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Protein

Phosphatidate cytidylyltransferase 2

Gene

Cds2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.By similarity

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase 3 (Gpat3), Glycerol-3-phosphate acyltransferase 1, mitochondrial (Gpam), Glycerol-3-phosphate acyltransferase 1, mitochondrial (Gpam), Glycerol-3-phosphate acyltransferase 1, mitochondrial (Gpam)
  2. 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (Agpat4)
  3. Phosphatidate cytidylyltransferase 2 (Cds2), Phosphatidate cytidylyltransferase (Cds2), Phosphatidate cytidylyltransferase 1 (Cds1), Phosphatidate cytidylyltransferase, mitochondrial (Tamm41)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase 2 (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase 2
CDP-DG synthase 2
CDP-diacylglycerol synthase 2
Short name:
CDS 2
CDP-diglyceride pyrophosphorylase 2
CDP-diglyceride synthase 2
CTP:phosphatidate cytidylyltransferase 2
Gene namesi
Name:Cds2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621186. Cds2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Transmembranei261 – 281HelicalSequence analysisAdd BLAST21
Transmembranei338 – 358HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000907181 – 443Phosphatidate cytidylyltransferase 2Add BLAST443

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20PhosphoserineCombined sources1
Modified residuei30PhosphothreonineCombined sources1
Modified residuei32PhosphoserineCombined sources1
Modified residuei34PhosphoserineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei50PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ91XU8.
PRIDEiQ91XU8.

PTM databases

iPTMnetiQ91XU8.
PhosphoSitePlusiQ91XU8.
SwissPalmiQ91XU8.

Expressioni

Gene expression databases

BgeeiENSRNOG00000021265.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028888.

Structurei

3D structure databases

ProteinModelPortaliQ91XU8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1440. Eukaryota.
COG0575. LUCA.
HOGENOMiHOG000209582.
HOVERGENiHBG002485.
InParanoidiQ91XU8.
KOiK00981.
PhylomeDBiQ91XU8.

Family and domain databases

InterProiIPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view]
PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91XU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTELRQRAVR EDAPPEDKES ESEAKLDGET ASDSESRAET APPPTSIDDT
60 70 80 90 100
PEVLNRALSN LSSRWKNWWV RGILTMAMIA FFFIIIYLGP MVLMMIVMCV
110 120 130 140 150
QIKCFHEIIT IGYNVYHSYD LPWFRTLSWY FLLCVNYFFY GETVTDYFFT
160 170 180 190 200
LVQREEPLRI LSKYHRFISF TLYLTGFCMF VLSLVKKHYR LQFYMFGWTH
210 220 230 240 250
VTLLIVVTQS HLVIHNLFEG MIWFIVPISC VICNDIMAYM FGFFFGRTPL
260 270 280 290 300
IKLSPKKTWE GFIGGFFATV VFGLLLSYVM SGYRCFVCPV EYNNDTNSFT
310 320 330 340 350
VDCEPSDLFR LQEYNIPGVI QSLVGWKTMR MYPFQIHSAL STFASLIGPF
360 370 380 390 400
GGFFASGFKR AFKIKDFANT IPGHGGIMDR FDCQYLMATF VNVYIASFIR
410 420 430 440
GPNPSKLIQQ FLTLRPDQQL HIFNTLKSHL TDKGILMSAL EEE
Length:443
Mass (Da):51,323
Last modified:December 1, 2001 - v1
Checksum:i5CA23C56AE2B043F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052898 mRNA. Translation: BAB61043.1.
RefSeqiNP_446095.1. NM_053643.1.
UniGeneiRn.212746.

Genome annotation databases

GeneIDi114101.
KEGGirno:114101.
UCSCiRGD:621186. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB052898 mRNA. Translation: BAB61043.1.
RefSeqiNP_446095.1. NM_053643.1.
UniGeneiRn.212746.

3D structure databases

ProteinModelPortaliQ91XU8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028888.

PTM databases

iPTMnetiQ91XU8.
PhosphoSitePlusiQ91XU8.
SwissPalmiQ91XU8.

Proteomic databases

PaxDbiQ91XU8.
PRIDEiQ91XU8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi114101.
KEGGirno:114101.
UCSCiRGD:621186. rat.

Organism-specific databases

CTDi8760.
RGDi621186. Cds2.

Phylogenomic databases

eggNOGiKOG1440. Eukaryota.
COG0575. LUCA.
HOGENOMiHOG000209582.
HOVERGENiHBG002485.
InParanoidiQ91XU8.
KOiK00981.
PhylomeDBiQ91XU8.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.

Miscellaneous databases

PROiQ91XU8.

Gene expression databases

BgeeiENSRNOG00000021265.

Family and domain databases

InterProiIPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view]
PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDS2_RAT
AccessioniPrimary (citable) accession number: Q91XU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.