Q91XV6 (FXYD6_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
FXYD domain-containing ion transport regulator 6

Alternative name(s):
Phosphohippolin
Vascular endothelial cell-specific protein 6
Short name=VESP6

Gene names

Name:	Fxyd6
Synonyms:	Php

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	94 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Expressed in the neuronal fibers of the medial part of lateral habenula nucleus, thalamus, hypothalamus, stria terminalis, zona incerta, amygdaloid body and cingulum, olfactory bulb, hippocampus, cerebral cortex and cerebellum. In the cerebellum there is a predominant expression pattern in the granule layer of lobules VI-IX of the posterior lobe. Ref.2
Sequence similarities	Belongs to the FXYD family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Ionic channel
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q91XV6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q91XV6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     20-20: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 94	77	FXYD domain-containing ion transport regulator 6		PRO_0000010376
Regions
	Topological domain	18 – 34	17	Extracellular Potential
	Transmembrane	35 – 57	23	Helical; Potential
	Topological domain	58 – 94	37	Cytoplasmic Potential
Natural variations
	Alternative sequence	20	1	Missing in isoform 2.		VSP_001586
Experimental info
	Sequence conflict	65	1	N → S in AAF66613. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 1C0D35FA0C572451	FASTA	94	10,388
	10 20 30 40 50 60 METVLILCSL LAPVVLASAA EKEKEKDPFY YDYQTLRIGG LVFAVVLFSV GILLILSRRC 70 80 90 KCSFNQKPRA PGDEEAQVEN LITTNAAEPQ KAEN
	Isoform 2 [UniParc]. Checksum: 4A8A5871BB802FE6	FASTA	93	10,317
	10 20 30 40 50 60 METVLILCSL LAPVVLASAE KEKEKDPFYY DYQTLRIGGL VFAVVLFSVG ILLILSRRCK 70 80 90 CSFNQKPRAP GDEEAQVENL ITTNAAEPQK AEN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of VESP6, a vascular endothelial cell specific protein." Aoki T., Toyoda H., Nishimoto S., Tawara J., Komurasaki T. Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Liver.
[2]	"Molecular cloning and characterization of a novel phospholemman-like protein from rat hippocampus." Yamaguchi F., Yamaguchi K., Tai Y., Sugimoto K., Tokuda M. Brain Res. Mol. Brain Res. 86:189-192(2001) [PubMed: 11165386] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY. Strain: Sprague-Dawley. Tissue: Hippocampus.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Lung.
[4]	Lubec G., Kang S.U., Lubec S. Submitted (SEP-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 25-37, MASS SPECTROMETRY. Strain: Sprague-Dawley. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB030908 mRNA. Translation: BAB62242.1. AF142439 mRNA. Translation: AAF66613.1. BC072528 mRNA. Translation: AAH72528.1.
IPI	IPI00208232. IPI00231244.
RefSeq	NP_071288.1. NM_022005.2.
UniGene	Rn.839.
3D structure databases
ProteinModelPortal	Q91XV6.
SMR	Q91XV6. Positions 21-88.
ModBase	Search...
Protein-protein interaction databases
STRING	Q91XV6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000022032; ENSRNOP00000022032; ENSRNOG00000016412.
GeneID	63847.
KEGG	rno:63847.
UCSC	NM_022005. rat.
Organism-specific databases
CTD	53826.
RGD	69315. Fxyd6.
Phylogenomic databases
eggNOG	maNOG20563.
GeneTree	ENSGT00530000063932.
HOVERGEN	HBG008212.
InParanoid	Q91XV6.
OMA	KDPFHYD.
OrthoDB	EOG4PG62F.
PhylomeDB	Q91XV6.
Gene expression databases
Genevestigator	Q91XV6.
Family and domain databases
InterPro	IPR000272. Ion-transport_regulator_FXYD. [Graphical view]
KO	K13363.
Pfam	PF02038. ATP1G1_PLM_MAT8. 1 hit. [Graphical view]
ProDom	PD005989. PD005989. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01310. FXYD. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	612448.

Entry information

Entry name

FXYD6_RAT

Accession

Primary (citable) accession number: Q91XV6
Secondary accession number(s): Q9JLR4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	December 1, 2001
Last modified:	November 16, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program