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Protein

Brain acid soluble protein 1

Gene

Basp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein domain specific binding Source: MGI
  • transcription corepressor activity Source: UniProtKB
  • transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  • glomerular visceral epithelial cell differentiation Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • substantia nigra development Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Brain acid soluble protein 1
Alternative name(s):
22 kDa neuronal tissue-enriched acidic protein
Neuronal axonal membrane protein NAP-22
Gene namesi
Name:Basp1
Synonyms:Nap22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1917600. Basp1.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: MGI
  • COP9 signalosome Source: Ensembl
  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: MGI
  • growth cone Source: UniProtKB-SubCell
  • nuclear speck Source: UniProtKB
  • nucleus Source: UniProtKB
  • plasma membrane Source: MGI
  • vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 226225Brain acid soluble protein 1PRO_0000142896Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity
Modified residuei31 – 311PhosphothreonineCombined sources
Modified residuei36 – 361PhosphothreonineCombined sources
Modified residuei40 – 401PhosphoserineCombined sources
Modified residuei92 – 921PhosphoserineCombined sources
Modified residuei128 – 1281PhosphoserineCombined sources
Modified residuei131 – 1311PhosphoserineBy similarity
Modified residuei160 – 1601PhosphoserineBy similarity
Modified residuei167 – 1671PhosphoserineBy similarity
Modified residuei169 – 1691PhosphoserineCombined sources
Modified residuei173 – 1731PhosphoserineCombined sources
Modified residuei192 – 1921PhosphoserineCombined sources

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ91XV3.
MaxQBiQ91XV3.
PaxDbiQ91XV3.
PRIDEiQ91XV3.

PTM databases

iPTMnetiQ91XV3.
PhosphoSiteiQ91XV3.
SwissPalmiQ91XV3.

Expressioni

Gene expression databases

BgeeiQ91XV3.
GenevisibleiQ91XV3. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213993. 2 interactions.
IntActiQ91XV3. 5 interactions.
MINTiMINT-1845518.
STRINGi10090.ENSMUSP00000053943.

Structurei

3D structure databases

ProteinModelPortaliQ91XV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BASP1 family.Curated

Phylogenomic databases

eggNOGiENOG410J14G. Eukaryota.
ENOG4112CMG. LUCA.
GeneTreeiENSGT00730000111450.
HOGENOMiHOG000095176.
InParanoidiQ91XV3.
KOiK17272.
OMAiFTHDSES.

Family and domain databases

InterProiIPR008408. BASP1.
[Graphical view]
PANTHERiPTHR23212. PTHR23212. 1 hit.
PfamiPF05466. BASP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91XV3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGKLSKKKK GYNVNDEKAK DKDKKAEGAG TEEEGTPKES EPQAAADATE
60 70 80 90 100
VKESTEEKPK DAADGEAKAE EKEADKAAAA KEEAPKAEPE KSEGAAEEQP
110 120 130 140 150
EPAPAPEQEA AAPGPAAGGE APKAGEASAE STGAADGAAP EEGEAKKTEA
160 170 180 190 200
PAAAGPEAKS DAAPAASDSK PSSAEPAPSS KETPAASEAP SSAAKAPAPA
210 220
APAAAEPQAE APAAAASSEQ SVAVKE
Length:226
Mass (Da):22,087
Last modified:January 23, 2007 - v3
Checksum:iB41CCAAB447C705D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046714 Genomic DNA. Translation: BAB62404.1.
CCDSiCCDS27398.1.
RefSeqiNP_081671.1. NM_027395.2.
UniGeneiMm.29586.

Genome annotation databases

EnsembliENSMUST00000058845; ENSMUSP00000053943; ENSMUSG00000045763.
GeneIDi70350.
KEGGimmu:70350.
UCSCiuc007vix.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046714 Genomic DNA. Translation: BAB62404.1.
CCDSiCCDS27398.1.
RefSeqiNP_081671.1. NM_027395.2.
UniGeneiMm.29586.

3D structure databases

ProteinModelPortaliQ91XV3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213993. 2 interactions.
IntActiQ91XV3. 5 interactions.
MINTiMINT-1845518.
STRINGi10090.ENSMUSP00000053943.

PTM databases

iPTMnetiQ91XV3.
PhosphoSiteiQ91XV3.
SwissPalmiQ91XV3.

Proteomic databases

EPDiQ91XV3.
MaxQBiQ91XV3.
PaxDbiQ91XV3.
PRIDEiQ91XV3.

Protocols and materials databases

DNASUi70350.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058845; ENSMUSP00000053943; ENSMUSG00000045763.
GeneIDi70350.
KEGGimmu:70350.
UCSCiuc007vix.2. mouse.

Organism-specific databases

CTDi10409.
MGIiMGI:1917600. Basp1.

Phylogenomic databases

eggNOGiENOG410J14G. Eukaryota.
ENOG4112CMG. LUCA.
GeneTreeiENSGT00730000111450.
HOGENOMiHOG000095176.
InParanoidiQ91XV3.
KOiK17272.
OMAiFTHDSES.

Miscellaneous databases

ChiTaRSiBasp1. mouse.
PROiQ91XV3.
SOURCEiSearch...

Gene expression databases

BgeeiQ91XV3.
GenevisibleiQ91XV3. MM.

Family and domain databases

InterProiIPR008408. BASP1.
[Graphical view]
PANTHERiPTHR23212. PTHR23212. 1 hit.
PfamiPF05466. BASP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse NAP-22 (22 kDa neuronal tissue-enriched acidic protein) gene."
    Hamada K., Sokawa Y., Maekawa S.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6J X CBA/J.
    Tissue: Spleen.
  2. Lubec G., Klug S., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 26-52; 92-123 AND 147-225, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain and Hippocampus.
  3. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-36 AND SER-92, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-31; THR-36; SER-40; SER-92; SER-128; SER-169; SER-173 AND SER-192, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Lung, Spleen and Testis.

Entry informationi

Entry nameiBASP1_MOUSE
AccessioniPrimary (citable) accession number: Q91XV3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.