Reviewed,
UniProtKB/Swiss-Prot Q91XU8 (CDS2_RAT)
Last modified
February 9, 2010.
Version 56.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Phosphatidate cytidylyltransferase 2 EC=2.7.7.41 Alternative name(s): CDP-diglyceride pyrophosphorylase 2 CDP-diglyceride synthase 2 CDP-diacylglycerol synthase 2 Short name=CDS 2 CTP:phosphatidate cytidylyltransferase 2 CDP-DG synthase 2 CDP-DAG synthase 2 | ||
| Gene names |
| ||
| Organism | Rattus norvegicus (Rat) | ||
| Taxonomic identifier | 10116 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 443 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin By similarity. |
| Catalytic activity | CTP + phosphatidate = diphosphate + CDP-diacylglycerol. |
| Pathway | |
| Subcellular location | Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side By similarity. |
| Sequence similarities | Belongs to the CDS family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Phospholipid biosynthesis |
| Cellular component | Membrane Mitochondrion Mitochondrion inner membrane |
| Domain | Transmembrane |
| Molecular function | Nucleotidyltransferase Transferase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial inner membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 443 | 443 | Phosphatidate cytidylyltransferase 2 | PRO_0000090718 | |||||
Regions | |||||||||
| Transmembrane | 78 – 98 | 21 | Potential | ||||||
| Transmembrane | 129 – 149 | 21 | Potential | ||||||
| Transmembrane | 165 – 185 | 21 | Potential | ||||||
| Transmembrane | 212 – 232 | 21 | Potential | ||||||
| Transmembrane | 261 – 281 | 21 | Potential | ||||||
| Transmembrane | 338 – 358 | 21 | Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 20 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 22 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 30 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 32 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 36 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 46 | 1 | Phosphoserine By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Gene cloning and characterization of rat CDP-diacylglycerol synthase type 2 (CDS2)." Saino-Saito S. Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Brain. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB052898 mRNA. Translation: BAB61043.1. |
| IPI | IPI00208200. |
| RefSeq | NP_446095.1. |
| UniGene | Rn.212746 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q91XU8. |
PTM databases | |
| PhosphoSite | Q91XU8. |
Genome annotation databases | |
| Ensembl | ENSRNOT00000028888; ENSRNOP00000028888; ENSRNOG00000021265; Rattus norvegicus. [Genome view] |
| GeneID | 114101. |
| KEGG | rno:114101. |
| UCSC | NM_053643. rat. |
Organism-specific databases | |
| CTD | 114101. |
| RGD | 621186. Cds2. |
Phylogenomic databases | |
| eggNOG | roNOG08599. |
| HOVERGEN | Q91XU8. |
| PhylomeDB | Q91XU8. |
Enzyme and pathway databases | |
| BRENDA | 2.7.7.41. 248. |
Gene expression databases | |
| ArrayExpress | Q91XU8. |
| Genevestigator | Q91XU8. |
| GermOnline | ENSRNOG00000021265. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR000374. PC_trans. IPR016720. PC_Trfase_euk. [Graphical view] |
| Pfam | PF01148. CTP_transf_1. 1 hit. [Graphical view] |
| PIRSF | PIRSF018269. PC_trans_euk. 1 hit. |
| PROSITE | PS01315. CDS. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 618261. |
Entry information
| Entry name | CDS2_RAT | ||||||||
| Accession | Primary (citable) accession number: Q91XU8 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


