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Q91XU0

- WRIP1_MOUSE

UniProt

Q91XU0 - WRIP1_MOUSE

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Protein

ATPase WRNIP1

Gene

Wrnip1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi263 – 2708ATPSequence Analysis

GO - Molecular functioni

  1. ATPase activity Source: UniProtKB
  2. ATP binding Source: UniProtKB-KW
  3. DNA binding Source: InterPro

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. DNA replication Source: UniProtKB-KW
  3. DNA synthesis involved in DNA repair Source: UniProtKB
  4. regulation of DNA-dependent DNA replication initiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

DNA damage, DNA replication

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase WRNIP1 (EC:3.6.1.3)
Alternative name(s):
Werner helicase-interacting protein 1
Gene namesi
Name:Wrnip1Imported
Synonyms:Whip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1926153. Wrnip1.

Subcellular locationi

Nucleus 1 Publication
Note: Colocalizes with WRN in granular structures in the nucleus.

GO - Cellular componenti

  1. nucleus Source: UniProtKB
  2. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 660660ATPase WRNIP1PRO_0000084786Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei75 – 751PhosphoserineBy similarity
Modified residuei85 – 851PhosphothreonineBy similarity
Modified residuei91 – 911PhosphoserineBy similarity
Modified residuei92 – 921Phosphoserine1 Publication
Modified residuei116 – 1161PhosphothreonineBy similarity
Modified residuei153 – 1531PhosphoserineBy similarity
Modified residuei529 – 5291PhosphotyrosineBy similarity
Modified residuei557 – 5571PhosphotyrosineBy similarity
Modified residuei628 – 6281N6-acetyllysineBy similarity

Post-translational modificationi

Sumoylated with SUMO1 and SUMO2/3.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ91XU0.
PaxDbiQ91XU0.
PRIDEiQ91XU0.

PTM databases

PhosphoSiteiQ91XU0.

Expressioni

Gene expression databases

BgeeiQ91XU0.
CleanExiMM_WRNIP1.
GenevestigatoriQ91XU0.

Interactioni

Subunit structurei

Homooligomer; most likely an octamer. Interacts with POLD1, POLD2 an POLD4. Interacts (via UBZ-type zinc finger) with polyubiquitin (By similarity). Interacts with the N-terminal domain of WRN.By similarity1 Publication

Protein-protein interaction databases

BioGridi219695. 2 interactions.
IntActiQ91XU0. 2 interactions.
MINTiMINT-4113108.

Structurei

3D structure databases

ProteinModelPortaliQ91XU0.
SMRiQ91XU0. Positions 12-46, 220-655.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Sequence Analysis

