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Q91XW7

- Q91XW7_RAT

UniProt

Q91XW7 - Q91XW7_RAT

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Protein

Caspase

Gene

Casp4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei206 – 2061UniRule annotation
Active sitei254 – 2541UniRule annotation

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: RefGenome
  2. scaffold protein binding Source: RGD

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
  2. apoptotic process Source: RGD
  3. execution phase of apoptosis Source: RefGenome
  4. inflammatory response Source: RGD
  5. regulation of inflammatory response Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseUniRule annotation

Enzyme and pathway databases

BRENDAi3.4.22.64. 248.

Protein family/group databases

MEROPSiC14.012.

Names & Taxonomyi

Protein namesi
Recommended name:
CaspaseUniRule annotation
Gene namesi
Name:Casp4Imported
Synonyms:Casp11Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi621757. Casp4.

Subcellular locationi

GO - Cellular componenti

  1. AIM2 inflammasome complex Source: RefGenome
  2. cytoplasm Source: RefGenome
  3. IPAF inflammasome complex Source: RefGenome
  4. neuronal cell body Source: RGD
  5. neuron projection Source: RGD
  6. NLRP3 inflammasome complex Source: RefGenome
  7. protein complex Source: RGD
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

ZymogenUniRule annotation

Expressioni

Gene expression databases

GenevestigatoriQ91XW7.

Structurei

3D structure databases

ProteinModelPortaliQ91XW7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C14A family.UniRule annotation
Contains CARD domain.SAAS annotation

Phylogenomic databases

HOVERGENiHBG076981.
PhylomeDBiQ91XW7.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiIPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR017350. Caspase_ICE-type.
IPR011029. DEATH-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
PF00656. Peptidase_C14. 1 hit.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91XW7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAENNHPDKP LKVLEELGKE FLTEYLEKLV QSNVLKLKEE EKQKFNNAER
60 70 80 90 100
SDKRWVFVDV LKRKHNQVGK MLLQTFLNVD SGSHHGEANL EMEEPEESVD
110 120 130 140 150
TLKLCSSEEF TRLCREKKQE IYPIKETNGR TRKALIICNT EFKHLSLRYG
160 170 180 190 200
ANIDISGMKG LLEELGYDVV VKEELTAEGM ESEMKDFAAL SEHQTSDSTF
210 220 230 240 250
LVVMSHGTLQ GLCGTMHSEA TPDVLLYDTI YQIFNNCHCP GLRDKPKVII
260 270 280 290 300
VQACRGGNSG EVWIRESSGA HSYRAVDLPR NMEADAVRMS HVEKDFIALY
310 320 330 340 350
STTPHHLSYR DKTRGSYFIS KLISCFRIHA CSCHLFDIFL KVQQSFEKAS
360 370
INSQMPTIDR ATLTRYFYLF PGN
Length:373
Mass (Da):42,690
Last modified:December 1, 2001 - v1
Checksum:i9D0F6B3EDFED7592
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029283 mRNA. Translation: AAK38735.1.
UniGeneiRn.16195.

Genome annotation databases

UCSCiRGD:621757. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029283 mRNA. Translation: AAK38735.1 .
UniGenei Rn.16195.

3D structure databases

ProteinModelPortali Q91XW7.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C14.012.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:621757. rat.

Organism-specific databases

RGDi 621757. Casp4.

Phylogenomic databases

HOVERGENi HBG076981.
PhylomeDBi Q91XW7.

Enzyme and pathway databases

BRENDAi 3.4.22.64. 248.

Gene expression databases

Genevestigatori Q91XW7.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProi IPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR017350. Caspase_ICE-type.
IPR011029. DEATH-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view ]
Pfami PF00619. CARD. 1 hit.
PF00656. Peptidase_C14. 1 hit.
[Graphical view ]
PIRSFi PIRSF038001. Caspase_ICE. 1 hit.
PRINTSi PR00376. IL1BCENZYME.
SMARTi SM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
PROSITEi PS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Induction of caspase-11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway."
    Hur J., Kim S.Y., Kim H., Cha S., Lee M.S., Suk K.
    FEBS Lett. 507:157-162(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: GliomaImported.

Entry informationi

Entry nameiQ91XW7_RAT
AccessioniPrimary (citable) accession number: Q91XW7
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)