|EMBL:BAC30087.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC30087.1};
RC   TISSUE=Hypothalamus {ECO:0000313|EMBL:BAC30087.1};
RG   The FANTOM Consortium;
RG   Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT   "The Transcriptional Landscape of the Mammalian Genome.";
RL   Science 309:1559-1563(2005).
RN   [11] {ECO:0000313|EMBL:BAC30087.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC30087.1};
RC   TISSUE=Hypothalamus {ECO:0000313|EMBL:BAC30087.1};
RX   PubMed=16141073; DOI=10.1126/science.1112009;
RG   RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT   "Antisense Transcription in the Mammalian Transcriptome.";
RL   Science 309:1564-1566(2005).
RN   [12] {ECO:0000313|Ensembl:ENSMUSP00000059598.2, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000059598.2,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [13] {ECO:0000313|Ensembl:ENSMUSP00000059598.2}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000059598.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AY013776; AAK26065.1; -; mRNA.
DR   EMBL; AK038663; BAC30087.1; -; mRNA.
DR   RefSeq; NP_444370.1; NM_053140.3.
DR   STRING; 10090.ENSMUSP00000059598; -.
DR   PaxDb; 10090-ENSMUSP00000059598; -.
DR   ProteomicsDB; 338945; -.
DR   Antibodypedia; 27205; 68 antibodies from 12 providers.
DR   DNASU; 93886; -.
DR   Ensembl; ENSMUST00000050034.3; ENSMUSP00000059598.2; ENSMUSG00000047033.3.
DR   GeneID; 93886; -.
DR   KEGG; mmu:93886; -.
DR   UCSC; uc008eqa.1; mouse.
DR   AGR; MGI:2136750; -.
DR   CTD; 56121; -.
DR   MGI; MGI:2136750; Pcdhb15.
DR   VEuPathDB; HostDB:ENSMUSG00000047033; -.
DR   eggNOG; KOG3594; Eukaryota.
DR   GeneTree; ENSGT00940000163469; -.
DR   HOGENOM; CLU_006480_3_0_1; -.
DR   OMA; IFRAELW; -.
DR   OrthoDB; 5402790at2759; -.
DR   TreeFam; TF332299; -.
DR   BioGRID-ORCS; 93886; 1 hit in 77 CRISPR screens.
DR   Proteomes; UP000000589; Chromosome 18.
DR   Bgee; ENSMUSG00000047033; Expressed in CA1 field of hippocampus and 108 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   CDD; cd11304; Cadherin_repeat; 5.
DR   Gene3D; 2.60.40.60; Cadherins; 6.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR032455; Cadherin_C.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR013164; Cadherin_N.
DR   PANTHER; PTHR24028; CADHERIN-87A; 1.
DR   PANTHER; PTHR24028:SF69; PROTOCADHERIN BETA-7; 1.
DR   Pfam; PF00028; Cadherin; 5.
DR   Pfam; PF08266; Cadherin_2; 1.
DR   Pfam; PF16492; Cadherin_C_2; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 5.
DR   SUPFAM; SSF49313; Cadherin-like; 6.
DR   PROSITE; PS00232; CADHERIN_1; 3.
DR   PROSITE; PS50268; CADHERIN_2; 6.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW   ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|MaxQB:Q91Y04,
KW   ECO:0007829|ProteomicsDB:Q91Y04};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           29..786
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015099506"
FT   TRANSMEM        687..710
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          27..133
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          134..242
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          243..347
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          348..451
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          452..561
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
FT   DOMAIN          568..676
FT                   /note="Cadherin"
FT                   /evidence="ECO:0000259|PROSITE:PS50268"
SQ   SEQUENCE   786 AA;  86292 MW;  0EA6C04986F6FA90 CRC64;
     MEARLEQAVQ KRQVLFLYVF LGASWASAEQ LQYSVAEETE RGTFLANLAK DLGLGLGELS
     AREARIVSDQ NTRFLLLSPL TGELILNEKL DREELCGPTE PCVLTFQLLL ERPFQIYRAA
     LHIKDINDNS PVFLDKEILL KISESTTPGA TLLLERAQDA DVGTNSLSNY TISPNDYFHI
     HVHDGGEGPI IPELVLDKML DREEIPEFTL TLTALDGGSP PRSGTALVQI LVLDINDNSP
     QFVQSLYKVQ SPENTPVGSL VVAVSARDLD TGSYGQIDYT FFYATERILQ TFQINSTSGE
     LYLKRELNYE AIQTYSITIQ ARDGGGLSGK CAVVVEVMDV NDNPPEFLLS SLNSPIPENS
     QETVVAVFKI RDRDSGNNGK TLCSIANDLP FVLKPSVENF YTLVTEKPLD RESNTEYNIT
     ITVTDMGIPR LTTQHTITVQ VSDINDNAPT FTQTSYTMFV RENNSPALHI GTISATDSDS
     GSNAHITYSL RLPHDPQLAL DSLISINADN GQLFALRALD YEALQAFEFH VGAIDQGSPA
     LSSQALVRVV ILDDNDNAPF VLYPMQNASA PYTELLPRAA EPGYLVTKVV AVDRDSGQNA
     WLSFQLLKAT EPGLFSVWAH NGEVRTTRLL SERDVPKHKL LVVVKDNGEP PRSASVTLHV
     LLVDGFSQPF LILPEVARDP AQEDDELTLY LVIALASVSS LFLVSVLLFV GVRLCRRARA
     ASPGVCFVPE EHFPGHLVDV SGAGTLSQNY QYEVCLTGGS GITSEFKFLS PIASNFLTES
     TGREIE
//