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Protein
Submitted name:

Protocadherin gamma A3

Gene

Pcdhga3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: GO_Central
  • cell-cell signaling Source: GO_Central
  • endosome to lysosome transport Source: MGI
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • lipid tube assembly involved in organelle fusion Source: MGI
  • nervous system development Source: GO_Central

Keywordsi

Biological processCell adhesionSAAS annotation
LigandCalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protocadherin gamma A3Imported
Submitted name:
Protocadherin gamma subfamily A, 3Imported
Gene namesi
Name:Pcdhga3Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1935215. Pcdhga3.

Subcellular locationi

  • Cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei686 – 711HelicalSequence analysisAdd BLAST26

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • intracellular Source: GOC
  • membrane Source: MGI

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501051033223 – 928Sequence analysisAdd BLAST906

Proteomic databases

TopDownProteomicsiQ91XY5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000023036.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 128CAInterPro annotationAdd BLAST87
Domaini152 – 237CAInterPro annotationAdd BLAST86
Domaini261 – 342CAInterPro annotationAdd BLAST82
Domaini366 – 447CAInterPro annotationAdd BLAST82
Domaini471 – 557CAInterPro annotationAdd BLAST87
Domaini588 – 666CAInterPro annotationAdd BLAST79

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
KOiK16495.
OMAiDSIENAH.
OrthoDBiEOG091G024L.

Family and domain databases

InterProiView protein in InterPro
IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
PfamiView protein in Pfam
PF00028. Cadherin. 4 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
PRINTSiPR00205. CADHERIN.
SMARTiView protein in SMART
SM00112. CA. 6 hits.
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiView protein in PROSITE
PS00232. CADHERIN_1. 3 hits.

Sequencei

Sequence statusi: Complete.

Q91XY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRLGQGTAG ALLCALLGTL CAAGFRQIRY SVPEELDKGS FVGNISKDLG
60 70 80 90 100
LEPRELAERG VRIISRGKSQ LFSLDPRSGS LVTRGRIDRE ELCAQSAPCL
110 120 130 140 150
VSFNILVEDK LKIFEVEVDI SDINDNAPSF PTEELEIKIG ELTVPGTRFP
160 170 180 190 200
LKTAFDPDVG MNALQNYKLN SNDYFSLAVN SVIDDAKYPE LVLERALDRE
210 220 230 240 250
KKAVHQLDLI ASDGGDPVHT SKLCIQVIVS DANDNPPVFT KPEYHVSVLE
260 270 280 290 300
NVPVGTRLIT VNATDPDEGF NAQVSYILDK MPGKIAQVFH LNSVTGDISI
310 320 330 340 350
LKSLDYEDAV FYEIKIEAQD GPGLFSRAKV LVTVLDVNDN APEVSVTSLT
360 370 380 390 400
GSVPEEAPAG REIALINVHD RDSGQNGQVT VFVLGNLPFT LEKSIDQYYR
410 420 430 440 450
LVTARSLDHE EVSQYNISLR ATDGGSPPLS TETHITLHVS DINDNPPTFT
460 470 480 490 500
HASYSAYIPE NNARGASIFS VTAQDPDTDK NAQVTYSLAE DTLQGLPLSS
510 520 530 540 550
YISINSNTGV LYALCSFDYE QFRDLQLQIT ARDSGTPPLS SNTTLNLFVL
560 570 580 590 600
DQNDNTPEIL YPTLPVDGST GVELAPRSAD PGYLVTKVVA VDKDSGQNAW
610 620 630 640 650
LSYRLLKASE PGLFSVGLHT GEVRTARALL DRDALKQSLV VAVQDHGQPP
660 670 680 690 700
LSATVTLTIA VADSIPDILG DLESIHTPAN PQNSDLTLYL VVAVAVVSCI
710 720 730 740 750
FLAFVIVLLA LRLRRWYSSR LQASGNGLAG IPASHFVGLD GVQAFLQTYS
760 770 780 790 800
QEVSLTAGSR KSHLIFPQPN YADTLISQES CGKSEPLIIP QDLLETKEDP
810 820 830 840 850
TLPQQAPPNT DWRFSQAQRP GTSGSQNGDE TGTWPNNQFD TEMLQAMILA
860 870 880 890 900
SASEAADGSS TLGGGAGTMG LSARYGPQFT LQHVPDYRQN VYIPGSNATL
910 920
TNAAGKRDGK APAGGNGNKK KSGKKEKK
Length:928
Mass (Da):100,175
Last modified:December 1, 2001 - v1
Checksum:i305A29485803FBBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020971 Genomic DNA. No translation available.
AC129315 Genomic DNA. No translation available.
BC060691 mRNA. Translation: AAH60691.1.
AY013797 mRNA. Translation: AAK26086.1.
RefSeqiNP_291064.1. NM_033586.2.
UniGeneiMm.247203.

Genome annotation databases

EnsembliENSMUST00000073447; ENSMUSP00000073150; ENSMUSG00000104346.
GeneIDi93711.
KEGGimmu:93711.
UCSCiuc008eqn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020971 Genomic DNA. No translation available.
AC129315 Genomic DNA. No translation available.
BC060691 mRNA. Translation: AAH60691.1.
AY013797 mRNA. Translation: AAK26086.1.
RefSeqiNP_291064.1. NM_033586.2.
UniGeneiMm.247203.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

TopDownProteomicsiQ91XY5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073447; ENSMUSP00000073150; ENSMUSG00000104346.
GeneIDi93711.
KEGGimmu:93711.
UCSCiuc008eqn.1. mouse.

Organism-specific databases

CTDi56112.
MGIiMGI:1935215. Pcdhga3.

Phylogenomic databases

GeneTreeiENSGT00840000129690.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
KOiK16495.
OMAiDSIENAH.
OrthoDBiEOG091G024L.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023036.

Family and domain databases

InterProiView protein in InterPro
IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
PfamiView protein in Pfam
PF00028. Cadherin. 4 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
PRINTSiPR00205. CADHERIN.
SMARTiView protein in SMART
SM00112. CA. 6 hits.
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiView protein in PROSITE
PS00232. CADHERIN_1. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ91XY5_MOUSE
AccessioniPrimary (citable) accession number: Q91XY5
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: June 7, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.