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Protein
Submitted name:

Protein Pcdhga3

Gene

Pcdhga3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.SAAS annotation

GO - Molecular functioni

GO - Biological processi

  • endosome to lysosome transport Source: MGI
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • lipid tube assembly involved in organelle fusion Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesionSAAS annotation

Keywords - Ligandi

CalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Protein Pcdhga3Imported
Submitted name:
Protocadherin gamma A3Imported
Submitted name:
Protocadherin gamma subfamily A, 3Imported
Gene namesi
Name:Pcdhga3Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1935215. Pcdhga3.

Subcellular locationi

  • Cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei686 – 71126HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: GOC
  • membrane Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 928906Sequence analysisPRO_5007928433Add
BLAST

Proteomic databases

TopDownProteomicsiQ91XY5.

PTM databases

PhosphoSiteiQ91XY5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000023036.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 13059CadherinInterPro annotationAdd
BLAST
Domaini131 – 239109CadherinInterPro annotationAdd
BLAST
Domaini240 – 344105CadherinInterPro annotationAdd
BLAST
Domaini345 – 449105CadherinInterPro annotationAdd
BLAST
Domaini450 – 559110CadherinInterPro annotationAdd
BLAST
Domaini576 – 680105CadherinInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains cadherin domains.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00840000129695.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
KOiK16495.
OMAiDSIENAH.
OrthoDBiEOG091G024L.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91XY5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRLGQGTAG ALLCALLGTL CAAGFRQIRY SVPEELDKGS FVGNISKDLG
60 70 80 90 100
LEPRELAERG VRIISRGKSQ LFSLDPRSGS LVTRGRIDRE ELCAQSAPCL
110 120 130 140 150
VSFNILVEDK LKIFEVEVDI SDINDNAPSF PTEELEIKIG ELTVPGTRFP
160 170 180 190 200
LKTAFDPDVG MNALQNYKLN SNDYFSLAVN SVIDDAKYPE LVLERALDRE
210 220 230 240 250
KKAVHQLDLI ASDGGDPVHT SKLCIQVIVS DANDNPPVFT KPEYHVSVLE
260 270 280 290 300
NVPVGTRLIT VNATDPDEGF NAQVSYILDK MPGKIAQVFH LNSVTGDISI
310 320 330 340 350
LKSLDYEDAV FYEIKIEAQD GPGLFSRAKV LVTVLDVNDN APEVSVTSLT
360 370 380 390 400
GSVPEEAPAG REIALINVHD RDSGQNGQVT VFVLGNLPFT LEKSIDQYYR
410 420 430 440 450
LVTARSLDHE EVSQYNISLR ATDGGSPPLS TETHITLHVS DINDNPPTFT
460 470 480 490 500
HASYSAYIPE NNARGASIFS VTAQDPDTDK NAQVTYSLAE DTLQGLPLSS
510 520 530 540 550
YISINSNTGV LYALCSFDYE QFRDLQLQIT ARDSGTPPLS SNTTLNLFVL
560 570 580 590 600
DQNDNTPEIL YPTLPVDGST GVELAPRSAD PGYLVTKVVA VDKDSGQNAW
610 620 630 640 650
LSYRLLKASE PGLFSVGLHT GEVRTARALL DRDALKQSLV VAVQDHGQPP
660 670 680 690 700
LSATVTLTIA VADSIPDILG DLESIHTPAN PQNSDLTLYL VVAVAVVSCI
710 720 730 740 750
FLAFVIVLLA LRLRRWYSSR LQASGNGLAG IPASHFVGLD GVQAFLQTYS
760 770 780 790 800
QEVSLTAGSR KSHLIFPQPN YADTLISQES CGKSEPLIIP QDLLETKEDP
810 820 830 840 850
TLPQQAPPNT DWRFSQAQRP GTSGSQNGDE TGTWPNNQFD TEMLQAMILA
860 870 880 890 900
SASEAADGSS TLGGGAGTMG LSARYGPQFT LQHVPDYRQN VYIPGSNATL
910 920
TNAAGKRDGK APAGGNGNKK KSGKKEKK
Length:928
Mass (Da):100,175
Last modified:December 1, 2001 - v1
Checksum:i305A29485803FBBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020971 Genomic DNA. No translation available.
AC129315 Genomic DNA. No translation available.
BC060691 mRNA. Translation: AAH60691.1.
AY013797 mRNA. Translation: AAK26086.1.
RefSeqiNP_291064.1. NM_033586.2.
UniGeneiMm.247203.

Genome annotation databases

EnsembliENSMUST00000073447; ENSMUSP00000073150; ENSMUSG00000104346.
GeneIDi93711.
KEGGimmu:93711.
UCSCiuc008eqn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020971 Genomic DNA. No translation available.
AC129315 Genomic DNA. No translation available.
BC060691 mRNA. Translation: AAH60691.1.
AY013797 mRNA. Translation: AAK26086.1.
RefSeqiNP_291064.1. NM_033586.2.
UniGeneiMm.247203.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ91XY5.

Proteomic databases

TopDownProteomicsiQ91XY5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073447; ENSMUSP00000073150; ENSMUSG00000104346.
GeneIDi93711.
KEGGimmu:93711.
UCSCiuc008eqn.1. mouse.

Organism-specific databases

CTDi56112.
MGIiMGI:1935215. Pcdhga3.

Phylogenomic databases

GeneTreeiENSGT00840000129695.
HOGENOMiHOG000220892.
HOVERGENiHBG054878.
KOiK16495.
OMAiDSIENAH.
OrthoDBiEOG091G024L.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023036.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR031904. Cadherin_CBD.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 4 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
PF15974. Cadherin_tail. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 6 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 5 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ91XY5_MOUSE
AccessioniPrimary (citable) accession number: Q91XY5
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.