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Q91XT5

- BCDO1_RAT

UniProt

Q91XT5 - BCDO1_RAT

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Protein
Beta,beta-carotene 15,15'-monooxygenase
Gene
Bcmo1, Bcdo, Bcdo1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Symmetrically cleaves beta-carotene into two molecules of retinal. The reaction proceeds in three stages, epoxidation of the 15,15'-double bond, hydration of the double bond leading to ring opening, and oxidative cleavage of the diol formed By similarity.

Catalytic activityi

Beta-carotene + O2 = 2 all-trans-retinal.

Cofactori

Binds 1 Fe2+ ion per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi172 – 1721Iron; catalytic By similarity
Metal bindingi237 – 2371Iron; catalytic By similarity
Metal bindingi308 – 3081Iron; catalytic By similarity
Metal bindingi514 – 5141Iron; catalytic By similarity

GO - Molecular functioni

  1. beta-carotene 15,15'-monooxygenase activity Source: RGD
  2. metal ion binding Source: UniProtKB-KW
  3. monooxygenase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. retinoid metabolic process Source: UniProtKB
  2. retinol metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta,beta-carotene 15,15'-monooxygenase (EC:1.14.99.36)
Alternative name(s):
Beta-carotene dioxygenase 1
Gene namesi
Name:Bcmo1
Synonyms:Bcdo, Bcdo1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi70981. Bcmo1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 566566Beta,beta-carotene 15,15'-monooxygenase
PRO_0000143935Add
BLAST

Proteomic databases

PRIDEiQ91XT5.

Expressioni

Gene expression databases

GenevestigatoriQ91XT5.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016880.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG3670.
HOGENOMiHOG000232156.
HOVERGENiHBG050679.
InParanoidiQ91XT5.
PhylomeDBiQ91XT5.

Family and domain databases

InterProiIPR004294. Carotenoid_Oase.
[Graphical view]
PANTHERiPTHR10543. PTHR10543. 1 hit.
PfamiPF03055. RPE65. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91XT5-1 [UniParc]FASTAAdd to Basket

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MEIIFGRNKK EQLEPLRATV TGSIPAWLQG TLLRNGPGMH TVGDSKYNHW    50
FDGLALLHSF SIRDGEVFYR SKYLQSDTYN ANIEANRIVV SEFGTMAYPD 100
PCKNIFSKAF SYLSHTIPDF TDNCLINIMK CGEDFYATTE TNYIRKIDPQ 150
TLETLEKVDY RKYVAVNLAT SHPHYDEAGN VLNMGTSIAD KGGTKYVMFK 200
IPATAPGSKK KGKNPLKHSE VFCSIPSRSL LSPSYYHSFG VTENYVVFLE 250
QPFKLDILKM ATAYMRGVSW ASCMTFCKED KTYIHIIDQK TRKPVPTKFY 300
TDPMVVFHHV NAYEEDGCVL FDVIAYEDNS LYQLFYLANL NKDFEEKSRL 350
TSVPTLRRFA VPLHVDKDAE VGSNLVKVSS TTATALKEKD DHVYCQPEVL 400
YEGLELPRIN YAHNGKPYRY IFAAEVQWSP VPTKILKYDV LTKSSLKWSE 450
ESCWPAEPLF VPTPGAKDED DGVILSAIIS TDPQKLPFLL ILDAKSFTEL 500
ARASVDVDMH LDLHGLFIPD AGWNAVKQTP AKTQEDENSD HPTGLTAPGL 550
GHGENDFTAG HGGKSL 566
Length:566
Mass (Da):63,637
Last modified:December 1, 2001 - v1
Checksum:iA1FF8A47BA6CE6E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB062912 mRNA. Translation: BAB60807.1.
UniGeneiRn.126587.

Genome annotation databases

UCSCiRGD:70981. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB062912 mRNA. Translation: BAB60807.1 .
UniGenei Rn.126587.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000016880.

Proteomic databases

PRIDEi Q91XT5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:70981. rat.

Organism-specific databases

RGDi 70981. Bcmo1.

Phylogenomic databases

eggNOGi COG3670.
HOGENOMi HOG000232156.
HOVERGENi HBG050679.
InParanoidi Q91XT5.
PhylomeDBi Q91XT5.

Enzyme and pathway databases

UniPathwayi UPA00912 .

Miscellaneous databases

NextBioi 618281.
PROi Q91XT5.

Gene expression databases

Genevestigatori Q91XT5.

Family and domain databases

InterProi IPR004294. Carotenoid_Oase.
[Graphical view ]
PANTHERi PTHR10543. PTHR10543. 1 hit.
Pfami PF03055. RPE65. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Regulation of beta-carotene 15,15'-dioxygenase in oxidative stress."
    Takitani K., Ban R., Tamai H.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Intestine.

Entry informationi

Entry nameiBCDO1_RAT
AccessioniPrimary (citable) accession number: Q91XT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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