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Protein
Submitted name:

Protein Pcdhga12

Gene

Pcdhga12

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.SAAS annotation

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesionSAAS annotation

Keywords - Ligandi

CalciumUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Pcdhga12Imported
Submitted name:
Protocadherin gamma A12Imported
Submitted name:
Protocadherin gamma subfamily A, 12Imported
Gene namesi
Name:Pcdhga12Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ91XY7.

Expressioni

Gene expression databases

BgeeiQ91XY7.
ExpressionAtlasiQ91XY7. baseline.
GenevestigatoriQ91XY7.

Structurei

3D structure databases

ProteinModelPortaliQ91XY7.
SMRiQ91XY7. Positions 27-681.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains cadherin domains.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118847.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
KOiK16495.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91XY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPMQRREDC KGLVFLGVLL GMLWKAGSTQ IRYSVPEELE KGSRVGNISK
60 70 80 90 100
DLGLEPRELE KRGVRIVSRG RAQLFALNPR SGSLVTAGRI DREELCMGSI
110 120 130 140 150
KCQLNLEILM EDIGKIYGVE IEVRDINDNA PYFRESELEI KMSENAAAGM
160 170 180 190 200
RFPLPHAWDP DIGKNSLQSY QLSPNAHFSL EVQNGADGNK YPELVLESSL
210 220 230 240 250
DREEKAAHLL VLTASDAGDP VRTGTARIRV MVVDANDNAP AFARSEYRVS
260 270 280 290 300
VRENVAVGTQ LLLVNATDPD EGANAEVIYS FRYVDDKAAK VFKLDSNLGT
310 320 330 340 350
ISTIGELNHE ESGFYEMEVQ ATDNAGYSAR AKVLVTVLDV NDNAPEVAIT
360 370 380 390 400
SLTNSVPENS PQGTLIALLN VNDQDSGENG QVICSIQENL PFKLEKSYGN
410 420 430 440 450
YYRLVTDAVL DREEVPSYNI TMTATDRGSP PLTTETHLAL DIADTNDNSP
460 470 480 490 500
VFLQASYWAY IPENNPRGAS IASVTAHDPD SDKNAQVTYS LAEDTHQGVP
510 520 530 540 550
LSSYVSINSD TGVLYALHSF DYEQFPDLQL QVIARDSGDP PLSSNVSLSL
560 570 580 590 600
FVLDQNDNVP EILYPTLPTD GSTGVELAPR SAEPGYLVTK VVAVDRDSGQ
610 620 630 640 650
NAWLSYRLLK ASEPGLFSVG LHTGEISTAR ALMDRDALKQ NLVVSVQDHG
660 670 680 690 700
QPPLSATVTL TVAIADSIPD VLADLDNLES PSTSETSGLT LYLVVAVAAV
710 720 730 740 750
STVFLVFVLV LLALRLRRWH SLRLLRAGGP GLADVAASHF VGVDGVQAFL
760 770 780 790 800
QTYSHEVSLT AGSRKSHLIF PQPNYADTLI SQESCEKTEP LLPSGDSVFS
810 820 830 840 850
KDNHALNQQA PPNTDWRFSQ AQRPGTSGSQ NGDETGTWPN NQFDTEMLQA
860 870 880 890 900
MILASASEAA DGSSTLGGGA GTMGLSARYG PQFTLQHVPD YRQNVYIPGS
910 920 930
NATLTNAAGK RDGKAPAGGN GNKKKSGKKE KK
Length:932
Mass (Da):100,834
Last modified:December 1, 2001 - v1
Checksum:i2FA4348E600D0575
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020971 Genomic DNA. No translation available.
AC129315 Genomic DNA. No translation available.
BC054528 mRNA. Translation: AAH54528.1.
BC056998 mRNA. Translation: AAH56998.1.
AY013795 mRNA. Translation: AAK26084.1.
RefSeqiNP_291073.1. NM_033595.4.
UniGeneiMm.247203.

Genome annotation databases

EnsembliENSMUST00000044851; ENSMUSP00000036359; ENSMUSG00000102428.
GeneIDi93724.
KEGGimmu:93724.
UCSCiuc008erd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020971 Genomic DNA. No translation available.
AC129315 Genomic DNA. No translation available.
BC054528 mRNA. Translation: AAH54528.1.
BC056998 mRNA. Translation: AAH56998.1.
AY013795 mRNA. Translation: AAK26084.1.
RefSeqiNP_291073.1. NM_033595.4.
UniGeneiMm.247203.

3D structure databases

ProteinModelPortaliQ91XY7.
SMRiQ91XY7. Positions 27-681.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ91XY7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044851; ENSMUSP00000036359; ENSMUSG00000102428.
GeneIDi93724.
KEGGimmu:93724.
UCSCiuc008erd.1. mouse.

Organism-specific databases

CTDi26025.

Phylogenomic databases

GeneTreeiENSGT00760000118847.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
KOiK16495.

Miscellaneous databases

NextBioi351555.

Gene expression databases

BgeeiQ91XY7.
ExpressionAtlasiQ91XY7. baseline.
GenevestigatoriQ91XY7.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
    Wu Q., Maniatis T.
    Cell 97:779-790(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.
  2. "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes."
    Wu Q., Maniatis T.
    Proc. Natl. Acad. Sci. U.S.A. 97:3124-3129(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.
  3. "Comparative DNA sequence analysis of mouse and human protocadherin gene clusters."
    Wu Q., Zhang T., Cheng J.-F., Kim Y., Grimwood J., Schmutz J., Dickson M., Noonan J.P., Zhang M.Q., Myers R.M., Maniatis T.
    Genome Res. 11:389-404(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  6. Ensembl
    Submitted (JAN-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ91XY7_MOUSE
AccessioniPrimary (citable) accession number: Q91XY7
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: April 1, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.