SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q91XU8

- CDS2_RAT

UniProt

Q91XU8 - CDS2_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Phosphatidate cytidylyltransferase 2

Gene
Cds2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin By similarity.

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi

GO - Molecular functioni

  1. phosphatidate cytidylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiREACT_199140. Synthesis of PG.
UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase 2 (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase 2
CDP-DG synthase 2
CDP-diacylglycerol synthase 2
Short name:
CDS 2
CDP-diglyceride pyrophosphorylase 2
CDP-diglyceride synthase 2
CTP:phosphatidate cytidylyltransferase 2
Gene namesi
Name:Cds2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621186. Cds2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei78 – 9821Helical; Reviewed predictionAdd
BLAST
Transmembranei129 – 14921Helical; Reviewed predictionAdd
BLAST
Transmembranei165 – 18521Helical; Reviewed predictionAdd
BLAST
Transmembranei212 – 23221Helical; Reviewed predictionAdd
BLAST
Transmembranei261 – 28121Helical; Reviewed predictionAdd
BLAST
Transmembranei338 – 35821Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Phosphatidate cytidylyltransferase 2PRO_0000090718Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201Phosphoserine By similarity
Modified residuei32 – 321Phosphoserine By similarity
Modified residuei34 – 341Phosphoserine By similarity
Modified residuei36 – 361Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ91XU8.
PRIDEiQ91XU8.

PTM databases

PhosphoSiteiQ91XU8.

Expressioni

Gene expression databases

GenevestigatoriQ91XU8.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028888.

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0575.
HOGENOMiHOG000209582.
HOVERGENiHBG002485.
KOiK00981.
PhylomeDBiQ91XU8.

Family and domain databases

InterProiIPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91XU8-1 [UniParc]FASTAAdd to Basket

« Hide

MTELRQRAVR EDAPPEDKES ESEAKLDGET ASDSESRAET APPPTSIDDT    50
PEVLNRALSN LSSRWKNWWV RGILTMAMIA FFFIIIYLGP MVLMMIVMCV 100
QIKCFHEIIT IGYNVYHSYD LPWFRTLSWY FLLCVNYFFY GETVTDYFFT 150
LVQREEPLRI LSKYHRFISF TLYLTGFCMF VLSLVKKHYR LQFYMFGWTH 200
VTLLIVVTQS HLVIHNLFEG MIWFIVPISC VICNDIMAYM FGFFFGRTPL 250
IKLSPKKTWE GFIGGFFATV VFGLLLSYVM SGYRCFVCPV EYNNDTNSFT 300
VDCEPSDLFR LQEYNIPGVI QSLVGWKTMR MYPFQIHSAL STFASLIGPF 350
GGFFASGFKR AFKIKDFANT IPGHGGIMDR FDCQYLMATF VNVYIASFIR 400
GPNPSKLIQQ FLTLRPDQQL HIFNTLKSHL TDKGILMSAL EEE 443
Length:443
Mass (Da):51,323
Last modified:December 1, 2001 - v1
Checksum:i5CA23C56AE2B043F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB052898 mRNA. Translation: BAB61043.1.
RefSeqiNP_446095.1. NM_053643.1.
UniGeneiRn.212746.

Genome annotation databases

GeneIDi114101.
KEGGirno:114101.
UCSCiRGD:621186. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB052898 mRNA. Translation: BAB61043.1 .
RefSeqi NP_446095.1. NM_053643.1.
UniGenei Rn.212746.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000028888.

PTM databases

PhosphoSitei Q91XU8.

Proteomic databases

PaxDbi Q91XU8.
PRIDEi Q91XU8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 114101.
KEGGi rno:114101.
UCSCi RGD:621186. rat.

Organism-specific databases

CTDi 8760.
RGDi 621186. Cds2.

Phylogenomic databases

eggNOGi COG0575.
HOGENOMi HOG000209582.
HOVERGENi HBG002485.
KOi K00981.
PhylomeDBi Q91XU8.

Enzyme and pathway databases

UniPathwayi UPA00557 ; UER00614 .
Reactomei REACT_199140. Synthesis of PG.

Miscellaneous databases

NextBioi 618261.
PROi Q91XU8.

Gene expression databases

Genevestigatori Q91XU8.

Family and domain databases

InterProi IPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view ]
Pfami PF01148. CTP_transf_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF018269. PC_trans_euk. 1 hit.
PROSITEi PS01315. CDS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Gene cloning and characterization of rat CDP-diacylglycerol synthase type 2 (CDS2)."
    Saino-Saito S.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain.

Entry informationi

Entry nameiCDS2_RAT
AccessioniPrimary (citable) accession number: Q91XU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi