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Protein

Caspase

Gene

Casp4

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei206 – 2061UniRule annotation
Active sitei254 – 2541UniRule annotation

GO - Molecular functioni

  • cysteine-type endopeptidase activity Source: InterPro
  • scaffold protein binding Source: RGD

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
  • apoptotic process Source: RGD
  • inflammatory response Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseUniRule annotationSAAS annotation

Enzyme and pathway databases

BRENDAi3.4.22.64. 5301.

Protein family/group databases

MEROPSiC14.012.

Names & Taxonomyi

Protein namesi
Recommended name:
CaspaseUniRule annotation
Gene namesi
Name:Casp4Imported
Synonyms:Casp11Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi621757. Casp4.

Subcellular locationi

GO - Cellular componenti

  • neuronal cell body Source: RGD
  • neuron projection Source: RGD
  • protein complex Source: RGD
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

ZymogenUniRule annotation

Proteomic databases

PaxDbiQ91XW7.

Interactioni

GO - Molecular functioni

  • scaffold protein binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058685.

Structurei

3D structure databases

ProteinModelPortaliQ91XW7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8080CARDInterPro annotationAdd
BLAST
Domaini130 – 258129CASPASE_P20InterPro annotationAdd
BLAST
Domaini286 – 37186CASPASE_P10InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C14A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
HOVERGENiHBG076981.
PhylomeDBiQ91XW7.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiIPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR011029. DEATH-like_dom.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A.
IPR017350. Pept_C14A_CASP1-typ.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52129. SSF52129. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91XW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENNHPDKP LKVLEELGKE FLTEYLEKLV QSNVLKLKEE EKQKFNNAER
60 70 80 90 100
SDKRWVFVDV LKRKHNQVGK MLLQTFLNVD SGSHHGEANL EMEEPEESVD
110 120 130 140 150
TLKLCSSEEF TRLCREKKQE IYPIKETNGR TRKALIICNT EFKHLSLRYG
160 170 180 190 200
ANIDISGMKG LLEELGYDVV VKEELTAEGM ESEMKDFAAL SEHQTSDSTF
210 220 230 240 250
LVVMSHGTLQ GLCGTMHSEA TPDVLLYDTI YQIFNNCHCP GLRDKPKVII
260 270 280 290 300
VQACRGGNSG EVWIRESSGA HSYRAVDLPR NMEADAVRMS HVEKDFIALY
310 320 330 340 350
STTPHHLSYR DKTRGSYFIS KLISCFRIHA CSCHLFDIFL KVQQSFEKAS
360 370
INSQMPTIDR ATLTRYFYLF PGN
Length:373
Mass (Da):42,690
Last modified:December 1, 2001 - v1
Checksum:i9D0F6B3EDFED7592
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029283 mRNA. Translation: AAK38735.1.
UniGeneiRn.16195.

Genome annotation databases

UCSCiRGD:621757. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY029283 mRNA. Translation: AAK38735.1.
UniGeneiRn.16195.

3D structure databases

ProteinModelPortaliQ91XW7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058685.

Protein family/group databases

MEROPSiC14.012.

Proteomic databases

PaxDbiQ91XW7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:621757. rat.

Organism-specific databases

RGDi621757. Casp4.

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
HOVERGENiHBG076981.
PhylomeDBiQ91XW7.

Enzyme and pathway databases

BRENDAi3.4.22.64. 5301.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiIPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR011029. DEATH-like_dom.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A.
IPR017350. Pept_C14A_CASP1-typ.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52129. SSF52129. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Induction of caspase-11 by inflammatory stimuli in rat astrocytes: lipopolysaccharide induction through p38 mitogen-activated protein kinase pathway."
    Hur J., Kim S.Y., Kim H., Cha S., Lee M.S., Suk K.
    FEBS Lett. 507:157-162(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: GliomaImported.

Entry informationi

Entry nameiQ91XW7_RAT
AccessioniPrimary (citable) accession number: Q91XW7
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.