Reviewed, UniProtKB/Swiss-Prot Q91XU8 (CDS2_RAT)

Names and origin

Protein names

Recommended name:
    Phosphatidate cytidylyltransferase 2
    EC=2.7.7.41
Alternative name(s):
    CDP-diglyceride pyrophosphorylase 2
    CDP-diglyceride synthase 2
    CDP-diacylglycerol synthase 2
      Short name=CDS 2
    CTP:phosphatidate cytidylyltransferase 2
    CDP-DG synthase 2
    CDP-DAG synthase 2

Gene names

Name:

Cds2

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	443 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin By similarity.
Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein; Matrix side By similarity.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane
Molecular function	Nucleotidyltransferase Transferase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 443	443	Phosphatidate cytidylyltransferase 2		PRO_0000090718
Regions
	Transmembrane	78 – 98	21	Potential
	Transmembrane	129 – 149	21	Potential
	Transmembrane	165 – 185	21	Potential
	Transmembrane	212 – 232	21	Potential
	Transmembrane	261 – 281	21	Potential
	Transmembrane	338 – 358	21	Potential
Amino acid modifications
	Modified residue	20	1	Phosphoserine By similarity
	Modified residue	22	1	Phosphoserine By similarity
	Modified residue	30	1	Phosphothreonine By similarity
	Modified residue	32	1	Phosphoserine By similarity
	Modified residue	36	1	Phosphoserine By similarity
	Modified residue	46	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q91XU8-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 5CA23C56AE2B043F	FASTA	443	51,323
	10 20 30 40 50 60 MTELRQRAVR EDAPPEDKES ESEAKLDGET ASDSESRAET APPPTSIDDT PEVLNRALSN 70 80 90 100 110 120 LSSRWKNWWV RGILTMAMIA FFFIIIYLGP MVLMMIVMCV QIKCFHEIIT IGYNVYHSYD 130 140 150 160 170 180 LPWFRTLSWY FLLCVNYFFY GETVTDYFFT LVQREEPLRI LSKYHRFISF TLYLTGFCMF 190 200 210 220 230 240 VLSLVKKHYR LQFYMFGWTH VTLLIVVTQS HLVIHNLFEG MIWFIVPISC VICNDIMAYM 250 260 270 280 290 300 FGFFFGRTPL IKLSPKKTWE GFIGGFFATV VFGLLLSYVM SGYRCFVCPV EYNNDTNSFT 310 320 330 340 350 360 VDCEPSDLFR LQEYNIPGVI QSLVGWKTMR MYPFQIHSAL STFASLIGPF GGFFASGFKR 370 380 390 400 410 420 AFKIKDFANT IPGHGGIMDR FDCQYLMATF VNVYIASFIR GPNPSKLIQQ FLTLRPDQQL 430 440 HIFNTLKSHL TDKGILMSAL EEE

References

[1]	"Gene cloning and characterization of rat CDP-diacylglycerol synthase type 2 (CDS2)." Saino-Saito S. Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB052898 mRNA. Translation: BAB61043.1.
IPI	IPI00208200.
RefSeq	NP_446095.1.
UniGene	Rn.212746
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q91XU8.
PTM databases
PhosphoSite	Q91XU8.
Genome annotation databases
Ensembl	ENSRNOT00000028888; ENSRNOP00000028888; ENSRNOG00000021265; Rattus norvegicus. [Genome view]
GeneID	114101.
KEGG	rno:114101.
UCSC	NM_053643. rat.
Organism-specific databases
CTD	114101.
RGD	621186. Cds2.
Phylogenomic databases
eggNOG	roNOG08599.
HOVERGEN	Q91XU8.
PhylomeDB	Q91XU8.
Enzyme and pathway databases
BRENDA	2.7.7.41. 248.
Gene expression databases
ArrayExpress	Q91XU8.
Genevestigator	Q91XU8.
GermOnline	ENSRNOG00000021265. Rattus norvegicus.
Family and domain databases
InterPro	IPR000374. PC_trans. IPR016720. PC_Trfase_euk. [Graphical view]
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PIRSF	PIRSF018269. PC_trans_euk. 1 hit.
PROSITE	PS01315. CDS. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	618261.

Entry information

Entry name

CDS2_RAT

Accession

Primary (citable) accession number: Q91XU8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	December 1, 2001
Last modified:	February 9, 2010
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)