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Reviewed, UniProtKB/Swiss-Prot Q91XT5 (BCDO1_RAT)

Last modified June 16, 2009. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Beta,beta-carotene 15,15'-monooxygenase
    EC=1.14.99.36
Alternative name(s):
    Beta-carotene dioxygenase 1
Gene names
Name: Bcmo1
Synonyms: Bcdo, Bcdo1
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

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Protein attributes

Sequence length566 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Symmetrically cleaves beta-carotene into two molecules of retinal. The reaction proceeds in three stages, epoxidation of the 15,15'-double bond, hydration of the double bond leading to ring opening, and oxidative cleavage of the diol formed By similarity.

Catalytic activity

Beta-carotene + O2 = 2 retinal.

Cofactor

Iron By similarity.

Pathway

Cofactor metabolism; retinol metabolism.

Sequence similarities

Belongs to the carotenoid oxygenase family.

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Ontologies

Keywords
   LigandIron
   Molecular functionDioxygenase
Oxidoreductase
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionbeta-carotene 15,15'-monooxygenase activity

Inferred from direct assay. Source: RGD

iron ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 566566Beta,beta-carotene 15,15'-monooxygenase
PRO_0000143935

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Sequences

Sequence LengthMass (Da)Tools
Q91XT5-1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: A1FF8A47BA6CE6E5

FASTA56663,637
        10         20         30         40         50         60 
MEIIFGRNKK EQLEPLRATV TGSIPAWLQG TLLRNGPGMH TVGDSKYNHW FDGLALLHSF 

        70         80         90        100        110        120 
SIRDGEVFYR SKYLQSDTYN ANIEANRIVV SEFGTMAYPD PCKNIFSKAF SYLSHTIPDF 

       130        140        150        160        170        180 
TDNCLINIMK CGEDFYATTE TNYIRKIDPQ TLETLEKVDY RKYVAVNLAT SHPHYDEAGN 

       190        200        210        220        230        240 
VLNMGTSIAD KGGTKYVMFK IPATAPGSKK KGKNPLKHSE VFCSIPSRSL LSPSYYHSFG 

       250        260        270        280        290        300 
VTENYVVFLE QPFKLDILKM ATAYMRGVSW ASCMTFCKED KTYIHIIDQK TRKPVPTKFY 

       310        320        330        340        350        360 
TDPMVVFHHV NAYEEDGCVL FDVIAYEDNS LYQLFYLANL NKDFEEKSRL TSVPTLRRFA 

       370        380        390        400        410        420 
VPLHVDKDAE VGSNLVKVSS TTATALKEKD DHVYCQPEVL YEGLELPRIN YAHNGKPYRY 

       430        440        450        460        470        480 
IFAAEVQWSP VPTKILKYDV LTKSSLKWSE ESCWPAEPLF VPTPGAKDED DGVILSAIIS 

       490        500        510        520        530        540 
TDPQKLPFLL ILDAKSFTEL ARASVDVDMH LDLHGLFIPD AGWNAVKQTP AKTQEDENSD 

       550        560 
HPTGLTAPGL GHGENDFTAG HGGKSL

« Hide

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References

[1]"Regulation of beta-carotene 15,15'-dioxygenase in oxidative stress."
Takitani K., Ban R., Tamai H.
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Intestine.

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Cross-references

Sequence databases

AB062912 mRNA. Translation: BAB60807.1.
IPIIPI00208162.
RefSeqNP_446100.1.
UniGeneRn.126587

3D structure databases

ModBaseSearch...

Proteomic databases

PRIDEQ91XT5.

Genome annotation databases

EnsemblENSRNOG00000012027. Rattus norvegicus. [Contig view]
GeneID114106.
KEGGrno:114106.

Organism-specific databases

RGD70981. Bcmo1.

Phylogenomic databases

HOVERGENQ91XT5.

Enzyme and pathway databases

BRENDA1.14.99.36. 248.

Gene expression databases

ArrayExpressQ91XT5.
GermOnlineENSRNOG00000012027. Rattus norvegicus.

Family and domain databases

InterProIPR004294. Carotenoid_Oase.
[Graphical view]
PANTHERPTHR10543. Carotenoid_Oase. 1 hit.
PfamPF03055. RPE65. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio618281.

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Entry information

Entry nameBCDO1_RAT
AccessionPrimary (citable) accession number: Q91XT5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 1, 2001
Last modified: June 16, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents