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Protein
Submitted name:

Protocadherin gamma A12

Gene

Pcdhga12

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell adhesionSAAS annotation
LigandCalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protocadherin gamma A12Imported
Submitted name:
Protocadherin gamma subfamily A, 12Imported
Gene namesi
Name:Pcdhga12Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1935229. Pcdhga12.

Subcellular locationi

  • Cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei689 – 714HelicalSequence analysisAdd BLAST26

GO - Cellular componenti

  • cell-cell junction Source: MGI
  • integral component of plasma membrane Source: GO_Central
  • membrane Source: MGI
  • plasma membrane Source: MGI

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000023036.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 131CAInterPro annotationAdd BLAST87
Domaini155 – 240CAInterPro annotationAdd BLAST86
Domaini264 – 345CAInterPro annotationAdd BLAST82
Domaini369 – 450CAInterPro annotationAdd BLAST82
Domaini474 – 560CAInterPro annotationAdd BLAST87
Domaini591 – 669CAInterPro annotationAdd BLAST79

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00880000138170.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
KOiK16495.
OMAiIGELNHE.
OrthoDBiEOG091G024L.

Family and domain databases

InterProiView protein in InterPro
IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
PfamiView protein in Pfam
PF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
PRINTSiPR00205. CADHERIN.
SMARTiView protein in SMART
SM00112. CA. 6 hits.
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiView protein in PROSITE
PS00232. CADHERIN_1. 3 hits.

Sequencei

Sequence statusi: Complete.

Q91XY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPMQRREDC KGLVFLGVLL GMLWKAGSTQ IRYSVPEELE KGSRVGNISK
60 70 80 90 100
DLGLEPRELE KRGVRIVSRG RAQLFALNPR SGSLVTAGRI DREELCMGSI
110 120 130 140 150
KCQLNLEILM EDIGKIYGVE IEVRDINDNA PYFRESELEI KMSENAAAGM
160 170 180 190 200
RFPLPHAWDP DIGKNSLQSY QLSPNAHFSL EVQNGADGNK YPELVLESSL
210 220 230 240 250
DREEKAAHLL VLTASDAGDP VRTGTARIRV MVVDANDNAP AFARSEYRVS
260 270 280 290 300
VRENVAVGTQ LLLVNATDPD EGANAEVIYS FRYVDDKAAK VFKLDSNLGT
310 320 330 340 350
ISTIGELNHE ESGFYEMEVQ ATDNAGYSAR AKVLVTVLDV NDNAPEVAIT
360 370 380 390 400
SLTNSVPENS PQGTLIALLN VNDQDSGENG QVICSIQENL PFKLEKSYGN
410 420 430 440 450
YYRLVTDAVL DREEVPSYNI TMTATDRGSP PLTTETHLAL DIADTNDNSP
460 470 480 490 500
VFLQASYWAY IPENNPRGAS IASVTAHDPD SDKNAQVTYS LAEDTHQGVP
510 520 530 540 550
LSSYVSINSD TGVLYALHSF DYEQFPDLQL QVIARDSGDP PLSSNVSLSL
560 570 580 590 600
FVLDQNDNVP EILYPTLPTD GSTGVELAPR SAEPGYLVTK VVAVDRDSGQ
610 620 630 640 650
NAWLSYRLLK ASEPGLFSVG LHTGEISTAR ALMDRDALKQ NLVVSVQDHG
660 670 680 690 700
QPPLSATVTL TVAIADSIPD VLADLDNLES PSTSETSGLT LYLVVAVAAV
710 720 730 740 750
STVFLVFVLV LLALRLRRWH SLRLLRAGGP GLADVAASHF VGVDGVQAFL
760 770 780 790 800
QTYSHEVSLT AGSRKSHLIF PQPNYADTLI SQESCEKTEP LLPSGDSVFS
810 820 830 840 850
KDNHALNQQA PPNTDWRFSQ AQRPGTSGSQ NGDETGTWPN NQFDTEMLQA
860 870 880 890 900
MILASASEAA DGSSTLGGGA GTMGLSARYG PQFTLQHVPD YRQNVYIPGS
910 920 930
NATLTNAAGK RDGKAPAGGN GNKKKSGKKE KK
Length:932
Mass (Da):100,834
Last modified:December 1, 2001 - v1
Checksum:i2FA4348E600D0575
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020971 Genomic DNA. No translation available.
AC129315 Genomic DNA. No translation available.
BC054528 mRNA. Translation: AAH54528.1.
BC056998 mRNA. Translation: AAH56998.1.
AY013795 mRNA. Translation: AAK26084.1.
RefSeqiNP_291073.1. NM_033595.4.
UniGeneiMm.247203.

Genome annotation databases

EnsembliENSMUST00000044851; ENSMUSP00000036359; ENSMUSG00000102428.
GeneIDi93724.
KEGGimmu:93724.
UCSCiuc008erd.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ91XY7_MOUSE
AccessioniPrimary (citable) accession number: Q91XY7
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: June 7, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported