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Protein
Submitted name:

MCG141291

Gene

Pcdhb16

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
  • cell adhesion Source: GO_Central
  • chemical synaptic transmission Source: UniProtKB
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • synapse assembly Source: UniProtKB

Keywordsi

Biological processCell adhesionSAAS annotation
LigandCalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
MCG141291Imported
Submitted name:
Protocadherin beta 16Imported
Gene namesi
Name:Pcdhb16Imported
ORF Names:mCG_141291Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2136752. Pcdhb16.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei688 – 711HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • photoreceptor connecting cilium Source: MGI
  • photoreceptor disc membrane Source: MGI
  • postsynaptic membrane Source: MGI
  • synapse Source: MGI

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_501068492129 – 802Sequence analysisAdd BLAST774

Expressioni

Gene expression databases

BgeeiENSMUSG00000047910.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056347.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 132CAInterPro annotationAdd BLAST87
Domaini156 – 241CAInterPro annotationAdd BLAST86
Domaini265 – 346CAInterPro annotationAdd BLAST82
Domaini369 – 450CAInterPro annotationAdd BLAST82
Domaini474 – 560CAInterPro annotationAdd BLAST87
Domaini590 – 671CAInterPro annotationAdd BLAST82

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00840000129690.
HOVERGENiHBG054878.
KOiK16494.
OMAiQVYIEVV.
OrthoDBiEOG091G024L.
TreeFamiTF332299.

Family and domain databases

InterProiView protein in InterPro
IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
PfamiView protein in Pfam
PF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PRINTSiPR00205. CADHERIN.
SMARTiView protein in SMART
SM00112. CA. 6 hits.
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiView protein in PROSITE
PS00232. CADHERIN_1. 2 hits.

Sequencei

Sequence statusi: Complete.

Q91Y03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEASRKLICR QRQVLFFFLL LGFPLTTAGE LRRYSVVEEK EGRSFVTNLV
60 70 80 90 100
KDLGLGQLEL SRRGAKVISK GNKLHLQLDQ ETGDLLLNEK VDREKLCGHT
110 120 130 140 150
EPCLLSFQVL LDNPLDIFQA ELEVTDINDH SPEFLDKEIM LKISESSLPG
160 170 180 190 200
ATFPLKNAQD MDVGQNGIDK YLISSNSYFR VLTRKRSDGK KYPELVLDRA
210 220 230 240 250
LDREEEAELR LTLTAQDGGS LPRSGTTEVH IEVLDINDNA PQFEQLFYKA
260 270 280 290 300
QIPEDSPIGF LIITVSATDK DIGVNGQISY SLFQVSDDIS KTFSIHPLTG
310 320 330 340 350
EVRLKEHLDF EKTQSYEINI EARDAGTFSG KCTILAQVLD VNDHAPEIIL
360 370 380 390 400
SAFTNSILEN LPETMVAVFS VSDLDSGENG KVSCSIQDDL PFFLKPSGEN
410 420 430 440 450
FYTLLSQKPL DRESVAEYNI TITVADMGSP ILKTQVNLTV QVSDINDNAP
460 470 480 490 500
IFTQTSYTMF IRENNSPALH IGTISATDSD SGSNAHITYS LLPPHDHQLA
510 520 530 540 550
LASFISINAD NGQLFVLRAL DYEALQAFEF HVGATDGGSP ALSSQALVRM
560 570 580 590 600
VVLDDNDNAP FVLYPMQNAS APYTELLPRA AEPGYLVTKV VAVDRDSGQN
610 620 630 640 650
AWLSFQLLKA TEPGLFSVWA HNGEVHTSRL LSERDVHKHR LILLVKDNGD
660 670 680 690 700
PPRSASVTLH VLLVDGFSQP YLPLPEVARD PDHEDSELTL YLVIALASVS
710 720 730 740 750
SLFLVSVLLF VGVRLCRRAR EVSLGGCSVP EGHFPGHLVD VSGTGTLSQS
760 770 780 790 800
YQYEVCLTGD SGTGEFKYLK PILPNFQDHS FRPEMGENPN SRNDWSFGIQ

LK
Length:802
Mass (Da):88,738
Last modified:December 1, 2001 - v1
Checksum:iA28513000DBCACBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020967 Genomic DNA. No translation available.
BC116625 mRNA. Translation: AAI16626.1.
AY013777 mRNA. Translation: AAK26066.1.
CH466528 Genomic DNA. Translation: EDL10155.1.
RefSeqiNP_444371.3. NM_053141.3.
UniGeneiMm.197441.

Genome annotation databases

EnsembliENSMUST00000051442; ENSMUSP00000056347; ENSMUSG00000047910.
GeneIDi93887.
KEGGimmu:93887.
UCSCiuc008eqb.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ91Y03_MOUSE
AccessioniPrimary (citable) accession number: Q91Y03
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: July 5, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported