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Q91XY7

- Q91XY7_MOUSE

UniProt

Q91XY7 - Q91XY7_MOUSE

Protein
Submitted name:

Protein Pcdhgb6

Gene

Pcdhga12

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.SAAS annotation

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. homophilic cell adhesion Source: InterPro

    Keywords - Biological processi

    Cell adhesionSAAS annotation

    Keywords - Ligandi

    CalciumUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein Pcdhgb6Imported
    Submitted name:
    Protocadherin gamma A12Imported
    Submitted name:
    Protocadherin gamma subfamily A, 12Imported
    Gene namesi
    Name:Pcdhga12Imported
    Synonyms:Pcdhgb6Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:1935197. Pcdhgb6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membraneSAAS annotation, Membrane

    Expressioni

    Gene expression databases

    GenevestigatoriQ91XY7.

    Family & Domainsi

    Sequence similaritiesi

    Contains cadherin domains.SAAS annotation

    Keywords - Domaini

    RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117438.
    HOGENOMiHOG000220892.
    HOVERGENiHBG054878.
    KOiK16495.
    OMAiLLMAWIC.

    Family and domain databases

    Gene3Di2.60.40.60. 6 hits.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR013164. Cadherin_N.
    [Graphical view]
    PfamiPF00028. Cadherin. 5 hits.
    PF08266. Cadherin_2. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    SMARTiSM00112. CA. 6 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 6 hits.
    PROSITEiPS00232. CADHERIN_1. 5 hits.
    PS50268. CADHERIN_2. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91XY7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIPMQRREDC KGLVFLGVLL GMLWKAGSTQ IRYSVPEELE KGSRVGNISK    50
    DLGLEPRELE KRGVRIVSRG RAQLFALNPR SGSLVTAGRI DREELCMGSI 100
    KCQLNLEILM EDIGKIYGVE IEVRDINDNA PYFRESELEI KMSENAAAGM 150
    RFPLPHAWDP DIGKNSLQSY QLSPNAHFSL EVQNGADGNK YPELVLESSL 200
    DREEKAAHLL VLTASDAGDP VRTGTARIRV MVVDANDNAP AFARSEYRVS 250
    VRENVAVGTQ LLLVNATDPD EGANAEVIYS FRYVDDKAAK VFKLDSNLGT 300
    ISTIGELNHE ESGFYEMEVQ ATDNAGYSAR AKVLVTVLDV NDNAPEVAIT 350
    SLTNSVPENS PQGTLIALLN VNDQDSGENG QVICSIQENL PFKLEKSYGN 400
    YYRLVTDAVL DREEVPSYNI TMTATDRGSP PLTTETHLAL DIADTNDNSP 450
    VFLQASYWAY IPENNPRGAS IASVTAHDPD SDKNAQVTYS LAEDTHQGVP 500
    LSSYVSINSD TGVLYALHSF DYEQFPDLQL QVIARDSGDP PLSSNVSLSL 550
    FVLDQNDNVP EILYPTLPTD GSTGVELAPR SAEPGYLVTK VVAVDRDSGQ 600
    NAWLSYRLLK ASEPGLFSVG LHTGEISTAR ALMDRDALKQ NLVVSVQDHG 650
    QPPLSATVTL TVAIADSIPD VLADLDNLES PSTSETSGLT LYLVVAVAAV 700
    STVFLVFVLV LLALRLRRWH SLRLLRAGGP GLADVAASHF VGVDGVQAFL 750
    QTYSHEVSLT AGSRKSHLIF PQPNYADTLI SQESCEKTEP LLPSGDSVFS 800
    KDNHALNQQA PPNTDWRFSQ AQRPGTSGSQ NGDETGTWPN NQFDTEMLQA 850
    MILASASEAA DGSSTLGGGA GTMGLSARYG PQFTLQHVPD YRQNVYIPGS 900
    NATLTNAAGK RDGKAPAGGN GNKKKSGKKE KK 932
    Length:932
    Mass (Da):100,834
    Last modified:December 1, 2001 - v1
    Checksum:i2FA4348E600D0575
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC020971 Genomic DNA. No translation available.
    AC129315 Genomic DNA. No translation available.
    BC054528 mRNA. Translation: AAH54528.1.
    BC056998 mRNA. Translation: AAH56998.1.
    AY013795 mRNA. Translation: AAK26084.1.
    RefSeqiNP_291073.1. NM_033595.4.
    UniGeneiMm.247203.

    Genome annotation databases

    EnsembliENSMUST00000044851; ENSMUSP00000036359; ENSMUSG00000023036.
    GeneIDi93724.
    KEGGimmu:93724.
    UCSCiuc008erd.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC020971 Genomic DNA. No translation available.
    AC129315 Genomic DNA. No translation available.
    BC054528 mRNA. Translation: AAH54528.1 .
    BC056998 mRNA. Translation: AAH56998.1 .
    AY013795 mRNA. Translation: AAK26084.1 .
    RefSeqi NP_291073.1. NM_033595.4.
    UniGenei Mm.247203.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044851 ; ENSMUSP00000036359 ; ENSMUSG00000023036 .
    GeneIDi 93724.
    KEGGi mmu:93724.
    UCSCi uc008erd.1. mouse.

    Organism-specific databases

    CTDi 26025.
    MGIi MGI:1935197. Pcdhgb6.

    Phylogenomic databases

    GeneTreei ENSGT00750000117438.
    HOGENOMi HOG000220892.
    HOVERGENi HBG054878.
    KOi K16495.
    OMAi LLMAWIC.

    Miscellaneous databases

    NextBioi 351555.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q91XY7.

    Family and domain databases

    Gene3Di 2.60.40.60. 6 hits.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR013164. Cadherin_N.
    [Graphical view ]
    Pfami PF00028. Cadherin. 5 hits.
    PF08266. Cadherin_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    SMARTi SM00112. CA. 6 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 6 hits.
    PROSITEi PS00232. CADHERIN_1. 5 hits.
    PS50268. CADHERIN_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
      Wu Q., Maniatis T.
      Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BrainImported.
    2. "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes."
      Wu Q., Maniatis T.
      Proc. Natl. Acad. Sci. U.S.A. 97:3124-3129(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BrainImported.
    3. "Comparative DNA sequence analysis of mouse and human protocadherin gene clusters."
      Wu Q., Zhang T., Cheng J.-F., Kim Y., Grimwood J., Schmutz J., Dickson M., Noonan J.P., Zhang M.Q., Myers R.M., Maniatis T.
      Genome Res. 11:389-404(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BrainImported.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6Imported.
      Tissue: BrainImported.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    6. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ91XY7_MOUSE
    AccessioniPrimary (citable) accession number: Q91XY7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 1, 2001
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3