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Q91XU8

- CDS2_RAT

UniProt

Q91XU8 - CDS2_RAT

Protein

Phosphatidate cytidylyltransferase 2

Gene

Cds2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.By similarity

    Catalytic activityi

    CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

    Pathwayi

    GO - Molecular functioni

    1. phosphatidate cytidylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Enzyme and pathway databases

    ReactomeiREACT_199140. Synthesis of PG.
    UniPathwayiUPA00557; UER00614.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidate cytidylyltransferase 2 (EC:2.7.7.41)
    Alternative name(s):
    CDP-DAG synthase 2
    CDP-DG synthase 2
    CDP-diacylglycerol synthase 2
    Short name:
    CDS 2
    CDP-diglyceride pyrophosphorylase 2
    CDP-diglyceride synthase 2
    CTP:phosphatidate cytidylyltransferase 2
    Gene namesi
    Name:Cds2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621186. Cds2.

    Subcellular locationi

    Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity; Matrix side By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 443443Phosphatidate cytidylyltransferase 2PRO_0000090718Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei20 – 201PhosphoserineBy similarity
    Modified residuei32 – 321PhosphoserineBy similarity
    Modified residuei34 – 341PhosphoserineBy similarity
    Modified residuei36 – 361PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ91XU8.
    PRIDEiQ91XU8.

    PTM databases

    PhosphoSiteiQ91XU8.

    Expressioni

    Gene expression databases

    GenevestigatoriQ91XU8.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000028888.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei78 – 9821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei129 – 14921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei212 – 23221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei261 – 28121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei338 – 35821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CDS family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0575.
    HOGENOMiHOG000209582.
    HOVERGENiHBG002485.
    KOiK00981.
    PhylomeDBiQ91XU8.

    Family and domain databases

    InterProiIPR000374. PC_trans.
    IPR016720. PC_Trfase_euk.
    [Graphical view]
    PfamiPF01148. CTP_transf_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
    PROSITEiPS01315. CDS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91XU8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTELRQRAVR EDAPPEDKES ESEAKLDGET ASDSESRAET APPPTSIDDT    50
    PEVLNRALSN LSSRWKNWWV RGILTMAMIA FFFIIIYLGP MVLMMIVMCV 100
    QIKCFHEIIT IGYNVYHSYD LPWFRTLSWY FLLCVNYFFY GETVTDYFFT 150
    LVQREEPLRI LSKYHRFISF TLYLTGFCMF VLSLVKKHYR LQFYMFGWTH 200
    VTLLIVVTQS HLVIHNLFEG MIWFIVPISC VICNDIMAYM FGFFFGRTPL 250
    IKLSPKKTWE GFIGGFFATV VFGLLLSYVM SGYRCFVCPV EYNNDTNSFT 300
    VDCEPSDLFR LQEYNIPGVI QSLVGWKTMR MYPFQIHSAL STFASLIGPF 350
    GGFFASGFKR AFKIKDFANT IPGHGGIMDR FDCQYLMATF VNVYIASFIR 400
    GPNPSKLIQQ FLTLRPDQQL HIFNTLKSHL TDKGILMSAL EEE 443
    Length:443
    Mass (Da):51,323
    Last modified:December 1, 2001 - v1
    Checksum:i5CA23C56AE2B043F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB052898 mRNA. Translation: BAB61043.1.
    RefSeqiNP_446095.1. NM_053643.1.
    UniGeneiRn.212746.

    Genome annotation databases

    GeneIDi114101.
    KEGGirno:114101.
    UCSCiRGD:621186. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB052898 mRNA. Translation: BAB61043.1 .
    RefSeqi NP_446095.1. NM_053643.1.
    UniGenei Rn.212746.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000028888.

    PTM databases

    PhosphoSitei Q91XU8.

    Proteomic databases

    PaxDbi Q91XU8.
    PRIDEi Q91XU8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 114101.
    KEGGi rno:114101.
    UCSCi RGD:621186. rat.

    Organism-specific databases

    CTDi 8760.
    RGDi 621186. Cds2.

    Phylogenomic databases

    eggNOGi COG0575.
    HOGENOMi HOG000209582.
    HOVERGENi HBG002485.
    KOi K00981.
    PhylomeDBi Q91XU8.

    Enzyme and pathway databases

    UniPathwayi UPA00557 ; UER00614 .
    Reactomei REACT_199140. Synthesis of PG.

    Miscellaneous databases

    NextBioi 618261.
    PROi Q91XU8.

    Gene expression databases

    Genevestigatori Q91XU8.

    Family and domain databases

    InterProi IPR000374. PC_trans.
    IPR016720. PC_Trfase_euk.
    [Graphical view ]
    Pfami PF01148. CTP_transf_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018269. PC_trans_euk. 1 hit.
    PROSITEi PS01315. CDS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene cloning and characterization of rat CDP-diacylglycerol synthase type 2 (CDS2)."
      Saino-Saito S.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Brain.

    Entry informationi

    Entry nameiCDS2_RAT
    AccessioniPrimary (citable) accession number: Q91XU8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3