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Q91XT5

- BCDO1_RAT

UniProt

Q91XT5 - BCDO1_RAT

Protein

Beta,beta-carotene 15,15'-monooxygenase

Gene

Bcmo1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Symmetrically cleaves beta-carotene into two molecules of retinal. The reaction proceeds in three stages, epoxidation of the 15,15'-double bond, hydration of the double bond leading to ring opening, and oxidative cleavage of the diol formed By similarity.By similarity

    Catalytic activityi

    Beta-carotene + O2 = 2 all-trans-retinal.

    Cofactori

    Binds 1 Fe2+ ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi172 – 1721Iron; catalyticBy similarity
    Metal bindingi237 – 2371Iron; catalyticBy similarity
    Metal bindingi308 – 3081Iron; catalyticBy similarity
    Metal bindingi514 – 5141Iron; catalyticBy similarity

    GO - Molecular functioni

    1. beta-carotene 15,15'-monooxygenase activity Source: RGD
    2. metal ion binding Source: UniProtKB-KW
    3. monooxygenase activity Source: UniProtKB-KW

    GO - Biological processi

    1. retinoid metabolic process Source: UniProtKB
    2. retinol metabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00912.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta,beta-carotene 15,15'-monooxygenase (EC:1.14.99.36)
    Alternative name(s):
    Beta-carotene dioxygenase 1
    Gene namesi
    Name:Bcmo1
    Synonyms:Bcdo, Bcdo1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi70981. Bcmo1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 566566Beta,beta-carotene 15,15'-monooxygenasePRO_0000143935Add
    BLAST

    Proteomic databases

    PRIDEiQ91XT5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ91XT5.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000016880.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the carotenoid oxygenase family.Curated

    Phylogenomic databases

    eggNOGiCOG3670.
    HOGENOMiHOG000232156.
    HOVERGENiHBG050679.
    InParanoidiQ91XT5.
    PhylomeDBiQ91XT5.

    Family and domain databases

    InterProiIPR004294. Carotenoid_Oase.
    [Graphical view]
    PANTHERiPTHR10543. PTHR10543. 1 hit.
    PfamiPF03055. RPE65. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q91XT5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEIIFGRNKK EQLEPLRATV TGSIPAWLQG TLLRNGPGMH TVGDSKYNHW    50
    FDGLALLHSF SIRDGEVFYR SKYLQSDTYN ANIEANRIVV SEFGTMAYPD 100
    PCKNIFSKAF SYLSHTIPDF TDNCLINIMK CGEDFYATTE TNYIRKIDPQ 150
    TLETLEKVDY RKYVAVNLAT SHPHYDEAGN VLNMGTSIAD KGGTKYVMFK 200
    IPATAPGSKK KGKNPLKHSE VFCSIPSRSL LSPSYYHSFG VTENYVVFLE 250
    QPFKLDILKM ATAYMRGVSW ASCMTFCKED KTYIHIIDQK TRKPVPTKFY 300
    TDPMVVFHHV NAYEEDGCVL FDVIAYEDNS LYQLFYLANL NKDFEEKSRL 350
    TSVPTLRRFA VPLHVDKDAE VGSNLVKVSS TTATALKEKD DHVYCQPEVL 400
    YEGLELPRIN YAHNGKPYRY IFAAEVQWSP VPTKILKYDV LTKSSLKWSE 450
    ESCWPAEPLF VPTPGAKDED DGVILSAIIS TDPQKLPFLL ILDAKSFTEL 500
    ARASVDVDMH LDLHGLFIPD AGWNAVKQTP AKTQEDENSD HPTGLTAPGL 550
    GHGENDFTAG HGGKSL 566
    Length:566
    Mass (Da):63,637
    Last modified:December 1, 2001 - v1
    Checksum:iA1FF8A47BA6CE6E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB062912 mRNA. Translation: BAB60807.1.
    UniGeneiRn.126587.

    Genome annotation databases

    UCSCiRGD:70981. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB062912 mRNA. Translation: BAB60807.1 .
    UniGenei Rn.126587.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000016880.

    Proteomic databases

    PRIDEi Q91XT5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:70981. rat.

    Organism-specific databases

    RGDi 70981. Bcmo1.

    Phylogenomic databases

    eggNOGi COG3670.
    HOGENOMi HOG000232156.
    HOVERGENi HBG050679.
    InParanoidi Q91XT5.
    PhylomeDBi Q91XT5.

    Enzyme and pathway databases

    UniPathwayi UPA00912 .

    Miscellaneous databases

    NextBioi 618281.
    PROi Q91XT5.

    Gene expression databases

    Genevestigatori Q91XT5.

    Family and domain databases

    InterProi IPR004294. Carotenoid_Oase.
    [Graphical view ]
    PANTHERi PTHR10543. PTHR10543. 1 hit.
    Pfami PF03055. RPE65. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regulation of beta-carotene 15,15'-dioxygenase in oxidative stress."
      Takitani K., Ban R., Tamai H.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Intestine.

    Entry informationi

    Entry nameiBCDO1_RAT
    AccessioniPrimary (citable) accession number: Q91XT5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3