Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q91XT5

- BCDO1_RAT

UniProt

Q91XT5 - BCDO1_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Beta,beta-carotene 15,15'-monooxygenase

Gene

Bco1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Symmetrically cleaves beta-carotene into two molecules of retinal. The reaction proceeds in three stages, epoxidation of the 15,15'-double bond, hydration of the double bond leading to ring opening, and oxidative cleavage of the diol formed (By similarity).By similarity

Catalytic activityi

Beta-carotene + O2 = 2 all-trans-retinal.

Cofactori

Fe2+By similarityNote: Binds 1 Fe(2+) ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi172 – 1721Iron; catalyticBy similarity
Metal bindingi237 – 2371Iron; catalyticBy similarity
Metal bindingi308 – 3081Iron; catalyticBy similarity
Metal bindingi514 – 5141Iron; catalyticBy similarity

GO - Molecular functioni

  1. beta-carotene 15,15'-monooxygenase activity Source: RGD
  2. metal ion binding Source: UniProtKB-KW
  3. monooxygenase activity Source: UniProtKB-KW

GO - Biological processi

  1. retinoid metabolic process Source: UniProtKB
  2. retinol metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta,beta-carotene 15,15'-monooxygenase (EC:1.14.99.36)
Alternative name(s):
Beta-carotene dioxygenase 1
Beta-carotene oxygenase 1Imported
Gene namesi
Name:Bco1Imported
Synonyms:Bcdo, Bcdo1, Bcmo1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi70981. Bco1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 566566Beta,beta-carotene 15,15'-monooxygenasePRO_0000143935Add
BLAST

Proteomic databases

PRIDEiQ91XT5.

Expressioni

Gene expression databases

GenevestigatoriQ91XT5.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016880.

Family & Domainsi

Sequence similaritiesi

Belongs to the carotenoid oxygenase family.Curated

Phylogenomic databases

eggNOGiCOG3670.
HOGENOMiHOG000232156.
HOVERGENiHBG050679.
InParanoidiQ91XT5.
PhylomeDBiQ91XT5.

Family and domain databases

InterProiIPR004294. Carotenoid_Oase.
[Graphical view]
PANTHERiPTHR10543. PTHR10543. 1 hit.
PfamiPF03055. RPE65. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q91XT5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEIIFGRNKK EQLEPLRATV TGSIPAWLQG TLLRNGPGMH TVGDSKYNHW
60 70 80 90 100
FDGLALLHSF SIRDGEVFYR SKYLQSDTYN ANIEANRIVV SEFGTMAYPD
110 120 130 140 150
PCKNIFSKAF SYLSHTIPDF TDNCLINIMK CGEDFYATTE TNYIRKIDPQ
160 170 180 190 200
TLETLEKVDY RKYVAVNLAT SHPHYDEAGN VLNMGTSIAD KGGTKYVMFK
210 220 230 240 250
IPATAPGSKK KGKNPLKHSE VFCSIPSRSL LSPSYYHSFG VTENYVVFLE
260 270 280 290 300
QPFKLDILKM ATAYMRGVSW ASCMTFCKED KTYIHIIDQK TRKPVPTKFY
310 320 330 340 350
TDPMVVFHHV NAYEEDGCVL FDVIAYEDNS LYQLFYLANL NKDFEEKSRL
360 370 380 390 400
TSVPTLRRFA VPLHVDKDAE VGSNLVKVSS TTATALKEKD DHVYCQPEVL
410 420 430 440 450
YEGLELPRIN YAHNGKPYRY IFAAEVQWSP VPTKILKYDV LTKSSLKWSE
460 470 480 490 500
ESCWPAEPLF VPTPGAKDED DGVILSAIIS TDPQKLPFLL ILDAKSFTEL
510 520 530 540 550
ARASVDVDMH LDLHGLFIPD AGWNAVKQTP AKTQEDENSD HPTGLTAPGL
560
GHGENDFTAG HGGKSL
Length:566
Mass (Da):63,637
Last modified:December 1, 2001 - v1
Checksum:iA1FF8A47BA6CE6E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062912 mRNA. Translation: BAB60807.1.
UniGeneiRn.126587.

Genome annotation databases

UCSCiRGD:70981. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062912 mRNA. Translation: BAB60807.1 .
UniGenei Rn.126587.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000016880.

Proteomic databases

PRIDEi Q91XT5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:70981. rat.

Organism-specific databases

RGDi 70981. Bco1.

Phylogenomic databases

eggNOGi COG3670.
HOGENOMi HOG000232156.
HOVERGENi HBG050679.
InParanoidi Q91XT5.
PhylomeDBi Q91XT5.

Enzyme and pathway databases

UniPathwayi UPA00912 .

Miscellaneous databases

NextBioi 618281.
PROi Q91XT5.

Gene expression databases

Genevestigatori Q91XT5.

Family and domain databases

InterProi IPR004294. Carotenoid_Oase.
[Graphical view ]
PANTHERi PTHR10543. PTHR10543. 1 hit.
Pfami PF03055. RPE65. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Regulation of beta-carotene 15,15'-dioxygenase in oxidative stress."
    Takitani K., Ban R., Tamai H.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Intestine.

Entry informationi

Entry nameiBCDO1_RAT
AccessioniPrimary (citable) accession number: Q91XT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 1, 2001
Last modified: November 26, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3