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Q91XY7

- Q91XY7_MOUSE

UniProt

Q91XY7 - Q91XY7_MOUSE

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Protein
Submitted name: Protein Pcdhgb6
Gene
Pcdhgb6, Pcdhga12
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain By similarity.SAAS annotations

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. homophilic cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesionSAAS annotations

Keywords - Ligandi

CalciumUniRule annotationSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Pcdhgb6Imported
Submitted name:
Protocadherin gamma A12Imported
Submitted name:
Protocadherin gamma subfamily A, 12Imported
Gene namesi
Name:Pcdhgb6Imported
Synonyms:Pcdhga12Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:1935197. Pcdhgb6.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotations, Membrane

Expressioni

Gene expression databases

GenevestigatoriQ91XY7.

Family & Domainsi

Sequence similaritiesi

Contains cadherin domains.SAAS annotations

Keywords - Domaini

RepeatSAAS annotations, Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00750000117438.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
KOiK16495.
OMAiLLMAWIC.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91XY7-1 [UniParc]FASTAAdd to Basket

« Hide

MIPMQRREDC KGLVFLGVLL GMLWKAGSTQ IRYSVPEELE KGSRVGNISK    50
DLGLEPRELE KRGVRIVSRG RAQLFALNPR SGSLVTAGRI DREELCMGSI 100
KCQLNLEILM EDIGKIYGVE IEVRDINDNA PYFRESELEI KMSENAAAGM 150
RFPLPHAWDP DIGKNSLQSY QLSPNAHFSL EVQNGADGNK YPELVLESSL 200
DREEKAAHLL VLTASDAGDP VRTGTARIRV MVVDANDNAP AFARSEYRVS 250
VRENVAVGTQ LLLVNATDPD EGANAEVIYS FRYVDDKAAK VFKLDSNLGT 300
ISTIGELNHE ESGFYEMEVQ ATDNAGYSAR AKVLVTVLDV NDNAPEVAIT 350
SLTNSVPENS PQGTLIALLN VNDQDSGENG QVICSIQENL PFKLEKSYGN 400
YYRLVTDAVL DREEVPSYNI TMTATDRGSP PLTTETHLAL DIADTNDNSP 450
VFLQASYWAY IPENNPRGAS IASVTAHDPD SDKNAQVTYS LAEDTHQGVP 500
LSSYVSINSD TGVLYALHSF DYEQFPDLQL QVIARDSGDP PLSSNVSLSL 550
FVLDQNDNVP EILYPTLPTD GSTGVELAPR SAEPGYLVTK VVAVDRDSGQ 600
NAWLSYRLLK ASEPGLFSVG LHTGEISTAR ALMDRDALKQ NLVVSVQDHG 650
QPPLSATVTL TVAIADSIPD VLADLDNLES PSTSETSGLT LYLVVAVAAV 700
STVFLVFVLV LLALRLRRWH SLRLLRAGGP GLADVAASHF VGVDGVQAFL 750
QTYSHEVSLT AGSRKSHLIF PQPNYADTLI SQESCEKTEP LLPSGDSVFS 800
KDNHALNQQA PPNTDWRFSQ AQRPGTSGSQ NGDETGTWPN NQFDTEMLQA 850
MILASASEAA DGSSTLGGGA GTMGLSARYG PQFTLQHVPD YRQNVYIPGS 900
NATLTNAAGK RDGKAPAGGN GNKKKSGKKE KK 932
Length:932
Mass (Da):100,834
Last modified:December 1, 2001 - v1
Checksum:i2FA4348E600D0575
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC020971 Genomic DNA. No translation available.
AC129315 Genomic DNA. No translation available.
BC054528 mRNA. Translation: AAH54528.1.
BC056998 mRNA. Translation: AAH56998.1.
AY013795 mRNA. Translation: AAK26084.1.
RefSeqiNP_291073.1. NM_033595.4.
UniGeneiMm.247203.

Genome annotation databases

EnsembliENSMUST00000044851; ENSMUSP00000036359; ENSMUSG00000023036.
GeneIDi93724.
KEGGimmu:93724.
UCSCiuc008erd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC020971 Genomic DNA. No translation available.
AC129315 Genomic DNA. No translation available.
BC054528 mRNA. Translation: AAH54528.1 .
BC056998 mRNA. Translation: AAH56998.1 .
AY013795 mRNA. Translation: AAK26084.1 .
RefSeqi NP_291073.1. NM_033595.4.
UniGenei Mm.247203.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000044851 ; ENSMUSP00000036359 ; ENSMUSG00000023036 .
GeneIDi 93724.
KEGGi mmu:93724.
UCSCi uc008erd.1. mouse.

Organism-specific databases

CTDi 26025.
MGIi MGI:1935197. Pcdhgb6.

Phylogenomic databases

GeneTreei ENSGT00750000117438.
HOGENOMi HOG000220892.
HOVERGENi HBG054878.
KOi K16495.
OMAi LLMAWIC.

Miscellaneous databases

NextBioi 351555.
SOURCEi Search...

Gene expression databases

Genevestigatori Q91XY7.

Family and domain databases

Gene3Di 2.60.40.60. 6 hits.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view ]
Pfami PF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
SMARTi SM00112. CA. 6 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 6 hits.
PROSITEi PS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A striking organization of a large family of human neural cadherin-like cell adhesion genes."
    Wu Q., Maniatis T.
    Cell 97:779-790(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.
  2. "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes."
    Wu Q., Maniatis T.
    Proc. Natl. Acad. Sci. U.S.A. 97:3124-3129(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.
  3. "Comparative DNA sequence analysis of mouse and human protocadherin gene clusters."
    Wu Q., Zhang T., Cheng J.-F., Kim Y., Grimwood J., Schmutz J., Dickson M., Noonan J.P., Zhang M.Q., Myers R.M., Maniatis T.
    Genome Res. 11:389-404(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  6. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ91XY7_MOUSE
AccessioniPrimary (citable) accession number: Q91XY7
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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