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Protein

Beta,beta-carotene 15,15'-dioxygenase

Gene

Bco1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism.By similarity

Catalytic activityi

Beta-carotene + O2 = 2 all-trans-retinal.By similarity

Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

Pathwayi: retinol metabolism

This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi172Iron; catalyticBy similarity1
Metal bindingi237Iron; catalyticBy similarity1
Metal bindingi308Iron; catalyticBy similarity1
Metal bindingi514Iron; catalyticBy similarity1

GO - Molecular functioni

  • beta-carotene 15,15'-monooxygenase activity Source: RGD
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • retinoid metabolic process Source: UniProtKB
  • retinol metabolic process Source: UniProtKB-UniPathway

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
LigandIron, Metal-binding

Enzyme and pathway databases

BRENDAi1.14.99.36 5301
UniPathwayiUPA00912

Names & Taxonomyi

Protein namesi
Recommended name:
Beta,beta-carotene 15,15'-dioxygenase (EC:1.13.11.63By similarity)
Alternative name(s):
Beta-carotene dioxygenase 1
Beta-carotene oxygenase 1Imported
Gene namesi
Name:Bco1Imported
Synonyms:Bcdo, Bcdo1, Bcmo1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi70981 Bco1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001439351 – 566Beta,beta-carotene 15,15'-dioxygenaseAdd BLAST566

Proteomic databases

PaxDbiQ91XT5
PRIDEiQ91XT5

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016880

Structurei

3D structure databases

SMRiQ91XT5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the carotenoid oxygenase family.Curated

Phylogenomic databases

eggNOGiKOG1285 Eukaryota
COG3670 LUCA
HOGENOMiHOG000232156
HOVERGENiHBG050679
InParanoidiQ91XT5
PhylomeDBiQ91XT5

Family and domain databases

InterProiView protein in InterPro
IPR004294 Carotenoid_Oase
PANTHERiPTHR10543 PTHR10543, 1 hit
PfamiView protein in Pfam
PF03055 RPE65, 1 hit

Sequencei

Sequence statusi: Complete.

Q91XT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIIFGRNKK EQLEPLRATV TGSIPAWLQG TLLRNGPGMH TVGDSKYNHW
60 70 80 90 100
FDGLALLHSF SIRDGEVFYR SKYLQSDTYN ANIEANRIVV SEFGTMAYPD
110 120 130 140 150
PCKNIFSKAF SYLSHTIPDF TDNCLINIMK CGEDFYATTE TNYIRKIDPQ
160 170 180 190 200
TLETLEKVDY RKYVAVNLAT SHPHYDEAGN VLNMGTSIAD KGGTKYVMFK
210 220 230 240 250
IPATAPGSKK KGKNPLKHSE VFCSIPSRSL LSPSYYHSFG VTENYVVFLE
260 270 280 290 300
QPFKLDILKM ATAYMRGVSW ASCMTFCKED KTYIHIIDQK TRKPVPTKFY
310 320 330 340 350
TDPMVVFHHV NAYEEDGCVL FDVIAYEDNS LYQLFYLANL NKDFEEKSRL
360 370 380 390 400
TSVPTLRRFA VPLHVDKDAE VGSNLVKVSS TTATALKEKD DHVYCQPEVL
410 420 430 440 450
YEGLELPRIN YAHNGKPYRY IFAAEVQWSP VPTKILKYDV LTKSSLKWSE
460 470 480 490 500
ESCWPAEPLF VPTPGAKDED DGVILSAIIS TDPQKLPFLL ILDAKSFTEL
510 520 530 540 550
ARASVDVDMH LDLHGLFIPD AGWNAVKQTP AKTQEDENSD HPTGLTAPGL
560
GHGENDFTAG HGGKSL
Length:566
Mass (Da):63,637
Last modified:December 1, 2001 - v1
Checksum:iA1FF8A47BA6CE6E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062912 mRNA Translation: BAB60807.1
UniGeneiRn.126587

Genome annotation databases

UCSCiRGD:70981 rat

Similar proteinsi

Entry informationi

Entry nameiBCDO1_RAT
AccessioniPrimary (citable) accession number: Q91XT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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