Phylogenomic databases

eggNOGiCOG2256.
GeneTreeiENSGT00390000008538.
HOVERGENiHBG062192.
InParanoidiQ91XU0.
KOiK07478.
OMAiPGHWDAD.
OrthoDBiEOG744T8W.
PhylomeDBiQ91XU0.
TreeFamiTF324547.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR008921. DNA_pol3_clamp-load_cplx_C.
IPR021886. MgsA_C.
IPR027417. P-loop_NTPase.
IPR006642. Znf_Rad18_put.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF12002. MgsA_C. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00734. ZnF_Rad18. 1 hit.
[Graphical view]
SUPFAMiSSF48019. SSF48019. 1 hit.
SSF52540. SSF52540. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q91XU0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVSGPEDDP FLSQLHQVQC PVCQQMMPAA HINSHLDRCL LLHPAGHAEP
60 70 80 90 100
AAGSHRAGER AKGPSPPGAK RRRLSESSAL KQPATPTAAE SSEGEGEEGD
110 120 130 140 150
DGGETESRES YDAPPTPSGA RLIPDFPVAR SSSPARKGMG KRPAAAAAAG
160 170 180 190 200
SASPRSWDEA EAQEEEEAGV DGDGDADVDG EDDPGHWDAD AADASFGVSA
210 220 230 240 250
GRAHPRALAA EEIRQMLEGK PLADKMRPDT LQDYIGQSRA VGQETLLRSL
260 270 280 290 300
LEANEIPSLI LWGPPGCGKT TLAHIIANNS KKHSIRFVTL SATNAKTNDV
310 320 330 340 350
RDVIKQAQNE KSFFKRKTIL FIDEIHRFNK SQQDTFLPHV ECGTITLIGA
360 370 380 390 400
TTENPSFQVN AALLSRCRVI VLEKLPVEAM VTILMRAINS LGIHVLDSSR
410 420 430 440 450
PTDPLSHSSN CSSEPSVFIE DKAVDTLAYL SDGDARTGLN GLQLAVLARL
460 470 480 490 500
SSRKVFCKKS GQTYSPSRVL ITENDVKEGL QRSHILYDRA GEEHYNCISA
510 520 530 540 550
LHKAMRGSDQ NASLYWLARM LEGGEDPLYV ARRLVRFASE DIGLADPSAL
560 570 580 590 600
AQAVAAYQGC HFIGMPECEV LLAQCVVYFA RAPKSIEVYS AYNNVKACLR
610 620 630 640 650
SHQGPLPPVP LHLRNAPTRL MKDLGYGKGY KYNPMYSEPV DQDYLPEELR
660
GVDFFKQRRC
Length:660
Mass (Da):71,794
Last modified:August 16, 2005 - v2
Checksum:iA9114A131B5F9763
GO
Isoform 2Curated (identifier: Q91XU0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     544-568: LADPSALAQAVAAYQGCHFIGMPEC → EWRRVCVGVGVLRGGVLTLVWSHAE
     569-660: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:568
Mass (Da):61,406
Checksum:i79994D96D710A287
GO

Sequence cautioni

The sequence AAG35725.1 differs from that shown. Reason: Frameshift at positions 191, 223 and 233. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti180 – 1801G → V in BAC34213. (PubMed:16141072)Curated
Sequence conflicti202 – 2032RA → P in AAG35725. 1 PublicationCurated
Sequence conflicti232 – 2321Q → H in AAG35725. 1 PublicationCurated
Sequence conflicti243 – 2431Q → E in BAB60708. (PubMed:11301316)Curated
Sequence conflicti453 – 4531R → K in BAB60708. (PubMed:11301316)Curated
Sequence conflicti455 – 4551V → M in AAH10482. (PubMed:15489334)Curated
Sequence conflicti499 – 4991S → C in BAC38404. (PubMed:16141072)Curated
Sequence conflicti566 – 5661P → H in BAB60708. (PubMed:11301316)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei544 – 56825LADPS…GMPEC → EWRRVCVGVGVLRGGVLTLV WSHAE in isoform 2. 1 PublicationVSP_051784Add
BLAST
Alternative sequencei569 – 66092Missing in isoform 2. 1 PublicationVSP_051785Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB056151 mRNA. Translation: BAB60708.1.
AK041886 mRNA. Translation: BAC31091.1.
AK050368 mRNA. Translation: BAC34213.1.
AK082078 mRNA. Translation: BAC38404.1.
AK167570 mRNA. Translation: BAE39633.1.
AK170542 mRNA. Translation: BAE41868.1.
AK170846 mRNA. Translation: BAE42069.1.
AL645808 Genomic DNA. Translation: CAI25647.1.
BC010482 mRNA. Translation: AAH10482.1.
BC058744 mRNA. Translation: AAH58744.1.
AF208046 mRNA. Translation: AAG35725.1. Frameshift.
CCDSiCCDS26427.1. [Q91XU0-1]
RefSeqiNP_084491.3. NM_030215.3. [Q91XU0-1]
UniGeneiMm.286680.

