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Protein

FXYD domain-containing ion transport regulator 6

Gene

Fxyd6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-5578775. Ion homeostasis.
R-RNO-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
FXYD domain-containing ion transport regulator 6
Alternative name(s):
Phosphohippolin
Vascular endothelial cell-specific protein 6
Short name:
VESP6
Gene namesi
Name:Fxyd6
Synonyms:Php
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi69315. Fxyd6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 3417ExtracellularSequence analysisAdd
BLAST
Transmembranei35 – 5723HelicalSequence analysisAdd
BLAST
Topological domaini58 – 9437CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 9477FXYD domain-containing ion transport regulator 6PRO_0000010376Add
BLAST

Proteomic databases

PaxDbiQ91XV6.
PRIDEiQ91XV6.

PTM databases

SwissPalmiQ91XV6.

Expressioni

Tissue specificityi

Expressed in the neuronal fibers of the medial part of lateral habenula nucleus, thalamus, hypothalamus, stria terminalis, zona incerta, amygdaloid body and cingulum, olfactory bulb, hippocampus, cerebral cortex and cerebellum. In the cerebellum there is a predominant expression pattern in the granule layer of lobules VI-IX of the posterior lobe.1 Publication

Gene expression databases

ExpressionAtlasiQ91XV6. baseline and differential.
GenevisibleiQ91XV6. RN.

Interactioni

Protein-protein interaction databases

BioGridi248902. 1 interaction.
STRINGi10116.ENSRNOP00000022032.

Structurei

3D structure databases

ProteinModelPortaliQ91XV6.
SMRiQ91XV6. Positions 21-88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FXYD family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZ88. Eukaryota.
ENOG410YUN8. LUCA.
GeneTreeiENSGT00530000063932.
HOGENOMiHOG000234467.
HOVERGENiHBG008212.
InParanoidiQ91XV6.
KOiK13363.
OMAiEEDPFNY.
OrthoDBiEOG72NRRZ.
PhylomeDBiQ91XV6.
TreeFamiTF333443.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q91XV6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METVLILCSL LAPVVLASAA EKEKEKDPFY YDYQTLRIGG LVFAVVLFSV
60 70 80 90
GILLILSRRC KCSFNQKPRA PGDEEAQVEN LITTNAAEPQ KAEN
Length:94
Mass (Da):10,388
Last modified:December 1, 2001 - v1
Checksum:i1C0D35FA0C572451
GO
Isoform 2 (identifier: Q91XV6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-20: Missing.

Show »
Length:93
Mass (Da):10,317
Checksum:i4A8A5871BB802FE6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651N → S in AAF66613 (PubMed:11165386).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei20 – 201Missing in isoform 2. 1 PublicationVSP_001586

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030908 mRNA. Translation: BAB62242.1.
AF142439 mRNA. Translation: AAF66613.1.
BC072528 mRNA. Translation: AAH72528.1.
RefSeqiNP_071288.1. NM_022005.2. [Q91XV6-1]
XP_008764393.1. XM_008766171.1. [Q91XV6-2]
UniGeneiRn.839.

Genome annotation databases

EnsembliENSRNOT00000022032; ENSRNOP00000022032; ENSRNOG00000016412. [Q91XV6-1]
GeneIDi63847.
KEGGirno:63847.
UCSCiRGD:69315. rat. [Q91XV6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030908 mRNA. Translation: BAB62242.1.
AF142439 mRNA. Translation: AAF66613.1.
BC072528 mRNA. Translation: AAH72528.1.
RefSeqiNP_071288.1. NM_022005.2. [Q91XV6-1]
XP_008764393.1. XM_008766171.1. [Q91XV6-2]
UniGeneiRn.839.

3D structure databases

ProteinModelPortaliQ91XV6.
SMRiQ91XV6. Positions 21-88.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi248902. 1 interaction.
STRINGi10116.ENSRNOP00000022032.

PTM databases

SwissPalmiQ91XV6.

Proteomic databases

PaxDbiQ91XV6.
PRIDEiQ91XV6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022032; ENSRNOP00000022032; ENSRNOG00000016412. [Q91XV6-1]
GeneIDi63847.
KEGGirno:63847.
UCSCiRGD:69315. rat. [Q91XV6-1]

Organism-specific databases

CTDi53826.
RGDi69315. Fxyd6.

Phylogenomic databases

eggNOGiENOG410IZ88. Eukaryota.
ENOG410YUN8. LUCA.
GeneTreeiENSGT00530000063932.
HOGENOMiHOG000234467.
HOVERGENiHBG008212.
InParanoidiQ91XV6.
KOiK13363.
OMAiEEDPFNY.
OrthoDBiEOG72NRRZ.
PhylomeDBiQ91XV6.
TreeFamiTF333443.

Enzyme and pathway databases

ReactomeiR-RNO-5578775. Ion homeostasis.
R-RNO-936837. Ion transport by P-type ATPases.

Miscellaneous databases

NextBioi612448.
PROiQ91XV6.

Gene expression databases

ExpressionAtlasiQ91XV6. baseline and differential.
GenevisibleiQ91XV6. RN.

Family and domain databases

InterProiIPR000272. Ion-transport_regulator_FXYD.
[Graphical view]
PfamiPF02038. ATP1G1_PLM_MAT8. 1 hit.
[Graphical view]
ProDomiPD005989. PD005989. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS01310. FXYD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of VESP6, a vascular endothelial cell specific protein."
    Aoki T., Toyoda H., Nishimoto S., Tawara J., Komurasaki T.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver.
  2. "Molecular cloning and characterization of a novel phospholemman-like protein from rat hippocampus."
    Yamaguchi F., Yamaguchi K., Tai Y., Sugimoto K., Tokuda M.
    Brain Res. Mol. Brain Res. 86:189-192(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Lung.
  4. Lubec G., Kang S.U., Lubec S.
    Submitted (SEP-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 25-37, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiFXYD6_RAT
AccessioniPrimary (citable) accession number: Q91XV6
Secondary accession number(s): Q9JLR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: February 17, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.