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Q91XT5 (BCDO1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta,beta-carotene 15,15'-monooxygenase

EC=1.14.99.36
Alternative name(s):
Beta-carotene dioxygenase 1
Gene names
Name:Bcmo1
Synonyms:Bcdo, Bcdo1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length566 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Symmetrically cleaves beta-carotene into two molecules of retinal. The reaction proceeds in three stages, epoxidation of the 15,15'-double bond, hydration of the double bond leading to ring opening, and oxidative cleavage of the diol formed By similarity.

Catalytic activity

Beta-carotene + O2 = 2 all-trans-retinal.

Cofactor

Binds 1 Fe2+ ion per subunit By similarity.

Pathway

Cofactor metabolism; retinol metabolism.

Sequence similarities

Belongs to the carotenoid oxygenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 566566Beta,beta-carotene 15,15'-monooxygenase
PRO_0000143935

Sites

Metal binding1721Iron; catalytic By similarity
Metal binding2371Iron; catalytic By similarity
Metal binding3081Iron; catalytic By similarity
Metal binding5141Iron; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
Q91XT5 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: A1FF8A47BA6CE6E5

FASTA56663,637
        10         20         30         40         50         60 
MEIIFGRNKK EQLEPLRATV TGSIPAWLQG TLLRNGPGMH TVGDSKYNHW FDGLALLHSF 

        70         80         90        100        110        120 
SIRDGEVFYR SKYLQSDTYN ANIEANRIVV SEFGTMAYPD PCKNIFSKAF SYLSHTIPDF 

       130        140        150        160        170        180 
TDNCLINIMK CGEDFYATTE TNYIRKIDPQ TLETLEKVDY RKYVAVNLAT SHPHYDEAGN 

       190        200        210        220        230        240 
VLNMGTSIAD KGGTKYVMFK IPATAPGSKK KGKNPLKHSE VFCSIPSRSL LSPSYYHSFG 

       250        260        270        280        290        300 
VTENYVVFLE QPFKLDILKM ATAYMRGVSW ASCMTFCKED KTYIHIIDQK TRKPVPTKFY 

       310        320        330        340        350        360 
TDPMVVFHHV NAYEEDGCVL FDVIAYEDNS LYQLFYLANL NKDFEEKSRL TSVPTLRRFA 

       370        380        390        400        410        420 
VPLHVDKDAE VGSNLVKVSS TTATALKEKD DHVYCQPEVL YEGLELPRIN YAHNGKPYRY 

       430        440        450        460        470        480 
IFAAEVQWSP VPTKILKYDV LTKSSLKWSE ESCWPAEPLF VPTPGAKDED DGVILSAIIS 

       490        500        510        520        530        540 
TDPQKLPFLL ILDAKSFTEL ARASVDVDMH LDLHGLFIPD AGWNAVKQTP AKTQEDENSD 

       550        560 
HPTGLTAPGL GHGENDFTAG HGGKSL 

« Hide

References

[1]"Regulation of beta-carotene 15,15'-dioxygenase in oxidative stress."
Takitani K., Ban R., Tamai H.
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Intestine.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB062912 mRNA. Translation: BAB60807.1.
UniGeneRn.126587.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000016880.

Proteomic databases

PRIDEQ91XT5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:70981. rat.

Organism-specific databases

RGD70981. Bcmo1.

Phylogenomic databases

eggNOGCOG3670.
HOGENOMHOG000232156.
HOVERGENHBG050679.
InParanoidQ91XT5.
PhylomeDBQ91XT5.

Enzyme and pathway databases

UniPathwayUPA00912.

Gene expression databases

GenevestigatorQ91XT5.

Family and domain databases

InterProIPR004294. Carotenoid_Oase.
[Graphical view]
PANTHERPTHR10543. PTHR10543. 1 hit.
PfamPF03055. RPE65. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio618281.
PROQ91XT5.

Entry information

Entry nameBCDO1_RAT
AccessionPrimary (citable) accession number: Q91XT5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways