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Q91XW7

- Q91XW7_RAT

UniProt

Q91XW7 - Q91XW7_RAT

Protein

Caspase

Gene

Casp4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei206 – 2061UniRule annotation
    Active sitei254 – 2541UniRule annotation

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: RefGenome
    2. protein binding Source: RGD
    3. scaffold protein binding Source: RGD

    GO - Biological processi

    1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
    2. apoptotic process Source: RGD
    3. execution phase of apoptosis Source: RefGenome
    4. inflammatory response Source: RGD
    5. regulation of inflammatory response Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol proteaseUniRule annotation

    Enzyme and pathway databases

    BRENDAi3.4.22.64. 248.

    Protein family/group databases

    MEROPSiC14.012.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CaspaseUniRule annotation
    Gene namesi
    Name:Casp4Imported
    Synonyms:Casp11Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi621757. Casp4.

    Subcellular locationi

    GO - Cellular componenti

    1. AIM2 inflammasome complex Source: RefGenome
    2. cytoplasm Source: RefGenome
    3. IPAF inflammasome complex Source: RefGenome
    4. neuronal cell body Source: RGD
    5. neuron projection Source: RGD
    6. NLRP3 inflammasome complex Source: RefGenome
    7. protein complex Source: RGD

    PTM / Processingi

    Keywords - PTMi

    ZymogenUniRule annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ91XW7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ91XW7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C14A family.UniRule annotation
    Contains CARD domain.SAAS annotation

    Phylogenomic databases

    HOVERGENiHBG076981.
    InParanoidiQ91XW7.
    PhylomeDBiQ91XW7.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    3.40.50.1460. 1 hit.
    InterProiIPR001315. CARD.
    IPR029030. Caspase-like_dom.
    IPR017350. Caspase_ICE-type.
    IPR011029. DEATH-like_dom.
    IPR011600. Pept_C14_caspase.
    IPR001309. Pept_C14_ICE_p20.
    IPR016129. Pept_C14_ICE_p20_AS.
    IPR002138. Pept_C14_p10.
    IPR015917. Pept_C14A_p45_core.
    [Graphical view]
    PfamiPF00619. CARD. 1 hit.
    PF00656. Peptidase_C14. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
    PRINTSiPR00376. IL1BCENZYME.
    SMARTiSM00114. CARD. 1 hit.
    SM00115. CASc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    PROSITEiPS50209. CARD. 1 hit.
    PS01122. CASPASE_CYS. 1 hit.
    PS01121. CASPASE_HIS. 1 hit.
    PS50207. CASPASE_P10. 1 hit.
    PS50208. CASPASE_P20. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91XW7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAENNHPDKP LKVLEELGKE FLTEYLEKLV QSNVLKLKEE EKQKFNNAER    50
    SDKRWVFVDV LKRKHNQVGK MLLQTFLNVD SGSHHGEANL EMEEPEESVD 100
    TLKLCSSEEF TRLCREKKQE IYPIKETNGR TRKALIICNT EFKHLSLRYG 150
    ANIDISGMKG LLEELGYDVV VKEELTAEGM ESEMKDFAAL SEHQTSDSTF 200
    LVVMSHGTLQ GLCGTMHSEA TPDVLLYDTI YQIFNNCHCP GLRDKPKVII 250
    VQACRGGNSG EVWIRESSGA HSYRAVDLPR NMEADAVRMS HVEKDFIALY 300
    STTPHHLSYR DKTRGSYFIS KLISCFRIHA CSCHLFDIFL KVQQSFEKAS 350
    INSQMPTIDR ATLTRYFYLF PGN 373
    Length:373
    Mass (Da):42,690
    Last modified:December 1, 2001 - v1
    Checksum:i9D0F6B3EDFED7592
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY029283 mRNA. Translation: AAK38735.1.
    UniGeneiRn.16195.

    Genome annotation databases

    UCSCiRGD:621757. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY029283 mRNA. Translation: AAK38735.1 .
    UniGenei Rn.16195.

    3D structure databases

    ProteinModelPortali Q91XW7.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C14.012.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:621757. rat.

    Organism-specific databases

    RGDi 621757. Casp4.

    Phylogenomic databases

    HOVERGENi HBG076981.
    InParanoidi Q91XW7.
    PhylomeDBi Q91XW7.

    Enzyme and pathway databases

    BRENDAi 3.4.22.64. 248.

    Gene expression databases

    Genevestigatori Q91XW7.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    3.40.50.1460. 1 hit.
    InterProi IPR001315. CARD.
    IPR029030. Caspase-like_dom.
    IPR017350. Caspase_ICE-type.
    IPR011029. DEATH-like_dom.
    IPR011600. Pept_C14_caspase.
    IPR001309. Pept_C14_ICE_p20.
    IPR016129. Pept_C14_ICE_p20_AS.
    IPR002138. Pept_C14_p10.
    IPR015917. Pept_C14A_p45_core.
    [Graphical view ]
    Pfami PF00619. CARD. 1 hit.
    PF00656. Peptidase_C14. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038001. Caspase_ICE. 1 hit.
    PRINTSi PR00376. IL1BCENZYME.
    SMARTi SM00114. CARD. 1 hit.
    SM00115. CASc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    PROSITEi PS50209. CARD. 1 hit.
    PS01122. CASPASE_CYS. 1 hit.
    PS01121. CASPASE_HIS. 1 hit.
    PS50207. CASPASE_P10. 1 hit.
    PS50208. CASPASE_P20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Induction of caspase-11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway."
      Hur J., Kim S.Y., Kim H., Cha S., Lee M.S., Suk K.
      FEBS Lett. 507:157-162(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: GliomaImported.

    Entry informationi

    Entry nameiQ91XW7_RAT
    AccessioniPrimary (citable) accession number: Q91XW7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 1, 2001
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)