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Q91XU8 (CDS2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidate cytidylyltransferase 2

EC=2.7.7.41
Alternative name(s):
CDP-DAG synthase 2
CDP-DG synthase 2
CDP-diacylglycerol synthase 2
Short name=CDS 2
CDP-diglyceride pyrophosphorylase 2
CDP-diglyceride synthase 2
CTP:phosphatidate cytidylyltransferase 2
Gene names
Name:Cds2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length443 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin By similarity.

Catalytic activity

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathway

Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side By similarity.

Sequence similarities

Belongs to the CDS family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 443443Phosphatidate cytidylyltransferase 2
PRO_0000090718

Regions

Transmembrane78 – 9821Helical; Potential
Transmembrane129 – 14921Helical; Potential
Transmembrane165 – 18521Helical; Potential
Transmembrane212 – 23221Helical; Potential
Transmembrane261 – 28121Helical; Potential
Transmembrane338 – 35821Helical; Potential

Amino acid modifications

Modified residue201Phosphoserine By similarity
Modified residue321Phosphoserine By similarity
Modified residue341Phosphoserine By similarity
Modified residue361Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q91XU8 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 5CA23C56AE2B043F

FASTA44351,323
        10         20         30         40         50         60 
MTELRQRAVR EDAPPEDKES ESEAKLDGET ASDSESRAET APPPTSIDDT PEVLNRALSN 

        70         80         90        100        110        120 
LSSRWKNWWV RGILTMAMIA FFFIIIYLGP MVLMMIVMCV QIKCFHEIIT IGYNVYHSYD 

       130        140        150        160        170        180 
LPWFRTLSWY FLLCVNYFFY GETVTDYFFT LVQREEPLRI LSKYHRFISF TLYLTGFCMF 

       190        200        210        220        230        240 
VLSLVKKHYR LQFYMFGWTH VTLLIVVTQS HLVIHNLFEG MIWFIVPISC VICNDIMAYM 

       250        260        270        280        290        300 
FGFFFGRTPL IKLSPKKTWE GFIGGFFATV VFGLLLSYVM SGYRCFVCPV EYNNDTNSFT 

       310        320        330        340        350        360 
VDCEPSDLFR LQEYNIPGVI QSLVGWKTMR MYPFQIHSAL STFASLIGPF GGFFASGFKR 

       370        380        390        400        410        420 
AFKIKDFANT IPGHGGIMDR FDCQYLMATF VNVYIASFIR GPNPSKLIQQ FLTLRPDQQL 

       430        440 
HIFNTLKSHL TDKGILMSAL EEE 

« Hide

References

[1]"Gene cloning and characterization of rat CDP-diacylglycerol synthase type 2 (CDS2)."
Saino-Saito S.
Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB052898 mRNA. Translation: BAB61043.1.
RefSeqNP_446095.1. NM_053643.1.
UniGeneRn.212746.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000028888.

PTM databases

PhosphoSiteQ91XU8.

Proteomic databases

PaxDbQ91XU8.
PRIDEQ91XU8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID114101.
KEGGrno:114101.
UCSCRGD:621186. rat.

Organism-specific databases

CTD8760.
RGD621186. Cds2.

Phylogenomic databases

eggNOGCOG0575.
HOGENOMHOG000209582.
HOVERGENHBG002485.
KOK00981.
PhylomeDBQ91XU8.

Enzyme and pathway databases

UniPathwayUPA00557; UER00614.

Gene expression databases

GenevestigatorQ91XU8.

Family and domain databases

InterProIPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view]
PfamPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PIRSFPIRSF018269. PC_trans_euk. 1 hit.
PROSITEPS01315. CDS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio618261.
PROQ91XU8.

Entry information

Entry nameCDS2_RAT
AccessionPrimary (citable) accession number: Q91XU8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways