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Protein
Submitted name:

Caspase 11

Gene

Casp4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • cysteine-type endopeptidase activity Source: InterPro
  • scaffold protein binding Source: RGD

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
  • apoptotic process Source: RGD
  • inflammatory response Source: RGD

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseSAAS annotation

Enzyme and pathway databases

BRENDAi3.4.22.64. 5301.

Protein family/group databases

MEROPSiC14.012.

Names & Taxonomyi

Protein namesi
Submitted name:
Caspase 11Imported
Gene namesi
Name:Casp4Imported
Synonyms:Casp11Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi621757. Casp4.

Subcellular locationi

GO - Cellular componenti

  • neuronal cell body Source: RGD
  • neuron projection Source: RGD
  • protein complex Source: RGD

PTM / Processingi

Proteomic databases

PaxDbiQ91XW7.

Interactioni

GO - Molecular functioni

  • scaffold protein binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058685.

Structurei

3D structure databases

ProteinModelPortaliQ91XW7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 80CARDInterPro annotationAdd BLAST80
Domaini130 – 258CASPASE_P20InterPro annotationAdd BLAST129
Domaini286 – 371CASPASE_P10InterPro annotationAdd BLAST86

Sequence similaritiesi

Belongs to the peptidase C14A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
HOVERGENiHBG076981.
PhylomeDBiQ91XW7.

Family and domain databases

CDDicd00032. CASc. 1 hit.
InterProiView protein in InterPro
IPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR011029. DEATH-like_dom.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A.
PfamiView protein in Pfam
PF00619. CARD. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiView protein in SMART
SM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52129. SSF52129. 1 hit.
PROSITEiView protein in PROSITE
PS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.

Sequencei

Sequence statusi: Complete.

Q91XW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENNHPDKP LKVLEELGKE FLTEYLEKLV QSNVLKLKEE EKQKFNNAER
60 70 80 90 100
SDKRWVFVDV LKRKHNQVGK MLLQTFLNVD SGSHHGEANL EMEEPEESVD
110 120 130 140 150
TLKLCSSEEF TRLCREKKQE IYPIKETNGR TRKALIICNT EFKHLSLRYG
160 170 180 190 200
ANIDISGMKG LLEELGYDVV VKEELTAEGM ESEMKDFAAL SEHQTSDSTF
210 220 230 240 250
LVVMSHGTLQ GLCGTMHSEA TPDVLLYDTI YQIFNNCHCP GLRDKPKVII
260 270 280 290 300
VQACRGGNSG EVWIRESSGA HSYRAVDLPR NMEADAVRMS HVEKDFIALY
310 320 330 340 350
STTPHHLSYR DKTRGSYFIS KLISCFRIHA CSCHLFDIFL KVQQSFEKAS
360 370
INSQMPTIDR ATLTRYFYLF PGN
Length:373
Mass (Da):42,690
Last modified:December 1, 2001 - v1
Checksum:i9D0F6B3EDFED7592
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029283 mRNA. Translation: AAK38735.1.
UniGeneiRn.16195.

Genome annotation databases

UCSCiRGD:621757. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029283 mRNA. Translation: AAK38735.1.
UniGeneiRn.16195.

3D structure databases

ProteinModelPortaliQ91XW7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058685.

Protein family/group databases

MEROPSiC14.012.

Proteomic databases

PaxDbiQ91XW7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:621757. rat.

Organism-specific databases

RGDi621757. Casp4.

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
HOVERGENiHBG076981.
PhylomeDBiQ91XW7.

Enzyme and pathway databases

BRENDAi3.4.22.64. 5301.

Family and domain databases

CDDicd00032. CASc. 1 hit.
InterProiView protein in InterPro
IPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR011029. DEATH-like_dom.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A.
PfamiView protein in Pfam
PF00619. CARD. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiView protein in SMART
SM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52129. SSF52129. 1 hit.
PROSITEiView protein in PROSITE
PS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ91XW7_RAT
AccessioniPrimary (citable) accession number: Q91XW7
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: June 7, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.