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Protein

ATPase WRNIP1

Gene

Wrnip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi263 – 270ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

DNA damage, DNA replication

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase WRNIP1 (EC:3.6.1.3)
Alternative name(s):
Werner helicase-interacting protein 1
Gene namesi
Name:Wrnip1Imported
Synonyms:Whip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1926153. Wrnip1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000847861 – 660ATPase WRNIP1Add BLAST660

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei65PhosphoserineBy similarity1
Modified residuei75PhosphoserineCombined sources1
Cross-linki81Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei85PhosphothreonineBy similarity1
Modified residuei91PhosphoserineCombined sources1
Modified residuei92PhosphoserineCombined sources1
Modified residuei116PhosphothreonineBy similarity1
Cross-linki141Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei153PhosphoserineBy similarity1
Cross-linki220Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki296Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki305Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki311Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki317Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki330Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki477Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei529PhosphotyrosineBy similarity1
Modified residuei557PhosphotyrosineBy similarity1
Cross-linki622Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei628N6-acetyllysine; alternateBy similarity1
Cross-linki628Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Cross-linki631Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Sumoylated with SUMO1 and SUMO2/3.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ91XU0.
PaxDbiQ91XU0.
PeptideAtlasiQ91XU0.
PRIDEiQ91XU0.

PTM databases

iPTMnetiQ91XU0.
PhosphoSitePlusiQ91XU0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021400.
CleanExiMM_WRNIP1.
GenevisibleiQ91XU0. MM.

Interactioni

Subunit structurei

May form homooligomers, possibly octamers. Directly interacts with POLD1, POLD2 and POLD4 (By similarity). Interacts with the N-terminal domain of WRN (PubMed:11301316). Interacts (via UBZ-type zinc finger) with polyubiquitin (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi219695. 2 interactors.
IntActiQ91XU0. 2 interactors.
MINTiMINT-4113108.
STRINGi10090.ENSMUSP00000021832.

Structurei

3D structure databases

ProteinModelPortaliQ91XU0.
SMRiQ91XU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2028. Eukaryota.
COG2256. LUCA.
GeneTreeiENSGT00390000008538.
HOVERGENiHBG062192.
InParanoidiQ91XU0.
KOiK07478.
OMAiPGHWDAD.
OrthoDBiEOG091G09JH.
PhylomeDBiQ91XU0.
TreeFamiTF324547.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR032423. AAA_assoc_2.
IPR003959. ATPase_AAA_core.
IPR008921. DNA_pol3_clamp-load_cplx_C.
IPR021886. MgsA_C.
IPR027417. P-loop_NTPase.
IPR006642. Znf_Rad18_put.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF16193. AAA_assoc_2. 1 hit.
PF12002. MgsA_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00734. ZnF_Rad18. 1 hit.
[Graphical view]
SUPFAMiSSF48019. SSF48019. 1 hit.
SSF52540. SSF52540. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q91XU0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVSGPEDDP FLSQLHQVQC PVCQQMMPAA HINSHLDRCL LLHPAGHAEP
60 70 80 90 100
AAGSHRAGER AKGPSPPGAK RRRLSESSAL KQPATPTAAE SSEGEGEEGD
110 120 130 140 150
DGGETESRES YDAPPTPSGA RLIPDFPVAR SSSPARKGMG KRPAAAAAAG
160 170 180 190 200
SASPRSWDEA EAQEEEEAGV DGDGDADVDG EDDPGHWDAD AADASFGVSA
210 220 230 240 250
GRAHPRALAA EEIRQMLEGK PLADKMRPDT LQDYIGQSRA VGQETLLRSL
260 270 280 290 300
LEANEIPSLI LWGPPGCGKT TLAHIIANNS KKHSIRFVTL SATNAKTNDV
310 320 330 340 350
RDVIKQAQNE KSFFKRKTIL FIDEIHRFNK SQQDTFLPHV ECGTITLIGA
360 370 380 390 400
TTENPSFQVN AALLSRCRVI VLEKLPVEAM VTILMRAINS LGIHVLDSSR
410 420 430 440 450
PTDPLSHSSN CSSEPSVFIE DKAVDTLAYL SDGDARTGLN GLQLAVLARL
460 470 480 490 500
SSRKVFCKKS GQTYSPSRVL ITENDVKEGL QRSHILYDRA GEEHYNCISA
510 520 530 540 550
LHKAMRGSDQ NASLYWLARM LEGGEDPLYV ARRLVRFASE DIGLADPSAL
560 570 580 590 600
AQAVAAYQGC HFIGMPECEV LLAQCVVYFA RAPKSIEVYS AYNNVKACLR
610 620 630 640 650
SHQGPLPPVP LHLRNAPTRL MKDLGYGKGY KYNPMYSEPV DQDYLPEELR
660
GVDFFKQRRC
Length:660
Mass (Da):71,794
Last modified:August 16, 2005 - v2
Checksum:iA9114A131B5F9763
GO
Isoform 2Curated (identifier: Q91XU0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     544-568: LADPSALAQAVAAYQGCHFIGMPEC → EWRRVCVGVGVLRGGVLTLVWSHAE
     569-660: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:568
Mass (Da):61,406
Checksum:i79994D96D710A287
GO

Sequence cautioni

The sequence AAG35725 differs from that shown. Reason: Frameshift at positions 191, 223 and 233.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti180G → V in BAC34213 (PubMed:16141072).Curated1
Sequence conflicti202 – 203RA → P in AAG35725 (Ref. 5) Curated2
Sequence conflicti232Q → H in AAG35725 (Ref. 5) Curated1
Sequence conflicti243Q → E in BAB60708 (PubMed:11301316).Curated1
Sequence conflicti453R → K in BAB60708 (PubMed:11301316).Curated1
Sequence conflicti455V → M in AAH10482 (PubMed:15489334).Curated1
Sequence conflicti499S → C in BAC38404 (PubMed:16141072).Curated1
Sequence conflicti566P → H in BAB60708 (PubMed:11301316).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_051784544 – 568LADPS…GMPEC → EWRRVCVGVGVLRGGVLTLV WSHAE in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_051785569 – 660Missing in isoform 2. 1 PublicationAdd BLAST92

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB056151 mRNA. Translation: BAB60708.1.
AK041886 mRNA. Translation: BAC31091.1.
AK050368 mRNA. Translation: BAC34213.1.
AK082078 mRNA. Translation: BAC38404.1.
AK167570 mRNA. Translation: BAE39633.1.
AK170542 mRNA. Translation: BAE41868.1.
AK170846 mRNA. Translation: BAE42069.1.
AL645808 Genomic DNA. Translation: CAI25647.1.
BC010482 mRNA. Translation: AAH10482.1.
BC058744 mRNA. Translation: AAH58744.1.
AF208046 mRNA. Translation: AAG35725.1. Frameshift.
CCDSiCCDS26427.1. [Q91XU0-1]
RefSeqiNP_084491.3. NM_030215.3. [Q91XU0-1]
UniGeneiMm.286680.

Genome annotation databases

EnsembliENSMUST00000021832; ENSMUSP00000021832; ENSMUSG00000021400. [Q91XU0-1]
GeneIDi78903.
KEGGimmu:78903.
UCSCiuc007pzs.2. mouse. [Q91XU0-2]
uc007pzt.2. mouse. [Q91XU0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB056151 mRNA. Translation: BAB60708.1.
AK041886 mRNA. Translation: BAC31091.1.
AK050368 mRNA. Translation: BAC34213.1.
AK082078 mRNA. Translation: BAC38404.1.
AK167570 mRNA. Translation: BAE39633.1.
AK170542 mRNA. Translation: BAE41868.1.
AK170846 mRNA. Translation: BAE42069.1.
AL645808 Genomic DNA. Translation: CAI25647.1.
BC010482 mRNA. Translation: AAH10482.1.
BC058744 mRNA. Translation: AAH58744.1.
AF208046 mRNA. Translation: AAG35725.1. Frameshift.
CCDSiCCDS26427.1. [Q91XU0-1]
RefSeqiNP_084491.3. NM_030215.3. [Q91XU0-1]
UniGeneiMm.286680.

3D structure databases

ProteinModelPortaliQ91XU0.
SMRiQ91XU0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi219695. 2 interactors.
IntActiQ91XU0. 2 interactors.
MINTiMINT-4113108.
STRINGi10090.ENSMUSP00000021832.

PTM databases

iPTMnetiQ91XU0.
PhosphoSitePlusiQ91XU0.

Proteomic databases

EPDiQ91XU0.
PaxDbiQ91XU0.
PeptideAtlasiQ91XU0.
PRIDEiQ91XU0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021832; ENSMUSP00000021832; ENSMUSG00000021400. [Q91XU0-1]
GeneIDi78903.
KEGGimmu:78903.
UCSCiuc007pzs.2. mouse. [Q91XU0-2]
uc007pzt.2. mouse. [Q91XU0-1]

Organism-specific databases

CTDi56897.
MGIiMGI:1926153. Wrnip1.

Phylogenomic databases

eggNOGiKOG2028. Eukaryota.
COG2256. LUCA.
GeneTreeiENSGT00390000008538.
HOVERGENiHBG062192.
InParanoidiQ91XU0.
KOiK07478.
OMAiPGHWDAD.
OrthoDBiEOG091G09JH.
PhylomeDBiQ91XU0.
TreeFamiTF324547.

Miscellaneous databases

PROiQ91XU0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021400.
CleanExiMM_WRNIP1.
GenevisibleiQ91XU0. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR032423. AAA_assoc_2.
IPR003959. ATPase_AAA_core.
IPR008921. DNA_pol3_clamp-load_cplx_C.
IPR021886. MgsA_C.
IPR027417. P-loop_NTPase.
IPR006642. Znf_Rad18_put.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF16193. AAA_assoc_2. 1 hit.
PF12002. MgsA_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00734. ZnF_Rad18. 1 hit.
[Graphical view]
SUPFAMiSSF48019. SSF48019. 1 hit.
SSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiWRIP1_MOUSE
AccessioniPrimary (citable) accession number: Q91XU0
Secondary accession number(s): Q3TCT7
, Q6PDF0, Q8BUW5, Q8BWP6, Q8BY55, Q921W3, Q9EQL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: November 30, 2016
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.