Genome annotation databases

EnsembliENSMUST00000021832; ENSMUSP00000021832; ENSMUSG00000021400. [Q91XU0-1]
GeneIDi78903.
KEGGimmu:78903.
UCSCiuc007pzs.2. mouse. [Q91XU0-2]
uc007pzt.2. mouse. [Q91XU0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB056151 mRNA. Translation: BAB60708.1 .
AK041886 mRNA. Translation: BAC31091.1 .
AK050368 mRNA. Translation: BAC34213.1 .
AK082078 mRNA. Translation: BAC38404.1 .
AK167570 mRNA. Translation: BAE39633.1 .
AK170542 mRNA. Translation: BAE41868.1 .
AK170846 mRNA. Translation: BAE42069.1 .
AL645808 Genomic DNA. Translation: CAI25647.1 .
BC010482 mRNA. Translation: AAH10482.1 .
BC058744 mRNA. Translation: AAH58744.1 .
AF208046 mRNA. Translation: AAG35725.1 . Frameshift.
CCDSi CCDS26427.1. [Q91XU0-1 ]
RefSeqi NP_084491.3. NM_030215.3. [Q91XU0-1 ]
UniGenei Mm.286680.

3D structure databases

ProteinModelPortali Q91XU0.
SMRi Q91XU0. Positions 12-46, 220-655.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 219695. 2 interactions.
IntActi Q91XU0. 2 interactions.
MINTi MINT-4113108.

PTM databases

PhosphoSitei Q91XU0.

Proteomic databases

MaxQBi Q91XU0.
PaxDbi Q91XU0.
PRIDEi Q91XU0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021832 ; ENSMUSP00000021832 ; ENSMUSG00000021400 . [Q91XU0-1 ]
GeneIDi 78903.
KEGGi mmu:78903.
UCSCi uc007pzs.2. mouse. [Q91XU0-2 ]
uc007pzt.2. mouse. [Q91XU0-1 ]

Organism-specific databases

CTDi 56897.
MGIi MGI:1926153. Wrnip1.

Phylogenomic databases

eggNOGi COG2256.
GeneTreei ENSGT00390000008538.
HOVERGENi HBG062192.
InParanoidi Q91XU0.
KOi K07478.
OMAi PGHWDAD.
OrthoDBi EOG744T8W.
PhylomeDBi Q91XU0.
TreeFami TF324547.

Miscellaneous databases

NextBioi 349714.
PROi Q91XU0.
SOURCEi Search...

Gene expression databases

Bgeei Q91XU0.
CleanExi MM_WRNIP1.
Genevestigatori Q91XU0.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR008921. DNA_pol3_clamp-load_cplx_C.
IPR021886. MgsA_C.
IPR027417. P-loop_NTPase.
IPR006642. Znf_Rad18_put.
[Graphical view ]
Pfami PF00004. AAA. 1 hit.
PF12002. MgsA_C. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM00734. ZnF_Rad18. 1 hit.
[Graphical view ]
SUPFAMi SSF48019. SSF48019. 1 hit.
SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel protein interacts with the Werner's syndrome gene product physically and functionally."
    Kawabe Y., Branzei D., Hayashi T., Suzuki H., Masuko T., Onoda F., Heo S.-J., Ikeda H., Shimamoto A., Furuichi Y., Seki M., Enomoto T.
    J. Biol. Chem. 276:20364-20369(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH WRN, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: C57BL/6Imported.
    Tissue: TestisImported.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Cerebellum, Liver, Placenta and Thymus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: Czech IIImported and FVB/N-3Imported.
    Tissue: Mammary glandImported.
  5. "Characterization of RuvB homologs in human and mouse."
    Shannon M., Ramirez M., Thelen M.P.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 182-660 (ISOFORM 1).
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiWRIP1_MOUSE
AccessioniPrimary (citable) accession number: Q91XU0
Secondary accession number(s): Q3TCT7
, Q6PDF0, Q8BUW5, Q8BWP6, Q8BY55, Q921W3, Q9EQL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: October 29, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3